MS Etiology and Pathogenesis

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Around 13% of MS cases are of genetic origin. 12 pathogenic variants.

Last post by frodo « Fri Aug 16, 2019 10:15 am
Replies: 1
by frodo » Tue Aug 13, 2019 7:38 am

First post

Of people diagnosed with MS, only 13% are believed to have a genetic form of the disease, but those presenting the mutations identified in this new...

Last post

HLA-DRB1 differences in allelic distribution between familial and sporadic multiple sclerosis in a Hellenic cohort

Conclusion: We propose...

1 Replies

85 Views

Last post by frodo
Fri Aug 16, 2019 10:15 am
PPMS and SPMS may be different

Last post by frodo « Sun Aug 11, 2019 3:53 am

by frodo » Sun Aug 11, 2019 3:53 am

Mitochondrial functionality and metabolism in T cells from progressive multiple sclerosis patients

Abstract

Patients with primary progressive...

0 Replies

48 Views

Last post by frodo
Sun Aug 11, 2019 3:53 am
Molecular mimicry agent finally found?

Last post by frodo « Sat Aug 10, 2019 10:13 am

by frodo » Sat Aug 10, 2019 10:13 am

Both EBNA-1 and Anoctamin-2 have been previously implicated.

Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1...

0 Replies

49 Views

Last post by frodo
Sat Aug 10, 2019 10:13 am
Lipid profile of cerebrospinal fluid

Last post by frodo « Sat Aug 10, 2019 9:28 am

by frodo » Sat Aug 10, 2019 9:28 am

Lipid profile of cerebrospinal fluid in multiple sclerosis patients: a potential tool for diagnosis

Discussion

MS is a chronic disease which is...

0 Replies

35 Views

Last post by frodo
Sat Aug 10, 2019 9:28 am
Plasma proteins: Closer to pathogenic types discrimination

Last post by frodo « Wed Jul 31, 2019 11:36 pm

by frodo » Wed Jul 31, 2019 11:36 pm

Plasma proteome in multiple sclerosis disease progression

Conclusions

Our results revealed eight novel biomarkers related to clinical and...

0 Replies

78 Views

Last post by frodo
Wed Jul 31, 2019 11:36 pm
Weird biomarker

Last post by frodo « Wed Jul 31, 2019 11:08 pm
Replies: 2
by frodo » Mon Jul 29, 2019 6:34 am

First post

Though I don't understand fully what they say, it seems that they have created a molecule with a fluorescent substrate surrounded by MBP proteins....

Last post

I agree. The T-cell model is dead. At least the CD4+ classic model.

2 Replies

85 Views

Last post by frodo
Wed Jul 31, 2019 11:08 pm
CSF from MS patients damage neurons in-vitro

Last post by frodo « Mon Jul 29, 2019 8:24 am
Replies: 1
by frodo » Mon Jul 22, 2019 12:56 am

First post

A metabolic perspective on CSF-mediated neurodegeneration in multiple sclerosis

Abstract

Multiple sclerosis is an autoimmune demyelinating...

Last post

Comments on the previous paper. A new paper in “Brain” identifies molecular mechanisms causing neuronal damage in multiple sclerosis patients with...

1 Replies

94 Views

Last post by frodo
Mon Jul 29, 2019 8:24 am
Projection neurons. Whatever they are, they are involved.

Last post by frodo « Mon Jul 29, 2019 8:09 am

by frodo » Mon Jul 29, 2019 8:09 am

Science daily report:

Scientists have discovered that a specific brain cell known as a 'projection neuron' has a central role to play in the...

0 Replies

33 Views

Last post by frodo
Mon Jul 29, 2019 8:09 am
1/6 of the children with MS are anti-MOG+

Last post by frodo « Mon Jul 29, 2019 5:06 am

by frodo » Mon Jul 29, 2019 5:06 am

Prospective characterization of children positive for anti-MOG antibodies meeting Multiple Sclerosis diagnostic criteria

Abstract

Objective: To...

0 Replies

35 Views

Last post by frodo
Mon Jul 29, 2019 5:06 am
An underlying process causes abnormalities in veins together with MS

Last post by frodo « Tue Jul 16, 2019 1:33 am
Replies: 1
by frodo » Thu May 09, 2019 1:41 am

First post

This paper points to the existence of an underlying process that causes the known MS lesions and, at the same time, some venous problems:

The...

Last post

More about the same subject. There is a whole book about it.

