MS Etiology and Pathogenesis

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Microglia in the pathogenesis of MS

Last post by Petr75 « Thu May 23, 2019 11:46 am
Replies: 11
by frodo » Mon Jul 23, 2018 11:13 am

First post

Microglia in the pathogenesis of MS

We postulate that the immune reaction initiates in the CNS and immune cells (including T cells/B cell)...

Last post

2019 Apr 17
Department of Pathology and Immunology, Washington University in St. Louis, St. Louis
Fifty Shades of Microglia

Abstract
In a recent...

11 Replies

1073 Views

Last post by Petr75
Thu May 23, 2019 11:46 am
Temelimab works. HERVs clearly implicated.

Last post by frodo « Mon May 20, 2019 11:38 am

by frodo » Mon May 20, 2019 11:38 am

Efficacy and Safety of Temelimab, an Antibody Antagonist of the Human Endogenous Retrovirus Type-W env Protein, in Participants with Relapsing...

0 Replies

39 Views

Last post by frodo
Mon May 20, 2019 11:38 am
Inside-out model: supporting papers.

Last post by frodo « Tue May 14, 2019 3:10 am
Replies: 3
by frodo » Wed Jan 30, 2019 2:28 am

First post

The inside-out model is an alternative theoretical model for MS that postulates that something within the neurons is the cause of the later...

Last post

Potential role of calcifying nanoparticles in the etiology of multiple sclerosis

There are currently two models to explain the development of...

3 Replies

207 Views

Last post by frodo
Tue May 14, 2019 3:10 am
miRNA dysregulation as the source of the disease

Last post by Petr75 « Sun May 12, 2019 8:46 am
Replies: 6
by frodo » Mon Oct 16, 2017 11:28 pm

First post

Micro-RNA ( miRNA ) has been proposed as a biomarker of axon degeneration, but some authors have proposed that they could be the source of the...

Last post

2019 Apr 15
Division of Neuroimmunology, Department of Neurology, University of Rostock, 18147 Rostock, Germany
Dysregulation of Inflammasome...

6 Replies

1062 Views

Last post by Petr75
Sun May 12, 2019 8:46 am
MS metabolic profile for MS. Closer to a blood test.

Last post by frodo « Thu May 09, 2019 3:02 am
Replies: 1
by frodo » Thu May 09, 2019 1:22 am

First post

Metabolome-based signature of disease pathology in MS

Highlights

• Six serum metabolites were predictive for MS in males.
• Results support...

Last post

And here other report about another possible blood test. By the way, TWEAK is this:

Interestingly, related to angiogenesis too.

Here comes the...

1 Replies

56 Views

Last post by frodo
Thu May 09, 2019 3:02 am
An underlying process causes abnormalities in veins together with MS

Last post by frodo « Thu May 09, 2019 1:41 am

by frodo » Thu May 09, 2019 1:41 am

This paper points to the existence of an underlying process that causes the known MS lesions and, at the same time, some venous problems:

The...

0 Replies

32 Views

Last post by frodo
Thu May 09, 2019 1:41 am
Viruses: Hypoxia and viruses reactivation. CCSVI?

Last post by Kinora « Fri May 03, 2019 1:36 pm
Replies: 6
by frodo » Sun Mar 11, 2018 10:14 am

First post

Could be this the explanation of the relationship between CCSVI and MS?

This article points out that endogenous retroviruses that are normally...

Last post

I use a bio-health device for blood flow. It is configured to increase blood flow at the capillary level though an configured, multi-layered wave...

6 Replies

966 Views

Last post by Kinora
Fri May 03, 2019 1:36 pm
Epstein Bar Virus - A Review of the Epstein Barr Virus in Relationship to MS

Last post by Kinora « Fri May 03, 2019 9:08 am

by Kinora » Fri May 03, 2019 9:08 am

+

With Poem-The Long and Winding Road reinterpreted.

0 Replies

44 Views

Last post by Kinora
Fri May 03, 2019 9:08 am
RNA signature of different lesion types in MS

Last post by frodo « Tue Apr 30, 2019 4:34 am

by frodo » Tue Apr 30, 2019 4:34 am

Unique RNA signature of different lesion types in the brain white matter in progressive multiple sclerosis

Conclusions

Our study is not...

