MS Etiology and Pathogenesis

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miRNA dysregulation as the source of the disease

Last post by Petr75 « Wed Oct 21, 2020 11:24 am
Replies: 14
by frodo » Mon Oct 16, 2017 11:28 pm

First post

Micro-RNA ( miRNA ) has been proposed as a biomarker of axon degeneration, but some authors have proposed that they could be the source of the...

Last post

2020 Aug 21
Clinical Neuroimmunology Unit, Division of Neuroscience, Institute of Experimental Neurology, San Raffaele Scientific Institute, Milan,...

14 Replies

2301 Views

Last post by Petr75
Wed Oct 21, 2020 11:24 am
Complex genetic signatures

Last post by Petr75 « Wed Oct 14, 2020 8:35 am

by Petr75 » Wed Oct 14, 2020 8:35 am

2020 Oct
Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy
Complex genetic signatures in immune...

0 Replies

99 Views

Last post by Petr75
Wed Oct 14, 2020 8:35 am
Focus on microglia again: TSPO-PET predicts progression.

Last post by frodo « Fri Oct 09, 2020 7:12 am

by frodo » Fri Oct 09, 2020 7:12 am

Brain TSPO-PET predicts later disease progression independent of relapses in multiple sclerosis

Abstract

Overactivation of microglia is...

0 Replies

245 Views

Last post by frodo
Fri Oct 09, 2020 7:12 am
specific CSF biomarkers review

Last post by frodo « Fri Oct 02, 2020 6:11 am

by frodo » Fri Oct 02, 2020 6:11 am

CSF biomarkers in multiple sclerosis: beyond neuroinflammation

making a long story short:

Diagnostic biomarkers: IgG oligoclonal bands, IgG...

0 Replies

186 Views

Last post by frodo
Fri Oct 02, 2020 6:11 am
lipids differentiate PPMS and SPMS

Last post by frodo « Fri Oct 02, 2020 4:47 am

by frodo » Fri Oct 02, 2020 4:47 am

Lipidomic UPLC-MS/MS Profiles of Normal-Appearing White Matter Differentiate Primary and Secondary Progressive Multiple Sclerosis

Abstract...

0 Replies

155 Views

Last post by frodo
Fri Oct 02, 2020 4:47 am
OCBs can separate MS from lyme

Last post by frodo « Thu Oct 01, 2020 6:44 am

by frodo » Thu Oct 01, 2020 6:44 am

Cerebrospinal fluid oligoclonal bands in Neuroborreliosis are specific for Borrelia burgdorferi

Background

Cerebrospinal fluid (CSF)...

0 Replies

188 Views

Last post by frodo
Thu Oct 01, 2020 6:44 am
EBNA1 (EBV protein) reactive to OCBs

Last post by frodo « Fri Sep 25, 2020 7:21 am

by frodo » Fri Sep 25, 2020 7:21 am

Antibodies from multiple sclerosis brain identified Epstein-Barr virus nuclear antigen 1 & 2 epitopes which are recognized by oligoclonal bands...

0 Replies

204 Views

Last post by frodo
Fri Sep 25, 2020 7:21 am
biomarkers review

Last post by frodo « Tue Sep 22, 2020 11:21 am

by frodo » Tue Sep 22, 2020 11:21 am

Development of robust targeted proteomics assays for cerebrospinal fluid biomarkers in multiple sclerosis

Background

Verification of...

0 Replies

189 Views

Last post by frodo
Tue Sep 22, 2020 11:21 am
Microglia in the pathogenesis of MS

Last post by Petr75 « Sun Sep 20, 2020 4:47 am
Replies: 19
by frodo » Mon Jul 23, 2018 11:13 am
1

2
First post

Microglia in the pathogenesis of MS

We postulate that the immune reaction initiates in the CNS and immune cells (including T cells/B cell)...

Last post

2020 Aug 20
Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia, Italy
Mitochondrial...
19 Replies

2930 Views

Last post by Petr75
Sun Sep 20, 2020 4:47 am
Creatine metabolic alterations in MS

Last post by frodo « Thu Sep 17, 2020 6:55 am

by frodo » Thu Sep 17, 2020 6:55 am

Creatine and multiple sclerosis

ABSTRACT

Multiple sclerosis (MS) is a complex and debilitating neurodegenerative disease, with unknown...

