A forum to discuss research on the origins of MS and its development.
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Last post by frodo
Tue Dec 10, 2019 3:52 am
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Dogs can smell MS
Replies: 2
by
frodo » Wed Dec 04, 2019 12:54 am
First post
These Dogs Know When Their Owners Are About to Have an MS Flare
Health and wellness touch everyone’s life differently. Here are some stories....
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Using Gas Chromatography Mass Spectrometry (GC-MS) for MS diagnosis.
Diagnosing Multiple Sclerosis Using Breath Biomarkers and GC-MS.
As a...
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- 146 Views
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Last post by frodo
Tue Dec 10, 2019 2:11 am
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MS clinical types are obsolete
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frodo » Sun Dec 08, 2019 4:57 am
After a whole age in which neurologist have classified the MS types by its clinical evolution, finally there is some work towards a pathological...
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- 157 Views
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Last post by frodo
Sun Dec 08, 2019 4:57 am
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MS linked to lipids dysregulation
Replies: 1
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frodo » Mon Dec 02, 2019 11:26 am
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Before reading the paper, it is interesting also this:
Specialized pro-resolving lipid mediators are differentially altered in peripheral blood...
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This caught my interest as there are a couple of proresolving mediator supplements available on the market. The assumption is they will cross BBB as...
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Last post by Anonymoose
Wed Dec 04, 2019 6:10 am
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MRZR+ MS cases are different from others
Replies: 1
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frodo » Mon Aug 26, 2019 5:08 am
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MRZR is a reaction about several viruses highly specific for MS, but little sensitive. This means that if you have MRZR is nearly sure that you have...
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Rheumatic diseases (lupus like diseases) and 60% of MS cases show antinuclear antibodies (ANA), leading to diagnosis confusion. MRZR can separate...
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Last post by frodo
Fri Nov 29, 2019 5:59 am
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Microglia in the pathogenesis of MS
Replies: 15
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frodo » Mon Jul 23, 2018 11:13 am
First post
Microglia in the pathogenesis of MS
We postulate that the immune reaction initiates in the CNS and immune cells (including T cells/B cell)...
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2019 Nov 15
Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School,...
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Last post by Petr75
Wed Nov 27, 2019 8:46 am
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MS defined as a CD8+ disease
Replies: 1
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frodo » Thu Oct 17, 2019 3:01 am
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This is the first time that I see some kind of concrete definition for MS, instead of defining it by a collection of symptoms and testing...
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Anti-CD20 therapy depletes activated myelin-specific CD8+ T cells in multiple sclerosis
Significance
Multiple sclerosis (MS) is an inflammatory...
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- 201 Views
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Last post by frodo
Sun Nov 24, 2019 6:03 am
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MS signature in plasma and CSF
Replies: 1
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frodo » Thu Oct 31, 2019 11:53 am
First post
Multiple sclerosis has a distinct lipid signature in plasma and cerebrospinal fluid
ABSTRACT
The diagnosis of multiple sclerosis (MS) has...
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2019 Oct 14
Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
HDL-cholesterol elevation associated with...
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- 146 Views
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Last post by Petr75
Thu Nov 21, 2019 10:29 pm
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Plasma exchange works in steroid-refractory MS
Replies: 1
by
frodo » Tue Nov 19, 2019 4:06 am
First post
Visual Outcomes of Plasma Exchange Treatment of Steroid-Refractory Optic Neuritis: A Retrospective Monocentric Analysis
Introduction :
In acute...
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Safety and efficacy of immunoadsorption versus plasma exchange in steroid-refractory relapse of multiple sclerosis and clinically isolated syndrome:...
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Last post by frodo
Tue Nov 19, 2019 4:11 am
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Prodromal MS: Biomarkers
Replies: 2
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frodo » Tue Aug 07, 2018 6:57 am
First post
Prodrome is the stage of a disease in which there are no noticeable symptoms, but nevertheless the disease is present. In MS this means that is a...
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Normalized cerebellar white matter and gray matter volume were significantly decreased in RIS compared to healthy controls.
Cerebellar volume loss...
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- 816 Views
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Last post by frodo
Thu Nov 07, 2019 7:16 am
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- 98 Views
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Last post by frodo
Thu Nov 07, 2019 5:44 am
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personalized medicine for MS
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frodo » Wed Nov 06, 2019 4:25 am
Thanks to ms-uk for the review
New genetic markers may make prognosis clearer
The original paper:
Early complement genes are associated with...
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Last post by frodo
Wed Nov 06, 2019 4:25 am
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An underlying process causes abnormalities in veins together with MS
Replies: 2
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frodo » Thu May 09, 2019 1:41 am
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This paper points to the existence of an underlying process that causes the known MS lesions and, at the same time, some venous problems:
The...
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Central vein sign: More about vascular problems and MS. 100% sensitivity.
Single Test to ARrive at Multiple Sclerosis (STAR-MS) diagnosis: A...
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- 306 Views
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Last post by frodo
Mon Nov 04, 2019 7:26 am
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IGM+ MS is different from normal MS
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frodo » Thu Oct 31, 2019 11:35 am
The oligoclonal bands in MS are IgG bands. There is a subset of patients with another immunoglobulin, IGM, that have a worse prognosis.