0 Replies

81 Views

Last post by frodo
Tue Apr 30, 2019 4:34 am
How EBV causes MS

Last post by frodo « Mon Apr 22, 2019 12:40 pm
Replies: 2
by frodo » Tue Apr 16, 2019 12:52 am

First post

In this review, the authors (Khan & Hassani) propose an integrated model of EBV involvement in MS pathology

Epstein-Barr Virus in Multiple...

Last post

It would be great to have a EBV vaccine to prevent new MS cases but that would not help to the already infected people.

It seems that...

2 Replies

190 Views

Last post by frodo
Mon Apr 22, 2019 12:40 pm
Up to 10% of MS cases are due to anti-Neurofascin autoantibody

Last post by frodo « Sun Apr 14, 2019 10:18 am

by frodo » Sun Apr 14, 2019 10:18 am

Anti-Neurofascin-155 is an auto-antibody whose presence has been separated from standard MS, like it was for anti-AQP4 and anti-MOG before.

This...

0 Replies

65 Views

Last post by frodo
Sun Apr 14, 2019 10:18 am
Report against division of MS in clinical types

Last post by frodo « Wed Apr 03, 2019 6:56 am

by frodo » Wed Apr 03, 2019 6:56 am

It is interesting that this is finally getting contested, because it was introduced artificially by the pharma industry to get interferons approved....

0 Replies

87 Views

Last post by frodo
Wed Apr 03, 2019 6:56 am
phd thesis about exosomes and miRNA

Last post by NHE « Tue Apr 02, 2019 10:11 pm
Replies: 1
by frodo » Tue Apr 02, 2019 3:05 am

First post

A phd thesis freely avaliable about exosomes and miRNA, in case anybody is interested.

Last post

Thanks. Here's the abstract...

Exosomal MicroRNA Signatures in Central Nervous System Diseases
Saeideh Ebrahimkhani, University of Sydney, Sep 30,...

1 Replies

107 Views

Last post by NHE
Tue Apr 02, 2019 10:11 pm
Toxicity of B Cell Products in Multiple Sclerosis

Last post by frodo « Sun Mar 31, 2019 11:30 am

by frodo » Sun Mar 31, 2019 11:30 am

Again, a new report of B-cells from MS patients secreting something toxic:

Toxicity of Released B Cell Products in Multiple Sclerosis

Abstract:...

0 Replies

71 Views

Last post by frodo
Sun Mar 31, 2019 11:30 am
Large Noncoding RNA in blood

Last post by Petr75 « Sat Mar 30, 2019 11:29 am
Replies: 1
by frodo » Wed Oct 04, 2017 12:30 pm

First post

Expression Analysis of Long Non-coding RNAs in the Blood of Multiple Sclerosis Patients.

Abstract

Multiple sclerosis (MS) is a chronic...

Last post

2019 Feb 27
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Integrative analysis of...

1 Replies

826 Views

Last post by Petr75
Sat Mar 30, 2019 11:29 am
Nfl increases BEFORE damage appears on MRI

Last post by frodo « Thu Mar 28, 2019 5:51 am

by frodo » Thu Mar 28, 2019 5:51 am

It seems that Nfl (neurofilament light) are an not just a biomarker, but also related to the pathogenesis and measurable WEEKS BEFORE the damage has...

0 Replies

98 Views

Last post by frodo
Thu Mar 28, 2019 5:51 am
MS are several diseases. Description of an iron responsive type.

Last post by frodo « Tue Mar 26, 2019 5:18 am

by frodo » Tue Mar 26, 2019 5:18 am

Identification of an iron-responsive subtype in two children diagnosed with relapsing-remitting multiple sclerosis using whole exome sequencing

In...

0 Replies

100 Views

Last post by frodo
Tue Mar 26, 2019 5:18 am
several types of alterations in NAWM and NAGM

Last post by frodo « Sat Mar 23, 2019 4:25 am

by frodo » Sat Mar 23, 2019 4:25 am

Exploring metabolite profiling of patients with secondary progressive multiple sclerosis

Synopsis

Proton magnetic resonance spectroscopic...

0 Replies

77 Views

Last post by frodo
Sat Mar 23, 2019 4:25 am
Microglial activation and NAWM appear together

Last post by frodo « Wed Mar 20, 2019 8:20 am
Replies: 1
by frodo » Thu May 17, 2018 1:13 am

First post

Microglial activation and NAWM appear together. A study found that microglial activation (shown by PET imaging) and Normal appearing white matter...