Molecular targets of angiogenesis and anti-angiogenesis therapy

1 Replies

125 Views

Last post by frodo
Tue Jul 16, 2019 1:33 am
miRNA dysregulation as the source of the disease

Last post by Petr75 « Sat Jul 13, 2019 11:12 am
Replies: 7
by frodo » Mon Oct 16, 2017 11:28 pm

First post

Micro-RNA ( miRNA ) has been proposed as a biomarker of axon degeneration, but some authors have proposed that they could be the source of the...

Last post

2019 May 25
Department of Neurology, Laboratory of Neuroimmunology, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland
Circular...

7 Replies

1193 Views

Last post by Petr75
Sat Jul 13, 2019 11:12 am
More about HERV's and microglia activation

Last post by frodo « Sat Jul 13, 2019 1:04 am

by frodo » Sat Jul 13, 2019 1:04 am

New review about the role of HERVs in microglia activation, following Kremer's paper from last May (available here This researchers confirm again the...

0 Replies

46 Views

Last post by frodo
Sat Jul 13, 2019 1:04 am
Extrinsic defect in B cells differentiation through alteration of T FH cells

Last post by frodo « Thu Jun 27, 2019 12:58 am

by frodo » Thu Jun 27, 2019 12:58 am

Report about a extrinsic defect in B cells differentiation through alteration of T FH cells:

Exploring T FH subsets involvement in Multiple...

0 Replies

76 Views

Last post by frodo
Thu Jun 27, 2019 12:58 am
More about Tcells. CD8+ Tcells dysregulation

Last post by frodo « Thu Jun 27, 2019 12:48 am

by frodo » Thu Jun 27, 2019 12:48 am

Alteration of CD8+ CD45RC in MS regulatory T cells functions

For the first time, we demonstrate an impairment of CD8+CD45RC(int) Tregs

We...

0 Replies

46 Views

Last post by frodo
Thu Jun 27, 2019 12:48 am
T-cells dysregulation

Last post by frodo « Tue Jun 25, 2019 7:18 am

by frodo » Tue Jun 25, 2019 7:18 am

Quantitative proteomic analyses of CD4+ and CD8+ T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy...

0 Replies

61 Views

Last post by frodo
Tue Jun 25, 2019 7:18 am
Temelimab works. HERVs clearly implicated.

Last post by frodo « Mon Jun 24, 2019 12:45 am
Replies: 1
by frodo » Mon May 20, 2019 11:38 am

First post

Efficacy and Safety of Temelimab, an Antibody Antagonist of the Human Endogenous Retrovirus Type-W env Protein, in Participants with Relapsing...

Last post

Let's call this the Kremer's paper because it seems that it will be cited a lot from now on.

pHERV-W envelope protein fuels microglial...

1 Replies

160 Views

Last post by frodo
Mon Jun 24, 2019 12:45 am
Cortical lesions and GA

Last post by frodo « Wed Jun 19, 2019 4:26 am

by frodo » Wed Jun 19, 2019 4:26 am

This paper is about the effects of Glatimer Acetate in MS, but they include a very deep review about the status of the research:

Some excerpts:...

0 Replies

64 Views

Last post by frodo
Wed Jun 19, 2019 4:26 am
Age of cells populations in MS

Last post by frodo « Wed Jun 19, 2019 4:01 am

by frodo » Wed Jun 19, 2019 4:01 am

Using Carbon14 the researchers can calculate the age of different cells (oligodendrocytes are myelin producing cells and OPC are oligodendrocyte...

0 Replies

59 Views

Last post by frodo
Wed Jun 19, 2019 4:01 am
Early MS lesions: Astrocytes involved

Last post by frodo « Wed Jun 19, 2019 3:33 am

by frodo » Wed Jun 19, 2019 3:33 am

Multiple Sclerosis: Destruction and Regeneration of Astrocytes in Acute Lesions

Abstract

There are reports that astrocyte perivascular endfeet...

0 Replies

44 Views

Last post by frodo
Wed Jun 19, 2019 3:33 am
Large Noncoding RNA in blood

Last post by Petr75 « Sat Jun 15, 2019 9:33 pm
Replies: 2
by frodo » Wed Oct 04, 2017 12:30 pm

First post

Expression Analysis of Long Non-coding RNAs in the Blood of Multiple Sclerosis Patients.

Abstract

Multiple sclerosis (MS) is a chronic...

Last post

2019 May 8
Division of Cellular and Molecular Biology, Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran
Department of...

