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Read the whole article here: http://multiplesclerosisnewstoday.com/2014/06/12/researchers-report-alternate-explanation-discovery-ccsvi-treatment-works-ms-patients/ Researchers Report Alternate Explanation Discovery Of How And Why CCSVI Treatment Works In MS Patients M.A. My question - what exactly ...

..... Such modified endothelial cell structure has been observed microscopically in the regions of scleroses and has been related to increased leakage of autoimmune cells. ..........................would result in a bad combination, increased porosity of the BBB and increased hypertension at the sa...

This is an incredible recent article in the New York Times that I think could have implications for future MS treatments, and may dovetail well with the idea that CCSVI treatment may work at least in part by stimulating the vagus nerve. In a recent pilot study on people with rheumatoid arthritis (a...

http://www.medscape.com/viewarticle/826467 "Perhaps the most striking finding in our study was the range of venous outflow anomalies detected that did not reflect pathology, but instead demonstrated the large natural variance in intracranial and extra-cranial venous anatomy," write the au...

........My view is that the CCSVI scientific community is getting quite close to providing a most persuasive description of all the major processes that underlie the mechanics of autoimmune attack on myelin, but it will only be persuasive to those who have the willingness to broaden their focus fro...

I looked this up. It seems that veins do have smooth muscle but far less than arteries. If someone who knows anatomy could please add an explanation. The usual pharmacological info is that calcium channel blockers work on arteries. MarkW Vein Structure The structure of veins is similar to that of ar...

Amlodipine is a calcium channel blocker often prescribed to lower blood pressure since it causes arterial dilation by relaxing smooth muscle. Do you think that amlodipine could help MS patients with CCSVI by potentially increasing cerebral perfusion? Hello NHE, The pharmacology of this does not see...

................I'm a very logical person, an engineer by trade and training. Like many others the inconsistencies in this disease drive me nuts and I've only just begun. I can't imagine the mental fortitude in the people that have been at if for years. Hello RuralLaundry, My pharmacy specialisatio...

Happy reading.......................MarkW Arq. Neuro-Psiquiatr. vol.72 no.2 São Paulo Feb. 2014 http://dx.doi.org/10.1590/0004-282X20130252 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000200152&lng=en&nrm=iso&tlng=en Guidelines Supplementation and therapeutic...

I won't be deciding what the scientists conducting these studies decide is the right approach.............We may be looking at this from slightly different perspectives. I agree completely that simplifying things is key to understanding how the independent variable (calcitriol and D3 doses) effect ...

My advice is to conduct 'proof of concept' trial in women with MS, which is a pharma industry approach. MarkW So far a handful of people have tested various doses of calcitriol. All are males with a progressive form of MS. All have seen positive changes which hold for approximately 3 months at whic...

Glad you had the Spanish adventure, Mark! As Dr. Weller discusses in his TED talk, you don't get the same thing from vitamin D---It's the way the UV rays release nitrates from our skin, and this in turn releases Treg cells from lymph nodes. Has to be rays from the sun or a special lamp via dendriti...

from minute 41 onward I talk about Vitamin D, and why I don’t like to see blood levels above 40. - See more at: http://truttmd.com/who-the-heck-is-paul-offit/#sthash.x3zR6OZa.dpuf There are a number of criticisms of the conclusions drawn by IOM from the NHANES all cause mortality data, particularly...

The sun is free. No prescription needed. 10-15 minutes of sunshine or UVB phototherapy sends Treg cells flowing from the lymph nodes to sites of inflammation in people with MS. People with MS had symptom relief in a study completed by German neurologists and published last week. Regulatory T cells ...

I was amused by your condescending statement below. Instead of replying I went back to topping up my Vit D3 levels on a sun-lounger in Spain. My advice, like that given by Squeakycat, is taken from peer reviewed journals, a much more reliable source of data than 'books'. I do my 'homework' in Oxford...