A forum to discuss research on the origins of MS and its development.
-
-
- 1 Replies
- 32 Views
-
Last post by Petr75
Mon Oct 21, 2019 10:41 am
-
-
MRS of the brain
Replies: 1
by
frodo » Thu Oct 10, 2019 6:52 am
First post
MRS (Magnetic Resonance Spectroscopy) allows to see the chemical composition of the brain.
Magnetic resonance spectroscopy (MRS) is a non-invasive...
Last post
Magnetic resonance spectroscopy evidence for declining gliosis in MS patients treated with ocrelizumab versus interferon beta-1a
Background...
- 1 Replies
- 54 Views
-
Last post by frodo
Sun Oct 20, 2019 9:13 am
-
-
MS defined as a CD8+ disease
by
frodo » Thu Oct 17, 2019 3:01 am
This is the first time that I see some kind of concrete definition for MS, instead of defining it by a collection of symptoms and testing...
- 0 Replies
- 40 Views
-
Last post by frodo
Thu Oct 17, 2019 3:01 am
-
-
- 0 Replies
- 33 Views
-
Last post by frodo
Tue Oct 15, 2019 6:28 am
-
-
Large Noncoding RNA in blood
Replies: 5
by
frodo » Wed Oct 04, 2017 12:30 pm
First post
Expression Analysis of Long Non-coding RNAs in the Blood of Multiple Sclerosis Patients.
Abstract
Multiple sclerosis (MS) is a chronic...
Last post
2019 Aug 6
Department of Cardiovascular Medicine, The Second Hospital Affiliated to Jilin University, Changchun, China
Exosomal long noncoding RNAs...
- 5 Replies
- 1010 Views
-
Last post by Petr75
Sat Oct 12, 2019 11:16 pm
-
-
- 0 Replies
- 29 Views
-
Last post by frodo
Wed Oct 09, 2019 11:40 am
-
-
MS induced by mistake
by
frodo » Wed Oct 09, 2019 11:35 am
An unfortunate accident has shown something that could replace EAE.
Multiple sclerosis associated with pembrolizumab in a patient with non-small...
- 0 Replies
- 32 Views
-
Last post by frodo
Wed Oct 09, 2019 11:35 am
-
-
Prodromal MS: Biomarkers
Replies: 1
by
frodo » Tue Aug 07, 2018 6:57 am
First post
Prodrome is the stage of a disease in which there are no noticeable symptoms, but nevertheless the disease is present. In MS this means that is a...
Last post
More about the same:
DNA methylation signatures of a large cohort monozygotic twins clinically discordant for multiple sclerosis
Abstract...
- 1 Replies
- 674 Views
-
Last post by frodo
Tue Oct 08, 2019 3:53 am
-
-
EBV-activated CD8+ Tcells infiltrate the MS brain
Replies: 1
by
frodo » Tue Oct 08, 2019 2:26 am
First post
More clues pointing to EBV as the culprit. And more evidence that EAE (a CD4+ disease) and MS have nothing to do.
EBV-activated CD8+ Tcells...
Last post
And maybe the mechanism by which the anti-EBV Tcells cause inflammation is because they cross-react with myelin MBP:
Myelin-specific CD8 T cells...
- 1 Replies
- 28 Views
-
Last post by frodo
Tue Oct 08, 2019 2:31 am
-
-
- 0 Replies
- 53 Views
-
Last post by frodo
Tue Oct 01, 2019 4:17 am
-
-
Myelocortical MS (MCMS)
Replies: 6
by
frodo » Thu Aug 23, 2018 5:03 am
First post
Researchers discover new subtype of multiple sclerosis (The Lancet)
Cleveland Clinic researchers have discovered a new subtype of multiple...
Last post
The cortical pathology is associated to a specific CSF profile:
Inflammatory intrathecal profiles and cortical damage in multiple sclerosis...
