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A comparison of Measles-Rubella-Zoster Reaction, Oligoclonal IgG Bands, Oligoclonal Kappa Free Light Chains and Kappa Index in Multiple Sclerosis https://www.sciencedirect.com/science/article/pii/S2211034823006260 Highlights • This article brings original data from a real-world practice and compare...

Human herpesvirus 6A and axonal injury before the clinical onset of multiple sclerosis https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awad374/7334584?login=false Abstract Recent research indicates that multiple sclerosis is preceded by a prodromal phase with elevated levels of ser...

Plasma IgG aggregates as biomarkers for multiple sclerosis https://www.sciencedirect.com/science/article/abs/pii/S1521661623005648 Abstract We recently reported that multiple sclerosis (MS) plasma contains IgG aggregates and induces complement-dependent neuronal cytotoxicity (Zhou et al., 2023). Us...

file:///home/jlgarcia/Downloads/Preprints202310.0148.v1.pdf Abstract : Optic neuritis (ON) is the most common cause of vision loss in young adults. It manifests as acute or subacute vision loss, often accompanied by retrobulbar discomfort or pain on eye movements. Typical ON is associated with Multi...

Cell-binding IgM in CSF is distinctive of multiple sclerosis and targets the iron transporter SCARA5 https://www.biorxiv.org/content/10.1101/2023.09.29.560121v1.abstract Abstract Intrathecal IgM production in multiple sclerosis (MS) is associated with a worse disease course. To investigate pathogen...

Absence of Oligoclonal Bands in Multiple Sclerosis: A Call for Differential Diagnosis https://www.mdpi.com/2077-0383/12/14/4656 Abstract Background : Immunoglobulin gamma (IgG) oligoclonal bands (OCB) in the cerebrospinal fluid (CSF) are absent in a small group of multiple sclerosis (MS) patients. ...

OCB negative MS - immunogenetically distinct Multiple sclerosis with and without CSF bands: Clinically indistinguishable but immunogenetically distinct https://n.neurology.org/content/67/6/1062/tab-article-info Abstract We sought to determine whether Swedish patients with multiple sclerosis (MS) wi...

MOG-IgA characterizes a subgroup of patients with central nervous system demyelination https://proceedings.science/bctrims-2023/papers/mog-iga-characterizes-a-subgroup-of-patients-with-central-nervous-system-demyeli?lang=en Abstract Introduction : The differential diagnosis of patients with seroneg...

Double-negative neuromyelitis optica spectrum disorder https://journals.sagepub.com/doi/full/10.1177/13524585231199819 Abstract Most patients with neuromyelitis optica spectrum disorders (NMOSD) test positive for aquaporin-4 antibody (AQP4-IgG) or myelin oligodendrocyte glycoprotein antibodies (MOG...

Myeloid cell iron uptake pathways and paramagnetic rim formation in multiple sclerosis https://link.springer.com/article/10.1007/s00401-023-02627-4 Abstract In multiple sclerosis (MS), sustained inflammatory activity can be visualized by iron-sensitive magnetic resonance imaging (MRI) at the edges ...

N-acetylglucosamine inhibits inflammation and neurodegeneration markers in multiple sclerosis: a mechanistic trial https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-023-02893-9 Results Prior to GlcNAc therapy, high serum levels of the inflammatory cytokines IFNγ, IL-17 and IL-6 a...

Bruton’s Tyrosine Kinase Inhibition in Multiple Sclerosis https://link.springer.com/article/10.1007/s11910-022-01229-z Purpose of Review Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) with a chronic and often progressive disease course. The current disease-mo...

Learning multiple sclerosis immunopathogenesis from anti-CD20 therapy https://www.pnas.org/doi/full/10.1073/pnas.2221544120 Summary: 1) By analyzing blood immune profiles of patients receiving disease-modifying immune therapies, we can learn how therapy impacts the immune system (“mode of action” t...

Updated March 2023: I think this refers to the same treatment Adoptive T-cell therapy targeting Epstein–Barr virus as a treatment for multiple sclerosis https://onlinelibrary.wiley.com/doi/full/10.1002/cti2.1444 Abstract Emergence of a definitive link between Epstein–Barr virus (EBV) and multiple sc...

Adoptive T-cell therapy targeting Epstein–Barr virus as a treatment for multiple sclerosis https://onlinelibrary.wiley.com/doi/full/10.1002/cti2.1444 Abstract Emergence of a definitive link between Epstein–Barr virus (EBV) and multiple sclerosis has provided an impetus to develop immune-based thera...