Revimmune (cyclophosphamide or cytoxan)

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Last post

Multiple Sclerosis drug Revimmune receives FDA designation

Last post by iKat « Mon Mar 17, 2014 12:43 pm
Replies: 6
by MSUK » Tue Jun 28, 2011 6:03 am

First post

The U.S. Food and Drug AdministrationbizWatch U.S. Food and Drug Administration granted Orphan Drug Designation to Revimmune, Accentia...

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i didn't think they were using this anymore. Are they going to start trials again? I think the HSCT seems to be more promising that this.

6 Replies

20308 Views

Last post by iKat
Mon Mar 17, 2014 12:43 pm
Cyclophosphamide so-so verdict in progressive MS

Last post by 1eye « Sat Dec 28, 2013 9:23 am
Replies: 3
by MSUK » Mon Oct 07, 2013 6:10 am

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Patients with secondary progressive multiple sclerosis who were able to stay on cyclophosphamide therapy had a lower risk of further disability, but...

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Since the experts still acknowledge that the cause of MS is unknown, your hypothesis is as good as theirs, in my opinion.

On the other hand, some...

3 Replies

4521 Views

Last post by 1eye
Sat Dec 28, 2013 9:23 am
Symptoms right after 1st HICY infusion?

Last post by plethora « Mon May 20, 2013 9:44 pm
Replies: 1
by NewHope » Sun May 19, 2013 9:17 am

First post

Hello,

I am currently undergoing HSCT (Hematopoietic Stem Cell Transplantation) with Dr Burt in Chicago which also involves large doses of chimo -...

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Hi,

I don't have any experience with HSCT, but have read a bit about it. The expert seems to be George Goss, who did HSCT a few years ago and has a...

1 Replies

4601 Views

Last post by plethora
Mon May 20, 2013 9:44 pm
vitamin D?

Last post by dulceemira « Mon Apr 29, 2013 10:40 am
Replies: 11
by RedPenguins » Mon May 25, 2009 5:49 pm

Does anyone know how much vitamin D (and what kind? d2 or d3??) the people who did hicy @ Rush are currently taking?

thanks,

keri

11 Replies

8210 Views

Last post by dulceemira
Mon Apr 29, 2013 10:40 am
HiCy in Europe

Last post by LR1234 « Mon Jul 16, 2012 7:15 am
Replies: 8
by Pesho » Thu Feb 23, 2012 1:45 pm

First post

Hello, I'm new to the disease and the forum :(. I'm searching for a cure like everyone else and the things I'm considering are HSCT or HiCy. Just...

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see MSRC website for personal experiences on many of these treatments.
They are very risky and not to be taken lightly especially if your MS is...

8 Replies

6785 Views

Last post by LR1234
Mon Jul 16, 2012 7:15 am
cytoxan therapy

Last post by LauraV « Mon Jul 02, 2012 9:54 am
Replies: 47
by MNManWithMS » Fri Apr 10, 2009 7:55 am
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First post

I've been all fo the FDA-approved drug therapies and received no positive benefits. My neurologist mentioned Cytoxan and I really like the idea of...

Last post

Is there much difference between MS cytoxan therapy and the cytoxan therapy they give for breast cancer? I took cytoxan with adriamycin (and...
47 Replies

30453 Views

Last post by LauraV
Mon Jul 02, 2012 9:54 am
Plans unveiled for new MS drug study for Cyrevia

Last post by MSUK « Tue May 08, 2012 1:14 am

by MSUK » Tue May 08, 2012 1:14 am

The leading physicians from Accentia Biopharmaceuticals, Inc. and Johns Hopkins University have presented plans for a randomized clinical trial to...

0 Replies

5004 Views

Last post by MSUK
Tue May 08, 2012 1:14 am
Cyrevia (Formerly Revimmune)

Last post by LR1234 « Wed Feb 22, 2012 4:10 pm
Replies: 1
by rssugg » Tue Jan 10, 2012 9:17 am

First post

In December, Accentia Bio changed the name of their Multiple Sclerosis therapy Revimmune (HiCy or High Dose Cytoxan) to Cyrevia.

As the company is...

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I am interested in this treatment....seems like its very risky but has the best chance of halting the disease.

