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Bob,

in the light of current knowledge it should be quite certain that if there was inflammation, there is also neurodegeneration present at the same time in the pathology of MS (not necessary vice versa, though).

-finn

Bob, Now to inject some logic to the situation...85% of people with MS are diagnosed with RRMS. 85% is such a high percentage that it's most logical to think of RRMS is the epitome of MS and what we consider the other phases are actually variants of RRMS. Well, maybe it's time for me to do some quo...

Dom, Apologies that my posts are double line spaced: I find it easier to compose them in notepad, and when I cut and paste them it just sort of happens. I like to use a text editor when composing posts, too. I have found WordPad better than Notepad, because it knows how to break lines inside the wi...

Bob, Not to disagree finn but in my view to possibly expand on what you are saying... thanks for giving me the opportunity to quote myself. I have always dreamed about it. There are several (more or less likely) ways to see the pathological process: Inflammation causes demyelination, and eventually...

Thanks Dignan! Like Dom already wrote, great find. This might have some implications to MS, too.

-finn

I believe in the BOTH theory. http://home.ix.netcom.com/~jdalton/ms-two-stages.pdf I'm sorry, but I just have to question Dr. Steinman's theory. Having a disease process firts driven by inflammation and then by neurodegeneration just doesn't make much sense to me, but I suppose the autoimmune camp ...

Bob, I suppose since the researchers disclose their financial interests we shouldn't doubt the findings of the studies, but I'm afraid it always makes me wonder. Considering the situation, I think, researchers should be required to post conflict of interest information at the end of their abstract....

Bob, Dignan, I appreciate your efforts, but I assume it's the number, not the length of posts that will take us to the next page. Luckily the link in Ian's post is shorter now, and this page looks good on Firefox again. Dignan, thanks for sharing another interesting study. According to it there mig...

Ian, I visited PubMed just to see what school of thoughts Zipp and Compston represent. After seeing the studies they've done I wouldn't be surprised if they both would argue that "MS is a inlammatory demyelinating disease with a neurodegenerative component". Anyway, enough of this now. En...

Ian, I only post what I see - unfortunately, many researchers still use animal models. You have also posted extracts based on animal models: Some time ago Sharon posted an abstract of a study by Tsunoda and Fujinami where they showed in an animal model that axonal degeneration can trigger demyelina...

Ian, if EAE and MS were similar diseases we would have been cured already. Quotes from your links: "Prof Perry used disease models to look at some of the factors which may be involved in tissue damage and subsequent disease progression during the relapsing remitting phase of the disease."...

Bob, One of my wife's uncle's was a finn and one of the nicest guys I've ever known, so I'm confident that all Finns aren't asses. I really don't understand what you're trying to say. You wrote that COB frustrates you. Well, sometimes I can definitely say the same about you. Lighten up! This is a d...

Ian, Perhaps the Fins do have some value. Well, at least we usually try to spell more carefully than some Englishmen seem to do. Seriously, thanks for sharing that piece of news from Finland in English. I have it in my files in Finnish, and I've been planning to translate and post it somewhere, but...

Bob, I'm not convinced that either autoimmune or non autoimmune's side of the argument requires or even benefits from a "versus" situation (regarding inflammation v neurodegeneration) as opposed to a "both" situation. I'd say you are referring to two processes that can be at lea...

Ian, for a man who has no opinion on this matter, you seem to have an awful lot to write about it ;-) Well, you have already written almost the same post earlier in this thread. I answered you then that I understand and respect your point of view and decision to start taking Campath. Ì still do. I ...