MS Etiology and Pathogenesis

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Coronavirus (COVID-19): What You Need To Know

Last post by jimmylegs « Sat May 30, 2020 8:08 am
Posted in General Discussion
Replies: 130
by jimmylegs » Sun Mar 15, 2020 4:10 am » in General Discussion
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First post

What You Need To Know About Coronavirus (COVID-19)

What does COVID-19 mean for people living with MS? Many disease modifying therapies (DMTs) for...

Last post

better; thank you zen. i suppose i ought to have specified titles with links. mea culpa.

Hydroxychloroquine or chloroquine with or without a...
130 Replies

11796 Views

Last post by jimmylegs
Sat May 30, 2020 8:08 am

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Last post

Four patterns of oligoclonal bands

Last post by frodo « Sat May 30, 2020 12:51 am

by frodo » Sat May 30, 2020 12:51 am

Kappa Free Light Chains and IgG Combined in a Novel Algorithm for the Detection of Multiple Sclerosis

Abstract

Background :
It is well known...

0 Replies

29 Views

Last post by frodo
Sat May 30, 2020 12:51 am
Biomarker: Antibodies in the patients’ cerebrospinal fluid are attracted to some peptides

Last post by frodo « Fri May 29, 2020 6:28 am

by frodo » Fri May 29, 2020 6:28 am

Nanoimmunosensor based on atomic force spectroscopy to detect anti-myelin basic protein related to early-stage multiple sclerosis

Highlights

•...

0 Replies

24 Views

Last post by frodo
Fri May 29, 2020 6:28 am
Microglia in the pathogenesis of MS

Last post by Petr75 « Thu May 28, 2020 10:46 am
Replies: 16
by frodo » Mon Jul 23, 2018 11:13 am
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First post

Microglia in the pathogenesis of MS

We postulate that the immune reaction initiates in the CNS and immune cells (including T cells/B cell)...

Last post

2020 Apr 29
Rudolf Boehm Institute for Pharmacology and Toxicology, University of Leipzig, Germany
Regulation of Microglial Functions by Purinergic...
16 Replies

2376 Views

Last post by Petr75
Thu May 28, 2020 10:46 am
Molecular heterogeneity of pathogenic mechanisms

Last post by frodo « Tue May 26, 2020 4:30 am

by frodo » Tue May 26, 2020 4:30 am

This paper points to the existence of seven molecular groups in MS. They have used something called SOMAscan-based models to group patients by their...

0 Replies

39 Views

Last post by frodo
Tue May 26, 2020 4:30 am
IGM+ MS could be different from normal MS

Last post by frodo « Thu May 21, 2020 2:48 am
Replies: 2
by frodo » Thu Oct 31, 2019 11:35 am

First post

The oligoclonal bands in MS are IgG bands. There is a subset of patients with another immunoglobulin, IGM, that have a worse prognosis.

This paper...

Last post

Four bands of IGM is absolutely specific (100%) for MS. No healthy subject shows that, but is not very sensitive. 60% of the MS patients do not show...

2 Replies

701 Views

Last post by frodo
Thu May 21, 2020 2:48 am
Model of cortical demyelination with cytokines

Last post by frodo « Tue May 19, 2020 4:59 am

by frodo » Tue May 19, 2020 4:59 am

Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration...

0 Replies

46 Views

Last post by frodo
Tue May 19, 2020 4:59 am
Biomarkers. Response to Fingolimod can be predicted.

Last post by frodo « Tue May 19, 2020 4:52 am
Replies: 2
by frodo » Thu Apr 19, 2018 12:31 pm

First post

Predicting therapeutic response to fingolimod treatment in multiple sclerosis patients

Summary

Fingolimod, an orally active immunomodulatory...

Last post

New biomarker for fingolimod: CD56bright

Abstract

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system, which...

2 Replies

1293 Views

Last post by frodo
Tue May 19, 2020 4:52 am
PhD thesis about patterns and plasmapheresis

Last post by frodo « Tue May 19, 2020 4:48 am

by frodo » Tue May 19, 2020 4:48 am

Apheresis therapy in immunopathologically classified multiple sclerosis patients

Conclusion

Our results show that the response to apheresis...

0 Replies

27 Views

Last post by frodo
Tue May 19, 2020 4:48 am
PPMS in children is different than in adults.

Last post by frodo « Tue May 19, 2020 4:42 am

by frodo » Tue May 19, 2020 4:42 am

The good news is that children PPMS responds to RRMS medications.

Interestingly, in contrast to the continuing progression Abdel-Mannan et al.3...

