MS Etiology and Pathogenesis

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miRNA dysregulation as the source of the disease

Last post by Petr75 « Mon Jan 18, 2021 11:56 pm
Replies: 15
by frodo » Mon Oct 16, 2017 11:28 pm
1

2
First post

Micro-RNA ( miRNA ) has been proposed as a biomarker of axon degeneration, but some authors have proposed that they could be the source of the...

Last post

2021 Jan 16
Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
Identification of...
15 Replies

2562 Views

Last post by Petr75
Mon Jan 18, 2021 11:56 pm
serum biomarkers: Phospholipids

Last post by frodo « Wed Jan 13, 2021 5:31 am

by frodo » Wed Jan 13, 2021 5:31 am

Serum phospholipidomics reveals altered lipid profile and promising biomarkers in multiple sclerosis

Conclusion

From this study, we can...

0 Replies

45 Views

Last post by frodo
Wed Jan 13, 2021 5:31 am
Western lifestyle: Possible link to antibiotics consumption

Last post by frodo « Tue Jan 12, 2021 10:40 am

by frodo » Tue Jan 12, 2021 10:40 am

Holistic solution to an old mystery : the global role of antibiotic consumption patterns in the spread of certain non-contagious diseases in EU...

0 Replies

45 Views

Last post by frodo
Tue Jan 12, 2021 10:40 am
New medical entity overlapping with MS: DAF

Last post by frodo « Tue Jan 12, 2021 9:05 am

by frodo » Tue Jan 12, 2021 9:05 am

After NMO and anti-MOG, and following the non-autoimmune models of MS, it seems that there is a new entity entering the scene:

Demyelination with...

0 Replies

46 Views

Last post by frodo
Tue Jan 12, 2021 9:05 am
subtyping RRMS

Last post by frodo « Tue Jan 05, 2021 3:00 pm

by frodo » Tue Jan 05, 2021 3:00 pm

Subtyping relapsing–remitting multiple sclerosis using structural MRI

Abstract
Background and purpose

Subtyping relapsing–remitting multiple...

0 Replies

61 Views

Last post by frodo
Tue Jan 05, 2021 3:00 pm
Dogs can smell MS

Last post by frodo « Tue Dec 22, 2020 12:27 pm
Replies: 3
by frodo » Wed Dec 04, 2019 12:54 am

First post

These Dogs Know When Their Owners Are About to Have an MS Flare

Health and wellness touch everyone’s life differently. Here are some stories....

Last post

Detecting Multiple Sclerosis via breath analysis using an eNose, a pilot study

Abstract

Objective: In the present study we investigated whether...

3 Replies

613 Views

Last post by frodo
Tue Dec 22, 2020 12:27 pm
Herpes simplex virus

Last post by Petr75 « Tue Dec 22, 2020 12:07 am

by Petr75 » Tue Dec 22, 2020 12:07 am

2020 Nov 19
Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
Positive...

0 Replies

56 Views

Last post by Petr75
Tue Dec 22, 2020 12:07 am
Microglia in the pathogenesis of MS

Last post by Petr75 « Tue Dec 15, 2020 10:32 am
Replies: 20
by frodo » Mon Jul 23, 2018 11:13 am
1

2
First post

Microglia in the pathogenesis of MS

We postulate that the immune reaction initiates in the CNS and immune cells (including T cells/B cell)...

Last post

2020 Nov 6
Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada
Microglia Diversity in Health and Multiple...
20 Replies

3281 Views

Last post by Petr75
Tue Dec 15, 2020 10:32 am
MRZ Reaction in PPMS

Last post by frodo « Tue Dec 01, 2020 5:45 am

by frodo » Tue Dec 01, 2020 5:45 am

Cerebrospinal Fluid Biomarkers in Relation to MRZ Reaction Status in Primary Progressive Multiple Sclerosis

Abstract

The MRZ reaction (MRZR)...

0 Replies

237 Views

Last post by frodo
Tue Dec 01, 2020 5:45 am
Iron heterogeneity in MS: Patterns can be separated!!

Last post by frodo « Tue Dec 01, 2020 5:37 am

by frodo » Tue Dec 01, 2020 5:37 am

Iron heterogeneity in early active multiple sclerosis lesions.

