MS Etiology and Pathogenesis

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Last post

several types of alterations in NAWM and NAGM

Last post by frodo « Sat Mar 23, 2019 4:25 am

by frodo » Sat Mar 23, 2019 4:25 am

Exploring metabolite profiling of patients with secondary progressive multiple sclerosis

Synopsis

Proton magnetic resonance spectroscopic...

0 Replies

25 Views

Last post by frodo
Sat Mar 23, 2019 4:25 am
Microglial activation and NAWM appear together

Last post by frodo « Wed Mar 20, 2019 8:20 am
Replies: 1
by frodo » Thu May 17, 2018 1:13 am

First post

Microglial activation and NAWM appear together. A study found that microglial activation (shown by PET imaging) and Normal appearing white matter...

Last post

This report points to three levels of damage in MS, being demyelination just the second stage.

Abstract

Quantifying white matter damage in...

1 Replies

570 Views

Last post by frodo
Wed Mar 20, 2019 8:20 am
miRNA dysregulation as the source of the disease

Last post by frodo « Wed Mar 20, 2019 8:11 am
Replies: 2
by frodo » Mon Oct 16, 2017 11:28 pm

First post

Micro-RNA ( miRNA ) has been proposed as a biomarker of axon degeneration, but some authors have proposed that they could be the source of the...

Last post

Thanks. Quite interesting. It seems that this week we have more news about miRNA disregulation.

Epstein-Barr virus and miRNAs: partners in crime in...

2 Replies

858 Views

Last post by frodo
Wed Mar 20, 2019 8:11 am
B-cells from MS patients secrete something toxic

Last post by frodo « Sat Mar 16, 2019 3:25 am

by frodo » Sat Mar 16, 2019 3:25 am

Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis

Most evidence from pathological studies suggests that...

0 Replies

31 Views

Last post by frodo
Sat Mar 16, 2019 3:25 am
Polineuropaties, CDIP and NF-155 in MS

Last post by frodo « Fri Mar 15, 2019 7:16 am
Replies: 1
by frodo » Fri Mar 15, 2019 7:15 am

1 Replies

21 Views

Last post by frodo
Fri Mar 15, 2019 7:16 am
ANA-positive MS and MRZ reaction

Last post by frodo « Mon Mar 11, 2019 9:05 am

by frodo » Mon Mar 11, 2019 9:05 am

Up to 60% of MS-patients present antinuclear autoantibodies (ANAs) in CSF and may be misdiagnosed. Regardless of the question about if ANA-positive...

0 Replies

40 Views

Last post by frodo
Mon Mar 11, 2019 9:05 am
The Interaction between Viral and Environmental Risk Factors

Last post by frodo « Mon Mar 11, 2019 3:03 am

by frodo » Mon Mar 11, 2019 3:03 am

The Interaction between Viral and Environmental Risk Factors in the Pathogenesis of Multiple Sclerosis

Abstract

Multiple sclerosis (MS) is a...

0 Replies

27 Views

Last post by frodo
Mon Mar 11, 2019 3:03 am
Metabolomics profile of MS

Last post by frodo « Mon Mar 11, 2019 1:49 am
Replies: 1
by frodo » Mon Mar 11, 2019 1:24 am

First post

Several viral infections mimic MS. Before immune supresion or modulation is important to be sure that there is no infection in the CNS or things...

Last post

Immune Cell Profiling of the Cerebrospinal Fluid Provides Pathogenetic Insights into Inflammatory Neuropathies

Objective: Utilize immune cell...

1 Replies

29 Views

Last post by frodo
Mon Mar 11, 2019 1:49 am
Oligoclonal bands are responsive to medication

Last post by frodo « Sun Mar 10, 2019 11:30 am
Replies: 2
by frodo » Tue Jan 15, 2019 5:39 am

First post

Cladribine reduces oligoclonal bands (OCB) in MS, and MS gets better without them. These are the conclusions of a study ( which also points to a...

Last post

Immune Cell Profiling of the Cerebrospinal Fluid Provides Pathogenetic Insights into Inflammatory Neuropathies

Objective: Utilize immune cell...

2 Replies

146 Views

Last post by frodo
Sun Mar 10, 2019 11:30 am
MSRV (MS retro-virus) and EBV interaction

Last post by NHE « Tue Mar 05, 2019 12:49 am
Replies: 1
by frodo » Mon Mar 04, 2019 5:28 am

First post

The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to in vivo imaging

Multiple sclerosis (MS) is a disease of...

Last post

The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to in vivo imaging

Free full text.

1 Replies

75 Views

Last post by NHE
Tue Mar 05, 2019 12:49 am
HERV and MSRV viruses implicated. Temelimab works against them.