0 Replies

26 Views

Last post by frodo
Tue May 19, 2020 4:42 am
Unknown circulating serum factors impair BBB integrity

Last post by frodo « Thu May 14, 2020 5:25 am

by frodo » Thu May 14, 2020 5:25 am

Immuno-metabolic impact of the multiple sclerosis patients’ sera on endothelial cells of the blood-brain barrier

Conclusions

Our data suggest...

0 Replies

47 Views

Last post by frodo
Thu May 14, 2020 5:25 am
biomarker for early MS

Last post by frodo « Wed May 13, 2020 8:06 am

by frodo » Wed May 13, 2020 8:06 am

Nearly 100% of sensitivity (96.68%) !!

Nanoimmunosensor based on atomic force spectroscopy to detect anti-myelin basic protein related to...

0 Replies

36 Views

Last post by frodo
Wed May 13, 2020 8:06 am
Interleukin IL9 in SPMS

Last post by frodo « Mon May 11, 2020 3:44 am

by frodo » Mon May 11, 2020 3:44 am

Interleukin-9 regulates macrophage activation in the (secondary) progressive multiple sclerosis brain

Abstract

Background

Multiple sclerosis...

0 Replies

34 Views

Last post by frodo
Mon May 11, 2020 3:44 am
Biomarker for PPMS

Last post by frodo « Mon May 11, 2020 3:24 am

by frodo » Mon May 11, 2020 3:24 am

NLRP3 inflammasome activity as biomarker for primary progressive multiple sclerosis

Increased activity of the NLRP3 inflammasome in immune cells...

0 Replies

32 Views

Last post by frodo
Mon May 11, 2020 3:24 am
plasmapheresis works for MS

Last post by frodo « Mon May 11, 2020 3:16 am

by frodo » Mon May 11, 2020 3:16 am

Double-blind, randomized controlled trial of therapeutic plasma exchanges vs sham exchanges in moderate-to-severe relapses of multiple sclerosis....

0 Replies

38 Views

Last post by frodo
Mon May 11, 2020 3:16 am
miRNA dysregulation as the source of the disease

Last post by Petr75 « Sat May 09, 2020 10:23 pm
Replies: 12
by frodo » Mon Oct 16, 2017 11:28 pm

First post

Micro-RNA ( miRNA ) has been proposed as a biomarker of axon degeneration, but some authors have proposed that they could be the source of the...

Last post

2020 Apr 21
Department of Medical Biology , Faculty of Medicine, Ege University, Izmir, Turkey; Department of Genetics, Tabriz Branch, Islamic Azad...

12 Replies

2044 Views

Last post by Petr75
Sat May 09, 2020 10:23 pm
New mimic set appart from MS

Last post by frodo « Tue May 05, 2020 5:09 am

by frodo » Tue May 05, 2020 5:09 am

This report speaks about a newly found kind of neurodegeneration that looks like PPMS. Some previously diagnosed PPMS patients are probably suffering...

0 Replies

58 Views

Last post by frodo
Tue May 05, 2020 5:09 am
CD20+ B-cell subsets in MS

Last post by frodo « Tue May 05, 2020 4:46 am

by frodo » Tue May 05, 2020 4:46 am

B-cells are known to play a role in MS. Specially those with the protein CD20, because anti-CD20 mabs slow the evolution of the disease.

This study...

0 Replies

35 Views

Last post by frodo
Tue May 05, 2020 4:46 am
Two micro-RNAs (146 and 145) as markers for inflammation

Last post by frodo « Tue May 05, 2020 2:33 am

by frodo » Tue May 05, 2020 2:33 am

Investigation the miRNA146a and miRNA155 gene expression levels in patients with multiple sclerosis

Highlights

• MicroRNA-146a and...

0 Replies

31 Views

Last post by frodo
Tue May 05, 2020 2:33 am
new MS mimic and biotin

Last post by frodo « Mon May 04, 2020 5:02 am

by frodo » Mon May 04, 2020 5:02 am

Biotin deficiency can appear as MS but it is not MS.

Any individual with multiple sclerosis who markedly improves neurologically with high-doses of...

0 Replies

43 Views

Last post by frodo
Mon May 04, 2020 5:02 am
Molecular biomarker could be pathogenic

Last post by frodo « Mon May 04, 2020 1:34 am

by frodo » Mon May 04, 2020 1:34 am

Chitinase 3-like 1 is neurotoxic in primary cultured neurons

Abstract

Chitinase 3-like 1 (CHI3L1) is known to play a role as prognostic...