2 Replies

924 Views

Last post by Petr75
Sat Jun 15, 2019 9:33 pm
Real PPMS passed (again) to mice

Last post by frodo « Sun Jun 02, 2019 8:03 am

by frodo » Sun Jun 02, 2019 8:03 am

This has been done previously (see for example posts or but this new result confirms again the previous results.

Intrathecal Injections of PPMS...

0 Replies

139 Views

Last post by frodo
Sun Jun 02, 2019 8:03 am
Dawson fingers in anti-MOG disease

Last post by frodo « Sat Jun 01, 2019 9:19 am

by frodo » Sat Jun 01, 2019 9:19 am

Anti-MOG disease makes around 10% of diagnosed MS patients and until now was reported only in atypical MS. Dawson fingers was considered one of the...

0 Replies

89 Views

Last post by frodo
Sat Jun 01, 2019 9:19 am
Inside-out model: supporting papers.

Last post by ElliotB « Thu May 30, 2019 7:10 am
Replies: 5
by frodo » Wed Jan 30, 2019 2:28 am

First post

The inside-out model is an alternative theoretical model for MS that postulates that something within the neurons is the cause of the later...

Last post

All very interesting theories, thanks for posting them!

5 Replies

398 Views

Last post by ElliotB
Thu May 30, 2019 7:10 am
Personalized medicine: Prediction of natalizumab response

Last post by frodo « Tue May 28, 2019 6:29 am

by frodo » Tue May 28, 2019 6:29 am

Identification of CD4+ T cell biomarkers for predicting the response of patients with relapsing‑remitting multiple sclerosis to natalizumab...

0 Replies

71 Views

Last post by frodo
Tue May 28, 2019 6:29 am
Neurofilament light as biomarker

Last post by frodo « Tue May 28, 2019 6:26 am

by frodo » Tue May 28, 2019 6:26 am

Cerebrospinal fluid neurofilament light chain in multiple sclerosis and its subtypes: a meta-analysis of case–control studies

Conclusions

CSF...

0 Replies

58 Views

Last post by frodo
Tue May 28, 2019 6:26 am
Review about proteomics for MS biomarkers

Last post by frodo « Tue May 28, 2019 6:24 am

by frodo » Tue May 28, 2019 6:24 am

Proteomic approaches to decipher mechanisms underlying pathogenesis in MS

Full PDF:

Conclusion

Proteomic analysis of CNS tissue and body...

0 Replies

54 Views

Last post by frodo
Tue May 28, 2019 6:24 am
T-cells from MS patients are toxic to mice neurons

Last post by frodo « Tue May 28, 2019 6:15 am

by frodo » Tue May 28, 2019 6:15 am

This report points to something toxic in MS T-cells

Peripheral T cells from multiple sclerosis patients trigger synaptotoxic alterations in central...

0 Replies

74 Views

Last post by frodo
Tue May 28, 2019 6:15 am
Microglia in the pathogenesis of MS

Last post by Petr75 « Thu May 23, 2019 11:46 am
Replies: 11
by frodo » Mon Jul 23, 2018 11:13 am

First post

Microglia in the pathogenesis of MS

We postulate that the immune reaction initiates in the CNS and immune cells (including T cells/B cell)...

Last post

2019 Apr 17
Department of Pathology and Immunology, Washington University in St. Louis, St. Louis
Fifty Shades of Microglia

Abstract
In a recent...

11 Replies

1202 Views

Last post by Petr75
Thu May 23, 2019 11:46 am
MS metabolic profile for MS. Closer to a blood test.

Last post by frodo « Thu May 09, 2019 3:02 am
Replies: 1
by frodo » Thu May 09, 2019 1:22 am

First post

Metabolome-based signature of disease pathology in MS

Highlights

• Six serum metabolites were predictive for MS in males.
• Results support...

Last post

And here other report about another possible blood test. By the way, TWEAK is this:

Interestingly, related to angiogenesis too.

Here comes the...

1 Replies

115 Views

Last post by frodo
Thu May 09, 2019 3:02 am
Viruses: Hypoxia and viruses reactivation. CCSVI?

Last post by Kinora « Fri May 03, 2019 1:36 pm
Replies: 6
by frodo » Sun Mar 11, 2018 10:14 am

First post

Could be this the explanation of the relationship between CCSVI and MS?

This article points out that endogenous retroviruses that are normally...

Last post

I use a bio-health device for blood flow. It is configured to increase blood flow at the capillary level though an configured, multi-layered wave...

