Search found 602 matches

by TwistedHelix
Fri Oct 03, 2008 4:36 am
Forum: General Discussion
Topic: Significant changes in MS brain blood flow
Replies: 8
Views: 4494

… Sort of takes us all the way back to the, " MS as a vascular disease", and, " MS and headaches", threads. It can't just be us who can see these patterns emerging, can it?

By the way, does anyone else keep reading, "salvia", as, "saliva"?
by TwistedHelix
Fri Oct 03, 2008 4:24 am
Forum: General Discussion
Topic: Personality aspects in multiple sclerosis
Replies: 21
Views: 5499

Bob, welcome to the Catheter Club! I've had a Foley in for over four years now and it does gradually get easier, although your week-long trial membership might not give it enough of a chance. I'm glad you got the operation over with, though. On the very first day that I had one fitted I ended up hav...
by TwistedHelix
Thu Oct 02, 2008 7:03 am
Forum: General Discussion
Topic: TREM-2 "in the wrong place"
Replies: 1
Views: 2077

TREM-2 "in the wrong place"

TREM-2 has previously been thought to play a role in MS. Now it has been found in the spinal fluid of MS patients: A protein that helps keep immune cells quiet is more abundant in the spinal fluid of patients with multiple sclerosis (MS), further boosting suspicion that the protein, TREM-2, may be a...
by TwistedHelix
Thu Oct 02, 2008 6:52 am
Forum: General Discussion
Topic: Quick test for MS
Replies: 5
Views: 2548

Quick test for MS

This could be an interesting development: one of the big problems with MS has been a suspicion that the disease process begins years or even decades before symptoms show. If that is what happens, we could be missing crucial points where intervention might be possible, or which at least might give us...
by TwistedHelix
Thu Oct 02, 2008 6:17 am
Forum: General Discussion
Topic: Hypercoagulation
Replies: 33
Views: 8655

it is a complicated syndrome involving a number of problems and co factors, mainly bacterial and also viral overgrowth in an otherwise susceptible person. 'Susceptible' is clearly partly genetics, possibly stress and it appears some nutritional factors (like vitamin d) that all come together in a p...
by TwistedHelix
Fri Sep 26, 2008 5:49 am
Forum: General Discussion
Topic: Naked clowns
Replies: 29
Views: 5748

Well, MS stopped at least one clown from performing, so at least that proves it's not all bad.

I've never been a clown, but the sight of me naked has often made people laugh. I wonder why that is?
by TwistedHelix
Fri Sep 26, 2008 5:39 am
Forum: General Discussion
Topic: Personality aspects in multiple sclerosis
Replies: 21
Views: 5499

Yes, Terry, that other thread got a bit heated, didn't it? I believe there is an enormous gulf between the phrases "caused by the mind", and, "all in the mind" but a lot of people hear the first phrase and assume it means the second. It's really difficult to find a suitable analo...
by TwistedHelix
Thu Sep 25, 2008 7:04 am
Forum: General Discussion
Topic: MRI'S
Replies: 18
Views: 4694

As you can see, this kind of thing seems to vary a lot from region to region and between individual doctors, so perhaps it's worth having a chat with him to see what his reasoning is. Some of them feel that, because lesion load has little correlation with disability, it's not really worth doing; oth...
by TwistedHelix
Thu Sep 25, 2008 6:42 am
Forum: General Discussion
Topic: Personality aspects in multiple sclerosis
Replies: 21
Views: 5499

Bags I get the services of Sherpa Lyon for the climb! All this talk about personality and brain structure has got me thinking: supposing regenerative medicine comes up trumps and you were offered the chance of growing a whole bundle of new nerve cells to repair the damage, but that it was highly lik...
by TwistedHelix
Thu Sep 25, 2008 5:35 am
Forum: General Discussion
Topic: Personality aspects in multiple sclerosis
Replies: 21
Views: 5499

I think there is a fundamental misunderstanding when talking about this subject which is why people get annoyed when they hear it: "stress" can be categorised as almost any emotional response to a stimulus, (it doesn't even have to be particularly negative), which causes, as all emotions d...
by TwistedHelix
Wed Sep 24, 2008 4:28 am
Forum: General Discussion
Topic: Personality aspects in multiple sclerosis
Replies: 21
Views: 5499

Hi Terry,
In my extensive studies of supervillains and their evil henchmen it seems it is possible to love yourself and hate the entire rest of humanity, so I presume the opposite must be equally possible!

BTW, still listening to the music?
by TwistedHelix
Tue Sep 23, 2008 5:32 am
Forum: General Discussion
Topic: Exciting
Replies: 4
Views: 2039

I know what you mean, Cure, but it might not be as bleak as that. Lingo 1 is part of the receptor complex which binds Nogo, and when Nogo binds it activates RhoA. This is a major inhibitor of axonal growth, so it might just be that controlling Lingo 1 will release the brakes on axonal regeneration. ...
by TwistedHelix
Tue Sep 23, 2008 4:42 am
Forum: General Discussion
Topic: Personality aspects in multiple sclerosis
Replies: 21
Views: 5499

Hi Thomas, I'm just catching up on TIMS having been preoccupied over the last few weeks with sinusitis, a stinking cold and some family problems, so I've just read your post. I too recognise myself in those psychological descriptions: I've always hated myself; never actually felt happy or satisfied,...
by TwistedHelix
Mon Sep 01, 2008 4:30 am
Forum: General Discussion
Topic: "Extreme makeover " for cells
Replies: 1
Views: 1892

"Extreme makeover " for cells

This looks like an exciting breakthrough and a promising new path for regenerative medicine to go down:

http://www.washingtonpost.com/wp-dyn/co ... 01829.html
by TwistedHelix
Mon Sep 01, 2008 4:14 am
Forum: General Discussion
Topic: Amantadine
Replies: 18
Views: 4886

Hi Cure, There are several types of antiviral drug, which interfere with different stages of the viral lifecycle. Amantadine works by blocking receptor proteins on the cell surface, thereby preventing the virus from entering the cell in the first place. I was wondering if somehow these " mother...

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