Abstract

OBJECTIVE :

Multiple sclerosis (MS) is a heterogeneous inflammatory...

0 Replies

167 Views

Last post by frodo
Tue Dec 01, 2020 5:37 am
lipid metabolism and MS

Last post by frodo « Wed Nov 18, 2020 12:40 am

by frodo » Wed Nov 18, 2020 12:40 am

Serum phospholipidomics reveals altered lipid profile and promising biomarkers in multiple sclerosis

Abstract

Multiple sclerosis is a...

0 Replies

213 Views

Last post by frodo
Wed Nov 18, 2020 12:40 am
Twins comparison suggest lipids metabolism implications

Last post by frodo « Thu Nov 12, 2020 4:04 am

by frodo » Thu Nov 12, 2020 4:04 am

Plasma lipidomics of monozygotic twins discordant for multiple sclerosis

Abstract

Blood biomarkers of multiple sclerosis (MS) can provide a...

0 Replies

211 Views

Last post by frodo
Thu Nov 12, 2020 4:04 am
MBP in saliva as biomarker

Last post by frodo « Tue Nov 10, 2020 5:13 am

by frodo » Tue Nov 10, 2020 5:13 am

Serum and saliva Myelin basic protein as Multiple sclerosis biomarker

Abstract:

Objective: Multiple sclerosis (MS) is considered as motor and...

0 Replies

181 Views

Last post by frodo
Tue Nov 10, 2020 5:13 am
type-1 diabetes and MS. New kind of cells discovered.

Last post by frodo « Fri Nov 06, 2020 5:09 am

by frodo » Fri Nov 06, 2020 5:09 am

Newly Discovered Hybrid Immune Cell Could Finally Explain The Cause of Type 1 Diabetes

Both the peptide and hybrid white cells were more likely...

0 Replies

198 Views

Last post by frodo
Fri Nov 06, 2020 5:09 am
New microglial modulator inhibits activated microglia

Last post by frodo « Fri Nov 06, 2020 2:45 am

by frodo » Fri Nov 06, 2020 2:45 am

The new modulator inhibits something called CSF1R and it has been shown to reduce altered microglia. They also say that NAWM microglia shows an...

0 Replies

183 Views

Last post by frodo
Fri Nov 06, 2020 2:45 am
changes in NAWM precede lesion development

Last post by frodo « Tue Nov 03, 2020 6:09 am

by frodo » Tue Nov 03, 2020 6:09 am

Role of Magnetic Resonance Imaging with Diffusion Sequences in Assessment of Multiple Sclerosis in Brain Versus Normally Appearing White Matter...

0 Replies

198 Views

Last post by frodo
Tue Nov 03, 2020 6:09 am
Retinal damage reflects MS progression, not relapses

Last post by frodo « Tue Nov 03, 2020 6:07 am

by frodo » Tue Nov 03, 2020 6:07 am

Retinal layer thinning is reflecting disability progression independent of relapse activity in multiple sclerosis

Background
PIRA (progression...

0 Replies

210 Views

Last post by frodo
Tue Nov 03, 2020 6:07 am
MS biomarker in serum

Last post by frodo « Tue Nov 03, 2020 6:04 am

by frodo » Tue Nov 03, 2020 6:04 am

Detection of Multiple Sclerosis Biomarkers in Serum by Ganglioside Microarrays and Surface Plasmon Resonance Imaging

Abstract

Multiple...

0 Replies

184 Views

Last post by frodo
Tue Nov 03, 2020 6:04 am
Complex genetic signatures

Last post by Petr75 « Wed Oct 14, 2020 8:35 am

by Petr75 » Wed Oct 14, 2020 8:35 am

2020 Oct
Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy
Complex genetic signatures in immune...

0 Replies

201 Views

Last post by Petr75
Wed Oct 14, 2020 8:35 am
Focus on microglia again: TSPO-PET predicts progression.

Last post by frodo « Fri Oct 09, 2020 7:12 am

by frodo » Fri Oct 09, 2020 7:12 am

Brain TSPO-PET predicts later disease progression independent of relapses in multiple sclerosis

Abstract

Overactivation of microglia is...

