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Roadmap for understanding mechanisms on how Epstein–Barr virus triggers multiple sclerosis and for translating these discoveries in clinical trials https://onlinelibrary.wiley.com/doi/full/10.1002/cti2.1438 Abstract Here, we offer a roadmap for what might be studied next in understanding how EBV tr...

Effects of Ibudilast on Retinal Atrophy in Progressive Multiple Sclerosis Subtypes https://n.neurology.org/content/early/2023/07/16/WNL.0000000000207551.abstract Discussion : Ibudilast treatment decreased GCIPL atrophy in PMS, driven by the PPMS cohort, with no effect seen in SPMS. Modulated atroph...

Advanced brain MRI may help understand the link between migraine and multiple sclerosis https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-023-01645-7 Conclusion In summary, there is clinical evidence for an association of migraine and MS. Both clinical studies as well as...

Smouldering Lesion in MS: Microglia, Lymphocytes and Pathobiochemical Mechanisms https://www.mdpi.com/1422-0067/24/16/12631 Abstract Multiple sclerosis (MS) is an immune-mediated, chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS). Immune cell inf...

Antibodies against the flotillin-1/2 complex in patients with multiple sclerosis https://academic.oup.com/braincomms/article/5/2/fcad109/7103320 Abstract Multiple sclerosis is a tissue-specific autoimmune disease of the central nervous system in which the antigen(s) remains elusive. Antibodies targ...

Transcriptome alterations in peripheral blood B cells of patients with multiple sclerosis receiving immune reconstitution therapy https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-023-02859-x Abstract Background Multiple sclerosis (MS) is a chronic, inflammatory and neurodegenera...

https://academic.oup.com/jnen/advance-article/doi/10.1093/jnen/nlad046/7204747?login=false Abstract The study was designed to examine microglia morphology in early and late forms of multiple sclerosis (MS). Archival paraffin embedded tissue samples from 25 cases were examined immunohistochemically. ...

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0287463 Background Predicting the long-term disability outcomes of multiple sclerosis (MS) cases is challenging. Objective We prospectively analysed our previous MS cohort with initial cerebrospinal fluid (CSF) proteomics data to reve...

https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-023-01598-7 Abstract Multiple sclerosis (MS) pathophysiology includes inflammation, demyelination and neurodegeneration, but the exact mechanisms of disease initiation and progression are unknown. A major feature of lesions is lack of ...

Carotenoids contribution in rapid diagnosis of multiple sclerosis by Raman spectroscopy https://www.sciencedirect.com/science/article/abs/pii/S0304416523000934 Highlights • Rapid and novel screening test of blood fraction reveals the biochemical fingerprint of multiple sclerosis (MS). • Raman spect...

Experimental Analysis of Tear Fluid and Its Processing for the Diagnosis of Multiple Sclerosis https://www.mdpi.com/1424-8220/23/11/5251 Conclusions According to this study, MS patients have altered tear proteomes. The tear proteome may be a good indicator of MS-related disorders and CNS inflammati...

metabolic alterations in the normal‑appearing grey and white matter of patients with clinically isolated syndrome https://www.spandidos-publications.com/10.3892/etm.2023.12048 Abstract Proton magnetic resonance spectroscopy (1H‑MRS) is an advanced method of examining metabolic profiles. The present...

Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown https://www.nature.com/articles/s41467-023-38703-2 Abstract Blood-brain barrier (BBB) breakdown and immune cell infiltration into the central nervous system (CNS) are early hallmarks of multiple scl...

Antibodies against the flotillin-1/2 complex in patients with multiple sclerosis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116574/ A long list of candidate antigens have been found, including the glial potassium channel KIR4.1, the flotillin-1/2 complex (FLOT1/2), anoctamin-2 (ANO2) or neurofa...

https://www.science.org/doi/10.1126/science.abm7930 [...] showed serum antibodies from MS patients are cross-reactive between amino acids 411–440 of the viral protein EBV nuclear antigen 1 (EBNA-1) and the human chloride-channel protein, anoctamin 2 (ANO2), which is associated with electrical conduc...