6 Replies

1059 Views

Last post by Kinora
Fri May 03, 2019 1:36 pm
Epstein Bar Virus - A Review of the Epstein Barr Virus in Relationship to MS

Last post by Kinora « Fri May 03, 2019 9:08 am

by Kinora » Fri May 03, 2019 9:08 am

+

With Poem-The Long and Winding Road reinterpreted.

0 Replies

99 Views

Last post by Kinora
Fri May 03, 2019 9:08 am
RNA signature of different lesion types in MS

Last post by frodo « Tue Apr 30, 2019 4:34 am

by frodo » Tue Apr 30, 2019 4:34 am

Unique RNA signature of different lesion types in the brain white matter in progressive multiple sclerosis

Conclusions

Our study is not...

0 Replies

117 Views

Last post by frodo
Tue Apr 30, 2019 4:34 am
How EBV causes MS

Last post by frodo « Mon Apr 22, 2019 12:40 pm
Replies: 2
by frodo » Tue Apr 16, 2019 12:52 am

First post

In this review, the authors (Khan & Hassani) propose an integrated model of EBV involvement in MS pathology

Epstein-Barr Virus in Multiple...

Last post

It would be great to have a EBV vaccine to prevent new MS cases but that would not help to the already infected people.

It seems that...

2 Replies

258 Views

Last post by frodo
Mon Apr 22, 2019 12:40 pm
Up to 10% of MS cases are due to anti-Neurofascin autoantibody

Last post by frodo « Sun Apr 14, 2019 10:18 am

by frodo » Sun Apr 14, 2019 10:18 am

Anti-Neurofascin-155 is an auto-antibody whose presence has been separated from standard MS, like it was for anti-AQP4 and anti-MOG before.

This...

0 Replies

116 Views

Last post by frodo
Sun Apr 14, 2019 10:18 am
Report against division of MS in clinical types

Last post by frodo « Wed Apr 03, 2019 6:56 am

by frodo » Wed Apr 03, 2019 6:56 am

It is interesting that this is finally getting contested, because it was introduced artificially by the pharma industry to get interferons approved....

0 Replies

118 Views

Last post by frodo
Wed Apr 03, 2019 6:56 am
phd thesis about exosomes and miRNA

Last post by NHE « Tue Apr 02, 2019 10:11 pm
Replies: 1
by frodo » Tue Apr 02, 2019 3:05 am

First post

A phd thesis freely avaliable about exosomes and miRNA, in case anybody is interested.

Last post

Thanks. Here's the abstract...

Exosomal MicroRNA Signatures in Central Nervous System Diseases
Saeideh Ebrahimkhani, University of Sydney, Sep 30,...

1 Replies

155 Views

Last post by NHE
Tue Apr 02, 2019 10:11 pm
Toxicity of B Cell Products in Multiple Sclerosis

Last post by frodo « Sun Mar 31, 2019 11:30 am

by frodo » Sun Mar 31, 2019 11:30 am

Again, a new report of B-cells from MS patients secreting something toxic:

Toxicity of Released B Cell Products in Multiple Sclerosis

Abstract:...

0 Replies

117 Views

Last post by frodo
Sun Mar 31, 2019 11:30 am
Nfl increases BEFORE damage appears on MRI

Last post by frodo « Thu Mar 28, 2019 5:51 am

by frodo » Thu Mar 28, 2019 5:51 am

It seems that Nfl (neurofilament light) are an not just a biomarker, but also related to the pathogenesis and measurable WEEKS BEFORE the damage has...

0 Replies

152 Views

Last post by frodo
Thu Mar 28, 2019 5:51 am
MS are several diseases. Description of an iron responsive type.

Last post by frodo « Tue Mar 26, 2019 5:18 am

by frodo » Tue Mar 26, 2019 5:18 am

Identification of an iron-responsive subtype in two children diagnosed with relapsing-remitting multiple sclerosis using whole exome sequencing

In...

0 Replies

176 Views

Last post by frodo
Tue Mar 26, 2019 5:18 am
several types of alterations in NAWM and NAGM

Last post by frodo « Sat Mar 23, 2019 4:25 am

by frodo » Sat Mar 23, 2019 4:25 am

Exploring metabolite profiling of patients with secondary progressive multiple sclerosis

Synopsis

Proton magnetic resonance spectroscopic...

0 Replies

109 Views

Last post by frodo
Sat Mar 23, 2019 4:25 am
Microglial activation and NAWM appear together

Last post by frodo « Wed Mar 20, 2019 8:20 am
Replies: 1
by frodo » Thu May 17, 2018 1:13 am

First post

Microglial activation and NAWM appear together. A study found that microglial activation (shown by PET imaging) and Normal appearing white matter...