Last post by NHE « Sun Mar 03, 2019 3:20 pm
Replies: 2
by frodo » Sat Mar 02, 2019 3:54 am

First post

MSRV is a retrovirus consistently found in MS lesions.

When active, MSRV produces a protein called MSRV-envelope protein, or MSRV-Env, which...

Last post

What is the magnetization transfer ratio? Does it correspond to gristy56's idea that it is magnetite which damages the myelin sheath and that by...

2 Replies

106 Views

Last post by NHE
Sun Mar 03, 2019 3:20 pm
Reports about the CSF toxicity

Last post by frodo « Wed Feb 27, 2019 5:36 am
Replies: 1
by frodo » Sat Dec 30, 2017 4:25 am

First post

I am collecting here some of the studies about the CSF toxicity. One of the most interesting studies of the previous years was the possibility of...

Last post

Last report found

Cerebrospinal Fluid Derived from Primary Progressive MS Delays Remyelination after Lysolecithin-induced Demyelination...

1 Replies

916 Views

Last post by frodo
Wed Feb 27, 2019 5:36 am
NATURE: Autoreplicating T-cells involved in MS

Last post by frodo « Wed Feb 27, 2019 3:09 am

by frodo » Wed Feb 27, 2019 3:09 am

Immune-cell crosstalk in multiple sclerosis

T cells from people with multiple sclerosis are more prone to divide in vitro than are T cells from...

0 Replies

31 Views

Last post by frodo
Wed Feb 27, 2019 3:09 am
NATURE: Specific T-cells induce grey matter degeneration

Last post by frodo « Wed Feb 27, 2019 2:34 am

by frodo » Wed Feb 27, 2019 2:34 am

An important article about T-cells has been published. There are some expert comments about it available at . They say that the progressive phase is...

0 Replies

32 Views

Last post by frodo
Wed Feb 27, 2019 2:34 am
new biomarker, in blood, and maybe able to classify patients

Last post by frodo « Thu Feb 21, 2019 6:47 pm

by frodo » Thu Feb 21, 2019 6:47 pm

Long non‐coding RNA AFAP1‐AS1 is upregulated in a subset of multiple sclerosis patients

Results

AFAP1‐AS1 was upregulated in male MS...

0 Replies

53 Views

Last post by frodo
Thu Feb 21, 2019 6:47 pm
Patterns thread: Selective treatment for the four patterns

Last post by frodo « Mon Feb 18, 2019 1:47 am
Replies: 14
by frodo » Sun Nov 26, 2017 4:04 am

First post

In this post I will try to keep track of the developments in the specific treatment of the four patterns, whose existence was at first disputed, but...

Last post

Mitochondrial defects in acute multiple sclerosis lesions.

Multiple sclerosis is a chronic inflammatory disease, which leads to focal plaques of...

14 Replies

1990 Views

Last post by frodo
Mon Feb 18, 2019 1:47 am
Vascular problems in MS

Last post by vesta « Mon Feb 11, 2019 12:48 am
Replies: 5
by frodo » Fri Aug 17, 2018 1:28 am

First post

Maybe CCSVI theory is wrong, but there must be something related to the vascular system in MS. Two more reports about vascular problems associated to...

Last post

I meant WILL refer to. Vesta

5 Replies

741 Views

Last post by vesta
Mon Feb 11, 2019 12:48 am
The picture of demyelinating diseases gets more complicated

Last post by frodo « Wed Feb 06, 2019 2:38 am

by frodo » Wed Feb 06, 2019 2:38 am

This is the current picture as far as the current knowledge suggest. The picture is more complex than previously thought, even if anti-neurofascin...

0 Replies

119 Views

Last post by frodo
Wed Feb 06, 2019 2:38 am
Immunoglobulin G analysis for diagnosis of MS

Last post by frodo « Tue Feb 05, 2019 11:49 pm

by frodo » Tue Feb 05, 2019 11:49 pm

High performance of cerebrospinal fluid immunoglobulin G analysis for diagnosis of multiple sclerosis

Background

The 2017 revision of the...

0 Replies

67 Views

Last post by frodo
Tue Feb 05, 2019 11:49 pm
Disordered immune system and lipid metabolism in MS

Last post by frodo « Tue Feb 05, 2019 2:38 am

by frodo » Tue Feb 05, 2019 2:38 am

A systems medicine approach reveals disordered immune system and lipid metabolism in multiple sclerosis patients

Identification of autoimmune...