Intrathecal...
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Last post by frodo
Thu Oct 31, 2019 11:35 am
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- 249 Views
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Last post by frodo
Thu Oct 24, 2019 8:03 am
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- 1 Replies
- 176 Views
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Last post by Petr75
Mon Oct 21, 2019 10:41 am
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MRS of the brain
Replies: 1
by
frodo » Thu Oct 10, 2019 6:52 am
First post
MRS (Magnetic Resonance Spectroscopy) allows to see the chemical composition of the brain.
Magnetic resonance spectroscopy (MRS) is a non-invasive...
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Magnetic resonance spectroscopy evidence for declining gliosis in MS patients treated with ocrelizumab versus interferon beta-1a
Background...
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- 193 Views
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Last post by frodo
Sun Oct 20, 2019 9:13 am
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- 170 Views
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Last post by frodo
Tue Oct 15, 2019 6:28 am
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Large Noncoding RNA in blood
Replies: 5
by
frodo » Wed Oct 04, 2017 12:30 pm
First post
Expression Analysis of Long Non-coding RNAs in the Blood of Multiple Sclerosis Patients.
Abstract
Multiple sclerosis (MS) is a chronic...
Last post
2019 Aug 6
Department of Cardiovascular Medicine, The Second Hospital Affiliated to Jilin University, Changchun, China
Exosomal long noncoding RNAs...
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Last post by Petr75
Sat Oct 12, 2019 11:16 pm
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- 144 Views
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Last post by frodo
Wed Oct 09, 2019 11:40 am
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MS induced by mistake
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frodo » Wed Oct 09, 2019 11:35 am
An unfortunate accident has shown something that could replace EAE.
Multiple sclerosis associated with pembrolizumab in a patient with non-small...
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- 170 Views
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Last post by frodo
Wed Oct 09, 2019 11:35 am
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EBV-activated CD8+ Tcells infiltrate the MS brain
Replies: 1
by
frodo » Tue Oct 08, 2019 2:26 am
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More clues pointing to EBV as the culprit. And more evidence that EAE (a CD4+ disease) and MS have nothing to do.
EBV-activated CD8+ Tcells...
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And maybe the mechanism by which the anti-EBV Tcells cause inflammation is because they cross-react with myelin MBP:
Myelin-specific CD8 T cells...
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- 105 Views
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Last post by frodo
Tue Oct 08, 2019 2:31 am
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- 177 Views
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Last post by frodo
Tue Oct 01, 2019 4:17 am
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Myelocortical MS (MCMS)
Replies: 6
by
frodo » Thu Aug 23, 2018 5:03 am
First post
Researchers discover new subtype of multiple sclerosis (The Lancet)
Cleveland Clinic researchers have discovered a new subtype of multiple...
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The cortical pathology is associated to a specific CSF profile:
Inflammatory intrathecal profiles and cortical damage in multiple sclerosis...
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- 1286 Views
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Last post by frodo
Tue Oct 01, 2019 4:07 am
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- 153 Views
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Last post by frodo
Tue Oct 01, 2019 3:34 am
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Smouldering lesions can be seen on MRI
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frodo » Tue Sep 24, 2019 1:34 am
A paper about seen smoldering lesions on MRI here:
A previous one about the same:
An not a paper, but a blog entry instead speaking about the...
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- 187 Views
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Last post by frodo
Tue Sep 24, 2019 1:34 am
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Review on biomarkers 2019
by
frodo » Tue Sep 24, 2019 1:23 am
Available on Barts MS research page:
there is a review covering the following 6 topics in biomarkers, presented at ECTRIMS 2019:
-serum...
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- 173 Views
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Last post by frodo
Tue Sep 24, 2019 1:23 am
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- 195 Views
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Last post by frodo
Mon Sep 16, 2019 7:05 am
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- 143 Views
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Last post by frodo
Sun Sep 15, 2019 11:20 am
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miRNA dysregulation as the source of the disease
Replies: 9
by
frodo » Mon Oct 16, 2017 11:28 pm
First post
Micro-RNA ( miRNA ) has been proposed as a biomarker of axon degeneration, but some authors have proposed that they could be the source of the...
Last post
2019 Jun 25
Laboratorio di Farmacologia Molecolare e Cellulare della Trasmissione Purinergica, Dipartimento di Scienze Farmacologiche e Biomolecolari...
- 9 Replies
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Last post by Petr75
Sat Sep 07, 2019 7:02 am
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- 118 Views
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Last post by frodo
Thu Sep 05, 2019 6:39 am
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closer to an urine test
Replies: 2
by
frodo » Mon Sep 02, 2019 11:45 pm
First post
Abstract
BACKGROUND: Systemic inflammation is a marker of ill health and has prognostic implications in multiple health settings. Urinary neopterin...
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Maybe it is related. It would be nice to have an update, but the problem with this kind of papers is that they are easily forgotten
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- 123 Views
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Last post by frodo
Thu Sep 05, 2019 6:38 am
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Temelimab works. HERVs clearly implicated.