0 Replies

37 Views

Last post by frodo
Mon May 04, 2020 1:34 am
NAWM (normal appearing white matter) description

Last post by frodo « Thu Apr 30, 2020 9:02 am

by frodo » Thu Apr 30, 2020 9:02 am

Two new papers about NAWM that point to metabolic changes

perilesional-NAWM is characterized by lower myelin and axonal content compared to...

0 Replies

39 Views

Last post by frodo
Thu Apr 30, 2020 9:02 am
new biomarker for citrullination (myelin degeneration)

Last post by frodo « Wed Apr 29, 2020 2:18 am

by frodo » Wed Apr 29, 2020 2:18 am

New Chemical Probes for Detection of Molecular Markers of Multiple Sclerosis

Abstract

Multiple sclerosis is a neurodegenerative disease of...

0 Replies

43 Views

Last post by frodo
Wed Apr 29, 2020 2:18 am
Overlaps of MS with NMO and anti-MOG

Last post by frodo « Wed Apr 29, 2020 2:11 am

by frodo » Wed Apr 29, 2020 2:11 am

An Attempt to Subclassify and Understand Further the MS/NMOSD “Overlap” Syndromes and Beyond

Abstract

Objective: An attempt to define and...

0 Replies

42 Views

Last post by frodo
Wed Apr 29, 2020 2:11 am
Diversity of IgGs in CSF

Last post by frodo « Wed Apr 29, 2020 2:06 am

by frodo » Wed Apr 29, 2020 2:06 am

IgGs in CSF are active in the hydroysis of some proteins. Maybe a new biomarker?

Abstract

It was recently shown that IgGs from sera of...

0 Replies

31 Views

Last post by frodo
Wed Apr 29, 2020 2:06 am
Another important immunoglobuling in CSF: IgA

Last post by frodo « Tue Apr 28, 2020 4:26 am

by frodo » Tue Apr 28, 2020 4:26 am

Development of the technique of isoelectricfocusing and immunodetection of immunoglobulin A in the healthcare context as support for the diagnosis of...

0 Replies

40 Views

Last post by frodo
Tue Apr 28, 2020 4:26 am
2011 proposal: environment is MS' main cause; genetics minor

Last post by Petr75 « Sat Apr 25, 2020 10:57 pm
Replies: 5
by jimmylegs » Thu Aug 30, 2018 10:32 am

First post

The major cause of multiple sclerosis is environmental: genetics has a minor role - Yes (2011)

Proposal
It is clear that multiple sclerosis (MS)...

Last post

2020 Apr
Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece
Environmental factors and risk of multiple...

5 Replies

1083 Views

Last post by Petr75
Sat Apr 25, 2020 10:57 pm
passing REAL MS to mice. New report 2020. An IgG-driven kind of MS found.

Last post by frodo « Wed Apr 22, 2020 12:41 am

by frodo » Wed Apr 22, 2020 12:41 am

There have been several reports previously about passing real PPMS (not RRMS nor SPMS) to mice by injections of CSF from patients. See for instance...

0 Replies

88 Views

Last post by frodo
Wed Apr 22, 2020 12:41 am
retinal layer atrophy in PPMS/SPMS

Last post by frodo « Fri Apr 17, 2020 1:42 am

by frodo » Fri Apr 17, 2020 1:42 am

This could shade some light into the pathogenesis. By the way, there is no myelin in the retina.

Progressive multiple sclerosis is associated...

0 Replies

107 Views

Last post by frodo
Fri Apr 17, 2020 1:42 am
Microglia in MS. Review.

Last post by frodo « Sun Apr 12, 2020 11:54 pm

by frodo » Sun Apr 12, 2020 11:54 pm

Microglia in Multiple Sclerosis: Friend or Foe?

Abstract

Microglia originate from myeloid progenitors in the embryonic yolk sac and play an...

0 Replies

137 Views

Last post by frodo
Sun Apr 12, 2020 11:54 pm
Human herpesvirus (HHV)-6A vs HHV-6B

Last post by frodo « Sun Apr 12, 2020 11:07 pm

by frodo » Sun Apr 12, 2020 11:07 pm

It seems that HHV-6A is associated to MS and its etiology. These resarchers found an increased serological response against a HHV-6A protein in MS....

0 Replies

113 Views

Last post by frodo
Sun Apr 12, 2020 11:07 pm
This looks important but I need help to understand it.

