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A recent report discovered a surprising amount of micro and nanoplastics in bottled water. https://www.npr.org/2024/01/10/1223730333/bottled-water-plastic-microplastic-nanoplastic-study Now we learn that these plastics are not inert and can also be found to accumulate in the vascular system contribu...

Neuroprotective effects of berry fruits on neurodegenerative diseases Neural Regen Res. 2014 Aug 15;9(16):1557-66. Recent clinical research has demonstrated that berry fruits can prevent age-related neurodegenerative diseases and improve motor and cognitive functions. The berry fruits are also capa...

This is the Saccharomyces boulardii probiotic I just ordered and received. 200 billion CFU , priced right at $24 - an exceptional value. https://www.amazon.com/dp/B0CLKF5NWP Some of the reviews aren't so good. I bought these to make fermented probiotic apple juice. After 48 hours there is zero ferm...

Keep in mind while billions of anything sounds like a lot, the population of bacteria in the gut is in the multiple trillions . Just for clarity, Saccharomyces boulardii is a yeast. The study posted used a S. boulardii supplement with just 1010 CFUs. In addition, I read a paper some time ago that s...

Perspective: The Impact of Fasting and Caloric Restriction on Neurodegenerative Diseases in Humans Adv Nutr. 2024 Mar 1:100197. Neurodegenerative diseases (ND) are characterized by the progressive functional and structural denaturation of neurons in the central and peripheral nervous systems. Despi...

Here's a good example with 5 billion CFUs.

Saccharomyces boulardii

More info... https://www.neurologylive.com/view/clemastine-arm-trap-ms-trial-halted-following-increased-disability-accumulation-progressive-ms In the trial, investigators halted the clemastine arm because of 3 participants who increased in disability 5-times faster than compared with 18-month “basel...

Study Reveals Side Effects of COVID-19 Vaccines COVID-19 vaccines produce some very serious side effects such as Guillain Barré syndrome, but for the most part these are rare. Terry Graedon - February 29, 2024 https://www.peoplespharmacy.com/articles/study-reveals-side-effects-of-covid-19-vaccines ...

This is from 2019. What Athletes Should Know About AICAR and Other Prohibited AMP Activated Protein Kinase Activators Education, Spirit of Sport / November 14, 2019 https://www.usada.org/spirit-of-sport/education/aicar-and-other-prohibited-amp-activated-protein-kinase-activators/ In recent years, AI...

Inhibition of CD40L with Frexalimab in Multiple Sclerosis N Engl J Med. 2024 Feb 15;390(7):589-600. Background : The CD40-CD40L costimulatory pathway regulates adaptive and innate immune responses and has been implicated in the pathogenesis of multiple sclerosis. Frexalimab is a second-generation a...

This paper from 2018 focused on MS (EAE). Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis Nature Commun. 2018 Oct 8;9(1):4126. Multiple Sclerosis (MS) is characterized by focal CNS inflammation leading to the death of oligodendrocytes (OLs...

A list of NervGen's relevant publications.

https://nervgen.com/journals-publications/

Lymph node targeted multi-epitope subunit vaccine promotes effective immunity to EBV in HLA-expressing mice Nat Commun. 2023 Aug 8;14(1):4371. The recent emergence of a causal link between Epstein-Barr virus (EBV) and multiple sclerosis has generated considerable interest in the development of an e...

First-Ever Vaccine Candidate Against Epstein-Barr Delivers Promising Results August 9, 2023 by David Nield https://www.sciencealert.com/first-ever-vaccine-candidate-against-epstein-barr-delivers-promising-results Researchers have made a significant breakthrough in the development of the first-ever ...

Here's an interview with the two founders of NervGen and the CEO. They discuss the background science leading to the development of NVG-291, the design of the current phase 1b-2a trial and plans for a larger phase 2 trial.