Discuss Ocrelizumab, a monoclonal antibody treatment for MS.
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Ocrevus Prescribing Information
Replies: 2
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NHE » Fri May 12, 2017 4:34 am
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Ocrevus Prescribing Information
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I need to find a new drug as I would like to father a child.
Ideally I would like something with:
No PML risk
Men can use who wish to father a child...
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Last post by orphansparrow
Tue Nov 14, 2017 10:02 am
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Ocrevus vs. Kesimpta
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NHE » Wed Mar 17, 2021 8:16 pm
Ocrevus and Kesimpta are two different anti-CD20 antibodies which induce B-cell depletion. Dr. Brandon Beaber presents an interesting comparison of...
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Last post by NHE
Wed Mar 17, 2021 8:16 pm
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Does anyone have an experience with Ocrevus that worsens progression?
Replies: 4
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motivation » Wed Jul 08, 2020 7:25 pm
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When I was on Abaugio I felt like things were stable in a sense. Sure I had foot drop. But I felt as though things were manageable.
Now today with...
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About two days after my last infusion I kinda crashed and burned for about a week or so. Seem to be back where I use to be now. Last one was five...
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Last post by HarbourBoy
Thu Jul 23, 2020 4:43 am
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Why Ocrevus is a new favorite drug by doctors?
Replies: 9
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Optimistic99 » Thu May 16, 2019 12:31 pm
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I am a new member of this family, and wanted to explore about this medicine.
I have been recently diagnosed with MS and 2 doctors in two different...
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Im kind of off meds right now. Due to my drs office dropping the ball, I was a couple months overdue on my last dose. And then a I've never seen that...
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Last post by NHE
Sat May 09, 2020 9:04 pm
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Covid19 and Ocrevus
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NHE » Thu Apr 23, 2020 2:54 pm
COVID-19 in a MS Patient Treated With Ocrelizumab: Does Immunosuppression Have a Protective Role?
Mult Scler Relat Disord. 2020 Apr 15;42:102120...
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Last post by NHE
Thu Apr 23, 2020 2:54 pm
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Seeking feedback on Ocrevus for PPMS, esp. from those 10-30 years POST DIAGNOSIS
Replies: 7
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jab54 » Wed Feb 20, 2019 2:15 pm
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Seeking feedback on Ocrevus for PPMS, esp. from those 10-30 years POST DIAGNOSIS but others too
Hello, interested in hearing everybody's feedback...
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I am due for my 2nd infusion in March or April.
Hey Jab,
Thanks for sharing for experience of first infusion, have you gone for a second one?...
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Last post by Optimistic99
Thu May 16, 2019 2:53 pm
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Reactivation of Hepatitis B Virus
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Petr75 » Mon Feb 25, 2019 10:12 am
2018 Dec 26
Department of Public Health and Infectious Diseases, Sapienza, University of Rome, Rome, Italy
Reactivation of Hepatitis B Virus With...
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Last post by Petr75
Mon Feb 25, 2019 10:12 am
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Last post by ElliotB
Sat Feb 09, 2019 4:23 am
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Ocrevus is a Wonder Drug for MS
Replies: 9
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seeva » Wed Jan 31, 2018 6:15 pm
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HI Friends please read a news today1st of feb SMH newspaper news
regards
seeva
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5. It has been clinically shown to STOP progression in some patients after 2 years of infusions.
in some patients?
FACT: The progression in some...
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Last post by ElliotB
Wed Jan 09, 2019 1:55 pm
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Second Infusion two weeks away, I feel like death? Any other
Replies: 11
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vender » Wed Oct 03, 2018 11:57 am
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Hello I get my next infusion in 10 days it will be my second infusion and was wondering does anyone else feel like complete shit? Yeah for the past 2...
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Have you had a MRI recently? If so, what were the results?
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Last post by ElliotB
Fri Nov 23, 2018 4:50 pm
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After first infusion no change in progression
Replies: 4
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vender » Tue Sep 11, 2018 5:04 am
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Hello all after my first infusion five months ago I feel no different at all. I am coming up on my second infusion and was wondering should I even...
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The clinical data says 2 years on ocrevus is needed to see a cessation of progression. Google the emerging results, Ocrevus is actually helping some...
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Last post by Kheuer
Wed Oct 31, 2018 4:29 am
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Ocrelizumab and male fertility
Replies: 3
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Pesho » Thu Mar 16, 2017 2:28 pm
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I've been on Ocrelizumab for 5 years now and it looks like it is working well. No regression during that time, only one very small attack without any...
