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Free review article. Epstein–Barr virus and multiple sclerosis: moving from questions of association to questions of mechanism https://onlinelibrary.wiley.com/doi/10.1002/cti2.1451 Excerpt Whilst it has been suspected for many years that molecular mimicry with self-antigens may be driving elevations...

https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.202250228 Emerging Imaging and Liquid Biomarkers in Multiple Sclerosis Abstract The advent of highly-effective disease modifying therapy has transformed the landscape of multiple sclerosis (MS) care over the last two decades. However, there remain...

Identification of neuropathology-based subgroups in MS https://www.medrxiv.org/content/10.1101/2023.05.15.23289980v1 Abstract Multiple sclerosis (MS) is a heterogeneous disorder with regards to clinical presentation and pathophysiology. Stratification into biologically distinct subgroups could enha...

EBNA1 is a EBV protein with several interesting segments: Some of them mimic the human proteins ANO2, GlialCam or CRYAB. Maybe other segments mimic other proteins. Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis https://www.science.org/doi/full/10.1...

A Predictive Autoantibody Signature in Multiple Sclerosis https://www.medrxiv.org/content/10.1101/2023.05.01.23288943v1 Abstract Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remains elusive. Here, the Department of Defense Serum...

A Predictive Autoantibody Signature in Multiple Sclerosis https://www.medrxiv.org/content/10.1101/2023.05.01.23288943v1 Abstract Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remains elusive. Here, the Department of Defense Serum...

Modulation of microglial metabolism facilitates regeneration https://www.sciencedirect.com/science/article/pii/S258900422300665X Highlights ● Microglia loaded with lipid adopt a phagocytosis-enhanced microglia (PEMs) phenotype. ● Rosiglitazone helps microglia adopt myelination-associated microglia ...

Chat GPT says this. Can plasma IgG antibodies form large aggregates? Yes, under certain conditions, plasma IgG antibodies can form large aggregates or immune complexes. Immune complexes are formed when antibodies bind to antigens, such as those found on the surface of pathogens, and then come togeth...

Multiple sclerosis plasma IgG aggregates induce complement-dependent neuronal apoptosis https://www.nature.com/articles/s41419-023-05783-3 Abstract Grey matter pathology is central to the progression of multiple sclerosis (MS). We discovered that MS plasma immunoglobulin G (IgG) antibodies, mainly ...

Progressive MS is associated with subpial type 3 lesions

https://www.mdpi.com/2227-9059/11/3/945

Progressive multiple sclerosis (MS) is a chronic disease with a unique pattern, which is histologically classified into the subpial type 3 lesions in the autopsy.

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Proteomics profiling reveals biomarkers for predicting diagnosis, disease activity and long-term ... https://assets.researchsquare.com/files/rs-2678518/v1/999b8ffa7e4e6ad5d926f7fc.pdf?c=1678947930 In summary, the 52 CSF proteins identified in the bigger discovery cohort represent a set of proteins ...

Diagnostic, Prognostic, and Disease Activity Biomarkers in Multiple Sclerosis https://gupea.ub.gu.se/handle/2077/74509 Abstract Multiple sclerosis (MS) is the most common immune-mediated disease of the central nervous system. While benign cases exist, if left untreated, MS results in the compoundin...

Not MS but somehow relates

https://www.nature.com/articles/s41467-023-36023-z

From bedside to bench: how existing therapies inform the relationship between Epstein–Barr virus and multiple sclerosis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947628/ Abstract Therapy for relapsing–remitting multiple sclerosis (MS) has advanced dramatically despite incomplete understanding o...

Cerebrospinal fluid–related tissue damage in multiple sclerosis patients with iron rim lesions https://journals.sagepub.com/doi/full/10.1177/13524585231155639 Background : In multiple sclerosis (MS), iron rim lesions (IRLs) are associated with pronounced tissue damage, higher disease severity and h...