MS Etiology and Pathogenesis

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Last post

Coronavirus (COVID-19): What You Need To Know

Last post by NHE « Mon Aug 03, 2020 1:09 pm
Posted in General Discussion
Replies: 147
by jimmylegs » Sun Mar 15, 2020 4:10 am » in General Discussion
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First post

What You Need To Know About Coronavirus (COVID-19)

What does COVID-19 mean for people living with MS? Many disease modifying therapies (DMTs) for...

Last post

One Man's COVID-19 Death Raises The Worst Fears Of Many People With Disabilities
July 31, 2020 3:29 PM ET

What Melissa Hickson says happened to...
147 Replies

15660 Views

Last post by NHE
Mon Aug 03, 2020 1:09 pm

Topics

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Last post

Novel blood-based biomarker for MS

Last post by frodo « Thu Aug 06, 2020 7:39 am

by frodo » Thu Aug 06, 2020 7:39 am

Blood platelet RNA enables the detection of multiple sclerosis

Background

In multiple sclerosis (MS), clinical assessment, MRI and...

0 Replies

16 Views

Last post by frodo
Thu Aug 06, 2020 7:39 am
Retinal damage is not due to inflammation but MS process itself

Last post by frodo « Thu Jul 30, 2020 11:52 pm

by frodo » Thu Jul 30, 2020 11:52 pm

Optical coherence tomography angiography in multiple sclerosis: A cross-sectional study

Objectives

To evaluate retinal axonal density and...

0 Replies

55 Views

Last post by frodo
Thu Jul 30, 2020 11:52 pm
Clinical course can be predicted

Last post by frodo « Thu Jul 30, 2020 11:49 pm

by frodo » Thu Jul 30, 2020 11:49 pm

Clinical course can be predicted by a panel of 28 CSF biomarkers

Disease phenotype prediction in multiple sclerosis

Abstract

Early...

0 Replies

30 Views

Last post by frodo
Thu Jul 30, 2020 11:49 pm
Biomarkers: Amino-acid and acylcarnitine profiles

Last post by frodo « Tue Jul 21, 2020 2:09 am

by frodo » Tue Jul 21, 2020 2:09 am

Changes in Amino Acid and Acylcarnitine Plasma Profiles for Distinguishing Patients with Multiple Sclerosis from Healthy Controls

Abstract...

0 Replies

42 Views

Last post by frodo
Tue Jul 21, 2020 2:09 am
Biomarker: N-glucosylation in Multiple Sclerosis

Last post by frodo « Tue Jul 21, 2020 1:54 am

by frodo » Tue Jul 21, 2020 1:54 am

A Multiple N-Glucosylated Peptide Epitope Efficiently Detecting Antibodies in Multiple Sclerosis

Abstract

Diagnostics of Multiple Sclerosis...

0 Replies

36 Views

Last post by frodo
Tue Jul 21, 2020 1:54 am
HIV prevents MS relapses

Last post by frodo « Tue Jul 21, 2020 1:33 am

by frodo » Tue Jul 21, 2020 1:33 am

Acquisition of human immunodeficiency virus infection in a patient with multiple sclerosis: could these conditions positively influence each other’s...

0 Replies

38 Views

Last post by frodo
Tue Jul 21, 2020 1:33 am
The lancet. Open call for using NFL in diagnosis and monitoring

Last post by frodo « Tue Jul 21, 2020 1:29 am
Replies: 1
by frodo » Thu Jun 25, 2020 1:26 am

First post

Neurofilament light in blood. What more is needed for clinical implementation?

Cerebrospinalfluid (CSF) neurofilament light (NfL) is the best...

Last post

Serum neurofilament light as a biomarker in progressive multiple sclerosis

Abstract

There is an unmet need in multiple sclerosis (MS) therapy...

1 Replies

53 Views

Last post by frodo
Tue Jul 21, 2020 1:29 am
Cacciaguerra’s criteria. Difference between MS, NMO and MOG

Last post by frodo « Tue Jul 21, 2020 1:26 am

by frodo » Tue Jul 21, 2020 1:26 am

Evaluation of brain and spinal cord lesion distribution criteria at disease onset in distinguishing NMOSD from MS and MOG antibody-associated...

0 Replies

35 Views

Last post by frodo
Tue Jul 21, 2020 1:26 am
cytotoxic B lymphocytes

Last post by frodo « Tue Jul 21, 2020 1:18 am

by frodo » Tue Jul 21, 2020 1:18 am

Study of b lymphocyte subpopulations in the peripheral blood and cephalorraquidian liquid of patients with primary progressive multiple sclerosis...