- 6 Replies
- 1189 Views
-
Last post by frodo
Tue Oct 01, 2019 4:07 am
-
-
- 0 Replies
- 26 Views
-
Last post by frodo
Tue Oct 01, 2019 3:34 am
-
-
Smouldering lesions can be seen on MRI
by
frodo » Tue Sep 24, 2019 1:34 am
A paper about seen smoldering lesions on MRI here:
A previous one about the same:
An not a paper, but a blog entry instead speaking about the...
- 0 Replies
- 68 Views
-
Last post by frodo
Tue Sep 24, 2019 1:34 am
-
-
Review on biomarkers 2019
by
frodo » Tue Sep 24, 2019 1:23 am
Available on Barts MS research page:
there is a review covering the following 6 topics in biomarkers, presented at ECTRIMS 2019:
-serum...
- 0 Replies
- 36 Views
-
Last post by frodo
Tue Sep 24, 2019 1:23 am
-
-
- 0 Replies
- 74 Views
-
Last post by frodo
Mon Sep 16, 2019 7:05 am
-
-
- 0 Replies
- 45 Views
-
Last post by frodo
Sun Sep 15, 2019 11:20 am
-
-
miRNA dysregulation as the source of the disease
Replies: 9
by
frodo » Mon Oct 16, 2017 11:28 pm
First post
Micro-RNA ( miRNA ) has been proposed as a biomarker of axon degeneration, but some authors have proposed that they could be the source of the...
Last post
2019 Jun 25
Laboratorio di Farmacologia Molecolare e Cellulare della Trasmissione Purinergica, Dipartimento di Scienze Farmacologiche e Biomolecolari...
- 9 Replies
- 1308 Views
-
Last post by Petr75
Sat Sep 07, 2019 7:02 am
-
-
- 0 Replies
- 34 Views
-
Last post by frodo
Thu Sep 05, 2019 6:39 am
-
-
closer to an urine test
Replies: 2
by
frodo » Mon Sep 02, 2019 11:45 pm
First post
Abstract
BACKGROUND: Systemic inflammation is a marker of ill health and has prognostic implications in multiple health settings. Urinary neopterin...
Last post
Maybe it is related. It would be nice to have an update, but the problem with this kind of papers is that they are easily forgotten
- 2 Replies
- 59 Views
-
Last post by frodo
Thu Sep 05, 2019 6:38 am
-
-
Temelimab works. HERVs clearly implicated.
Replies: 4
by
frodo » Mon May 20, 2019 11:38 am
First post
Efficacy and Safety of Temelimab, an Antibody Antagonist of the Human Endogenous Retrovirus Type-W env Protein, in Participants with Relapsing...
Last post
And here a new review about the role of HERVs in microglia activation, following Kremer's paper from last May.
This researchers confirm again the...
- 4 Replies
- 234 Views
-
Last post by frodo
Sun Sep 01, 2019 11:14 am
-
-
Ashton Embry: Multiple Factors in MS Etiology
Replies: 1
by
NHE » Mon Aug 26, 2019 2:56 pm
First post
Ashton Embry published a review paper in 2004 discussing multiple factors in MS etiology. Note, this paper predates CCSVI so it does not address...
Last post
I agree about the multifactiorial source of MS, but in the sense that probably there exists different kinds of MS, each one of them with a different...
- 1 Replies
- 94 Views
-
Last post by frodo
Tue Aug 27, 2019 4:13 am
-
-
MRZR+ MS cases are different from others
by
frodo » Mon Aug 26, 2019 5:08 am
MRZR is a reaction about several viruses highly specific for MS, but little sensitive. This means that if you have MRZR is nearly sure that you have...
- 0 Replies
- 52 Views
-
Last post by frodo
Mon Aug 26, 2019 5:08 am
-
-
Around 13% of MS cases are of genetic origin. 12 pathogenic variants.
Replies: 1
by
frodo » Tue Aug 13, 2019 7:38 am
First post
Of people diagnosed with MS, only 13% are believed to have a genetic form of the disease, but those presenting the mutations identified in this new...
Last post
HLA-DRB1 differences in allelic distribution between familial and sporadic multiple sclerosis in a Hellenic cohort
Conclusion: We propose...
