MS Etiology and Pathogenesis

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Last post

Research in heterogeneity: New paper about patterns discrimination

Last post by frodo « Tue Jan 21, 2020 1:23 am
Replies: 1
by frodo » Tue Jan 21, 2020 1:18 am

First post

New paper about discriminating the four pathological patterns:

The main idea is that there are four patterns of MS (one of them, IV very rare and...

Last post

Papers about tests for discriminating the patterns

- September 2019 : Multiplexed imaging of immune cells in staged multiple sclerosis lesions by...

1 Replies

40 Views

Last post by frodo
Tue Jan 21, 2020 1:23 am
Biomarkers. Response to Fingolimod can be predicted.

Last post by frodo « Mon Jan 20, 2020 9:09 am
Replies: 1
by frodo » Thu Apr 19, 2018 12:31 pm

First post

Predicting therapeutic response to fingolimod treatment in multiple sclerosis patients

Summary

Fingolimod, an orally active immunomodulatory...

Last post

Combinatorial allosteric modulation of agonist response in a self-interacting G-protein coupled receptor

The structural plasticity of G-protein...

1 Replies

756 Views

Last post by frodo
Mon Jan 20, 2020 9:09 am
Two new reports about EBV

Last post by frodo « Mon Jan 20, 2020 8:18 am

by frodo » Mon Jan 20, 2020 8:18 am

The interaction of Multiple Sclerosis risk loci with Epstein-Barr virus phenotypes implicates the virus in pathogenesis

Conclusion

We believe...

0 Replies

19 Views

Last post by frodo
Mon Jan 20, 2020 8:18 am
Reports about the CSF toxicity

Last post by frodo « Mon Jan 20, 2020 4:40 am
Replies: 2
by frodo » Sat Dec 30, 2017 4:25 am

First post

I am collecting here some of the studies about the CSF toxicity. One of the most interesting studies of the previous years was the possibility of...

Last post

Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine...

2 Replies

1084 Views

Last post by frodo
Mon Jan 20, 2020 4:40 am
Relationship between MS and type-1 diabetes

Last post by frodo « Mon Jan 20, 2020 4:25 am
Replies: 2
by frodo » Mon Jan 13, 2020 12:52 am

First post

Type-1 diabetes is the most common diabetes in children and autoimmune. These people are three-times more prone to develop MS than the general...

Last post

Not always MS and type1 diabetes are related. But MS could be more than one disease, and maybe a subtype is related.

An ancestral retroviral...

2 Replies

54 Views

Last post by frodo
Mon Jan 20, 2020 4:25 am
Lassman review for 2019. Top four MS papers.

Last post by frodo « Mon Jan 20, 2020 12:51 am

by frodo » Mon Jan 20, 2020 12:51 am

1. Neuronal vulnerability and multilineage diversity in multiple sclerosis (Schirmer et al 2019)

The study supports the importance of meningeal...

0 Replies

18 Views

Last post by frodo
Mon Jan 20, 2020 12:51 am
personalized medicine for MS

Last post by frodo « Fri Jan 17, 2020 9:31 am
Replies: 3
by frodo » Wed Nov 06, 2019 4:25 am

First post

Thanks to ms-uk for the review

New genetic markers may make prognosis clearer

The original paper:

Early complement genes are associated with...

Last post

Pre-treatment T-cell subsets associate with fingolimod treatment responsiveness in multiple sclerosis

Abstract

Biomarkers predicting fingolimod...

3 Replies

164 Views

Last post by frodo
Fri Jan 17, 2020 9:31 am
IGM+ MS could be different from normal MS

Last post by frodo « Fri Jan 17, 2020 2:42 am
Replies: 1
by frodo » Thu Oct 31, 2019 11:35 am

First post

The oligoclonal bands in MS are IgG bands. There is a subset of patients with another immunoglobulin, IGM, that have a worse prognosis.

This paper...

Last post

Immunoglobulin M oligoclonal bands: Biomarker of targetable inflammation in primary progressive multiple sclerosis

Objective

To identify a...

1 Replies

211 Views

Last post by frodo
Fri Jan 17, 2020 2:42 am
Ms artificially induced in humans

Last post by frodo « Wed Jan 15, 2020 4:15 am
Replies: 1
by frodo » Wed Jan 15, 2020 4:09 am

First post

Sometimes some MS patients get a kind of artificially induced MS while they are treated for other conditions. There are several reports about it...

Last post

Well. Not the same but I have found a paper in which they describe the action of TNF in mice, similar to the previous auto-antibody.

TNFR2 limits...

