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okay, so I do think that Amiloride may very well be a bit of a game changer for me but it is still early days. I started on 5mg daily although the trial used 10mg but I noticed after only a few days that the amiloride made my leg a bit stiffer. However this has now settled down a bit and I am now on...

Amiloride has been around for donkey's years. It is safe but is a diuretic so ought to be making me want to visit the privy rather more frequently. So far so good. What is very exciting here is that the acid sensing channels are genetically implicated in a Sardinian population of MS patients. I have...

Yes, I will try to find some more objective measures than the tingling stuff but I am quite encouraged to have found that "Holy Basil" has such exciting properties, no wonder they call it Holy.

Well, my symptoms remain much as they were but the pain in my left foot is lower and the tingling is more subdued so now it feels more numb rather than crawling. The right leg is stronger but this is likely as result of coming off the tizanidine/benzodiazepines and instead drinking whiskey to kill t...

A recent successful bone marrow transplant study for MS revealed that significantly diminished T helper 17 cells (TH17) was the cause of the arrested disease and recovery of patients as per this article: http://www.ottawacitizen.com/health/Ottawa+doctors+behind+breakthrough+report/8180666/story.html...

The Holy Basil supplements are doing something!!! Ocimum tenuiflorum. Sci Rep. 2011;1:201. doi: 10.1038/srep00201. Epub 2011 Dec 19. Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis. Pareek TK, Belkadi A, K...

salvia miltiorrhiza is great for lowering endothelin - 1. Biochim Biophys Acta. 2006 Jan;1760(1):1-9. Epub 2005 Oct 3. Cryptotanshinone inhibits endothelin-1 expression and stimulates nitric oxide production in human vascular endothelial cells. Zhou Z, Wang SQ, Liu Y, Miao AD. Source Laboratory of B...

Thanks Cureo. I doubled the dose of tizanidine and this HAS helped hugely. Apparently 4mg is the conventional amount not 2mg as prescribed.

Thanks Cureo. I've also recently about a month ago started tizanidine 2mg and it is completely unpredictable, initially makes the night spasms worse for about 2 hours, then zonks me out for about 3 hours and then I end up wide awake with or without spasms! Do you have night spasms and does anything ...

Hi, yes I need to remember to take the probiotic and the magnesium (I use citrate) And some capsaicin tablets at lunch and then things will move!

I have updated the charts to show that I have stabilized in a worse state since the last angioplasty. I have had to take tizanidine 2mg for the night spasms in order to get to sleep and I am now wearing an orthotic to help with the foot drop. I am now doing intensive physiotherapy. Unfortunately I h...

Well, I must give the anatabine another go. It's the tobacco plant anti inflammatory I tried a few weeks ago. It definitely has anti inflammatory effects but is a powerful tumour necrosis factor suppressant which may be bad in ms.

http://www.scribd.com/doc/116812544 Wow, have I had a rollercoaster since July and my 3rd and likely final CCSVI treatment (though maybe in a another decade!). I had major deteriorations within 24 hours of my comprehensive ballooning of the jugulars, azygous and left renal stenting. Eventually at t...

Hi Points North, I actually stopped the Anatabine after about 5 days as I was really unsure about the effects on TNF alpha and the blockade of this is obviously bad in some MS patients. But I have since been reading up on minocycline and its inhibition of TNF alpha in the microglia. I took minocycli...

Perhaps take anatabine when a flare is coming on? I have decided to stop the anatabine and see how the spasticity fares...really not sure about this one! Folia Med (Plovdiv). 2011 Apr-Jun;53(2):29-35. Clinical and laboratory study of pro-inflammatory and antiinflammatory cytokines in women with mult...