- 1 Replies
- 130 Views
-
Last post by frodo
Fri Aug 16, 2019 10:15 am
-
-
PPMS and SPMS may be different
by
frodo » Sun Aug 11, 2019 3:53 am
Mitochondrial functionality and metabolism in T cells from progressive multiple sclerosis patients
Abstract
Patients with primary progressive...
- 0 Replies
- 97 Views
-
Last post by frodo
Sun Aug 11, 2019 3:53 am
-
-
Molecular mimicry agent finally found?
by
frodo » Sat Aug 10, 2019 10:13 am
Both EBNA-1 and Anoctamin-2 have been previously implicated.
Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1...
- 0 Replies
- 86 Views
-
Last post by frodo
Sat Aug 10, 2019 10:13 am
-
-
Lipid profile of cerebrospinal fluid
by
frodo » Sat Aug 10, 2019 9:28 am
Lipid profile of cerebrospinal fluid in multiple sclerosis patients: a potential tool for diagnosis
Discussion
MS is a chronic disease which is...
- 0 Replies
- 58 Views
-
Last post by frodo
Sat Aug 10, 2019 9:28 am
-
-
- 0 Replies
- 95 Views
-
Last post by frodo
Wed Jul 31, 2019 11:36 pm
-
-
Weird biomarker
Replies: 2
by
frodo » Mon Jul 29, 2019 6:34 am
First post
Though I don't understand fully what they say, it seems that they have created a molecule with a fluorescent substrate surrounded by MBP proteins....
Last post
I agree. The T-cell model is dead. At least the CD4+ classic model.
- 2 Replies
- 109 Views
-
Last post by frodo
Wed Jul 31, 2019 11:08 pm
-
-
CSF from MS patients damage neurons in-vitro
Replies: 1
by
frodo » Mon Jul 22, 2019 12:56 am
First post
A metabolic perspective on CSF-mediated neurodegeneration in multiple sclerosis
Abstract
Multiple sclerosis is an autoimmune demyelinating...
Last post
Comments on the previous paper. A new paper in “Brain” identifies molecular mechanisms causing neuronal damage in multiple sclerosis patients with...
- 1 Replies
- 124 Views
-
Last post by frodo
Mon Jul 29, 2019 8:24 am
-
-
- 0 Replies
- 50 Views
-
Last post by frodo
Mon Jul 29, 2019 8:09 am
-
-
- 0 Replies
- 60 Views
-
Last post by frodo
Mon Jul 29, 2019 5:06 am
-
-
An underlying process causes abnormalities in veins together with MS
Replies: 1
by
frodo » Thu May 09, 2019 1:41 am
First post
This paper points to the existence of an underlying process that causes the known MS lesions and, at the same time, some venous problems:
The...
Last post
More about the same subject. There is a whole book about it.
Molecular targets of angiogenesis and anti-angiogenesis therapy
- 1 Replies
- 148 Views
-
Last post by frodo
Tue Jul 16, 2019 1:33 am
-
-
- 0 Replies
- 71 Views
-
Last post by frodo
Sat Jul 13, 2019 1:04 am
-
-
- 0 Replies
- 101 Views
-
Last post by frodo
Thu Jun 27, 2019 12:58 am
-
-
- 0 Replies
- 60 Views
-
Last post by frodo
Thu Jun 27, 2019 12:48 am
-
-
T-cells dysregulation
by
frodo » Tue Jun 25, 2019 7:18 am
Quantitative proteomic analyses of CD4+ and CD8+ T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy...
- 0 Replies
- 77 Views
-
Last post by frodo
Tue Jun 25, 2019 7:18 am
-
-
Cortical lesions and GA
by
frodo » Wed Jun 19, 2019 4:26 am
This paper is about the effects of Glatimer Acetate in MS, but they include a very deep review about the status of the research:
Some excerpts:...
- 0 Replies
- 89 Views
-
Last post by frodo
Wed Jun 19, 2019 4:26 am
-
-
Age of cells populations in MS
by
frodo » Wed Jun 19, 2019 4:01 am
Using Carbon14 the researchers can calculate the age of different cells (oligodendrocytes are myelin producing cells and OPC are oligodendrocyte...