1 Replies

5549 Views

Last post by LR1234
Wed Feb 22, 2012 4:10 pm
Analysis of 40 JH HiCy Patients

Last post by rssugg « Tue Nov 22, 2011 7:31 am
Replies: 6
by Frank » Thu Sep 01, 2011 2:47 am

First post

Treatment of RRMS with high dose cyclophosphamide induction

CyclophosphamideBackground: Previous studies have described stabilization of aggressive...

Last post

While everyone else was looking and hoping for CCSVI, Revimmune has been slowly getting their ducks in order and is poised to get on the market...

6 Replies

6385 Views

Last post by rssugg
Tue Nov 22, 2011 7:31 am
Is cyclo really going to help?

Last post by criptastic « Tue Nov 08, 2011 11:23 am
Replies: 3
by Grenaway10 » Sat Nov 05, 2011 7:30 pm

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I'm 19 and I decided to do cyclo and I have been home for 4days and was in the hospital for 9 to do the cyclo, but I am already having a attack! So I...

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Hi,

I don't have MS, but another autoimmune disease. I also had several exacerbations in the first few weeks/months following the HiCy. It is...

3 Replies

5099 Views

Last post by criptastic
Tue Nov 08, 2011 11:23 am
Gots me a date...

Last post by criptastic « Thu Jun 02, 2011 10:02 am
Replies: 4
by msmything » Wed Jun 01, 2011 7:18 pm

First post

Finally, after months of staff changes and screw ups I have a date to enter RUSH's HiCy program.

I'm over the moon, but now that it's real I'M...

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Oh, OK.

I was 48.

4 Replies

5369 Views

Last post by criptastic
Thu Jun 02, 2011 10:02 am
Hopkins video

Last post by RedPenguins « Fri Apr 29, 2011 8:36 am
Replies: 23
by Lyon » Fri Jan 21, 2011 3:20 pm
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First post

..

Last post

Hi Linda,

I did Copaxone after treatment, from June 09 to early January 10. then I stopped bc I knew I wanted to get pregnant. I am on nothing now...
23 Replies

12422 Views

Last post by RedPenguins
Fri Apr 29, 2011 8:36 am
Immunizations?

Last post by msmything « Fri Apr 29, 2011 3:34 am
Replies: 4
by Looking88 » Mon Dec 27, 2010 3:33 pm

First post

Does a person have to re-take their childhood immunizations after the Revimmune protocol?

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I found out that I will receive the first of my childhood ones in about a year, I want to be able to be around children in the future! (grandkids)...

4 Replies

5510 Views

Last post by msmything
Fri Apr 29, 2011 3:34 am
Tysabri and Revimmune?

Last post by RedPenguins « Thu Apr 28, 2011 7:55 pm
Replies: 3
by Looking88 » Wed Jan 05, 2011 6:14 am

First post

Anyone have any insight on using Tysabri to bridge the gap until being able to get Revimmune treatment? Know of any problems going from Tysabri to...

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I had a few (2 or 3?) Tysabri treatments before doing HiCy. My last treatment was 30 days before I had HiCy at Hopkins.

3 Replies

5306 Views

Last post by RedPenguins
Thu Apr 28, 2011 7:55 pm
Starting Chemo for MS in 9 Days. Am I nutz?

Last post by PatGF « Tue Feb 22, 2011 11:24 am
Replies: 6
by Chris1967 » Sat Jan 15, 2011 11:56 am

First post

Chris here, was wondering if anyone could help. I am scheduled to start cyclophosphomide therapy in 9 days. Its a major infusion, four hours, every...

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I'm glad you are getting great information to make your treatment choices. I was given Cytoxan in 2007 during a particularly bad relapse. I took it...

6 Replies

7189 Views

Last post by PatGF
Tue Feb 22, 2011 11:24 am
HiCy Success Stories

Last post by Algis « Sat Jan 15, 2011 10:36 pm
Replies: 2
by Looking88 » Sat Jan 08, 2011 5:29 am

First post

I am having trouble tracking down the long term success stories of HiCy.
Most of the HiCy participant blogs only go for a year and then stop.

Maybe...

Last post

Feels great has no signs of disease activity, either on scan or otherwise.

May I ask: how disabled was she before the treatment?

Thank you :)

2 Replies

5412 Views

Last post by Algis
Sat Jan 15, 2011 10:36 pm
What tests prior?

