Objective: To report on a case of progressive multifocal leukoencephalopathy (PML) after natalizumab (NTZ) treatment discontinuation.
Case report: She is a 24-years-old woman who developed a very active multiple sclerosis in 1999 when she was 12. Between 2000 and 2004 she was treated with immunomodulants (GA and interferon) and XX underwent 3 cycles of Mithoxantrone for a cumulative dose of 45 mg. Then for continuous clinical and MRI activity she started natalizumab treatment in May 2007. During this therapy she did not have any disease activity and she had a very good quality of life.
In September 2010 she was tested for anti-JCV antibodies resulting positive.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1768
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