0 Replies

26 Views

Last post by frodo
Tue Jul 21, 2020 1:18 am
Last review about EBV

Last post by frodo « Fri Jul 17, 2020 9:13 am

by frodo » Fri Jul 17, 2020 9:13 am

State of the Art and Future Challenges in Multiple Sclerosis Research and Medical Management: An Insight into the 5th International Porto Congress of...

0 Replies

60 Views

Last post by frodo
Fri Jul 17, 2020 9:13 am
Biomarker in the skin. Fibroblasts

Last post by frodo « Tue Jul 14, 2020 7:41 am

by frodo » Tue Jul 14, 2020 7:41 am

Information about fibroblasts in wikipedia:

Signatures of cell stress and altered bioenergetics in skin fibroblasts from patients with multiple...

0 Replies

43 Views

Last post by frodo
Tue Jul 14, 2020 7:41 am
The picture of demyelinating diseases gets more complicated

Last post by frodo « Mon Jul 13, 2020 8:50 am
Replies: 1
by frodo » Wed Feb 06, 2019 2:38 am

First post

This is the current picture as far as the current knowledge suggest. The picture is more complex than previously thought, even if anti-neurofascin...

Last post

Immunoadsorption and Plasma Exchange in Seropositive and Seronegative Immune-Mediated Neuropathies

Abstract

The inflammatory neuropathies are...

1 Replies

613 Views

Last post by frodo
Mon Jul 13, 2020 8:50 am
Biomarkers: MRZ reaction distinguish MS and other disorders

Last post by frodo « Mon Jul 13, 2020 8:26 am
Replies: 1
by frodo » Mon Feb 05, 2018 9:28 am

First post

The MRZ reaction helps to distinguish rheumatologic disorders with central nervous involvement from multiple sclerosis.

Some rheumatologic...

Last post

Antibodies to Epstein-Barr virus and neurotropic viruses in multiple sclerosis and optic neuritis

Abstract

Antibody indices to MRZ are of...

1 Replies

822 Views

Last post by frodo
Mon Jul 13, 2020 8:26 am
IMPORTANT: Dysfunctional RNA‐binding proteins in MS

Last post by frodo « Mon Jul 13, 2020 8:21 am

by frodo » Mon Jul 13, 2020 8:21 am

As far as I know this is the first time that something like this has been reported.

Neuronal RNA‐binding protein dysfunction in multiple sclerosis...

0 Replies

28 Views

Last post by frodo
Mon Jul 13, 2020 8:21 am
Siponimod reduces progression with or without relapses

Last post by frodo « Mon Jul 13, 2020 8:12 am

by frodo » Mon Jul 13, 2020 8:12 am

Siponimod Affects Disability Progression in Patients with Secondary Progressive Multiple Sclerosis Independent of Relapse Activity

Background :...

0 Replies

31 Views

Last post by frodo
Mon Jul 13, 2020 8:12 am
Highly active MS and specific treatment

Last post by frodo « Tue Jun 30, 2020 12:37 am

by frodo » Tue Jun 30, 2020 12:37 am

It is not an official but regulatory agencies considered the highly active MS (HAMS) separated from the rest in their approval processes for...

0 Replies

75 Views

Last post by frodo
Tue Jun 30, 2020 12:37 am
Microglia are the culprits for slowly expanding lesions

Last post by frodo « Mon Jun 29, 2020 12:17 am

by frodo » Mon Jun 29, 2020 12:17 am

Slowly expanding lesions are suspected to be the cause of the MS progressive phase. Microglia and macrophages are cells that look similar and were...

0 Replies

37 Views

Last post by frodo
Mon Jun 29, 2020 12:17 am
biomarkers review 2020 and more fingers pointing to EBV

Last post by frodo « Mon Jun 29, 2020 12:11 am

by frodo » Mon Jun 29, 2020 12:11 am

Molecular Biomarkers in the Cerebrospinal Fluid in Multiple Sclerosis

Multiple sclerosis (MS) is a chronic autoimmune disease affecting the spinal...

0 Replies

39 Views

Last post by frodo
Mon Jun 29, 2020 12:11 am
Three new genetic variants of MS

Last post by frodo « Thu Jun 25, 2020 1:33 am

by frodo » Thu Jun 25, 2020 1:33 am

Neurological phenotypes in patients with NLRP3-, MEFV-, and TNFRSF1A low-penetrance variants

Background

Neurological manifestations and the...