Replies: 4
by
frodo » Mon May 20, 2019 11:38 am
First post
Efficacy and Safety of Temelimab, an Antibody Antagonist of the Human Endogenous Retrovirus Type-W env Protein, in Participants with Relapsing...
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And here a new review about the role of HERVs in microglia activation, following Kremer's paper from last May.
This researchers confirm again the...
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- 328 Views
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Last post by frodo
Sun Sep 01, 2019 11:14 am
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Ashton Embry: Multiple Factors in MS Etiology
Replies: 1
by
NHE » Mon Aug 26, 2019 2:56 pm
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Ashton Embry published a review paper in 2004 discussing multiple factors in MS etiology. Note, this paper predates CCSVI so it does not address...
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I agree about the multifactiorial source of MS, but in the sense that probably there exists different kinds of MS, each one of them with a different...
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Last post by frodo
Tue Aug 27, 2019 4:13 am
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Around 13% of MS cases are of genetic origin. 12 pathogenic variants.
Replies: 1
by
frodo » Tue Aug 13, 2019 7:38 am
First post
Of people diagnosed with MS, only 13% are believed to have a genetic form of the disease, but those presenting the mutations identified in this new...
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HLA-DRB1 differences in allelic distribution between familial and sporadic multiple sclerosis in a Hellenic cohort
Conclusion: We propose...
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- 225 Views
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Last post by frodo
Fri Aug 16, 2019 10:15 am
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PPMS and SPMS may be different
by
frodo » Sun Aug 11, 2019 3:53 am
Mitochondrial functionality and metabolism in T cells from progressive multiple sclerosis patients
Abstract
Patients with primary progressive...
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- 196 Views
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Last post by frodo
Sun Aug 11, 2019 3:53 am
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Molecular mimicry agent finally found?
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frodo » Sat Aug 10, 2019 10:13 am
Both EBNA-1 and Anoctamin-2 have been previously implicated.
Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1...
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- 157 Views
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Last post by frodo
Sat Aug 10, 2019 10:13 am
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Lipid profile of cerebrospinal fluid
by
frodo » Sat Aug 10, 2019 9:28 am
Lipid profile of cerebrospinal fluid in multiple sclerosis patients: a potential tool for diagnosis
Discussion
MS is a chronic disease which is...
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- 147 Views
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Last post by frodo
Sat Aug 10, 2019 9:28 am
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- 189 Views
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Last post by frodo
Wed Jul 31, 2019 11:36 pm
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Weird biomarker
Replies: 2
by
frodo » Mon Jul 29, 2019 6:34 am
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Though I don't understand fully what they say, it seems that they have created a molecule with a fluorescent substrate surrounded by MBP proteins....
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I agree. The T-cell model is dead. At least the CD4+ classic model.
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Last post by frodo
Wed Jul 31, 2019 11:08 pm
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CSF from MS patients damage neurons in-vitro
Replies: 1
by
frodo » Mon Jul 22, 2019 12:56 am
First post
A metabolic perspective on CSF-mediated neurodegeneration in multiple sclerosis
Abstract
Multiple sclerosis is an autoimmune demyelinating...
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Comments on the previous paper. A new paper in “Brain” identifies molecular mechanisms causing neuronal damage in multiple sclerosis patients with...
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- 204 Views
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Last post by frodo
Mon Jul 29, 2019 8:24 am
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- 126 Views
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Last post by frodo
Mon Jul 29, 2019 8:09 am
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- 127 Views
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Last post by frodo
Mon Jul 29, 2019 5:06 am
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- 143 Views
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Last post by frodo
Sat Jul 13, 2019 1:04 am
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- 199 Views
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Last post by frodo
Thu Jun 27, 2019 12:58 am
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- 131 Views
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Last post by frodo
Thu Jun 27, 2019 12:48 am
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T-cells dysregulation
by
frodo » Tue Jun 25, 2019 7:18 am
Quantitative proteomic analyses of CD4+ and CD8+ T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy...
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- 171 Views
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Last post by frodo
Tue Jun 25, 2019 7:18 am
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Cortical lesions and GA
by
frodo » Wed Jun 19, 2019 4:26 am
This paper is about the effects of Glatimer Acetate in MS, but they include a very deep review about the status of the research:
Some excerpts:...
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- 157 Views
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Last post by frodo
Wed Jun 19, 2019 4:26 am
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Age of cells populations in MS
by
frodo » Wed Jun 19, 2019 4:01 am
Using Carbon14 the researchers can calculate the age of different cells (oligodendrocytes are myelin producing cells and OPC are oligodendrocyte...
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- 163 Views
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Last post by frodo
Wed Jun 19, 2019 4:01 am
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Early MS lesions: Astrocytes involved
by
frodo » Wed Jun 19, 2019 3:33 am
Multiple Sclerosis: Destruction and Regeneration of Astrocytes in Acute Lesions
Abstract
There are reports that astrocyte perivascular endfeet...
- 0 Replies
- 149 Views
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Last post by frodo
Wed Jun 19, 2019 3:33 am
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