Last post by frodo « Sat Apr 11, 2020 3:15 am
Replies: 2
by frodo » Wed Apr 08, 2020 2:23 am

First post

This paper looks important. They have even made a video to explain it, but I cannot understand it. If anyone of you knows what are they talking about...

Last post

Thank you. I was expecting something more concrete, but it is interesting anyway.

2 Replies

176 Views

Last post by frodo
Sat Apr 11, 2020 3:15 am
Hints for a new astrocytic target

Last post by frodo « Fri Apr 03, 2020 3:20 am

by frodo » Fri Apr 03, 2020 3:20 am

After the discovery of AQP4 and MOG it seems that there is room for a third astrocytic target (this paper talks about NMOSD but it could include...

0 Replies

365 Views

Last post by frodo
Fri Apr 03, 2020 3:20 am
Epstein Bar Virus - A Review of the Epstein Barr Virus in Relationship to MS

Last post by Scott1 « Thu Mar 26, 2020 7:02 pm
Replies: 4
by Kinora » Fri May 03, 2019 9:08 am

First post

+

With Poem-The Long and Winding Road reinterpreted.

Last post

Hi,
I don't think that there is a contraindication if you take both but I'd check the dosing. You can't cut a slice of butter with a sledgehammer. It...

4 Replies

550 Views

Last post by Scott1
Thu Mar 26, 2020 7:02 pm
one of the mi-RNA predicts response to interferon

Last post by frodo « Fri Mar 13, 2020 4:50 am

by frodo » Fri Mar 13, 2020 4:50 am

miR-504 expression level is increased in multiple sclerosis patients responder to interferon-beta

Abstract

Multiple sclerosis is...

0 Replies

1844 Views

Last post by frodo
Fri Mar 13, 2020 4:50 am
OCBs in MS target patient-specific peptides

Last post by frodo « Tue Feb 25, 2020 4:51 am

by frodo » Tue Feb 25, 2020 4:51 am

New data speaking about different MS pathogenesis in each patient. It seems that a OCB signature has never been found because it does not exist. OCBs...

0 Replies

1170 Views

Last post by frodo
Tue Feb 25, 2020 4:51 am
Quantitative Magnetisation Transfer MRI shows microscopic damage

Last post by frodo « Tue Feb 11, 2020 1:50 am

by frodo » Tue Feb 11, 2020 1:50 am

Multiparametric qMTI Assessment and Monitoring of Normal Appearing White Matter and Classified T1 Hypointense Lesions in Relapsing-Remitting Multiple...

0 Replies

913 Views

Last post by frodo
Tue Feb 11, 2020 1:50 am
inflammatory infiltration into the cortex through the meninges underlies MS

Last post by frodo « Thu Jan 30, 2020 6:23 am

by frodo » Thu Jan 30, 2020 6:23 am

A “kissing lesion”: In-vivo 7T evidence of meningeal inflammation in early multiple sclerosis

Background:

The role of cortical lesions (CLs) in...

0 Replies

929 Views

Last post by frodo
Thu Jan 30, 2020 6:23 am
Four antioxidant biomarkers predict MS diagnosis

Last post by frodo « Tue Jan 28, 2020 6:54 am

by frodo » Tue Jan 28, 2020 6:54 am

Four antioxidant biomarkers (adiponectin, zinc, TRAP, and SH groups) and sTNFR2 showed the best diagnostic model to externally validate the MS...

0 Replies

976 Views

Last post by frodo
Tue Jan 28, 2020 6:54 am
IgG index better than oligoclonal bands

Last post by frodo « Tue Jan 28, 2020 5:50 am

by frodo » Tue Jan 28, 2020 5:50 am

The diagnostic value of IgG index versus oligoclonal bands in cerebrospinal fluid of patients with multiple sclerosis

Background

Diagnostic...

0 Replies

848 Views

Last post by frodo
Tue Jan 28, 2020 5:50 am
Research in heterogeneity: New paper about patterns discrimination

Last post by frodo « Tue Jan 21, 2020 1:23 am
Replies: 1
by frodo » Tue Jan 21, 2020 1:18 am

First post

New paper about discriminating the four pathological patterns:

The main idea is that there are four patterns of MS (one of them, IV very rare and...

Last post

Papers about tests for discriminating the patterns

- September 2019 : Multiplexed imaging of immune cells in staged multiple sclerosis lesions by...

1 Replies

468 Views

Last post by frodo
Tue Jan 21, 2020 1:23 am
Two new reports about EBV

Last post by frodo « Mon Jan 20, 2020 8:18 am

by frodo » Mon Jan 20, 2020 8:18 am

The interaction of Multiple Sclerosis risk loci with Epstein-Barr virus phenotypes implicates the virus in pathogenesis

Conclusion

We believe...