0 Replies

51 Views

Last post by frodo
Thu Jun 25, 2020 1:33 am
Biotin treatment can turn PPMS into relapsing

Last post by frodo « Tue Jun 23, 2020 8:46 am

by frodo » Tue Jun 23, 2020 8:46 am

There are contradicting reports on this topic. See for instance

Relapses During High-Dose Biotin Treatment in Progressive Multiple Sclerosis: a...

0 Replies

74 Views

Last post by frodo
Tue Jun 23, 2020 8:46 am
Automatic segmentation of different lesion types

Last post by frodo « Tue Jun 23, 2020 8:44 am

by frodo » Tue Jun 23, 2020 8:44 am

Identification of Multiple Sclerosis lesion subtypes and their quantitative assessments with EDSS using neuroimaging

Abstract

It would be...

0 Replies

29 Views

Last post by frodo
Tue Jun 23, 2020 8:44 am
STIR Imaging of Intracranial Disease

Last post by frodo « Tue Jun 23, 2020 8:34 am

by frodo » Tue Jun 23, 2020 8:34 am

Postcontrast STIR imaging offers additional information, not obtained with other sequences:

Postcontrast STIR Imaging of Intracranial Disease...

0 Replies

27 Views

Last post by frodo
Tue Jun 23, 2020 8:34 am
prognosis based in a blood test

Last post by frodo « Tue Jun 16, 2020 2:33 am

by frodo » Tue Jun 16, 2020 2:33 am

Clues to prognosis in multiple sclerosis found in the blood

Neurofilament light (NfL) and microRNAs (miRNAs) can help to predict the course that...

0 Replies

200 Views

Last post by frodo
Tue Jun 16, 2020 2:33 am
The division of MS in "types" was made up just to approve interferons

Last post by frodo « Tue Jun 16, 2020 2:26 am
Replies: 1
by frodo » Tue Jun 16, 2020 2:21 am

First post

Multiple sclerosis – a review

There has been a reduction in the proportion of people with PPMS. This is probably related to the fact that there...

Last post

New type under research. They are trying to achieve a standard definition for agressive MS. Maybe this will be more interesting than the previous...

1 Replies

110 Views

Last post by frodo
Tue Jun 16, 2020 2:26 am
Microglia in the pathogenesis of MS

Last post by NHE « Sat Jun 13, 2020 4:30 pm
Replies: 18
by frodo » Mon Jul 23, 2018 11:13 am
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2
First post

Microglia in the pathogenesis of MS

We postulate that the immune reaction initiates in the CNS and immune cells (including T cells/B cell)...

Last post

2020 Apr 28
School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, United States
Lipid and Lipoprotein Metabolism in...
18 Replies

2548 Views

Last post by NHE
Sat Jun 13, 2020 4:30 pm
Hint for a new NMO variant confused into the MS spectrum

Last post by frodo « Thu Jun 11, 2020 5:46 am

by frodo » Thu Jun 11, 2020 5:46 am

After classifying atypical cases in four groups, the classical MS, anti-AQP4 and anti-MOG groups appear, but a fourth group unclassifiable also...

0 Replies

123 Views

Last post by frodo
Thu Jun 11, 2020 5:46 am
biomarker for response to interferon beta-1b

Last post by frodo « Tue Jun 09, 2020 2:38 am

by frodo » Tue Jun 09, 2020 2:38 am

A long-term follow-up study on biochemical and clinical biomarkers of response to interferon beta-1b treatment in relapsing-remitting multiple...

0 Replies

122 Views

Last post by frodo
Tue Jun 09, 2020 2:38 am
CCSVI ten years later

Last post by frodo « Thu Jun 04, 2020 12:39 am

by frodo » Thu Jun 04, 2020 12:39 am

Chronic cerebrospinal venous insufficiency, ten years after. New headlights on a venous disease that enriched the vascular world

Pdf available...

0 Replies

180 Views

Last post by frodo
Thu Jun 04, 2020 12:39 am
Four patterns of oligoclonal bands

Last post by frodo « Sat May 30, 2020 12:51 am

by frodo » Sat May 30, 2020 12:51 am

Kappa Free Light Chains and IgG Combined in a Novel Algorithm for the Detection of Multiple Sclerosis

Abstract

Background :
It is well known...