1 Replies

38 Views

Last post by frodo
Wed Jan 15, 2020 4:15 am
Biomarkers: Interleukin-17

Last post by frodo « Tue Jan 14, 2020 12:58 am
Replies: 3
by frodo » Mon Jan 13, 2020 1:28 am

First post

Source:

Remarks:

1- The mean of serum level of IL-17 in the MS and NMO subjects was significantly higher than healthy subjects.
2 - The mean of...

Last post

Please confirm that the URL is correct and give us the title to the paper where these remarks were found.

Sorry. I thought it was working...

3 Replies

61 Views

Last post by frodo
Tue Jan 14, 2020 12:58 am
Image biomarkers: Ribbon‐like subpial cortical demyelination specific to MS

Last post by frodo « Mon Jan 13, 2020 9:48 am

by frodo » Mon Jan 13, 2020 9:48 am

Extensive subpial cortical demyelination is specific to multiple sclerosis

Abstract

Cortical demyelinated lesions are frequent and widespread...

0 Replies

16 Views

Last post by frodo
Mon Jan 13, 2020 9:48 am
Anti-Angiogenesis therapy in MS

Last post by frodo « Thu Jan 09, 2020 6:37 am

by frodo » Thu Jan 09, 2020 6:37 am

Anti-Angiogenesis therapy in MS

Is the title of a book about the subject. It is interesting to see that some people still research about this link.

0 Replies

56 Views

Last post by frodo
Thu Jan 09, 2020 6:37 am
Smouldering lesions can be seen on MRI

Last post by frodo « Thu Jan 09, 2020 4:43 am
Replies: 1
by frodo » Tue Sep 24, 2019 1:34 am

First post

A paper about seen smoldering lesions on MRI here:

A previous one about the same:

An not a paper, but a blog entry instead speaking about the...

Last post

More information about the discovery

1 Replies

283 Views

Last post by frodo
Thu Jan 09, 2020 4:43 am
B-cell types and MS

Last post by frodo « Wed Jan 08, 2020 6:39 am

by frodo » Wed Jan 08, 2020 6:39 am

Induction of brain‐infiltrating T‐bet–expressing B cells in multiple sclerosis

Here, we aimed to explore the CNS transmigration capacity of...

0 Replies

43 Views

Last post by frodo
Wed Jan 08, 2020 6:39 am
Plasma exchange works in steroid-refractory MS

Last post by frodo « Fri Dec 27, 2019 12:01 pm
Replies: 2
by frodo » Tue Nov 19, 2019 4:06 am

First post

Visual Outcomes of Plasma Exchange Treatment of Steroid-Refractory Optic Neuritis: A Retrospective Monocentric Analysis

Introduction :
In acute...

Last post

Comparing Plasma Exchange to Escalated Methyl Prednisolone in Refractory Multiple Sclerosis Relapses

Abstract

Intravenous methyl prednisolone...

2 Replies

170 Views

Last post by frodo
Fri Dec 27, 2019 12:01 pm
Biomarkers: Status at the end of 2019

Last post by frodo « Fri Dec 27, 2019 11:53 am

by frodo » Fri Dec 27, 2019 11:53 am

A review about the status of several MS biomarkers at the end of 2019

Conclusions

Molecular biomarkers enable individual decisions and are an...

0 Replies

47 Views

Last post by frodo
Fri Dec 27, 2019 11:53 am
More than 200 genetic variants

Last post by frodo « Thu Dec 26, 2019 10:43 am

by frodo » Thu Dec 26, 2019 10:43 am

0 Replies

51 Views

Last post by frodo
Thu Dec 26, 2019 10:43 am
Dimethyl fumarate associates with CD8+ cells reduction

Last post by frodo « Thu Dec 19, 2019 5:21 am

by frodo » Thu Dec 19, 2019 5:21 am

IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis

Abstract

IL-17-producing CD8+...

0 Replies

74 Views

Last post by frodo
Thu Dec 19, 2019 5:21 am
is MS an autoimmune disease?

Last post by frodo « Wed Dec 18, 2019 7:19 am

by frodo » Wed Dec 18, 2019 7:19 am

This paper lists evidence for and against the autoimmune classification. It is interesting to note that one of the main reasons supporting...

0 Replies

87 Views

Last post by frodo
Wed Dec 18, 2019 7:19 am
Detecting early MS

Last post by frodo « Wed Dec 18, 2019 6:53 am

by frodo » Wed Dec 18, 2019 6:53 am

Detecting neurodegenerative pathology in multiple sclerosis before irreversible brain tissue loss sets in

Abstract

Background

Multiple...