Last post by criptastic « Mon Jan 10, 2011 7:33 am
Replies: 12
by msmything » Mon Nov 08, 2010 6:03 am

First post

Hi everyone!
It looks as if I am accepted by Rush, for a mid january start.

I have 2 questions actually.

First is what insurance covers without a...

Last post

I have myasthenia gravis.

12 Replies

6489 Views

Last post by criptastic
Mon Jan 10, 2011 7:33 am
HiCy and Mesenchymal Stem Cells?

Last post by Looking88 « Sat Jan 08, 2011 7:24 am

by Looking88 » Sat Jan 08, 2011 7:24 am

Anybody know if HiCy treatment wipes out your Mesenchymal stem cells?

Seems it would be nice to be able to follow HiCy with Mesenchymal stem cell...

0 Replies

4747 Views

Last post by Looking88
Sat Jan 08, 2011 7:24 am
Accentia biopharmaceuticals announces strategic agreement

Last post by Frank « Mon Nov 29, 2010 11:11 am
Replies: 1
by MSUK » Mon Nov 29, 2010 5:09 am

First post

Accentia biopharmaceuticals announces strategic agreement with Baxter

Accentia Biopharmaceuticals, Inc. today announced a strategic agreement...

Last post

How is this going to effect the availability of Cyclophosphamide? It is widely used for other indications e.g. cancer, immuno-ablation in ASCT,...

1 Replies

4920 Views

Last post by Frank
Mon Nov 29, 2010 11:11 am
starting this week, few questions...

Last post by criptastic « Thu Oct 07, 2010 11:21 am
Replies: 7
by jackson233 » Sun Oct 03, 2010 2:25 pm

First post

Hi everyone,

I am starting therapy in the coming weeks and had a few simple questions about the therapy. I understand that my 'infusions' will take...

Last post

Mediport is good. I've had it since 2001. Again, good luck and keep us (ME) posted. We seem to be the only active posters here for a good while!

Crip

7 Replies

5820 Views

Last post by criptastic
Thu Oct 07, 2010 11:21 am
Deleted

Last post by ms_turophile « Wed Aug 11, 2010 9:18 am

by ms_turophile » Wed Aug 11, 2010 9:18 am

Deleted

0 Replies

4971 Views

Last post by ms_turophile
Wed Aug 11, 2010 9:18 am
Any new information about Revimmune trial?

Last post by AJWANTSACURE « Tue Jul 27, 2010 1:44 pm
Replies: 3
by Frank » Thu Jun 24, 2010 4:49 am

First post

I just had a look at the Accentia website where the Revimmune trial status is still pending . Is there any new information about any advance or...

Last post

I spoke with Dr. Harrison at JH, tey are not taking any patients for HI-CY at this time

3 Replies

5674 Views

Last post by AJWANTSACURE
Tue Jul 27, 2010 1:44 pm
Symptoms

Last post by happytown « Sun Jun 20, 2010 8:15 pm
Replies: 2
by AJWANTSACURE » Mon May 17, 2010 1:38 pm

First post

im headed down to the Mayoclinic in FL. in June to see a neuro about HiCy. I hope and pray I get it.

now i know everyone is ddifferent, on average...

Last post

That is awesome you all are going to get HiCy. I have talked to Mayo Clinic about it and am supposed to call them back in July to schedule for...

2 Replies

5401 Views

Last post by happytown
Sun Jun 20, 2010 8:15 pm
My 9 month HiCy follow-up

Last post by happytown « Mon Jun 14, 2010 11:34 am
Replies: 23
by mommasan » Thu Mar 26, 2009 6:00 am
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First post

Had my 9 month at Hopkins. I should preface this by saying that my symptoms have increased over the last 2 months but no reactivation. I will list...

Last post

I have decided to get this treatment also. I am so excited I can hardly wait!
23 Replies

13455 Views

Last post by happytown
Mon Jun 14, 2010 11:34 am
1 yr post HiCy (2nd round)...Great news!

Last post by ssmme « Mon May 31, 2010 11:56 am
Replies: 6
by RedPenguins » Mon May 03, 2010 10:26 pm

First post

Well, this board is mostly dead now...but figured I'd drop a quick update in case anyone ever stops by.

This week marks 1 year since I underwent a...

Last post

Keri congratulations, having a baby is wonderful. So it took to rounds of treatment for you to see improvements? I'm currently in a clinical trial...