0 Replies

135 Views

Last post by frodo
Sat May 30, 2020 12:51 am
Biomarker: Antibodies in the patients’ cerebrospinal fluid are attracted to some peptides

Last post by frodo « Fri May 29, 2020 6:28 am

by frodo » Fri May 29, 2020 6:28 am

Nanoimmunosensor based on atomic force spectroscopy to detect anti-myelin basic protein related to early-stage multiple sclerosis

Highlights

•...

0 Replies

124 Views

Last post by frodo
Fri May 29, 2020 6:28 am
Molecular heterogeneity of pathogenic mechanisms

Last post by frodo « Tue May 26, 2020 4:30 am

by frodo » Tue May 26, 2020 4:30 am

This paper points to the existence of seven molecular groups in MS. They have used something called SOMAscan-based models to group patients by their...

0 Replies

135 Views

Last post by frodo
Tue May 26, 2020 4:30 am
IGM+ MS could be different from normal MS

Last post by frodo « Thu May 21, 2020 2:48 am
Replies: 2
by frodo » Thu Oct 31, 2019 11:35 am

First post

The oligoclonal bands in MS are IgG bands. There is a subset of patients with another immunoglobulin, IGM, that have a worse prognosis.

This paper...

Last post

Four bands of IGM is absolutely specific (100%) for MS. No healthy subject shows that, but is not very sensitive. 60% of the MS patients do not show...

2 Replies

763 Views

Last post by frodo
Thu May 21, 2020 2:48 am
Model of cortical demyelination with cytokines

Last post by frodo « Tue May 19, 2020 4:59 am

by frodo » Tue May 19, 2020 4:59 am

Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration...

0 Replies

153 Views

Last post by frodo
Tue May 19, 2020 4:59 am
Biomarkers. Response to Fingolimod can be predicted.

Last post by frodo « Tue May 19, 2020 4:52 am
Replies: 2
by frodo » Thu Apr 19, 2018 12:31 pm

First post

Predicting therapeutic response to fingolimod treatment in multiple sclerosis patients

Summary

Fingolimod, an orally active immunomodulatory...

Last post

New biomarker for fingolimod: CD56bright

Abstract

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system, which...

2 Replies

1317 Views

Last post by frodo
Tue May 19, 2020 4:52 am
PhD thesis about patterns and plasmapheresis

Last post by frodo « Tue May 19, 2020 4:48 am

by frodo » Tue May 19, 2020 4:48 am

Apheresis therapy in immunopathologically classified multiple sclerosis patients

Conclusion

Our results show that the response to apheresis...

0 Replies

113 Views

Last post by frodo
Tue May 19, 2020 4:48 am
PPMS in children is different than in adults.

Last post by frodo « Tue May 19, 2020 4:42 am

by frodo » Tue May 19, 2020 4:42 am

The good news is that children PPMS responds to RRMS medications.

Interestingly, in contrast to the continuing progression Abdel-Mannan et al.3...

0 Replies

120 Views

Last post by frodo
Tue May 19, 2020 4:42 am
Unknown circulating serum factors impair BBB integrity

Last post by frodo « Thu May 14, 2020 5:25 am

by frodo » Thu May 14, 2020 5:25 am

Immuno-metabolic impact of the multiple sclerosis patients’ sera on endothelial cells of the blood-brain barrier

Conclusions

Our data suggest...

0 Replies

138 Views

Last post by frodo
Thu May 14, 2020 5:25 am
biomarker for early MS

Last post by frodo « Wed May 13, 2020 8:06 am

by frodo » Wed May 13, 2020 8:06 am

Nearly 100% of sensitivity (96.68%) !!

Nanoimmunosensor based on atomic force spectroscopy to detect anti-myelin basic protein related to...

0 Replies

131 Views

Last post by frodo
Wed May 13, 2020 8:06 am
Interleukin IL9 in SPMS

Last post by frodo « Mon May 11, 2020 3:44 am

by frodo » Mon May 11, 2020 3:44 am

Interleukin-9 regulates macrophage activation in the (secondary) progressive multiple sclerosis brain

Abstract

Background

Multiple sclerosis...

0 Replies

129 Views

Last post by frodo
Mon May 11, 2020 3:44 am
Biomarker for PPMS

Last post by frodo « Mon May 11, 2020 3:24 am

by frodo » Mon May 11, 2020 3:24 am

NLRP3 inflammasome activity as biomarker for primary progressive multiple sclerosis

Increased activity of the NLRP3 inflammasome in immune cells...