0 Replies

803 Views

Last post by frodo
Mon Jan 20, 2020 8:18 am
Reports about the CSF toxicity

Last post by frodo « Mon Jan 20, 2020 4:40 am
Replies: 2
by frodo » Sat Dec 30, 2017 4:25 am

First post

I am collecting here some of the studies about the CSF toxicity. One of the most interesting studies of the previous years was the possibility of...

Last post

Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine...

2 Replies

1405 Views

Last post by frodo
Mon Jan 20, 2020 4:40 am
Relationship between MS and type-1 diabetes

Last post by frodo « Mon Jan 20, 2020 4:25 am
Replies: 2
by frodo » Mon Jan 13, 2020 12:52 am

First post

Type-1 diabetes is the most common diabetes in children and autoimmune. These people are three-times more prone to develop MS than the general...

Last post

Not always MS and type1 diabetes are related. But MS could be more than one disease, and maybe a subtype is related.

An ancestral retroviral...

2 Replies

492 Views

Last post by frodo
Mon Jan 20, 2020 4:25 am
Lassman review for 2019. Top four MS papers.

Last post by frodo « Mon Jan 20, 2020 12:51 am

by frodo » Mon Jan 20, 2020 12:51 am

1. Neuronal vulnerability and multilineage diversity in multiple sclerosis (Schirmer et al 2019)

The study supports the importance of meningeal...

0 Replies

838 Views

Last post by frodo
Mon Jan 20, 2020 12:51 am
personalized medicine for MS

Last post by frodo « Fri Jan 17, 2020 9:31 am
Replies: 3
by frodo » Wed Nov 06, 2019 4:25 am

First post

Thanks to ms-uk for the review

New genetic markers may make prognosis clearer

The original paper:

Early complement genes are associated with...

Last post

Pre-treatment T-cell subsets associate with fingolimod treatment responsiveness in multiple sclerosis

Abstract

Biomarkers predicting fingolimod...

3 Replies

524 Views

Last post by frodo
Fri Jan 17, 2020 9:31 am
Ms artificially induced in humans by mistake

Last post by frodo « Wed Jan 15, 2020 4:15 am
Replies: 1
by frodo » Wed Jan 15, 2020 4:09 am

First post

Sometimes some MS patients get a kind of artificially induced MS while they are treated for other conditions. There are several reports about it...

Last post

Well. Not the same but I have found a paper in which they describe the action of TNF in mice, similar to the previous auto-antibody.

TNFR2 limits...

1 Replies

338 Views

Last post by frodo
Wed Jan 15, 2020 4:15 am
Biomarkers: Interleukin-17

Last post by frodo « Tue Jan 14, 2020 12:58 am
Replies: 3
by frodo » Mon Jan 13, 2020 1:28 am

First post

Source:

Remarks:

1- The mean of serum level of IL-17 in the MS and NMO subjects was significantly higher than healthy subjects.
2 - The mean of...

Last post

Please confirm that the URL is correct and give us the title to the paper where these remarks were found.

Sorry. I thought it was working...

3 Replies

406 Views

Last post by frodo
Tue Jan 14, 2020 12:58 am
Image biomarkers: Ribbon‐like subpial cortical demyelination specific to MS

Last post by frodo « Mon Jan 13, 2020 9:48 am

by frodo » Mon Jan 13, 2020 9:48 am

Extensive subpial cortical demyelination is specific to multiple sclerosis

Abstract

Cortical demyelinated lesions are frequent and widespread...

0 Replies

403 Views

Last post by frodo
Mon Jan 13, 2020 9:48 am
Anti-Angiogenesis therapy in MS

Last post by frodo « Thu Jan 09, 2020 6:37 am

by frodo » Thu Jan 09, 2020 6:37 am

Anti-Angiogenesis therapy in MS

Is the title of a book about the subject. It is interesting to see that some people still research about this link.

0 Replies

625 Views

Last post by frodo
Thu Jan 09, 2020 6:37 am
Smouldering lesions can be seen on MRI

Last post by frodo « Thu Jan 09, 2020 4:43 am
Replies: 1
by frodo » Tue Sep 24, 2019 1:34 am

First post

A paper about seen smoldering lesions on MRI here:

A previous one about the same:

An not a paper, but a blog entry instead speaking about the...

Last post

More information about the discovery

1 Replies

815 Views

Last post by frodo
Thu Jan 09, 2020 4:43 am

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