0 Replies

338 Views

Last post by frodo
Fri Oct 09, 2020 7:12 am
specific CSF biomarkers review

Last post by frodo « Fri Oct 02, 2020 6:11 am

by frodo » Fri Oct 02, 2020 6:11 am

CSF biomarkers in multiple sclerosis: beyond neuroinflammation

making a long story short:

Diagnostic biomarkers: IgG oligoclonal bands, IgG...

0 Replies

246 Views

Last post by frodo
Fri Oct 02, 2020 6:11 am
lipids differentiate PPMS and SPMS

Last post by frodo « Fri Oct 02, 2020 4:47 am

by frodo » Fri Oct 02, 2020 4:47 am

Lipidomic UPLC-MS/MS Profiles of Normal-Appearing White Matter Differentiate Primary and Secondary Progressive Multiple Sclerosis

Abstract...

0 Replies

234 Views

Last post by frodo
Fri Oct 02, 2020 4:47 am
OCBs can separate MS from lyme

Last post by frodo « Thu Oct 01, 2020 6:44 am

by frodo » Thu Oct 01, 2020 6:44 am

Cerebrospinal fluid oligoclonal bands in Neuroborreliosis are specific for Borrelia burgdorferi

Background

Cerebrospinal fluid (CSF)...

0 Replies

261 Views

Last post by frodo
Thu Oct 01, 2020 6:44 am
EBNA1 (EBV protein) reactive to OCBs

Last post by frodo « Fri Sep 25, 2020 7:21 am

by frodo » Fri Sep 25, 2020 7:21 am

Antibodies from multiple sclerosis brain identified Epstein-Barr virus nuclear antigen 1 & 2 epitopes which are recognized by oligoclonal bands...

0 Replies

259 Views

Last post by frodo
Fri Sep 25, 2020 7:21 am
biomarkers review

Last post by frodo « Tue Sep 22, 2020 11:21 am

by frodo » Tue Sep 22, 2020 11:21 am

Development of robust targeted proteomics assays for cerebrospinal fluid biomarkers in multiple sclerosis

Background

Verification of...

0 Replies

242 Views

Last post by frodo
Tue Sep 22, 2020 11:21 am
Creatine metabolic alterations in MS

Last post by frodo « Thu Sep 17, 2020 6:55 am

by frodo » Thu Sep 17, 2020 6:55 am

Creatine and multiple sclerosis

ABSTRACT

Multiple sclerosis (MS) is a complex and debilitating neurodegenerative disease, with unknown...

0 Replies

274 Views

Last post by frodo
Thu Sep 17, 2020 6:55 am
Two molecular types of lesions via MRI

Last post by frodo « Mon Sep 14, 2020 1:34 am

by frodo » Mon Sep 14, 2020 1:34 am

Characterization of multiple sclerosis lesions with distinct clinical correlates through quantitative diffusion MRI

Highlights :

• Macroscopic...

0 Replies

280 Views

Last post by frodo
Mon Sep 14, 2020 1:34 am
Characteristics of multiple sclerosis in patients of Middle Eastern and North African

Last post by Petr75 « Sat Sep 05, 2020 8:40 pm

by Petr75 » Sat Sep 05, 2020 8:40 pm

2020 Aug 11
Division of Neurology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada/Division of Neurology,...

0 Replies

267 Views

Last post by Petr75
Sat Sep 05, 2020 8:40 pm
Three different biopsy patterns

Last post by frodo « Thu Sep 03, 2020 12:31 am

by frodo » Thu Sep 03, 2020 12:31 am

Different pathological processes for acute white matter lesions in multiple sclerosis

Abstract

Introduction :

Multiple sclerosis (MS) has...

0 Replies

233 Views

Last post by frodo
Thu Sep 03, 2020 12:31 am
A pathogenic B cell transcriptome in active multiple sclerosis

Last post by frodo « Tue Sep 01, 2020 5:25 am

by frodo » Tue Sep 01, 2020 5:25 am

A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis

Abstract

Central nervous system B cells have several...