- 0 Replies
- 79 Views
-
Last post by frodo
Wed Jun 19, 2019 4:01 am
-
-
Early MS lesions: Astrocytes involved
by
frodo » Wed Jun 19, 2019 3:33 am
Multiple Sclerosis: Destruction and Regeneration of Astrocytes in Acute Lesions
Abstract
There are reports that astrocyte perivascular endfeet...
- 0 Replies
- 66 Views
-
Last post by frodo
Wed Jun 19, 2019 3:33 am
-
-
Real PPMS passed (again) to mice
by
frodo » Sun Jun 02, 2019 8:03 am
This has been done previously (see for example posts or but this new result confirms again the previous results.
Intrathecal Injections of PPMS...
- 0 Replies
- 186 Views
-
Last post by frodo
Sun Jun 02, 2019 8:03 am
-
-
Dawson fingers in anti-MOG disease
by
frodo » Sat Jun 01, 2019 9:19 am
Anti-MOG disease makes around 10% of diagnosed MS patients and until now was reported only in atypical MS. Dawson fingers was considered one of the...
- 0 Replies
- 120 Views
-
Last post by frodo
Sat Jun 01, 2019 9:19 am
-
-
Inside-out model: supporting papers.
Replies: 5
by
frodo » Wed Jan 30, 2019 2:28 am
First post
The inside-out model is an alternative theoretical model for MS that postulates that something within the neurons is the cause of the later...
Last post
All very interesting theories, thanks for posting them!
- 5 Replies
- 440 Views
-
Last post by ElliotB
Thu May 30, 2019 7:10 am
-
-
- 0 Replies
- 104 Views
-
Last post by frodo
Tue May 28, 2019 6:29 am
-
-
Neurofilament light as biomarker
by
frodo » Tue May 28, 2019 6:26 am
Cerebrospinal fluid neurofilament light chain in multiple sclerosis and its subtypes: a meta-analysis of case–control studies
Conclusions
CSF...
- 0 Replies
- 78 Views
-
Last post by frodo
Tue May 28, 2019 6:26 am
-
-
- 0 Replies
- 74 Views
-
Last post by frodo
Tue May 28, 2019 6:24 am
-
-
- 0 Replies
- 100 Views
-
Last post by frodo
Tue May 28, 2019 6:15 am
-
-
Microglia in the pathogenesis of MS
Replies: 11
by
frodo » Mon Jul 23, 2018 11:13 am
First post
Microglia in the pathogenesis of MS
We postulate that the immune reaction initiates in the CNS and immune cells (including T cells/B cell)...
Last post
2019 Apr 17
Department of Pathology and Immunology, Washington University in St. Louis, St. Louis
Fifty Shades of Microglia
Abstract
In a recent...
- 11 Replies
- 1264 Views
-
Last post by Petr75
Thu May 23, 2019 11:46 am
-
-
MS metabolic profile for MS. Closer to a blood test.
Replies: 1
by
frodo » Thu May 09, 2019 1:22 am
First post
Metabolome-based signature of disease pathology in MS
Highlights
• Six serum metabolites were predictive for MS in males.
• Results support...
Last post
And here other report about another possible blood test. By the way, TWEAK is this:
Interestingly, related to angiogenesis too.
Here comes the...
- 1 Replies
- 134 Views
-
Last post by frodo
Thu May 09, 2019 3:02 am
-
-
Viruses: Hypoxia and viruses reactivation. CCSVI?
Replies: 6
by
frodo » Sun Mar 11, 2018 10:14 am
First post
Could be this the explanation of the relationship between CCSVI and MS?
This article points out that endogenous retroviruses that are normally...
Last post
I use a bio-health device for blood flow. It is configured to increase blood flow at the capillary level though an configured, multi-layered wave...
- 6 Replies
- 1098 Views
-
Last post by Kinora
Fri May 03, 2019 1:36 pm
-
-
- 0 Replies
- 128 Views
-
Last post by Kinora
Fri May 03, 2019 9:08 am
Forum permissions
You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