0 Replies

90 Views

Last post by frodo
Tue Feb 05, 2019 2:38 am
maybe B-cells are not so important

Last post by frodo « Sun Feb 03, 2019 9:43 am
Replies: 2
by frodo » Sun Feb 03, 2019 7:41 am

First post

The success of anti-CD20 monoclonal antibodies has put the focus on CD20 B-cells, but it could be that the mechanism of action is about depleting...

Last post

I would say that for reduction of disease activity they mean relapses, not progresion.

2 Replies

99 Views

Last post by frodo
Sun Feb 03, 2019 9:43 am
CSF can separate RRMS from PPMS

Last post by frodo « Sun Feb 03, 2019 7:49 am

by frodo » Sun Feb 03, 2019 7:49 am

Biochemical Differences in Cerebrospinal Fluid between Secondary Progressive and Relapsing–Remitting Multiple Sclerosis

To better understand the...

0 Replies

90 Views

Last post by frodo
Sun Feb 03, 2019 7:49 am
Inside-out model: supporting papers.

Last post by frodo « Sun Feb 03, 2019 7:46 am
Replies: 2
by frodo » Wed Jan 30, 2019 2:28 am

First post

The inside-out model is an alternative theoretical model for MS that postulates that something within the neurons is the cause of the later...

Last post

Altered human oligodendrocyte heterogeneity in multiple sclerosis

Oligodendrocyte (OL) pathology is increasingly implicated in neurodegenerative...

2 Replies

109 Views

Last post by frodo
Sun Feb 03, 2019 7:46 am
Multi-shell diffusion MRI shows early WM changes

Last post by frodo « Sun Feb 03, 2019 1:46 am

by frodo » Sun Feb 03, 2019 1:46 am

It seems that multi-shell diffusion is some kind of new MRI protocol able to show the white matter early damage.

Evidence of early microstructural...

0 Replies

59 Views

Last post by frodo
Sun Feb 03, 2019 1:46 am
status of the research as of 2019

Last post by frodo « Wed Jan 30, 2019 1:07 am

by frodo » Wed Jan 30, 2019 1:07 am

There is a review here summarising the status of knowledge:

Excerpts:

- Evidence from MRI and pathological assessment (biopsies and autopsies)...

0 Replies

90 Views

Last post by frodo
Wed Jan 30, 2019 1:07 am
Multiple sclerosis in 2018: new therapies and biomarkers

Last post by frodo « Mon Jan 28, 2019 7:52 am

by frodo » Mon Jan 28, 2019 7:52 am

Multiple sclerosis in 2018: new therapies and biomarkers

From my point of view, there are two remarkable advances:

- Ibudilast, a...

0 Replies

71 Views

Last post by frodo
Mon Jan 28, 2019 7:52 am
2018 update: Incidence and prevalence rates of Multiple Sclerosis in Canada

Last post by frodo « Mon Jan 28, 2019 6:12 am
Replies: 2
by jimmylegs » Sun Jan 27, 2019 7:38 am

First post

PHAC releases incidence and prevalence rates of Multiple Sclerosis in Canada (2018)

Background:

The Canadian Chronic Disease Surveillance System...

Last post

Just a remark. Prevalence rate increase could be due to a longer life and could be a good thing. Incidence rate increase is the big problem, but they...

2 Replies

89 Views

Last post by frodo
Mon Jan 28, 2019 6:12 am
Pre-active lesions hold clues to stop MS

Last post by frodo « Wed Jan 23, 2019 6:25 am

by frodo » Wed Jan 23, 2019 6:25 am

Preactive lesions in multiple sclerosis

Compelling evidence is accumulating for pathological changes in normal-appearing white matter of MS...

0 Replies

99 Views

Last post by frodo
Wed Jan 23, 2019 6:25 am
Biomarker for response to interferon

Last post by frodo « Tue Jan 22, 2019 4:28 am

by frodo » Tue Jan 22, 2019 4:28 am

Semaphorin 4A as a biomarker of multiple sclerosis and neuromyelitis optica spectrum disorder

Abstract

Selecting appropriate treatment from...

0 Replies

57 Views

Last post by frodo
Tue Jan 22, 2019 4:28 am
IMPORTANT: New type of MS discovered. Myelocortical MS.

Last post by frodo « Sat Jan 12, 2019 9:33 am
Replies: 4
by frodo » Thu Aug 23, 2018 5:03 am

First post

Researchers discover new subtype of multiple sclerosis (The Lancet)

Cleveland Clinic researchers have discovered a new subtype of multiple...

Last post

Perhaps you should research the scientific correctness of statements that you make before you post things on the board.

That statement is not...

4 Replies

945 Views

Last post by frodo
Sat Jan 12, 2019 9:33 am
Wolfson Institute of Preventive Medicine. EBV is MS cause.