Last post

This report points to three levels of damage in MS, being demyelination just the second stage.

Abstract

Quantifying white matter damage in...

1 Replies

653 Views

Last post by frodo
Wed Mar 20, 2019 8:20 am
B-cells from MS patients secrete something toxic, maybe exosomes.

Last post by frodo « Sat Mar 16, 2019 3:25 am

by frodo » Sat Mar 16, 2019 3:25 am

Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis

Most evidence from pathological studies suggests that...

0 Replies

139 Views

Last post by frodo
Sat Mar 16, 2019 3:25 am
Polineuropaties, CDIP and NF-155 in MS

Last post by frodo « Fri Mar 15, 2019 7:16 am
Replies: 1
by frodo » Fri Mar 15, 2019 7:15 am

1 Replies

100 Views

Last post by frodo
Fri Mar 15, 2019 7:16 am
ANA-positive MS and MRZ reaction

Last post by frodo « Mon Mar 11, 2019 9:05 am

by frodo » Mon Mar 11, 2019 9:05 am

Up to 60% of MS-patients present antinuclear autoantibodies (ANAs) in CSF and may be misdiagnosed. Regardless of the question about if ANA-positive...

0 Replies

104 Views

Last post by frodo
Mon Mar 11, 2019 9:05 am
The Interaction between Viral and Environmental Risk Factors

Last post by frodo « Mon Mar 11, 2019 3:03 am

by frodo » Mon Mar 11, 2019 3:03 am

The Interaction between Viral and Environmental Risk Factors in the Pathogenesis of Multiple Sclerosis

Abstract

Multiple sclerosis (MS) is a...

0 Replies

96 Views

Last post by frodo
Mon Mar 11, 2019 3:03 am
Metabolomics profile of MS

Last post by frodo « Mon Mar 11, 2019 1:49 am
Replies: 1
by frodo » Mon Mar 11, 2019 1:24 am

First post

Several viral infections mimic MS. Before immune supresion or modulation is important to be sure that there is no infection in the CNS or things...

Last post

Immune Cell Profiling of the Cerebrospinal Fluid Provides Pathogenetic Insights into Inflammatory Neuropathies

Objective: Utilize immune cell...

1 Replies

127 Views

Last post by frodo
Mon Mar 11, 2019 1:49 am
Oligoclonal bands are responsive to medication

Last post by frodo « Sun Mar 10, 2019 11:30 am
Replies: 2
by frodo » Tue Jan 15, 2019 5:39 am

First post

Cladribine reduces oligoclonal bands (OCB) in MS, and MS gets better without them. These are the conclusions of a study ( which also points to a...

Last post

Immune Cell Profiling of the Cerebrospinal Fluid Provides Pathogenetic Insights into Inflammatory Neuropathies

Objective: Utilize immune cell...

2 Replies

268 Views

Last post by frodo
Sun Mar 10, 2019 11:30 am
MSRV (MS retro-virus) and EBV interaction

Last post by NHE « Tue Mar 05, 2019 12:49 am
Replies: 1
by frodo » Mon Mar 04, 2019 5:28 am

First post

The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to in vivo imaging

Multiple sclerosis (MS) is a disease of...

Last post

The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to in vivo imaging

Free full text.

1 Replies

189 Views

Last post by NHE
Tue Mar 05, 2019 12:49 am
HERV and MSRV viruses implicated. Temelimab works against them.

Last post by NHE « Sun Mar 03, 2019 3:20 pm
Replies: 2
by frodo » Sat Mar 02, 2019 3:54 am

First post

MSRV is a retrovirus consistently found in MS lesions.

When active, MSRV produces a protein called MSRV-envelope protein, or MSRV-Env, which...

Last post

What is the magnetization transfer ratio? Does it correspond to gristy56's idea that it is magnetite which damages the myelin sheath and that by...

2 Replies

272 Views

Last post by NHE
Sun Mar 03, 2019 3:20 pm
Reports about the CSF toxicity

Last post by frodo « Wed Feb 27, 2019 5:36 am
Replies: 1
by frodo » Sat Dec 30, 2017 4:25 am

First post

I am collecting here some of the studies about the CSF toxicity. One of the most interesting studies of the previous years was the possibility of...

Last post

Last report found

Cerebrospinal Fluid Derived from Primary Progressive MS Delays Remyelination after Lysolecithin-induced Demyelination...

1 Replies

1013 Views

Last post by frodo
Wed Feb 27, 2019 5:36 am

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