0 Replies

214 Views

Last post by frodo
Thu Sep 17, 2020 6:55 am
Two molecular types of lesions via MRI

Last post by frodo « Mon Sep 14, 2020 1:34 am

by frodo » Mon Sep 14, 2020 1:34 am

Characterization of multiple sclerosis lesions with distinct clinical correlates through quantitative diffusion MRI

Highlights :

• Macroscopic...

0 Replies

226 Views

Last post by frodo
Mon Sep 14, 2020 1:34 am
Characteristics of multiple sclerosis in patients of Middle Eastern and North African

Last post by Petr75 « Sat Sep 05, 2020 8:40 pm

by Petr75 » Sat Sep 05, 2020 8:40 pm

2020 Aug 11
Division of Neurology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada/Division of Neurology,...

0 Replies

206 Views

Last post by Petr75
Sat Sep 05, 2020 8:40 pm
Three different biopsy patterns

Last post by frodo « Thu Sep 03, 2020 12:31 am

by frodo » Thu Sep 03, 2020 12:31 am

Different pathological processes for acute white matter lesions in multiple sclerosis

Abstract

Introduction :

Multiple sclerosis (MS) has...

0 Replies

173 Views

Last post by frodo
Thu Sep 03, 2020 12:31 am
A pathogenic B cell transcriptome in active multiple sclerosis

Last post by frodo « Tue Sep 01, 2020 5:25 am

by frodo » Tue Sep 01, 2020 5:25 am

A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis

Abstract

Central nervous system B cells have several...

0 Replies

162 Views

Last post by frodo
Tue Sep 01, 2020 5:25 am
Reelin depletion for MS

Last post by jimmylegs « Sun Aug 30, 2020 10:48 am

by jimmylegs » Sun Aug 30, 2020 10:48 am

Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes

...Our findings suggest Reelin...

0 Replies

169 Views

Last post by jimmylegs
Sun Aug 30, 2020 10:48 am
Mass cytometry provides insight into the role of B cells

Last post by frodo « Thu Aug 27, 2020 5:43 am

by frodo » Thu Aug 27, 2020 5:43 am

Mass cytometry provides unprecedented insight into the role of B cells during the pathogenesis of multiple sclerosis

Abstract

In recent...

0 Replies

166 Views

Last post by frodo
Thu Aug 27, 2020 5:43 am
NFL shows silent relapses in PPMS cases

Last post by frodo « Tue Aug 25, 2020 8:51 am

by frodo » Tue Aug 25, 2020 8:51 am

PPMS is supposed to advance in absence of relapses. Anyway, it seems than some silent relapses can be seen via NFL

CSF neurofilament light chain...

0 Replies

177 Views

Last post by frodo
Tue Aug 25, 2020 8:51 am
Response to b-cell depletion can be predicted

Last post by frodo « Sun Aug 23, 2020 11:38 pm

by frodo » Sun Aug 23, 2020 11:38 pm

Autoantibodies against central nervous system antigens in a subset of B cell–dominant multiple sclerosis patients

Significance

Multiple...

0 Replies

159 Views

Last post by frodo
Sun Aug 23, 2020 11:38 pm
PET differentiates pathological variants of MS

Last post by frodo « Thu Aug 20, 2020 11:46 pm

by frodo » Thu Aug 20, 2020 11:46 pm

TSPO PET With 18F-GE-180 to Differentiate Variants of Multiple Sclerosis

Relapsing-Remitting Multiple Sclerosis, Tumefactive Demyelination, and...

0 Replies

95 Views

Last post by frodo
Thu Aug 20, 2020 11:46 pm
Retinal damage could be due to subclinical inflammation in optic nerve

Last post by frodo « Thu Aug 20, 2020 2:52 am
Replies: 1
by frodo » Tue Aug 11, 2020 2:32 am

First post

Retinal and brain damage during multiple sclerosis course: inflammatory activity is a key factor in the first 5 years

The mechanisms by which...

Last post

Characterization of Retinal vascular changes in Multiple Sclerosis using Adaptive Optics and OCTA

Abstract

Purpose : Characterize...