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The mechanism of action should not cause infertility.
Ocrevus is a human monoclonal antibody that has a very high binding affinity to CD20...
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Last post by Kheuer
Wed Oct 31, 2018 4:22 am
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Last post by undisclosED
Wed Apr 25, 2018 2:11 pm
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Last post by MSUK
Fri Jan 12, 2018 5:51 am
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Ocrelizumab (Ocrevus) safety footprints create real worries
Replies: 3
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Cliffhanger » Sun Nov 20, 2016 11:44 pm
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FOR SOME REASON, many tends to underestimate the risks with Ocrelizumab ( Ocrevus ) - it is far to much blue sky (sorry) opinions aired about this,...
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Thank you @Cliffhanger My husband's doctor really wants him to start this, and it seems so promising, but we are just not sure. It seems we have...
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Last post by orphansparrow
Wed Nov 29, 2017 2:55 pm
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OCREVUS ON PBS IN AUSTRALIA
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seeva » Wed Nov 29, 2017 3:06 am
Hi friends any one know when OCREVUS will be approved by AUSTRALIAN PBS BOARD
Your help appreciated
regards
seeva
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Last post by seeva
Wed Nov 29, 2017 3:06 am
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Ocrevus questions
Replies: 17
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HUD45 » Wed Apr 26, 2017 6:28 am
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Hi. I am still wondering if there are patients out there starting the Ocrevus infusion process? From insurance authorization to infusion and side...
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My husband is set to get his first infusion in a couple days. However, we are considering waiting (against the advice of his doctor) because I want...
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Last post by Pesho
Thu Nov 16, 2017 11:39 am
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Last post by orphansparrow
Wed Nov 15, 2017 9:02 pm
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Ocrevus (Ocrelizumab) - clear doubts about safety
Replies: 6
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Cliffhanger » Wed Jan 11, 2017 5:12 pm
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Hey all!
Happy new year everyone!
I get right down to the core in my post.
Ocrevus will soon probably be approved by to FDA. But how will FDA view...
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@Cliffhanger
Thank you so much for this Cliff. I appreciate all the opinions from those who have been living with and studying MS for quite a while....
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Last post by orphansparrow
Wed Nov 15, 2017 9:01 pm
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Last post by MSUK
Fri Nov 10, 2017 6:26 am
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Last post by MSUK
Fri Oct 27, 2017 7:06 am
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Deaths overshadow ocrelizumab trials in MS
Replies: 4
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MSUK » Thu May 20, 2010 9:08 pm
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Swiss drugmaker Roche AG and Biogen Idec Inc. are discontinuing development of ocrelizumab in patients with rheumatoid arthritis (RA), after an...
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From what I talked with my Neurologists doses for RA are much higher than for MS. There were deaths in the MS Trial Opera but they were few and it...
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Last post by Pesho
Wed Oct 18, 2017 11:09 am
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Investigation launched after Ocrevus patient develops PML
Replies: 1
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MSUK » Fri May 26, 2017 2:05 am
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Investigation launched after Ocrevus patient develops rare brain infection
It has been reported by Reuters, that Roche, the maker of Ocrevus, is...
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On Tsybari for years, switch to ocrevus and got PML a couple days later. I'm guessing it has nothing to do with the new med.
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Last post by Anunymouse
Wed Oct 18, 2017 5:51 am
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Progressive MS and Ocrizumab?
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MSUK » Fri Oct 06, 2017 5:04 am
Do you have progressive MS and are currently, or have used
Ocrizumab? If so we would like to hear your experiences for an article in New Pathways...
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Last post by MSUK
Fri Oct 06, 2017 5:04 am
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Insurance Approval
Replies: 2
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CayB » Sat Aug 19, 2017 9:50 am
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Aetna just turned down my doctor's request to put me on Ocrevus. I have RR and have been on Avonex and currently on Tecfidera. (Both of which they...
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My doctor has handled all of the interactions with Aetna. I don't know what UPMC is - seems to be a hospital in Pittsburgh. We've gone through one...
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Last post by CayB
Sat Sep 23, 2017 9:06 am
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FDA approves its first drug for PPMS patients
Replies: 5
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MSUK » Fri Mar 31, 2017 2:44 am
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The US Food and Drug Administration (FDA) has approved Ocrevus, otherwise known as ocrelizumab, to treat adult patients with relapsing and primary...
