Search found 1747 matches
- Sun May 21, 2023 12:53 am
- Forum: MS Etiology and Pathogenesis
- Topic: EBV in MS. Review
- Replies: 0
- Views: 1844
EBV in MS. Review
Free review article. Epstein–Barr virus and multiple sclerosis: moving from questions of association to questions of mechanism https://onlinelibrary.wiley.com/doi/10.1002/cti2.1451 Excerpt Whilst it has been suspected for many years that molecular mimicry with self-antigens may be driving elevations...
- Fri May 19, 2023 10:28 am
- Forum: MS Etiology and Pathogenesis
- Topic: review about biomarkers 2023
- Replies: 0
- Views: 1754
review about biomarkers 2023
https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.202250228 Emerging Imaging and Liquid Biomarkers in Multiple Sclerosis Abstract The advent of highly-effective disease modifying therapy has transformed the landscape of multiple sclerosis (MS) care over the last two decades. However, there remain...
- Fri May 19, 2023 10:02 am
- Forum: MS Etiology and Pathogenesis
- Topic: neuropathologic groups proposal
- Replies: 0
- Views: 1241
neuropathologic groups proposal
Identification of neuropathology-based subgroups in MS https://www.medrxiv.org/content/10.1101/2023.05.15.23289980v1 Abstract Multiple sclerosis (MS) is a heterogeneous disorder with regards to clinical presentation and pathophysiology. Stratification into biologically distinct subgroups could enha...
- Fri May 19, 2023 9:49 am
- Forum: MS Etiology and Pathogenesis
- Topic: The picture gets more complex: ANO2 + GlialCam + CRYAB
- Replies: 2
- Views: 1460
The picture gets more complex: ANO2 + GlialCam + CRYAB
EBNA1 is a EBV protein with several interesting segments: Some of them mimic the human proteins ANO2, GlialCam or CRYAB. Maybe other segments mimic other proteins. Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis https://www.science.org/doi/full/10.1...
- Sun May 07, 2023 1:39 am
- Forum: General Discussion
- Topic: Predictive test found using defense database. 10 million individuals
- Replies: 0
- Views: 1043
Predictive test found using defense database. 10 million individuals
A Predictive Autoantibody Signature in Multiple Sclerosis https://www.medrxiv.org/content/10.1101/2023.05.01.23288943v1 Abstract Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remains elusive. Here, the Department of Defense Serum...
- Sun May 07, 2023 1:23 am
- Forum: MS Etiology and Pathogenesis
- Topic: Predictive test found using defense database. 10 million individuals
- Replies: 0
- Views: 1563
Predictive test found using defense database. 10 million individuals
A Predictive Autoantibody Signature in Multiple Sclerosis https://www.medrxiv.org/content/10.1101/2023.05.01.23288943v1 Abstract Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remains elusive. Here, the Department of Defense Serum...
- Tue Apr 18, 2023 10:29 am
- Forum: MS Etiology and Pathogenesis
- Topic: Modulation of microglial metabolism facilitates regeneration
- Replies: 0
- Views: 1152
Modulation of microglial metabolism facilitates regeneration
Modulation of microglial metabolism facilitates regeneration https://www.sciencedirect.com/science/article/pii/S258900422300665X Highlights ● Microglia loaded with lipid adopt a phagocytosis-enhanced microglia (PEMs) phenotype. ● Rosiglitazone helps microglia adopt myelination-associated microglia ...
- Thu Apr 13, 2023 9:30 am
- Forum: MS Etiology and Pathogenesis
- Topic: Nature: There is something in plasma that produces neuronal apoptosis
- Replies: 1
- Views: 1197
Chat GPT can say something about the subject
Chat GPT says this. Can plasma IgG antibodies form large aggregates? Yes, under certain conditions, plasma IgG antibodies can form large aggregates or immune complexes. Immune complexes are formed when antibodies bind to antigens, such as those found on the surface of pathogens, and then come togeth...
- Thu Apr 13, 2023 9:14 am
- Forum: MS Etiology and Pathogenesis
- Topic: Nature: There is something in plasma that produces neuronal apoptosis
- Replies: 1
- Views: 1197
Nature: There is something in plasma that produces neuronal apoptosis
Multiple sclerosis plasma IgG aggregates induce complement-dependent neuronal apoptosis https://www.nature.com/articles/s41419-023-05783-3 Abstract Grey matter pathology is central to the progression of multiple sclerosis (MS). We discovered that MS plasma immunoglobulin G (IgG) antibodies, mainly ...
- Thu Mar 23, 2023 2:46 am
- Forum: MS Etiology and Pathogenesis
- Topic: Pathological subtypes identification
- Replies: 1
- Views: 1635
Re: Pathological subtypes identification
Progressive MS is associated with subpial type 3 lesions
https://www.mdpi.com/2227-9059/11/3/945
Progressive multiple sclerosis (MS) is a chronic disease with a unique pattern, which is histologically classified into the subpial type 3 lesions in the autopsy.
Free full text.
https://www.mdpi.com/2227-9059/11/3/945
Progressive multiple sclerosis (MS) is a chronic disease with a unique pattern, which is histologically classified into the subpial type 3 lesions in the autopsy.
Free full text.
- Tue Mar 21, 2023 2:55 am
- Forum: MS Etiology and Pathogenesis
- Topic: Proteomics profiling biomarkers
- Replies: 0
- Views: 1698
Proteomics profiling biomarkers
Proteomics profiling reveals biomarkers for predicting diagnosis, disease activity and long-term ... https://assets.researchsquare.com/files/rs-2678518/v1/999b8ffa7e4e6ad5d926f7fc.pdf?c=1678947930 In summary, the 52 CSF proteins identified in the bigger discovery cohort represent a set of proteins ...
- Sat Mar 18, 2023 7:14 am
- Forum: MS Etiology and Pathogenesis
- Topic: Biomarkers in MS
- Replies: 0
- Views: 1625
Biomarkers in MS
Diagnostic, Prognostic, and Disease Activity Biomarkers in Multiple Sclerosis https://gupea.ub.gu.se/handle/2077/74509 Abstract Multiple sclerosis (MS) is the most common immune-mediated disease of the central nervous system. While benign cases exist, if left untreated, MS results in the compoundin...
- Thu Mar 02, 2023 8:33 am
- Forum: MS Etiology and Pathogenesis
- Topic: ALS (not MS) possible molecular mechanism found
- Replies: 0
- Views: 1532
- Tue Feb 28, 2023 2:45 am
- Forum: MS Etiology and Pathogenesis
- Topic: Review: Models about how EBV causes MS
- Replies: 0
- Views: 1675
Review: Models about how EBV causes MS
From bedside to bench: how existing therapies inform the relationship between Epstein–Barr virus and multiple sclerosis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947628/ Abstract Therapy for relapsing–remitting multiple sclerosis (MS) has advanced dramatically despite incomplete understanding o...
- Thu Feb 23, 2023 12:58 pm
- Forum: MS Etiology and Pathogenesis
- Topic: CSF OCBs indicate smouldering lesions
- Replies: 0
- Views: 1195
CSF OCBs indicate smouldering lesions
Cerebrospinal fluid–related tissue damage in multiple sclerosis patients with iron rim lesions https://journals.sagepub.com/doi/full/10.1177/13524585231155639 Background : In multiple sclerosis (MS), iron rim lesions (IRLs) are associated with pronounced tissue damage, higher disease severity and h...