0 Replies

52 Views

Last post by frodo
Wed Dec 18, 2019 6:53 am
Mitochondria in MS

Last post by frodo « Wed Dec 18, 2019 6:32 am
Replies: 3
by frodo » Sat Dec 16, 2017 5:11 am

First post

Increased levels of cell-free mitochondrial DNA in the cerebrospinal fluid of patients with multiple sclerosis

Last post

It is unknown (for me) wether they refer to human neurons.

3 Replies

998 Views

Last post by frodo
Wed Dec 18, 2019 6:32 am
lesion evolution

Last post by frodo « Tue Dec 17, 2019 1:30 am

by frodo » Tue Dec 17, 2019 1:30 am

This article refers to the four possible evolutive types of lesions (active, inactive, chronic active, remyelinating)

Molecular signature of...

0 Replies

62 Views

Last post by frodo
Tue Dec 17, 2019 1:30 am
Recent advances in understanding multiple sclerosis

Last post by frodo « Tue Dec 17, 2019 1:16 am

by frodo » Tue Dec 17, 2019 1:16 am

Status of the research as of Dec. 2019

Abstract

Emerging data point to important contributions of both autoimmune inflammation and progressive...

0 Replies

64 Views

Last post by frodo
Tue Dec 17, 2019 1:16 am
Herpesvirus HHV-6B strain linked to MS

Last post by frodo « Tue Dec 10, 2019 3:52 am

by frodo » Tue Dec 10, 2019 3:52 am

0 Replies

231 Views

Last post by frodo
Tue Dec 10, 2019 3:52 am
Dogs can smell MS

Last post by frodo « Tue Dec 10, 2019 2:11 am
Replies: 2
by frodo » Wed Dec 04, 2019 12:54 am

First post

These Dogs Know When Their Owners Are About to Have an MS Flare

Health and wellness touch everyone’s life differently. Here are some stories....

Last post

Using Gas Chromatography Mass Spectrometry (GC-MS) for MS diagnosis.

Diagnosing Multiple Sclerosis Using Breath Biomarkers and GC-MS.

As a...

2 Replies

179 Views

Last post by frodo
Tue Dec 10, 2019 2:11 am
MS clinical types are obsolete

Last post by frodo « Sun Dec 08, 2019 4:57 am

by frodo » Sun Dec 08, 2019 4:57 am

Since Charcot times, neurologist classify the MS types by its clinical evolution. This is so deeply stablished that even when NMO was considered a...

0 Replies

185 Views

Last post by frodo
Sun Dec 08, 2019 4:57 am
MS linked to lipids dysregulation

Last post by Anonymoose « Wed Dec 04, 2019 6:10 am
Replies: 1
by frodo » Mon Dec 02, 2019 11:26 am

First post

Before reading the paper, it is interesting also this:

Specialized pro-resolving lipid mediators are differentially altered in peripheral blood...

Last post

This caught my interest as there are a couple of proresolving mediator supplements available on the market. The assumption is they will cross BBB as...

1 Replies

161 Views

Last post by Anonymoose
Wed Dec 04, 2019 6:10 am
MRZR+ MS cases are different from others

Last post by frodo « Fri Nov 29, 2019 5:59 am
Replies: 1
by frodo » Mon Aug 26, 2019 5:08 am

First post

MRZR is a reaction about several viruses highly specific for MS, but little sensitive. This means that if you have MRZR is nearly sure that you have...

Last post

Rheumatic diseases (lupus like diseases) and 60% of MS cases show antinuclear antibodies (ANA), leading to diagnosis confusion. MRZR can separate...

1 Replies

252 Views

Last post by frodo
Fri Nov 29, 2019 5:59 am
Microglia in the pathogenesis of MS

Last post by Petr75 « Wed Nov 27, 2019 8:46 am
Replies: 15
by frodo » Mon Jul 23, 2018 11:13 am
1

2
First post

Microglia in the pathogenesis of MS

We postulate that the immune reaction initiates in the CNS and immune cells (including T cells/B cell)...

Last post

2019 Nov 15
Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School,...
15 Replies

1660 Views

Last post by Petr75
Wed Nov 27, 2019 8:46 am
MS defined as a CD8+ disease

Last post by frodo « Sun Nov 24, 2019 6:03 am
Replies: 1
by frodo » Thu Oct 17, 2019 3:01 am

First post

This is the first time that I see some kind of concrete definition for MS, instead of defining it by a collection of symptoms and testing...

Last post

Anti-CD20 therapy depletes activated myelin-specific CD8+ T cells in multiple sclerosis

Significance

Multiple sclerosis (MS) is an inflammatory...

