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Ceramide is implicated in humoral peripheral and intrathecal autoimmune response in MS patients https://www.sciencedirect.com/science/article/pii/S221103482300069X Highlights • Increased levels of anti-ceramide IgG were detected in cerebrospinal fluid and serum of patients with multiple sclerosis. ...

ATR-FTIR spectroscopy of plasma supported by multivariate analysis discriminates multiple sclerosis disease https://www.nature.com/articles/s41598-023-29617-6 Abstract Multiple sclerosis (MS) is one of the most common neurodegenerative diseases showing various symptoms both of physical and cognitiv...

MRZ reaction refers to Measles-Rubella-Zoster viruses for diagnosis. An improved set has been proposed. Antibodies to expanded virus antigen panels show elevated diagnostic sensitivities in multiple sclerosis and optic neuritis https://www.sciencedirect.com/science/article/abs/pii/S0165247823000226 ...

Tissue-resident memory t cells https://www.sciencedirect.com/science/article/pii/S016557282300022X Abstract Presence of EBV infected B cells and EBV-specific CD8 T cells in the multiple sclerosis (MS) brain suggests a role for virus-driven immunopathology in brain inflammation. Tissue-resident memo...

These authors expand the classification for atypical MS to 4 new variants, according to the lesion type: - Classic atypical MS : infiltrative, megacystic, Baló’s-like, and ring-like - New atypical MS : Tumefactive demyelinating lesion (TDL)-onset MS, Acute disseminated encephalomyelitis (ADEM)-like ...

Paramagnetic rim lesions are associated with pathogenic CSF profiles and worse clinical status in multiple sclerosis: A retrospective cross-sectional study https://journals.sagepub.com/doi/abs/10.1177/13524585221102921?journalCode=msja Background : Paramagnetic rims have been observed as a feature ...

Extensive Brain Pathologic Alterations Detected with 7.0-T MR Spectroscopic Imaging Associated with Disability in Multiple Sclerosis https://pubs.rsna.org/doi/10.1148/radiol.210614 Background MR spectroscopic imaging (MRSI) allows in vivo assessment of brain metabolism and is of special interest in...

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Hypothesis: Viral infections of pregnant women may be early triggers of childhood type 1 diabetes and other autoimmune disease https://www.sciencedirect.com/science/article/abs/pii/S0896841122001858 Abstract Children and adolescents with early onset autoimmune diseases have a different seasonality ...

Osteopontin Is Associated with Multiple Sclerosis Relapses https://www.mdpi.com/2227-9059/11/1/178 Background : Osteopontin, an extracellular matrix protein involved in bone remodeling, tissue repair and inflammation, has previously been associated with increased inflammation and neurodegeneration ...

Optical coherence tomography reflects clinically relevant gray matter damage in patients with multiple sclerosis https://link.springer.com/article/10.1007/s00415-022-11535-8 Background: Retinal degeneration leading to optical coherence tomography (OCT) changes is frequent in patients with multiple s...

Significant retinal microvascular impairments in multiple sclerosis assessed through optical coherence tomography angiography https://www.sciencedirect.com/science/article/abs/pii/S2211034823000093 Abstract Purpose: Multiple sclerosis (MS) is associated with different ocular disorders. This study a...

This could be a new biomarker. Whole-blood methylation signatures are associated with and accurately classify multiple sclerosis disease severity https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-022-01397-2 Abstract Background The variation in multiple sclerosis (MS) dise...

Magnetization transfer saturation reveals subclinical optic nerve injury in pediatric-onset multiple sclerosis https://journals.sagepub.com/doi/full/10.1177/13524585221137500 Abstract Background : The presence of subclinical optic nerve (ON) injury in youth living with pediatric-onset MS has not be...

Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A consensus statement https://journals.sagepub.com/doi/full/10.1177/13524585221134217 Abstract Cerebrospinal fluid (CSF) analysis is of utmost importance for diagnosis and differential diagnosis of patients with su...