Search found 1747 matches
- Wed Feb 22, 2023 1:09 am
- Forum: MS Etiology and Pathogenesis
- Topic: Disordered immune system and lipid metabolism in MS
- Replies: 1
- Views: 1399
Re: Disordered immune system and lipid metabolism in MS
Ceramide is implicated in humoral peripheral and intrathecal autoimmune response in MS patients https://www.sciencedirect.com/science/article/pii/S221103482300069X Highlights • Increased levels of anti-ceramide IgG were detected in cerebrospinal fluid and serum of patients with multiple sclerosis. ...
- Fri Feb 17, 2023 4:43 am
- Forum: MS Etiology and Pathogenesis
- Topic: closer to a blood test for diagnosis
- Replies: 0
- Views: 1445
closer to a blood test for diagnosis
ATR-FTIR spectroscopy of plasma supported by multivariate analysis discriminates multiple sclerosis disease https://www.nature.com/articles/s41598-023-29617-6 Abstract Multiple sclerosis (MS) is one of the most common neurodegenerative diseases showing various symptoms both of physical and cognitiv...
- Mon Feb 13, 2023 5:00 am
- Forum: MS Etiology and Pathogenesis
- Topic: MRZ reaction updated
- Replies: 0
- Views: 713
MRZ reaction updated
MRZ reaction refers to Measles-Rubella-Zoster viruses for diagnosis. An improved set has been proposed. Antibodies to expanded virus antigen panels show elevated diagnostic sensitivities in multiple sclerosis and optic neuritis https://www.sciencedirect.com/science/article/abs/pii/S0165247823000226 ...
- Sat Jan 28, 2023 4:10 am
- Forum: MS Etiology and Pathogenesis
- Topic: Tissue-resident memory t cells
- Replies: 0
- Views: 863
Tissue-resident memory t cells
Tissue-resident memory t cells https://www.sciencedirect.com/science/article/pii/S016557282300022X Abstract Presence of EBV infected B cells and EBV-specific CD8 T cells in the multiple sclerosis (MS) brain suggests a role for virus-driven immunopathology in brain inflammation. Tissue-resident memo...
- Thu Jan 26, 2023 1:03 am
- Forum: MS Etiology and Pathogenesis
- Topic: An order for the MS spectrum
- Replies: 0
- Views: 740
An order for the MS spectrum
These authors expand the classification for atypical MS to 4 new variants, according to the lesion type: - Classic atypical MS : infiltrative, megacystic, Baló’s-like, and ring-like - New atypical MS : Tumefactive demyelinating lesion (TDL)-onset MS, Acute disseminated encephalomyelitis (ADEM)-like ...
- Wed Jan 25, 2023 4:42 am
- Forum: MS Etiology and Pathogenesis
- Topic: Iron rim in lesions (smouldering MS) associated to CSF profile
- Replies: 0
- Views: 1103
Iron rim in lesions (smouldering MS) associated to CSF profile
Paramagnetic rim lesions are associated with pathogenic CSF profiles and worse clinical status in multiple sclerosis: A retrospective cross-sectional study https://journals.sagepub.com/doi/abs/10.1177/13524585221102921?journalCode=msja Background : Paramagnetic rims have been observed as a feature ...
- Mon Jan 23, 2023 4:13 am
- Forum: MS Etiology and Pathogenesis
- Topic: Metabolic abnormalities visible under MRI
- Replies: 0
- Views: 833
Metabolic abnormalities visible under MRI
Extensive Brain Pathologic Alterations Detected with 7.0-T MR Spectroscopic Imaging Associated with Disability in Multiple Sclerosis https://pubs.rsna.org/doi/10.1148/radiol.210614 Background MR spectroscopic imaging (MRSI) allows in vivo assessment of brain metabolism and is of special interest in...
- Mon Jan 23, 2023 3:15 am
- Forum: MS Etiology and Pathogenesis
- Topic: Microglia in MS. Review
- Replies: 1
- Views: 1558
- Sun Jan 15, 2023 2:50 am
- Forum: MS Etiology and Pathogenesis
- Topic: Hypothesis: Viral infections during pregnancy as a factor
- Replies: 0
- Views: 764
Hypothesis: Viral infections during pregnancy as a factor
Hypothesis: Viral infections of pregnant women may be early triggers of childhood type 1 diabetes and other autoimmune disease https://www.sciencedirect.com/science/article/abs/pii/S0896841122001858 Abstract Children and adolescents with early onset autoimmune diseases have a different seasonality ...
- Sun Jan 15, 2023 2:48 am
- Forum: MS Etiology and Pathogenesis
- Topic: Osteopontin Is Associated with relapses
- Replies: 0
- Views: 582
Osteopontin Is Associated with relapses
Osteopontin Is Associated with Multiple Sclerosis Relapses https://www.mdpi.com/2227-9059/11/1/178 Background : Osteopontin, an extracellular matrix protein involved in bone remodeling, tissue repair and inflammation, has previously been associated with increased inflammation and neurodegeneration ...
- Sun Jan 15, 2023 2:46 am
- Forum: MS Etiology and Pathogenesis
- Topic: The earliest damage could be the optic nerve
- Replies: 2
- Views: 1136
Related. OCT reflects clinically relevant gray matter damage
Optical coherence tomography reflects clinically relevant gray matter damage in patients with multiple sclerosis https://link.springer.com/article/10.1007/s00415-022-11535-8 Background: Retinal degeneration leading to optical coherence tomography (OCT) changes is frequent in patients with multiple s...
- Fri Jan 06, 2023 11:49 am
- Forum: MS Etiology and Pathogenesis
- Topic: The earliest damage could be the optic nerve
- Replies: 2
- Views: 1136
Related. Retinal microvasculature
Significant retinal microvascular impairments in multiple sclerosis assessed through optical coherence tomography angiography https://www.sciencedirect.com/science/article/abs/pii/S2211034823000093 Abstract Purpose: Multiple sclerosis (MS) is associated with different ocular disorders. This study a...
- Fri Jan 06, 2023 11:48 am
- Forum: MS Etiology and Pathogenesis
- Topic: blood methylation is associated with severity
- Replies: 0
- Views: 923
blood methylation is associated with severity
This could be a new biomarker. Whole-blood methylation signatures are associated with and accurately classify multiple sclerosis disease severity https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-022-01397-2 Abstract Background The variation in multiple sclerosis (MS) dise...
- Fri Dec 23, 2022 11:42 am
- Forum: MS Etiology and Pathogenesis
- Topic: The earliest damage could be the optic nerve
- Replies: 2
- Views: 1136
The earliest damage could be the optic nerve
Magnetization transfer saturation reveals subclinical optic nerve injury in pediatric-onset multiple sclerosis https://journals.sagepub.com/doi/full/10.1177/13524585221137500 Abstract Background : The presence of subclinical optic nerve (ON) injury in youth living with pediatric-onset MS has not be...
- Tue Dec 20, 2022 12:06 am
- Forum: MS Etiology and Pathogenesis
- Topic: kappa free light chains for diagnosis
- Replies: 0
- Views: 1317
kappa free light chains for diagnosis
Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A consensus statement https://journals.sagepub.com/doi/full/10.1177/13524585221134217 Abstract Cerebrospinal fluid (CSF) analysis is of utmost importance for diagnosis and differential diagnosis of patients with su...