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Has any one recently been on this new drug, and how are you doing? I am PPMS, my doctor would like me to start, I am cautious, thoughts?
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Last post by JCB
Sun Aug 06, 2017 3:08 pm
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Ocrevus
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DiannaB » Wed Apr 12, 2017 7:39 am
Has anyone in the clinical trial of Ocrevus taken Rituxan with success? I have taken Rituxan and it was unsuccessful. I'm not sure if it would work...
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Last post by DiannaB
Wed Apr 12, 2017 7:39 am
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Last post by MSUK
Fri Mar 10, 2017 7:53 am
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US extends review of Roche MS drug Ocrevus by three months
Replies: 1
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frodo » Fri Dec 30, 2016 11:46 am
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Given that Ocrelizumab is a humanized version of Rituxan I suppose this report belongs here.
By the way. Could be the title of this subforum...
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Very soon Ocrevus will need a place to be discussed.
Done.
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Last post by NHE
Sat Dec 31, 2016 7:15 pm
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Ocrelizumab Conference in November
Replies: 1
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Nenebird54 » Sat Oct 22, 2016 12:35 pm
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I have been asked to attend as a Patient Advisor. Would be happy to bring questions from all you fine folks. This drug is being targeted for both...
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turns out i developed a bug and didn't make the trip.
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Last post by Nenebird54
Sat Nov 19, 2016 4:02 pm
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Last post by MSUK
Mon Sep 26, 2016 3:27 am
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Ocrelizumab accepted for EMA review
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MSUK » Thu Jun 30, 2016 12:26 am
Roche has announced that the European Medicines Agency (EMA) has validated the company’s Marketing Authorisation Application (MAA) of ocrelizumab for...
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Last post by MSUK
Thu Jun 30, 2016 12:26 am
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Ocrelizumab (Ocrevus) not the answer in PPMS - far from it.
Replies: 17
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Cliffhanger » Fri May 20, 2016 12:16 pm
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Hi!
I am a new member at this page. But I have been reading this page for several years. So today I pull myself together and registered :-D It is a...
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I am tempted to recuse myself from MS altogether, because since my CCSVI procedure I have had few relapses and little progression. My problems are...
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Last post by 1eye
Fri Jun 10, 2016 3:59 pm
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New drug reduces progression for primary progressive MS....
Replies: 22
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MSUK » Mon Sep 28, 2015 7:40 am
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Study finds new drug reduces progression for primary progressive MS patients
Genentech, a member of the Roche Group, has announced positive results...
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No. I am not in a clinical trial, nor am I qualified even if testing myself could be unbiased. Nobody is testing me. I expect I will do better once...
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Last post by 1eye
Wed Mar 09, 2016 7:40 pm
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FDA grants ocrelizumab 'breakthrough therapy designation...
Replies: 4
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MSUK » Thu Feb 18, 2016 1:12 am
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FDA grants ocrelizumab 'breakthrough therapy designation' for primary progressive MS
Roche Holding AG announced yesterday that it had received...
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This is from Wikipedia:
In March 2010, Roche announced the suspension of clinical trials in rheumatoid arthritis and lupus erythematosus. This...
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Last post by SarahLonglands
Thu Feb 18, 2016 1:29 pm
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Roche drug ocrelizumab clears final hurdle
Replies: 5
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MSUK » Mon Dec 21, 2015 3:10 am
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In September pharmaceutical company Hoffmann–La Roche announced positive results from three large clinical trials of ocrelizumab, an injectable...
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This is not the final hurdle if you have relapsing-remitting.
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Last post by 1eye
Sun Dec 27, 2015 9:56 am
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Last post by Manu
Mon Oct 26, 2015 2:20 am
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Roche drug shows promise for less common form of MS
Replies: 3
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MSUK » Thu Oct 08, 2015 11:33 pm
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Swiss drugmaker Roche has said its experimental treatment for multiple sclerosis performed better in a late-stage clinical trial than a commonly used...
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This part is related to the RRMS trial and they are talking abouth interferon-beta
It's interesting that many of these new MAB drugs are compared...
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Last post by MSbro
Sat Oct 10, 2015 5:55 am
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Studies provide positive results for new MS drug
Replies: 5
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MSUK » Tue Jun 30, 2015 1:59 am
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Genentech has announced positive results from two studies evaluating ocrelizumab for people with relapsing multiple sclerosis (MS).