Last post by Kheuer « Wed Jan 09, 2019 8:50 am
Replies: 1
by frodo » Sun Dec 23, 2018 5:51 am

First post

There is strong evidence that Epstein Barr Virus (EBV) infection is a cause of Multiple Sclerosis. Immunisation against
EBV could in future prevent...

Last post

EBV and the Human Herpes Virus family activate the epigenetic pathway for the MS genetically prone.

The EBV does not cause MS.

An inflammatory...

1 Replies

491 Views

Last post by Kheuer
Wed Jan 09, 2019 8:50 am
miR-223 in MS: Strong biomarker and probably pathogenic

Last post by frodo « Wed Jan 09, 2019 8:23 am
Replies: 2
by frodo » Fri Dec 21, 2018 6:05 am

First post

The miR-223: An Inflammatory MicroRNA Involved in Pathogenesis of Multiple Sclerosis

Full text link:

Abstract:

Multiple sclerosis (MS) is the...

Last post

Interesting. Both articles say more or less the opposite. For the first authors miR-223 is bad and for the others is good, but anyway they agree in...

2 Replies

599 Views

Last post by frodo
Wed Jan 09, 2019 8:23 am
Targeting progression in MS (PPMS+SPMS)

Last post by frodo « Tue Jan 08, 2019 1:09 am

by frodo » Tue Jan 08, 2019 1:09 am

Source:

In 2018, the distinguishing pathological features of white matter lesions in patients with progressive multiple sclerosis (MS) were...

0 Replies

204 Views

Last post by frodo
Tue Jan 08, 2019 1:09 am
miRNA dysregulation links EBV infection and vitamin D

Last post by frodo « Thu Dec 27, 2018 7:21 am

by frodo » Thu Dec 27, 2018 7:21 am

Integrational analysis of miRNAs data sets as a plausible missing linker between Epstein-Barr virus and vitamin D in relapsing remitting MS patients...

0 Replies

367 Views

Last post by frodo
Thu Dec 27, 2018 7:21 am
summary of advances during 2018

Last post by frodo « Thu Dec 27, 2018 7:18 am

by frodo » Thu Dec 27, 2018 7:18 am

summary of advances during 2018

0 Replies

362 Views

Last post by frodo
Thu Dec 27, 2018 7:18 am
Human endogenous retro-viruses HERVs and link to diabetes

Last post by frodo « Thu Dec 27, 2018 7:12 am
Replies: 1
by frodo » Sun Dec 23, 2018 5:43 am

First post

Not all the research points to EBV. HERVs could be also involved.

Preclinical research demonstrated that pathogenic HERV-W protein negatively...

Last post

Answering to myself, it seems that the HERVs retroviruses activation could be due to EBV. Therefore, it seems that all the evidence about HERV-W also...

1 Replies

362 Views

Last post by frodo
Thu Dec 27, 2018 7:12 am
New entity set apart from MS. Anti-Neurofascin demyelinating disease.

Last post by frodo « Tue Dec 25, 2018 9:29 am

by frodo » Tue Dec 25, 2018 9:29 am

After separation of Neuromyelitis optica (anti-AQP4) and anti-MOG demyelinating disease from MS, it seems that there is a new type of MS that could...

0 Replies

438 Views

Last post by frodo
Tue Dec 25, 2018 9:29 am
Microglia in the pathogenesis of MS

Last post by Petr75 « Sun Dec 23, 2018 11:01 am
Replies: 9
by frodo » Mon Jul 23, 2018 11:13 am

First post

Microglia in the pathogenesis of MS

We postulate that the immune reaction initiates in the CNS and immune cells (including T cells/B cell)...

Last post

2018 Nov 21
Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Stanley Center for...

9 Replies

903 Views

Last post by Petr75
Sun Dec 23, 2018 11:01 am
Atypical MS cases

Last post by frodo « Sat Dec 22, 2018 8:40 am

by frodo » Sat Dec 22, 2018 8:40 am

Multiple Sclerosis with atypical MRI presentation: results of a nationwide multicenter study in 57 consecutive cases.

They speak about four weird...

0 Replies

456 Views

Last post by frodo
Sat Dec 22, 2018 8:40 am
Diferential diagnosis by CSF metab.: MS vs encephalomyelitis

Last post by frodo « Sat Dec 22, 2018 8:25 am

by frodo » Sat Dec 22, 2018 8:25 am

This is specially important to avoid misdiagnosis but also to elucidate pathogenesis.

NMR metabolomics of cerebrospinal fluid differentiates...

