This Is MS Multiple Sclerosis Knowledge & Support Community

-Lori, -CureOrBust, -gwa It is a part of natural course of MS. If you interested in numbers browse for such study about 20-30 years ago range, I believe that it was German or Swedish study. If it is far from your reach, take any recent article on pregnancy and MS. Why women are protected from MS rel...

-Bob, -Harry,-finn Thank you all for response. No one will make a lot of friends disputing EAE as unsuitable model for MS drugs discovery, that's true. Mouse MS does not exist, that's true also. All new developed drugs for human MS are drugs designed to treat mouse/rat EAE. They will work partially ...

Well, rounds we go, let's keep our labs busy. About EAE and MS First, a couple of words about inflammation. Biological role of inflammation – get rid of intruders and clean up the place. In EAE model the lesions of demyelination produced in absolutely non-physiological way by injection of brain extr...

MJ benefit in MS was clinically proven about 20 years ago. Unfortunately this study was closed down, and results were discussed as unsuitable for public. Biologically, MJ is 100% natural product which is good for humans. Oppositely, alcohol is bad for humans. There we have another distortion in mode...

My knowledge of myelin thickness was limited to the assumed differences between the genders (based on the mice studies--men have thicker myelin than women I think ??) and I didn't realize there was so much general variation in myelin thickness that was itself dependent on the thickness of the axon....

This is not in the least intended to be hostile because in your time here much of what you've said seems very sensible and it seems you have a direct knowledge of neurological functions. On the other hand, some things you mention directly contradict what we're used to hearing. I'm in the search of ...

Thanks to administration of this forum for possibility to share opinions in an unobstructed way. Damaged brain tissue will never be the same; this is a price of highest level of differentiation. Therefore, whatever happens with brain, every single component of it will suffer, more or less, and, of c...

-finn 1. It was definitely not my intention to write rhetoric comments here; I consider it waste of time. But if it looks that way, well, I apologize. When I learned from you that several MS researchers have stated that MS could be two-stage disease I felt myself uneasy. Science is very complicated ...

Quite agree with the comment about my english, some of my posts are not 'polished' and spell-checked, sorry guys, sometimes it's simply matter of having not so much time.
I'll improve it.

Kind regards,
Tony

-dignan Quote- These studies have consistently shown the presence of diffuse normal-appearing WM damage, marked gray matter involvement and significant cortical functional reorganization, as well as the occurrence of the neurodegenerative component of MS from the earliest clinical stages of the dise...

-Manchester Thanks for response, touchy matter indeed. People differ, they have different background, different level of education and different access to information different life experience, etc., therefore everyone’s opinion must be different by default. I share my personal opinion here, that’s ...

- Manchester Thank you for the post. I would like to add some comments. In common, I hold a neutral position on drug industry; we need them anyway to have old and new drugs for treatment. But it doesn’t mean that I accept everything they did, do or will do. The “weakest link” in really big Pharma co...

Yep, it is very emotional indeed. "Che" - style declarations (he was a pediatrician, by the way :)) I think this idea is totally wrong. Let me use this analogy. You personally have a spare 2000 every months. Then you decide to donate 100 bucks to charity, sometimes more, sometimes less. Bu...

- Dom The specific mechanism(s) by which TYSABRI exerts its effects in multiple sclerosis have not been fully defined. In multiple sclerosis, lesions are believed to occur when activated inflammatory cells, including T -lymphocytes, cross the blood-brain barrier (BBB). Leukocyte migration across the...

“If we can create a totally chemically defined system for growing human embryonic stem cells without any risk of contamination, it would make life much easier for scientists than it is at the moment,” says Kahn. “And that’s our goal.” Godspeed. So far all growing stem cells are badly contaminated. ...