0 Replies

213 Views

Last post by frodo
Tue Sep 01, 2020 5:25 am
Reelin depletion for MS

Last post by jimmylegs « Sun Aug 30, 2020 10:48 am

by jimmylegs » Sun Aug 30, 2020 10:48 am

Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes

...Our findings suggest Reelin...

0 Replies

215 Views

Last post by jimmylegs
Sun Aug 30, 2020 10:48 am
Mass cytometry provides insight into the role of B cells

Last post by frodo « Thu Aug 27, 2020 5:43 am

by frodo » Thu Aug 27, 2020 5:43 am

Mass cytometry provides unprecedented insight into the role of B cells during the pathogenesis of multiple sclerosis

Abstract

In recent...

0 Replies

218 Views

Last post by frodo
Thu Aug 27, 2020 5:43 am
NFL shows silent relapses in PPMS cases

Last post by frodo « Tue Aug 25, 2020 8:51 am

by frodo » Tue Aug 25, 2020 8:51 am

PPMS is supposed to advance in absence of relapses. Anyway, it seems than some silent relapses can be seen via NFL

CSF neurofilament light chain...

0 Replies

229 Views

Last post by frodo
Tue Aug 25, 2020 8:51 am
Response to b-cell depletion can be predicted

Last post by frodo « Sun Aug 23, 2020 11:38 pm

by frodo » Sun Aug 23, 2020 11:38 pm

Autoantibodies against central nervous system antigens in a subset of B cell–dominant multiple sclerosis patients

Significance

Multiple...

0 Replies

216 Views

Last post by frodo
Sun Aug 23, 2020 11:38 pm
PET differentiates pathological variants of MS

Last post by frodo « Thu Aug 20, 2020 11:46 pm

by frodo » Thu Aug 20, 2020 11:46 pm

TSPO PET With 18F-GE-180 to Differentiate Variants of Multiple Sclerosis

Relapsing-Remitting Multiple Sclerosis, Tumefactive Demyelination, and...

0 Replies

139 Views

Last post by frodo
Thu Aug 20, 2020 11:46 pm
Retinal damage could be due to subclinical inflammation in optic nerve

Last post by frodo « Thu Aug 20, 2020 2:52 am
Replies: 1
by frodo » Tue Aug 11, 2020 2:32 am

First post

Retinal and brain damage during multiple sclerosis course: inflammatory activity is a key factor in the first 5 years

The mechanisms by which...

Last post

Characterization of Retinal vascular changes in Multiple Sclerosis using Adaptive Optics and OCTA

Abstract

Purpose : Characterize...

1 Replies

264 Views

Last post by frodo
Thu Aug 20, 2020 2:52 am
OCB+ and OCB- patients show different evolution

Last post by frodo « Thu Aug 20, 2020 12:25 am

by frodo » Thu Aug 20, 2020 12:25 am

It seems that OCB-negative patients show less cerebelar lesions than OCB-positives.

Advanced MRI features in relapsing multiple sclerosis patients...

0 Replies

142 Views

Last post by frodo
Thu Aug 20, 2020 12:25 am
Biomarker for response to interferon: ADC values

Last post by frodo « Thu Aug 20, 2020 12:03 am

by frodo » Thu Aug 20, 2020 12:03 am

The role of ADC values within the normal-appearing brain in the prognosis of multiple sclerosis activity during interferon-β therapy in the 3-year...

0 Replies

149 Views

Last post by frodo
Thu Aug 20, 2020 12:03 am
Specific image biomarker: Paramagnetic rim lesions

Last post by frodo « Wed Aug 19, 2020 11:48 pm

by frodo » Wed Aug 19, 2020 11:48 pm

Currently there is no specific single test to diagnose MS. This won't be the first one because of its low sensitivity, but they say that specificity...

0 Replies

134 Views

Last post by frodo
Wed Aug 19, 2020 11:48 pm
Biotin could make MS worse

Last post by frodo « Wed Aug 19, 2020 5:07 am
Replies: 2
by frodo » Tue Aug 11, 2020 2:13 am

First post

Not good news for those on Biotin, but very interesting from the point of view of the pathogenesis research.

The Rise and Fall of High-Dose Biotin...

Last post

I didn't know that. Thanks.