The studies...
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I agree that it is not a good solution but until we dont have a better sight in MS this is the best . I can understand your brothers fear, I have...
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Last post by MSbro
Wed Jul 01, 2015 9:42 am
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Ocrelizumab
Replies: 10
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Lars » Tue May 05, 2009 12:24 pm
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I was going through the clinical trials list and saw that Ocrelizumab is, or is still recruiting for phase 2. I'm wondering if this is really just...
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Got some bad case of sour throat... Almost a month now, going trough a second course of antibiotics and a whole bunch of other medicine. And it is...
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Last post by Pesho
Wed Oct 31, 2012 1:14 pm
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Ocrelizumab treatment
Replies: 5
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kenneth65 » Wed Sep 19, 2012 4:43 pm
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Hi all hope all is well Today we went to the doctors to do a follow up for my wife that has MS turns out she graded at 5 Man this was not a good day...
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This is still in trial. I'm in it, but it could be ocrelizumab or rebif. Think I'm on ocrelizumab, because I don't have any side effects from the...
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Last post by Pesho
Sun Sep 23, 2012 12:55 pm
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Ocrelizumab shows promise in MS
Replies: 2
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MSUK » Tue Nov 01, 2011 12:30 am
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An investigational biologic drug that deactivates antibody-producing B cells reduced gadolinium-enhancing T1 lesions in multiple sclerosis patients,...
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I'll be starting in the phase III study on 7th feb 2012.
I read a lot of promissing things as being possible to hold down the attacks with 85-90%....
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Last post by Manu
Mon Jan 30, 2012 4:34 am
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Last post by MSUK
Thu Oct 20, 2011 12:21 am
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Ocrelizumab
Replies: 2
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dignan » Mon Jul 16, 2007 9:18 am
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Ocrelizumab is a new anti-CD20 drug that is being called a second-generation rituxan. Genentech and Biogen are collaborating on it and it is supposed...
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i hope that they do a combination trial with ocrelizumab and copaxone. really, i think more combination trials with copaxone should be done,...
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Last post by charlesd
Sun Jan 09, 2011 8:04 pm
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Positive mid-stage results for MS drug ocrelizumab
Replies: 1
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MSUK » Sat Nov 13, 2010 12:37 am
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Roche Holding AG Friday said mid-stage trials of a experimental multiple sclerosis medicine ocrelizumab showed the drug to significantly reduce...
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They are definitely moving this one along. I moved ocrelizumab to phase 3 on the pipeline list as they are starting a phase 3 trial for primary...
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Last post by dignan
Sat Nov 13, 2010 9:34 am
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Biogen, Genentech amend deal on MS drug
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MSUK » Thu Oct 21, 2010 10:45 pm
Biogen Idec Inc. and Genentech said Thursday they amended their development agreement on a potential multiple sclerosis treatment.
Genentech, a unit...
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Last post by MSUK
Thu Oct 21, 2010 10:45 pm
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Roche, Biogen report one death in MS drug trial
Replies: 3
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MSUK » Tue Oct 19, 2010 11:20 pm
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Roche Holding AG and Biogen Idec Inc reported data from a mid-stage trial of their experimental multiple sclerosis drug ocrelizumab on Friday that...
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I wonder how they studied anything before god's gift of CCSVI came down from the heavens to show science the platonic state of medical perfection....
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Last post by rainer
Wed Oct 20, 2010 5:36 pm
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Last post by MSUK
Sat Oct 16, 2010 1:37 am
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Ocrelizumab
Replies: 3
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scoobyjude » Wed Mar 10, 2010 4:16 pm
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The Opportunity That Wasn't
By Brian Orelli
March 9, 2010
Opportunistic infections aren't an opportunity for Roche and Biogen Idec (Nasdaq: BIIB)....
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Actually---even though some people HAVE DIED from this drug, the MS trials continue...
Swiss drugmaker Roche AG and Biogen Idec Inc. are...
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Last post by cheerleader
Wed May 19, 2010 8:40 pm
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Ocrelizumab Trial
Replies: 6
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Milo » Wed Jan 14, 2009 7:04 am
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Is anyone here participating or considering the Ocrelizumab trial? I have my first infusion next week.
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Thanks for the clarification Milo!
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Last post by Loobie
Fri Jan 16, 2009 4:52 am
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