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The pathogenesis of multiple sclerosis: a series of unfortunate events Clin Exp Immunol. 2023 Dec 11;214(1):1-17. Multiple sclerosis (MS) is characterized by the chronic inflammatory destruction of myelinated axons in the central nervous system. Several ideas have been put forward to clarify the ro...

Ineffective control of Epstein-Barr-virus-induced autoimmunity increases the risk for multiple sclerosis Cell. 2023 Dec 21;186(26):5705-5718. Highlights : • Control of autoimmunity by NKG2C+ NK cell responses is severely impaired in MS patients • MS-patient-derived GlialCAM-specific cells evade con...

Inverse association between Mediterranean diet and risk of multiple sclerosis Mult Scler. 2023 Aug;29(9):1118-1125. Objective : There is some evidence implicating diet in the development of inflammatory diseases. We aimed to study the influence of dietary habits on the risk of developing multiple s...

Phase II study of ketogenic diets in relapsing multiple sclerosis: safety, tolerability and potential clinical benefits J Neurol Neurosurg Psychiatry. 2022 Jun;93(6):637-644. Background : Dietary changes impact human physiology and immune function and have potential as therapeutic strategies. Objec...

Diagnostic Performance of Cortical Lesions and the Central Vein Sign in Multiple Sclerosis JAMA Neurol. 2023 Dec 11:e234737. Importance : Multiple sclerosis (MS) misdiagnosis remains an important issue in clinical practice. Objective : To quantify the performance of cortical lesions (CLs) and centr...

Serum Glial Fibrillary Acidic Protein Compared With Neurofilament Light Chain as a Biomarker for Disease Progression in Multiple Sclerosis JAMA Neurol. 2023 Mar 1;80(3):287-297. Importance : There is a lack of validated biomarkers for disability progression independent of relapse activity (PIRA) in...

Agreed. Ketones are good for the brain. The video I posted doesn't dispute that. What it does present though, is that it matters where you get that protein and fat. Eat your coconut oil.

Here's an interesting presentation in support of a plant based diet.

120 capsules, still 300mg each capsule , and is an even better value being about 25% less expensive as the other supplements mentioned: https://www.amazon.com/Vegan-Labs-Antioxidant-Protection-Supplement/dp/B0C6X5H3HL/ According to the label, that supplement is regular R-Lipoic acid. It's not Na-R-...

OR you could take a high potency and stabilized R-ALA supplement that has up to 40x the absorption. 600mg per 2 capsule serving, but you could just take 1 probably for 300mg which is what I did when I took this supplement, reasonably priced too: https://www.amazon.com/Stabilized-R-Alpha-Increased-A...

I take this one and on closer inspection I think it might be Na- RALA - see the back. https://www.lifeextensioneurope.com/super-r-lipoic-acid-eu Yes, that's the stabilized version with better absorption. The brand I take suggests taking it on an empty stomach. Do you do that? I take mine in between...

Something else to consider about supplement formulations, many manufacturers add bioperene (Black Pepper Fruit Extract) to their formulations. It is thought that bioperene promotes nutrient absorption (apparently clinical studies support this claim) . Some of the supplements I take have bioperene a...

That's why I place the ? in the end of my phrase. Although Benfotiamine isn't the best B1 form for multiple sclerosis, in my humble opinion this is Allithiamine. When I do a search for allithiamine this one from Ecological Formulas is the most prevalent product that comes up. https://www.lifeextens...

Hi Cure, I was in the open label study for about 4 years. They did measure cognitive issues (PSAT and memory tests) and did the fatigue questionnaire (self reported) at every visit, and suicide potential checks. This was of course in addition to physical performance (25ft walk etc), and a few eye si...

Should [benfotiamine] be avoided? https://www.semanticscholar.org/paper/Inhibition-of-thiamine-transport-in-Saccharomyces-Iwashima-Wakabayashi/827caec8adb4b17e5d14fe2c997b64a4f76c13fc?p2df The paper discusses thiamine disulfide and O-benzoyl thiamine disulfide. Neither of these molecules are benfot...