2 Replies

333 Views

Last post by frodo
Wed Aug 19, 2020 5:07 am
anti-CD20 works on B-cells but also on T-cells

Last post by frodo « Wed Aug 19, 2020 4:56 am

by frodo » Wed Aug 19, 2020 4:56 am

Most reports state that anti-CD20 treatment suppresses inflammation, but it also has an effect on the cd8+ T-cell attack.

Unraveling the T–B tangle...

0 Replies

164 Views

Last post by frodo
Wed Aug 19, 2020 4:56 am
biochemical signature of progressive multiple sclerosis

Last post by frodo « Mon Aug 17, 2020 2:47 am

by frodo » Mon Aug 17, 2020 2:47 am

A biochemical signature of progressive multiple sclerosis

Abstract

Currently, very few treatments for patients in the progressive phases of...

0 Replies

298 Views

Last post by frodo
Mon Aug 17, 2020 2:47 am
Failed trials that can yield some clues into pathogenesis

Last post by frodo « Mon Aug 17, 2020 12:33 am

by frodo » Mon Aug 17, 2020 12:33 am

This paper speaks about several failures in clinical trials. Among them Atacicept, Tabalumab, Abatacept, Vitamin D, Temelimab (surprinsingly),...

0 Replies

250 Views

Last post by frodo
Mon Aug 17, 2020 12:33 am
biomarkers for pediatric MS

Last post by frodo « Wed Aug 12, 2020 11:14 am

by frodo » Wed Aug 12, 2020 11:14 am

Analysis of plasma protein biomarkers in childhood onset multiple sclerosis

Highlights

• Significant proteomic differences were found between...

0 Replies

255 Views

Last post by frodo
Wed Aug 12, 2020 11:14 am
biomarker for response to IFNbeta

Last post by frodo « Wed Aug 12, 2020 10:58 am

by frodo » Wed Aug 12, 2020 10:58 am

IFI35 as a biomolecular marker of neuroinflammation and treatment response in multiple sclerosis

Highlights

• No biomarker is available for...

0 Replies

247 Views

Last post by frodo
Wed Aug 12, 2020 10:58 am
Metallic elements in MS

Last post by frodo « Wed Aug 12, 2020 12:12 am

by frodo » Wed Aug 12, 2020 12:12 am

A preliminary study of the concentration of metallic elements in the blood of patients with multiple sclerosis as measured by icp‑MS

It is...

0 Replies

222 Views

Last post by frodo
Wed Aug 12, 2020 12:12 am
Biomarker for the progressive phase

Last post by frodo « Tue Aug 11, 2020 2:06 am

by frodo » Tue Aug 11, 2020 2:06 am

Distinctive sphingolipid patterns in chronic multiple sclerosis lesions

Abstract

Multiple sclerosis (MS) is a CNS disease characterized by...

0 Replies

228 Views

Last post by frodo
Tue Aug 11, 2020 2:06 am
Rituxan better than Fingolimod, Dymethyl fumarate and Natalizumab

Last post by frodo « Tue Aug 11, 2020 2:03 am

by frodo » Tue Aug 11, 2020 2:03 am

Rituxan better than Fingolimod, Dymethyl fumarate and Natalizumab

Interpretation

RTX demonstrated superior effectiveness and discontinuation...

0 Replies

221 Views

Last post by frodo
Tue Aug 11, 2020 2:03 am
Novel blood-based biomarker for MS

Last post by frodo « Thu Aug 06, 2020 7:39 am

by frodo » Thu Aug 06, 2020 7:39 am

Blood platelet RNA enables the detection of multiple sclerosis

Background

In multiple sclerosis (MS), clinical assessment, MRI and...

0 Replies

236 Views

Last post by frodo
Thu Aug 06, 2020 7:39 am
Retinal damage is not due to inflammation but MS process itself

Last post by frodo « Thu Jul 30, 2020 11:52 pm

by frodo » Thu Jul 30, 2020 11:52 pm

Optical coherence tomography angiography in multiple sclerosis: A cross-sectional study

Objectives

To evaluate retinal axonal density and...

0 Replies

262 Views

Last post by frodo
Thu Jul 30, 2020 11:52 pm

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