1 Replies

183 Views

Last post by frodo
Thu Aug 20, 2020 2:52 am
OCB+ and OCB- patients show different evolution

Last post by frodo « Thu Aug 20, 2020 12:25 am

by frodo » Thu Aug 20, 2020 12:25 am

It seems that OCB-negative patients show less cerebelar lesions than OCB-positives.

Advanced MRI features in relapsing multiple sclerosis patients...

0 Replies

92 Views

Last post by frodo
Thu Aug 20, 2020 12:25 am
Biomarker for response to interferon: ADC values

Last post by frodo « Thu Aug 20, 2020 12:03 am

by frodo » Thu Aug 20, 2020 12:03 am

The role of ADC values within the normal-appearing brain in the prognosis of multiple sclerosis activity during interferon-β therapy in the 3-year...

0 Replies

85 Views

Last post by frodo
Thu Aug 20, 2020 12:03 am
Specific image biomarker: Paramagnetic rim lesions

Last post by frodo « Wed Aug 19, 2020 11:48 pm

by frodo » Wed Aug 19, 2020 11:48 pm

Currently there is no specific single test to diagnose MS. This won't be the first one because of its low sensitivity, but they say that specificity...

0 Replies

83 Views

Last post by frodo
Wed Aug 19, 2020 11:48 pm
Biotin could make MS worse

Last post by frodo « Wed Aug 19, 2020 5:07 am
Replies: 2
by frodo » Tue Aug 11, 2020 2:13 am

First post

Not good news for those on Biotin, but very interesting from the point of view of the pathogenesis research.

The Rise and Fall of High-Dose Biotin...

Last post

I didn't know that. Thanks.

2 Replies

247 Views

Last post by frodo
Wed Aug 19, 2020 5:07 am
anti-CD20 works on B-cells but also on T-cells

Last post by frodo « Wed Aug 19, 2020 4:56 am

by frodo » Wed Aug 19, 2020 4:56 am

Most reports state that anti-CD20 treatment suppresses inflammation, but it also has an effect on the cd8+ T-cell attack.

Unraveling the T–B tangle...

0 Replies

102 Views

Last post by frodo
Wed Aug 19, 2020 4:56 am
biochemical signature of progressive multiple sclerosis

Last post by frodo « Mon Aug 17, 2020 2:47 am

by frodo » Mon Aug 17, 2020 2:47 am

A biochemical signature of progressive multiple sclerosis

Abstract

Currently, very few treatments for patients in the progressive phases of...

0 Replies

245 Views

Last post by frodo
Mon Aug 17, 2020 2:47 am
Failed trials that can yield some clues into pathogenesis

Last post by frodo « Mon Aug 17, 2020 12:33 am

by frodo » Mon Aug 17, 2020 12:33 am

This paper speaks about several failures in clinical trials. Among them Atacicept, Tabalumab, Abatacept, Vitamin D, Temelimab (surprinsingly),...

0 Replies

195 Views

Last post by frodo
Mon Aug 17, 2020 12:33 am
biomarkers for pediatric MS

Last post by frodo « Wed Aug 12, 2020 11:14 am

by frodo » Wed Aug 12, 2020 11:14 am

Analysis of plasma protein biomarkers in childhood onset multiple sclerosis

Highlights

• Significant proteomic differences were found between...

0 Replies

199 Views

Last post by frodo
Wed Aug 12, 2020 11:14 am
biomarker for response to IFNbeta

Last post by frodo « Wed Aug 12, 2020 10:58 am

by frodo » Wed Aug 12, 2020 10:58 am

IFI35 as a biomolecular marker of neuroinflammation and treatment response in multiple sclerosis

Highlights

• No biomarker is available for...

0 Replies

196 Views

Last post by frodo
Wed Aug 12, 2020 10:58 am
Metallic elements in MS

Last post by frodo « Wed Aug 12, 2020 12:12 am

by frodo » Wed Aug 12, 2020 12:12 am

A preliminary study of the concentration of metallic elements in the blood of patients with multiple sclerosis as measured by icp‑MS

It is...

0 Replies

174 Views

Last post by frodo
Wed Aug 12, 2020 12:12 am
Biomarker for the progressive phase

Last post by frodo « Tue Aug 11, 2020 2:06 am

by frodo » Tue Aug 11, 2020 2:06 am

Distinctive sphingolipid patterns in chronic multiple sclerosis lesions

Abstract

Multiple sclerosis (MS) is a CNS disease characterized by...

