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I am a little perplexed at your insistence that zinc deficiency is a root cause when there is as much evidence pointing to zinc supplementations potential to exacerbate MS as there is pointing to its benefits. You're a smart guy with time to do your research. As for me, I'm steering clear of zinc su...

Conclusions. Our data suggest that raising serum UA levels by the oral administration of inosine treatment may benefit patients with MS. Improvements in EDSS and a reduction in lesion activity were noted. Studies in a larger cohort are indicated and will help to elucidate the mechanistic effects of ...

Conclusions. Our data suggest that raising serum UA levels by the oral administration of inosine treatment may benefit patients with MS. Improvements in EDSS and a reduction in lesion activity were noted. Studies in a larger cohort are indicated and will help to elucidate the mechanistic effects of ...

Inosine is about more than just uric acid levels. It promotes axon regeneration and is neuroprotective. It actually offers some hope for restoring lost function and made lesion disappear in 2 patients during phase I trials.

It sounds like you're doing plenty of research. Just wanted to point out that there are multiple considerations with zinc and it is possible to do more harm than good. Individuals who test low in zinc may have reason to consider it. I like the PUFAs because there is a lot of upside without much down...

Couldn't find the article, here is a link to Dr Herndons home page:

http://m.ummchealth.com/doctors/herndon_robert/

I am referencing page 93 of "Dietary Supplements and Multiple Sclerosis, A Health Professional's Guide" by Allen C Bowling, MD, PhD and Thomas M Stewart, JD, PA-C, MS They in turn reference many other works. As near as I can tell the EAE results come from an article in the Journal of Neuro...

My thoughts: - too much vitamin D. At 8000 IU per day (+ the vit D in your fish oil) it will over-accumulate in your system - Zinc stimulates pro-inflammatory cytokine release and T-cell proliferation and worsened EAE in mice. - PUFAs (fish oil, evening primrose oil, safflower oil, etc) have the mos...

I have been on copaxone over 10 years. I believe I have gone secondary progressive. In 10 years on copaxone I had no major relapses. However, over the past year or two my legs have started degrading. I tried adding LDN and had my first relapse in 10 years. The copaxone hasn't caused the fatigue and ...

"I had an exacerbation(s) while on LDN treatment for Multiple Sclerosis. My details are as follows:" I am _39__ years old I am male I have RR and/or SP MS for _10__ years My exacerbation(s) while on LDN affected my _legs, cognition, speech____ (body part/function e.g., eyes, legs, cognitiv...