6 Replies

6448 Views

Last post by ssmme
Mon May 31, 2010 11:56 am
DENIED BY CHICAGO

Last post by AJWANTSACURE « Tue May 04, 2010 2:45 am
Replies: 2
by AJWANTSACURE » Tue Apr 27, 2010 5:29 am

First post

because i have a brain stimulator, chicago will not accept me. I qualify in every other aspect.

They shoould haave done more research, because...

Last post

Red - trried jh, they r on hold right now. trying the mayo clinic in FL

2 Replies

5539 Views

Last post by AJWANTSACURE
Tue May 04, 2010 2:45 am
cyclophosphamide for MS

Last post by belsadie « Sun Apr 11, 2010 4:58 am
Replies: 28
by amielzbth » Tue Mar 30, 2010 11:51 am
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First post

My fiance is probably going to end up doing this. Has anyone here done it? Or is this Hici the same thing? Please let me know the side effects as you...

Last post

Sorry if I sounded like a naysayer... You're absolutely right. My brain MRI's show no advancement and healing has to be encouraged I do feel some...
28 Replies

14037 Views

Last post by belsadie
Sun Apr 11, 2010 4:58 am
How Do I Get It????????

Last post by tashenoir « Tue Mar 02, 2010 5:30 pm
Replies: 3
by AJWANTSACURE » Tue Feb 23, 2010 2:43 pm

First post

plain and simple - HOW DO I GET HICY?

Last post

First you have to want it! Sounds like you do! Research it like crazy, so you know what is going to happen.
Make a choice of how you want it. John...

3 Replies

5326 Views

Last post by tashenoir
Tue Mar 02, 2010 5:30 pm
3 month post hicy (round 2) update

Last post by AJWANTSACURE « Fri Feb 26, 2010 4:11 am
Replies: 8
by RedPenguins » Mon Aug 03, 2009 11:16 pm

First post

Hi again everyone,

Well, it is with sadness that I report that things have been on a downslide for the last two weeks. My previous update, I was on...

Last post

Duke University Hospital gives HiCy? As in duke University Hosp in Durham, NC? That is 20 min from me....guess i should get on the phone and find out...

8 Replies

7242 Views

Last post by AJWANTSACURE
Fri Feb 26, 2010 4:11 am
GoodBye Tysabri Hello HiCy?

Last post by chrishasms « Sat Feb 20, 2010 10:58 am
Replies: 3
by tashenoir » Wed Feb 17, 2010 2:03 pm

First post

Just asking for prayers for I will be in Chicago on Monday for my consultation to get HiCy.

Thanks everyone and I wall let you all know, maybe...

Last post

Best thing I ever did. I just came back from my neuro yesterday and I am 2 years out in March. No progression or lesions in 2 years.

3 Replies

5651 Views

Last post by chrishasms
Sat Feb 20, 2010 10:58 am
Chrishadms you tube video and facebook video

Last post by scorpion « Mon Feb 15, 2010 8:58 am
Replies: 11
by msisnotforme » Sun Feb 07, 2010 12:44 pm

First post

I am a friend of Chris who has sat in the corner watching how Revimmune and how CSVI is working. I don't really know how to post but I am going to...

Last post

Great news about your foot Chris!!!! It sounds like Revimmune has really worked for you!! Chris I do not think anyone would disagree with you about...

11 Replies

7102 Views

Last post by scorpion
Mon Feb 15, 2010 8:58 am
HDC news

Last post by mshusband « Sun Feb 07, 2010 11:27 am
Replies: 3
by ElMarino » Fri Feb 05, 2010 4:33 am

First post

I hust saw this article:

Last post

I'm telling you ... once CCSVI treatment gets up and running everywhere, the next is stem cells. I know they call this Revimmune ... but what it is...

3 Replies

5501 Views

Last post by mshusband
Sun Feb 07, 2010 11:27 am
UPDATE FOR REVIMMUNERS

Last post by Axiom « Sun Feb 07, 2010 8:22 am
Replies: 2
by chrishasms » Tue Jan 26, 2010 8:33 am

First post

2 years out. No lesions in 2 years. MRI yesterday clean with more lesion healing. No disease progression in 2 years.

Last post

Yes, very good news indeed, congratulations Chris!

This section of TIMS has been very quiet lately. Thanks so much for coming back to post your...