0 Replies

166 Views

Last post by frodo
Tue Aug 11, 2020 2:06 am
Rituxan better than Fingolimod, Dymethyl fumarate and Natalizumab

Last post by frodo « Tue Aug 11, 2020 2:03 am

by frodo » Tue Aug 11, 2020 2:03 am

Rituxan better than Fingolimod, Dymethyl fumarate and Natalizumab

Interpretation

RTX demonstrated superior effectiveness and discontinuation...

0 Replies

159 Views

Last post by frodo
Tue Aug 11, 2020 2:03 am
Novel blood-based biomarker for MS

Last post by frodo « Thu Aug 06, 2020 7:39 am

by frodo » Thu Aug 06, 2020 7:39 am

Blood platelet RNA enables the detection of multiple sclerosis

Background

In multiple sclerosis (MS), clinical assessment, MRI and...

0 Replies

170 Views

Last post by frodo
Thu Aug 06, 2020 7:39 am
Retinal damage is not due to inflammation but MS process itself

Last post by frodo « Thu Jul 30, 2020 11:52 pm

by frodo » Thu Jul 30, 2020 11:52 pm

Optical coherence tomography angiography in multiple sclerosis: A cross-sectional study

Objectives

To evaluate retinal axonal density and...

0 Replies

196 Views

Last post by frodo
Thu Jul 30, 2020 11:52 pm
Clinical course can be predicted

Last post by frodo « Thu Jul 30, 2020 11:49 pm

by frodo » Thu Jul 30, 2020 11:49 pm

Clinical course can be predicted by a panel of 28 CSF biomarkers

Disease phenotype prediction in multiple sclerosis

Abstract

Early...

0 Replies

152 Views

Last post by frodo
Thu Jul 30, 2020 11:49 pm
Biomarkers: Amino-acid and acylcarnitine profiles

Last post by frodo « Tue Jul 21, 2020 2:09 am

by frodo » Tue Jul 21, 2020 2:09 am

Changes in Amino Acid and Acylcarnitine Plasma Profiles for Distinguishing Patients with Multiple Sclerosis from Healthy Controls

Abstract...

0 Replies

205 Views

Last post by frodo
Tue Jul 21, 2020 2:09 am
Biomarker: N-glucosylation in Multiple Sclerosis

Last post by frodo « Tue Jul 21, 2020 1:54 am

by frodo » Tue Jul 21, 2020 1:54 am

A Multiple N-Glucosylated Peptide Epitope Efficiently Detecting Antibodies in Multiple Sclerosis

Abstract

Diagnostics of Multiple Sclerosis...

0 Replies

169 Views

Last post by frodo
Tue Jul 21, 2020 1:54 am
HIV prevents MS relapses

Last post by frodo « Tue Jul 21, 2020 1:33 am

by frodo » Tue Jul 21, 2020 1:33 am

Acquisition of human immunodeficiency virus infection in a patient with multiple sclerosis: could these conditions positively influence each other’s...

0 Replies

199 Views

Last post by frodo
Tue Jul 21, 2020 1:33 am
The lancet. Open call for using NFL in diagnosis and monitoring

Last post by frodo « Tue Jul 21, 2020 1:29 am
Replies: 1
by frodo » Thu Jun 25, 2020 1:26 am

First post

Neurofilament light in blood. What more is needed for clinical implementation?

Cerebrospinalfluid (CSF) neurofilament light (NfL) is the best...

Last post

Serum neurofilament light as a biomarker in progressive multiple sclerosis

Abstract

There is an unmet need in multiple sclerosis (MS) therapy...

1 Replies

152 Views

Last post by frodo
Tue Jul 21, 2020 1:29 am
Cacciaguerra’s criteria. Difference between MS, NMO and MOG

Last post by frodo « Tue Jul 21, 2020 1:26 am

by frodo » Tue Jul 21, 2020 1:26 am

Evaluation of brain and spinal cord lesion distribution criteria at disease onset in distinguishing NMOSD from MS and MOG antibody-associated...

0 Replies

157 Views

Last post by frodo
Tue Jul 21, 2020 1:26 am
cytotoxic B lymphocytes

Last post by frodo « Tue Jul 21, 2020 1:18 am

by frodo » Tue Jul 21, 2020 1:18 am

Study of b lymphocyte subpopulations in the peripheral blood and cephalorraquidian liquid of patients with primary progressive multiple sclerosis...