1 Replies

282 Views

Last post by frodo
Sun Nov 24, 2019 6:03 am
MS signature in plasma and CSF

Last post by Petr75 « Thu Nov 21, 2019 10:29 pm
Replies: 1
by frodo » Thu Oct 31, 2019 11:53 am

First post

Multiple sclerosis has a distinct lipid signature in plasma and cerebrospinal fluid

ABSTRACT

The diagnosis of multiple sclerosis (MS) has...

Last post

2019 Oct 14
Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
HDL-cholesterol elevation associated with...

1 Replies

206 Views

Last post by Petr75
Thu Nov 21, 2019 10:29 pm
Prodromal MS: Biomarkers

Last post by frodo « Thu Nov 07, 2019 7:16 am
Replies: 2
by frodo » Tue Aug 07, 2018 6:57 am

First post

Prodrome is the stage of a disease in which there are no noticeable symptoms, but nevertheless the disease is present. In MS this means that is a...

Last post

Normalized cerebellar white matter and gray matter volume were significantly decreased in RIS compared to healthy controls.

Cerebellar volume loss...

2 Replies

867 Views

Last post by frodo
Thu Nov 07, 2019 7:16 am
Ceramides link MS and vascular problems

Last post by frodo « Thu Nov 07, 2019 5:44 am

by frodo » Thu Nov 07, 2019 5:44 am

0 Replies

119 Views

Last post by frodo
Thu Nov 07, 2019 5:44 am
An underlying process causes abnormalities in veins together with MS

Last post by frodo « Mon Nov 04, 2019 7:26 am
Replies: 2
by frodo » Thu May 09, 2019 1:41 am

First post

This paper points to the existence of an underlying process that causes the known MS lesions and, at the same time, some venous problems:

The...

Last post

Central vein sign: More about vascular problems and MS. 100% sensitivity.

Single Test to ARrive at Multiple Sclerosis (STAR-MS) diagnosis: A...

2 Replies

433 Views

Last post by frodo
Mon Nov 04, 2019 7:26 am
There is also demyelination outside the lesions

Last post by frodo « Thu Oct 24, 2019 8:03 am

by frodo » Thu Oct 24, 2019 8:03 am

Florbetapir PET/MR imaging to assess demyelination in multiple sclerosis

Conclusion

Our findings demonstrate that florbetapir PET imaging can...

0 Replies

385 Views

Last post by frodo
Thu Oct 24, 2019 8:03 am
Possibility of nasal bacteria involved in MS pathogenesis

Last post by Petr75 « Mon Oct 21, 2019 10:41 am
Replies: 1
by frodo » Mon Oct 21, 2019 1:06 am

First post

Bacterial transportable toxins of the nasopharyngeal microbiota in multiple sclerosis. Nose-to-brain direct

Abstract

Intranasal...

Last post

Thanks

1 Replies

234 Views

Last post by Petr75
Mon Oct 21, 2019 10:41 am
MRS of the brain

Last post by frodo « Sun Oct 20, 2019 9:13 am
Replies: 1
by frodo » Thu Oct 10, 2019 6:52 am

First post

MRS (Magnetic Resonance Spectroscopy) allows to see the chemical composition of the brain.

Magnetic resonance spectroscopy (MRS) is a non-invasive...

Last post

Magnetic resonance spectroscopy evidence for declining gliosis in MS patients treated with ocrelizumab versus interferon beta-1a

Background...

1 Replies

255 Views

Last post by frodo
Sun Oct 20, 2019 9:13 am
Herpes virus induces demyelination in rats

Last post by frodo « Tue Oct 15, 2019 6:28 am

by frodo » Tue Oct 15, 2019 6:28 am

Nothing to do with EAE

Herpes Simplex Virus 1 induces brain inflammation and multifocal demyelination in cotton rats Sigmodon hispidus...

0 Replies

242 Views

Last post by frodo
Tue Oct 15, 2019 6:28 am
Large Noncoding RNA in blood

Last post by Petr75 « Sat Oct 12, 2019 11:16 pm
Replies: 5
by frodo » Wed Oct 04, 2017 12:30 pm

First post

Expression Analysis of Long Non-coding RNAs in the Blood of Multiple Sclerosis Patients.

Abstract

Multiple sclerosis (MS) is a chronic...

Last post

2019 Aug 6
Department of Cardiovascular Medicine, The Second Hospital Affiliated to Jilin University, Changchun, China
Exosomal long noncoding RNAs...

5 Replies

1201 Views

Last post by Petr75
Sat Oct 12, 2019 11:16 pm
Correlation of clinical courses and pathophysiological types

Last post by frodo « Wed Oct 09, 2019 11:40 am

by frodo » Wed Oct 09, 2019 11:40 am

Correlation of clinical courses and pathophysiological types

Discussion

Prior histopathological studies of relapsing and progressive MS...