2 Replies

5771 Views

Last post by Axiom
Sun Feb 07, 2010 8:22 am
Anyone heard Dr. Kerr is leaving Hopkins?

Last post by scorpion « Sat Jan 23, 2010 6:20 pm
Replies: 2
by steven73 » Sat Jan 16, 2010 7:04 am

First post

I received a letter telling me that my next three appointments have been rescheduled with a different doctor so I called and was told he's taking a...

Last post

Any updates Chris? Just wondering how you were doing.

2 Replies

5543 Views

Last post by scorpion
Sat Jan 23, 2010 6:20 pm
cytoxan user with questions

Last post by msmything « Mon Dec 28, 2009 4:34 pm
Replies: 1
by ldybug477 » Mon Sep 28, 2009 5:42 pm

First post

Hello forum! I see a lot of posts about the hicy dosage and I don't believe that what I'm doing is considered that.

I initially started almost 5...

Last post

Hi Idybug, I'm sorry no one has given you any input, I for one, have never heard of this protocol.Maybe you could post this question in the copaxone...

1 Replies

5535 Views

Last post by msmything
Mon Dec 28, 2009 4:34 pm
Australian treated by this method in Sydney !

Last post by deluxe_diagnosis « Wed Dec 16, 2009 4:04 am

by deluxe_diagnosis » Wed Dec 16, 2009 4:04 am

G'day all ..deluxe here..

long time aussie lurker here with no official dx.

( limboland they call it I think )

Anyway I read this article in...

0 Replies

5023 Views

Last post by deluxe_diagnosis
Wed Dec 16, 2009 4:04 am
JH article on HDC

Last post by Frank « Tue Nov 17, 2009 12:23 am

by Frank » Tue Nov 17, 2009 12:23 am

Thats so frustrating! Why is there no funding from the NIH or the health insurances (who would safe a lot of money if HDC gets approved)?

--Frank...

0 Replies

5071 Views

Last post by Frank
Tue Nov 17, 2009 12:23 am
so happ today!

Last post by chrishasms « Sun Sep 06, 2009 11:07 am
Replies: 3
by mommyju » Thu Sep 03, 2009 12:23 pm

First post

My husband just got his first appointment scheduled at Johns Hopkins for December 09!!!
Wondering how long after his first appointment he will get...

Last post

123

3 Replies

5822 Views

Last post by chrishasms
Sun Sep 06, 2009 11:07 am
How many at JH now?!

Last post by greenwave « Thu Sep 03, 2009 1:19 pm
Replies: 43
by RedPenguins » Thu Jul 10, 2008 6:01 pm
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First post

Ohmygosh - I can count 7 people, including myself, that are here in Baltimore right now receiving HiCy! I'm sure there are more - but these are just...

Last post

We were in a similar boat as you. My husband was diagnosed just over a year ago. He had a rough relapse, and he wanted to get it earlier rather than...
43 Replies

21192 Views

Last post by greenwave
Thu Sep 03, 2009 1:19 pm
how long did it take for some of you to get in JH??

Last post by mommyju « Thu Sep 03, 2009 12:16 pm
Replies: 5
by mommyju » Fri Aug 28, 2009 12:07 pm

First post

Hello everybody, my name is Juliana I am new to this board...

my husband has MS and we are trying to get him into JH for Revimmune treatment ASAP...

Last post

Just got an appointment for my husband for December!!! Yeahhh!

5 Replies

5929 Views

Last post by mommyju
Thu Sep 03, 2009 12:16 pm
Schedule of Post HiCy Follow Up Appointments...

Last post by pvns2005 « Sat Aug 29, 2009 7:09 pm
Replies: 3
by steven73 » Thu Aug 20, 2009 2:55 am

First post

I just completed my first year of every three month appointments. Are we supposed to follow up every three months for the second year as well?...

Last post

My Neuro here in Alabama orders all my tests and he does my labs, EDSS and MSFC at his office then they fax all the results to Dr. Kerr's office. My...

3 Replies

5764 Views

Last post by pvns2005
Sat Aug 29, 2009 7:09 pm
Chris' update

Last post by chrishasms « Mon Aug 17, 2009 9:55 am
Replies: 8
by chrishasms » Wed Jun 18, 2008 9:21 pm

First post

I got one up on my site.