0 Replies

136 Views

Last post by frodo
Mon May 11, 2020 3:24 am
plasmapheresis works for MS

Last post by frodo « Mon May 11, 2020 3:16 am

by frodo » Mon May 11, 2020 3:16 am

Double-blind, randomized controlled trial of therapeutic plasma exchanges vs sham exchanges in moderate-to-severe relapses of multiple sclerosis....

0 Replies

131 Views

Last post by frodo
Mon May 11, 2020 3:16 am
miRNA dysregulation as the source of the disease

Last post by Petr75 « Sat May 09, 2020 10:23 pm
Replies: 12
by frodo » Mon Oct 16, 2017 11:28 pm

First post

Micro-RNA ( miRNA ) has been proposed as a biomarker of axon degeneration, but some authors have proposed that they could be the source of the...

Last post

2020 Apr 21
Department of Medical Biology , Faculty of Medicine, Ege University, Izmir, Turkey; Department of Genetics, Tabriz Branch, Islamic Azad...

12 Replies

2086 Views

Last post by Petr75
Sat May 09, 2020 10:23 pm
New mimic set appart from MS

Last post by frodo « Tue May 05, 2020 5:09 am

by frodo » Tue May 05, 2020 5:09 am

This report speaks about a newly found kind of neurodegeneration that looks like PPMS. Some previously diagnosed PPMS patients are probably suffering...

0 Replies

154 Views

Last post by frodo
Tue May 05, 2020 5:09 am
CD20+ B-cell subsets in MS

Last post by frodo « Tue May 05, 2020 4:46 am

by frodo » Tue May 05, 2020 4:46 am

B-cells are known to play a role in MS. Specially those with the protein CD20, because anti-CD20 mabs slow the evolution of the disease.

This study...

0 Replies

134 Views

Last post by frodo
Tue May 05, 2020 4:46 am
Two micro-RNAs (146 and 145) as markers for inflammation

Last post by frodo « Tue May 05, 2020 2:33 am

by frodo » Tue May 05, 2020 2:33 am

Investigation the miRNA146a and miRNA155 gene expression levels in patients with multiple sclerosis

Highlights

• MicroRNA-146a and...

0 Replies

119 Views

Last post by frodo
Tue May 05, 2020 2:33 am
new MS mimic and biotin

Last post by frodo « Mon May 04, 2020 5:02 am

by frodo » Mon May 04, 2020 5:02 am

Biotin deficiency can appear as MS but it is not MS.

Any individual with multiple sclerosis who markedly improves neurologically with high-doses of...

0 Replies

160 Views

Last post by frodo
Mon May 04, 2020 5:02 am
Molecular biomarker could be pathogenic

Last post by frodo « Mon May 04, 2020 1:34 am

by frodo » Mon May 04, 2020 1:34 am

Chitinase 3-like 1 is neurotoxic in primary cultured neurons

Abstract

Chitinase 3-like 1 (CHI3L1) is known to play a role as prognostic...

0 Replies

139 Views

Last post by frodo
Mon May 04, 2020 1:34 am
NAWM (normal appearing white matter) description

Last post by frodo « Thu Apr 30, 2020 9:02 am

by frodo » Thu Apr 30, 2020 9:02 am

Two new papers about NAWM that point to metabolic changes

perilesional-NAWM is characterized by lower myelin and axonal content compared to...

0 Replies

80 Views

Last post by frodo
Thu Apr 30, 2020 9:02 am
new biomarker for citrullination (myelin degeneration)

Last post by frodo « Wed Apr 29, 2020 2:18 am

by frodo » Wed Apr 29, 2020 2:18 am

New Chemical Probes for Detection of Molecular Markers of Multiple Sclerosis

Abstract

Multiple sclerosis is a neurodegenerative disease of...

0 Replies

69 Views

Last post by frodo
Wed Apr 29, 2020 2:18 am
Overlaps of MS with NMO and anti-MOG

Last post by frodo « Wed Apr 29, 2020 2:11 am

by frodo » Wed Apr 29, 2020 2:11 am

An Attempt to Subclassify and Understand Further the MS/NMOSD “Overlap” Syndromes and Beyond

Abstract

Objective: An attempt to define and...

0 Replies

72 Views

Last post by frodo
Wed Apr 29, 2020 2:11 am

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