Search found 602 matches

by TwistedHelix
Sat Aug 30, 2008 5:20 am
Forum: General Discussion
Topic: Amantadine
Replies: 18
Views: 4889

I wonder if the drug's antiviral action is responsible for you guys feeling worse? If you have a persistent, low grade viral infection that the body hasn't dealt with, to suddenly begin fighting it because of the presence of amantadine would make you feel quite ill for a while, in much the same way ...
by TwistedHelix
Sat Aug 30, 2008 5:08 am
Forum: General Discussion
Topic: Dramtic decrease in EDSS with Liver Transplant ? Why ?
Replies: 60
Views: 14535

Excellent suggestion Frank! Comparing patients post transplant, who have received the same immunosuppressive drugs, is the perfect way to find out whether it is the drugs or the transplanted organ which is having an effect,
by TwistedHelix
Thu Aug 28, 2008 6:36 am
Forum: General Discussion
Topic: Amantadine
Replies: 18
Views: 4889

Hi Marcia, I've been taking exactly the same dose as you for about five years now. The effect was very gradual over about five or six months, but comparing before and after the difference has been profound – before, a 20 minute conversation would leave me exhausted for days, now, I talk all the time...
by TwistedHelix
Thu Aug 28, 2008 6:21 am
Forum: General Discussion
Topic: Dramtic decrease in EDSS with Liver Transplant ? Why ?
Replies: 60
Views: 14535

Well, this is fascinating and unexpected. My immediate thought was that it has something to do with the immunosuppressive drugs – as they hinted – and if it's not that, then it might be something to do with the liver itself. The liver performs so many functions that it can never be completely discou...
by TwistedHelix
Thu Aug 28, 2008 5:59 am
Forum: General Discussion
Topic: My vascular (?) problems - related to MS?
Replies: 16
Views: 14339

Thank you so much for all that information… I wonder if my doctor avoided using the word "angioma" because he knows that words ending in "...oma" tend to freak me out a bit, (with the possible exception of " Oklahoma"). My carers have been giving me funny looks just lat...
by TwistedHelix
Wed Aug 27, 2008 4:38 am
Forum: General Discussion
Topic: Michelle Obama: Her Father's MS
Replies: 30
Views: 11544

Not just hurricanes: useless farts are in the news here all the time.
It's just that on this side of the Atlantic we call them " politicians".
by TwistedHelix
Wed Aug 27, 2008 4:15 am
Forum: General Discussion
Topic: My vascular (?) problems - related to MS?
Replies: 16
Views: 14339

Hello Cheer, I like your thinking, especially about the difference between RR and PP MS reflecting the different behaviour of these marks. One of my carers took a picture of mine with her phone, but it's a bit poor and the bright red colour doesn't show up at all well– in the photo they don't look m...
by TwistedHelix
Tue Aug 26, 2008 7:55 am
Forum: General Discussion
Topic: *UPdate* Visit with New Neuro Doc
Replies: 21
Views: 4883

Increased sex drive ? … Sounds awful !
by TwistedHelix
Tue Aug 26, 2008 7:17 am
Forum: General Discussion
Topic: *UPdate* Visit with New Neuro Doc
Replies: 21
Views: 4883

Just one more thing I forgot to mention, tt89: you sound as if you're really unwell, and once you get diagnosed with MS doctors tend to put on a pair of blinkers… they simply can't see anything else. But of course you're just as prone to other illnesses as anybody else, (in fact maybe more so, since...
by TwistedHelix
Tue Aug 26, 2008 6:21 am
Forum: General Discussion
Topic: *UPdate* Visit with New Neuro Doc
Replies: 21
Views: 4883

Hello tt89, I'm sorry to hear you're having such a rough time: not only a bundle of awful symptoms but a load of confusing advice from the medics. My first reaction when I read your post was that the doctor seems to suspect progressive MS based on how severe your symptoms are – this is not normally ...
by TwistedHelix
Fri Aug 22, 2008 7:09 am
Forum: General Discussion
Topic: My vascular (?) problems - related to MS?
Replies: 16
Views: 14339

This document is quite dense to read: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003037 But basically it says this: T cells, specifically CD8 T cells, use a protein called perforin as part of their weaponry. Perforin punches holes in the membranes of enemy cells in order to ...
by TwistedHelix
Thu Aug 21, 2008 6:02 am
Forum: General Discussion
Topic: My vascular (?) problems - related to MS?
Replies: 16
Views: 14339

Hi Damjan, They certainly resemble ITP, and MS as a vascular disease has been discussed quite a few times on this website. My torso has a couple of clusters of markings similar to this except they are not purple and they don't appear to be temporary: they are bright scarlet and have been there for a...
by TwistedHelix
Thu Aug 21, 2008 5:21 am
Forum: General Discussion
Topic: Pictures
Replies: 599
Views: 102541

Hey Robbie, It was really great to see you in real life, but also a little bit strange – you see, your movements seem to be exactly the same as I was a few years ago: clonus in your left leg especially, as Carole said, if you put your foot too far back on the footplate so that it's resting on the ba...
by TwistedHelix
Mon Aug 18, 2008 9:45 am
Forum: General Discussion
Topic: Not specific to MS
Replies: 6
Views: 2560

… Hormones in food… I hadn't thought of that! In this country we have a situation where some male fish become feminised or even change sex completely because of oestrogen in our river water, excreted by women on the pill. Not directly in our food chain, of course, but certainly in our environment; t...
by TwistedHelix
Mon Aug 18, 2008 6:48 am
Forum: General Discussion
Topic: Not specific to MS
Replies: 6
Views: 2560

Whenever I see mention of the timing of certain illnesses being important subsequently, I am always reminded of the thymus, (where T cells mature). When puberty begins, the flood of sex hormones in the body cause the thymus to involute, (atrophy and turn to fat), so it would seem obvious that an ant...

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