0 Replies

192 Views

Last post by frodo
Wed Oct 09, 2019 11:40 am
MS induced by mistake

Last post by frodo « Wed Oct 09, 2019 11:35 am

by frodo » Wed Oct 09, 2019 11:35 am

An unfortunate accident has shown something that could replace EAE.

Multiple sclerosis associated with pembrolizumab in a patient with non-small...

0 Replies

234 Views

Last post by frodo
Wed Oct 09, 2019 11:35 am
EBV-activated CD8+ Tcells infiltrate the MS brain

Last post by frodo « Tue Oct 08, 2019 2:31 am
Replies: 1
by frodo » Tue Oct 08, 2019 2:26 am

First post

More clues pointing to EBV as the culprit. And more evidence that EAE (a CD4+ disease) and MS have nothing to do.

EBV-activated CD8+ Tcells...

Last post

And maybe the mechanism by which the anti-EBV Tcells cause inflammation is because they cross-react with myelin MBP:

Myelin-specific CD8 T cells...

1 Replies

204 Views

Last post by frodo
Tue Oct 08, 2019 2:31 am
Fractional Anisotropy on DWI MRI shows microstructural damage

Last post by frodo « Tue Oct 01, 2019 4:17 am

by frodo » Tue Oct 01, 2019 4:17 am

Resolving the cognitive clinico-radiological paradox – Microstructural degeneration of fronto-striatal-thalamic loops in early active multiple...

0 Replies

291 Views

Last post by frodo
Tue Oct 01, 2019 4:17 am
Myelocortical MS (MCMS)

Last post by frodo « Tue Oct 01, 2019 4:07 am
Replies: 6
by frodo » Thu Aug 23, 2018 5:03 am

First post

Researchers discover new subtype of multiple sclerosis (The Lancet)

Cleveland Clinic researchers have discovered a new subtype of multiple...

Last post

The cortical pathology is associated to a specific CSF profile:

Inflammatory intrathecal profiles and cortical damage in multiple sclerosis...

6 Replies

1353 Views

Last post by frodo
Tue Oct 01, 2019 4:07 am
23% of MS patients show IgM production

Last post by frodo « Tue Oct 01, 2019 3:34 am

by frodo » Tue Oct 01, 2019 3:34 am

Intrathecal IgM production (Immunoglobulin M) occurred in 23% of the MS patients.

0 Replies

216 Views

Last post by frodo
Tue Oct 01, 2019 3:34 am
Review on biomarkers 2019

Last post by frodo « Tue Sep 24, 2019 1:23 am

by frodo » Tue Sep 24, 2019 1:23 am

Available on Barts MS research page:

there is a review covering the following 6 topics in biomarkers, presented at ECTRIMS 2019:

-serum...

0 Replies

247 Views

Last post by frodo
Tue Sep 24, 2019 1:23 am
biological MS begins 6 years before clinical MS

Last post by frodo « Mon Sep 16, 2019 7:05 am

by frodo » Mon Sep 16, 2019 7:05 am

Serum Neurofilament Light Chain Levels in Patients With Presymptomatic Multiple Sclerosis.

Abstract

Importance:

Unrecognized...

0 Replies

308 Views

Last post by frodo
Mon Sep 16, 2019 7:05 am
Passing REAL MS to mice again. Now with EBV antigens.

Last post by frodo « Sun Sep 15, 2019 11:20 am

by frodo » Sun Sep 15, 2019 11:20 am

Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine...

0 Replies

183 Views

Last post by frodo
Sun Sep 15, 2019 11:20 am
miRNA dysregulation as the source of the disease

Last post by Petr75 « Sat Sep 07, 2019 7:02 am
Replies: 9
by frodo » Mon Oct 16, 2017 11:28 pm

First post

Micro-RNA ( miRNA ) has been proposed as a biomarker of axon degeneration, but some authors have proposed that they could be the source of the...

Last post

2019 Jun 25
Laboratorio di Farmacologia Molecolare e Cellulare della Trasmissione Purinergica, Dipartimento di Scienze Farmacologiche e Biomolecolari...

9 Replies

1475 Views

Last post by Petr75
Sat Sep 07, 2019 7:02 am
T-cell analysis predicts response to Natalizumab

Last post by frodo « Thu Sep 05, 2019 6:39 am

by frodo » Thu Sep 05, 2019 6:39 am

Abstract.

Multiple sclerosis (MS) is a chronic inflamma-tory disease of the central nervous system of autoimmune etiopathogenesis, and is...

0 Replies

166 Views

Last post by frodo
Thu Sep 05, 2019 6:39 am

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