Last post

No nothing new to report really. I do feel like the disease progression has been slowed dramatically.

The more I watch this CCSVI stuff the more its...

8 Replies

7456 Views

Last post by chrishasms
Mon Aug 17, 2009 9:55 am
HiCy PPMS Trial

Last post by indigoinmotion « Mon Jul 27, 2009 9:55 am
Replies: 2
by Sport » Mon Jul 06, 2009 8:57 am

First post

At my appointment with Dr. Kerr last Sept he mentioned that he would be starting a trial of HiCy with a few PPMS patients and he said that he would...

Last post

so discouraging. thanks for checking into this. maybe stem cells is where it's at??

2 Replies

5864 Views

Last post by indigoinmotion
Mon Jul 27, 2009 9:55 am
My update!

Last post by indigoinmotion « Thu Jul 23, 2009 12:34 pm
Replies: 3
by RedPenguins » Tue Jul 21, 2009 8:28 pm

First post

Hi everyone,

Sorry, I haven't been around lately... (and geez, I missed a lot - especially the CCSVI stuff....gonna head over to that board in a...

Last post

Hi Keri,
Great news!! I'm so happy for you!!
Can you tell me what your condition/symptoms were prior to the treatment?
Live it up, girl!!!
Indigo

3 Replies

5710 Views

Last post by indigoinmotion
Thu Jul 23, 2009 12:34 pm
CCSVI before HiCy

Last post by chrishasms « Mon Jul 20, 2009 7:41 am
Replies: 5
by LR1234 » Sun Jul 19, 2009 6:59 am

First post

Hi,

Mel had hicy before having stents placed. I wonder if having stents placed and then trying to apply for hicy might not be allowed.

I wonder if...

Last post

You are low on blood about 1 week. Then everything is pretty much back to normal within 2 weeks. I would suggest Revimmune first but the more I am...

5 Replies

6266 Views

Last post by chrishasms
Mon Jul 20, 2009 7:41 am
Dosage?

Last post by patientx « Fri Jul 17, 2009 12:43 pm
Replies: 16
by LR1234 » Mon Jul 13, 2009 8:15 am
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First post

What is the dosage given of the cyclophosphamide?
I found this article online and was wondering if the dosage is similar.

The objective of this case...

Last post

This might answer your question:
16 Replies

11538 Views

Last post by patientx
Fri Jul 17, 2009 12:43 pm
Hi-Cy - where and how much?

Last post by rssugg « Wed Jul 15, 2009 7:58 am
Replies: 7
by MSGREG » Sun May 24, 2009 7:35 am

First post

Hello Everyone: Thank you for posting so many positive comments. It always makes me happy to read them and to know there is some hope to at least...

Last post

Good good! Getting on with life is a good thing! I'm glad everyone is well. Good luck!

7 Replies

7136 Views

Last post by rssugg
Wed Jul 15, 2009 7:58 am
question

Last post by chrishasms « Wed Jun 24, 2009 5:14 pm
Replies: 10
by guitarguy » Wed Jun 24, 2009 5:44 am

First post

I read revimmune doesnt work with people who dont have any enhancenced lesions. Has anyone recently had this treatment who has not shown...

Last post

Ya its wild for me with Asthma. Ever since that treatment I rarely ever use my inhalers and if I do its the Albuterol inhaler on a dusty day. The...

10 Replies

6515 Views

Last post by chrishasms
Wed Jun 24, 2009 5:14 pm
Keri??

Last post by LR1234 « Wed Jun 17, 2009 1:21 am
Replies: 4
by chrishasms » Wed Jun 03, 2009 2:10 pm

First post

How are you???

Last post

Keri I hope you are ok and that we hear from you soon

L x

4 Replies

6091 Views

Last post by LR1234
Wed Jun 17, 2009 1:21 am
Got an email from Dr. Kerr regarding my MRI on Thursday.

Last post by Sharon « Sat Jun 06, 2009 8:45 am
Replies: 3
by chrishasms » Sat Jun 06, 2009 7:34 am

First post

got it. the MRI looks great Chris. The MS is completely and totally inactive. Good news!!

That is the email I got from the good doctor verbatim....

Last post

Yes, you deserve a break - HAPPY BIRTHDAY!!

3 Replies

6328 Views

Last post by Sharon
Sat Jun 06, 2009 8:45 am

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