0 Replies

140 Views

Last post by frodo
Tue Jul 21, 2020 1:18 am
Last review about EBV

Last post by frodo « Fri Jul 17, 2020 9:13 am

by frodo » Fri Jul 17, 2020 9:13 am

State of the Art and Future Challenges in Multiple Sclerosis Research and Medical Management: An Insight into the 5th International Porto Congress of...

0 Replies

231 Views

Last post by frodo
Fri Jul 17, 2020 9:13 am
Biomarker in the skin. Fibroblasts

Last post by frodo « Tue Jul 14, 2020 7:41 am

by frodo » Tue Jul 14, 2020 7:41 am

Information about fibroblasts in wikipedia:

Signatures of cell stress and altered bioenergetics in skin fibroblasts from patients with multiple...

0 Replies

171 Views

Last post by frodo
Tue Jul 14, 2020 7:41 am
The picture of demyelinating diseases gets more complicated

Last post by frodo « Mon Jul 13, 2020 8:50 am
Replies: 1
by frodo » Wed Feb 06, 2019 2:38 am

First post

This is the current picture as far as the current knowledge suggest. The picture is more complex than previously thought, even if anti-neurofascin...

Last post

Immunoadsorption and Plasma Exchange in Seropositive and Seronegative Immune-Mediated Neuropathies

Abstract

The inflammatory neuropathies are...

1 Replies

687 Views

Last post by frodo
Mon Jul 13, 2020 8:50 am
Biomarkers: MRZ reaction distinguish MS and other disorders

Last post by frodo « Mon Jul 13, 2020 8:26 am
Replies: 1
by frodo » Mon Feb 05, 2018 9:28 am

First post

The MRZ reaction helps to distinguish rheumatologic disorders with central nervous involvement from multiple sclerosis.

Some rheumatologic...

Last post

Antibodies to Epstein-Barr virus and neurotropic viruses in multiple sclerosis and optic neuritis

Abstract

Antibody indices to MRZ are of...

1 Replies

887 Views

Last post by frodo
Mon Jul 13, 2020 8:26 am
IMPORTANT: Dysfunctional RNA‐binding proteins in MS

Last post by frodo « Mon Jul 13, 2020 8:21 am

by frodo » Mon Jul 13, 2020 8:21 am

As far as I know this is the first time that something like this has been reported.

Neuronal RNA‐binding protein dysfunction in multiple sclerosis...

0 Replies

153 Views

Last post by frodo
Mon Jul 13, 2020 8:21 am
Siponimod reduces progression with or without relapses

Last post by frodo « Mon Jul 13, 2020 8:12 am

by frodo » Mon Jul 13, 2020 8:12 am

Siponimod Affects Disability Progression in Patients with Secondary Progressive Multiple Sclerosis Independent of Relapse Activity

Background :...

0 Replies

195 Views

Last post by frodo
Mon Jul 13, 2020 8:12 am
Highly active MS and specific treatment

Last post by frodo « Tue Jun 30, 2020 12:37 am

by frodo » Tue Jun 30, 2020 12:37 am

It is not an official but regulatory agencies considered the highly active MS (HAMS) separated from the rest in their approval processes for...

0 Replies

183 Views

Last post by frodo
Tue Jun 30, 2020 12:37 am
Microglia are the culprits for slowly expanding lesions

Last post by frodo « Mon Jun 29, 2020 12:17 am

by frodo » Mon Jun 29, 2020 12:17 am

Slowly expanding lesions are suspected to be the cause of the MS progressive phase. Microglia and macrophages are cells that look similar and were...

0 Replies

114 Views

Last post by frodo
Mon Jun 29, 2020 12:17 am
biomarkers review 2020 and more fingers pointing to EBV

Last post by frodo « Mon Jun 29, 2020 12:11 am

by frodo » Mon Jun 29, 2020 12:11 am

Molecular Biomarkers in the Cerebrospinal Fluid in Multiple Sclerosis

Multiple sclerosis (MS) is a chronic autoimmune disease affecting the spinal...

0 Replies

131 Views

Last post by frodo
Mon Jun 29, 2020 12:11 am

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