0 Replies

446 Views

Last post by frodo
Sat Dec 22, 2018 8:25 am
PPMS vs. RRMS/SPMS pathogenesis

Last post by frodo « Sat Dec 22, 2018 8:15 am

by frodo » Sat Dec 22, 2018 8:15 am

Pathogenic Mechanisms associated with Different Clinical Courses of Multiple Sclerosis

In the majority of patients multiple sclerosis starts with...

0 Replies

454 Views

Last post by frodo
Sat Dec 22, 2018 8:15 am
Epstein Barr Virus review

Last post by frodo « Fri Dec 21, 2018 1:32 am

by frodo » Fri Dec 21, 2018 1:32 am

The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to in vivo imaging

Conclusion

The conclusion drawn from...

0 Replies

477 Views

Last post by frodo
Fri Dec 21, 2018 1:32 am
Biomarkers of the underlying process

Last post by frodo « Sun Dec 09, 2018 11:07 am

by frodo » Sun Dec 09, 2018 11:07 am

Cerebrospinal Fluid Biomarkers Link Toxic Astrogliosis and Microglial Activation to Multiple Sclerosis Severity

HIGHLIGHTS

• Microglial/myeloid...

0 Replies

776 Views

Last post by frodo
Sun Dec 09, 2018 11:07 am
Blood indicators of clinical status and plasma exchange prog

Last post by frodo « Sat Dec 08, 2018 12:53 am

by frodo » Sat Dec 08, 2018 12:53 am

Blood plasma thermal behavior and protein oxidation as indicators of multiple sclerosis clinical status and plasma exchange therapy progression...

0 Replies

774 Views

Last post by frodo
Sat Dec 08, 2018 12:53 am
Anyone thought to have MS should be tested for biotinidase d

Last post by frodo « Sat Dec 01, 2018 12:16 am

by frodo » Sat Dec 01, 2018 12:16 am

ALL INDIVIDUALS THOUGHT TO HAVE MULIPLE SCLEROSIS SHOULD BE TESTED FOR BIOTINIDASE DEFICIENCY

Highlights

• Adults with biotinidase deficiency...

0 Replies

911 Views

Last post by frodo
Sat Dec 01, 2018 12:16 am
FINALLY AN AUTOANTIGEN - And gut microbioma connections.

Last post by frodo « Sun Oct 21, 2018 3:01 am
Replies: 1
by frodo » Thu Oct 18, 2018 3:06 am

First post

Maybe you have notice that I was completely sure about MS not being autoimmune.

Well, maybe I was wrong. Let's see if this report is confirmed....

Last post

More news about this. A clinical trial is coming up.

It seems that the autoimmune system can be re-educated. The same team in Zurich is trying to...

1 Replies

668 Views

Last post by frodo
Sun Oct 21, 2018 3:01 am
what is an HLA DRB3 positive patient?

Last post by frodo « Fri Oct 19, 2018 11:17 am

by frodo » Fri Oct 19, 2018 11:17 am

Regarding my last post about an antigen found, it only appears in a group of patients that they call DRB3 positive. I have taken a look at what means...

0 Replies

681 Views

Last post by frodo
Fri Oct 19, 2018 11:17 am
National MS society web: The word "autoimmune"dissapears.

Last post by jimmylegs « Wed Oct 17, 2018 12:43 pm
Replies: 5
by frodo » Mon Oct 08, 2018 9:31 am

First post

After several years saying MS is an autoimmune disease that ... now they begin like this:

Multiple sclerosis (MS) is an unpredictable, often...

Last post

related

Taking into account the results of B‐cell‐depleting drugs, the production of autoantibodies as the driving force in MS pathology has...

5 Replies

676 Views

Last post by jimmylegs
Wed Oct 17, 2018 12:43 pm
Diagnosis based in serum lipids. Focus on lipid metabolism?

Last post by frodo « Sun Oct 14, 2018 12:22 pm

by frodo » Sun Oct 14, 2018 12:22 pm

Excerpts:

Based on increasing evidence suggesting that MS pathology involves alterations in bioactive lipid metabolism , the present analysis was...

0 Replies

564 Views

Last post by frodo
Sun Oct 14, 2018 12:22 pm
2018 correspondence - MS Genetics: Overview & New Directions

Last post by jimmylegs « Sun Sep 30, 2018 4:18 am

by jimmylegs » Sun Sep 30, 2018 4:18 am

Genetics of Multiple Sclerosis: An Overview and New Directions

Abstract
The contribution of genetic inheritance in multiple sclerosis was...

0 Replies

523 Views

Last post by jimmylegs
Sun Sep 30, 2018 4:18 am

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