Last post

This report points to three levels of damage in MS, being demyelination just the second stage.

Abstract

Quantifying white matter damage in...

1 Replies

615 Views

Last post by frodo
Wed Mar 20, 2019 8:20 am
B-cells from MS patients secrete something toxic, maybe exosomes.

Last post by frodo « Sat Mar 16, 2019 3:25 am

by frodo » Sat Mar 16, 2019 3:25 am

Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis

Most evidence from pathological studies suggests that...

0 Replies

83 Views

Last post by frodo
Sat Mar 16, 2019 3:25 am
Polineuropaties, CDIP and NF-155 in MS

Last post by frodo « Fri Mar 15, 2019 7:16 am
Replies: 1
by frodo » Fri Mar 15, 2019 7:15 am

1 Replies

63 Views

Last post by frodo
Fri Mar 15, 2019 7:16 am
ANA-positive MS and MRZ reaction

Last post by frodo « Mon Mar 11, 2019 9:05 am

by frodo » Mon Mar 11, 2019 9:05 am

Up to 60% of MS-patients present antinuclear autoantibodies (ANAs) in CSF and may be misdiagnosed. Regardless of the question about if ANA-positive...

0 Replies

74 Views

Last post by frodo
Mon Mar 11, 2019 9:05 am
The Interaction between Viral and Environmental Risk Factors

Last post by frodo « Mon Mar 11, 2019 3:03 am

by frodo » Mon Mar 11, 2019 3:03 am

The Interaction between Viral and Environmental Risk Factors in the Pathogenesis of Multiple Sclerosis

Abstract

Multiple sclerosis (MS) is a...

0 Replies

57 Views

Last post by frodo
Mon Mar 11, 2019 3:03 am
Metabolomics profile of MS

Last post by frodo « Mon Mar 11, 2019 1:49 am
Replies: 1
by frodo » Mon Mar 11, 2019 1:24 am

First post

Several viral infections mimic MS. Before immune supresion or modulation is important to be sure that there is no infection in the CNS or things...

Last post

Immune Cell Profiling of the Cerebrospinal Fluid Provides Pathogenetic Insights into Inflammatory Neuropathies

Objective: Utilize immune cell...

1 Replies

81 Views

Last post by frodo
Mon Mar 11, 2019 1:49 am
Oligoclonal bands are responsive to medication

Last post by frodo « Sun Mar 10, 2019 11:30 am
Replies: 2
by frodo » Tue Jan 15, 2019 5:39 am

First post

Cladribine reduces oligoclonal bands (OCB) in MS, and MS gets better without them. These are the conclusions of a study ( which also points to a...

Last post

Immune Cell Profiling of the Cerebrospinal Fluid Provides Pathogenetic Insights into Inflammatory Neuropathies

Objective: Utilize immune cell...

2 Replies

214 Views

Last post by frodo
Sun Mar 10, 2019 11:30 am
MSRV (MS retro-virus) and EBV interaction

Last post by NHE « Tue Mar 05, 2019 12:49 am
Replies: 1
by frodo » Mon Mar 04, 2019 5:28 am

First post

The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to in vivo imaging

Multiple sclerosis (MS) is a disease of...

Last post

The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to in vivo imaging

Free full text.

1 Replies

134 Views

Last post by NHE
Tue Mar 05, 2019 12:49 am
HERV and MSRV viruses implicated. Temelimab works against them.

Last post by NHE « Sun Mar 03, 2019 3:20 pm
Replies: 2
by frodo » Sat Mar 02, 2019 3:54 am

First post

MSRV is a retrovirus consistently found in MS lesions.

When active, MSRV produces a protein called MSRV-envelope protein, or MSRV-Env, which...

Last post

What is the magnetization transfer ratio? Does it correspond to gristy56's idea that it is magnetite which damages the myelin sheath and that by...

2 Replies

188 Views

Last post by NHE
Sun Mar 03, 2019 3:20 pm
Reports about the CSF toxicity

Last post by frodo « Wed Feb 27, 2019 5:36 am
Replies: 1
by frodo » Sat Dec 30, 2017 4:25 am

First post

I am collecting here some of the studies about the CSF toxicity. One of the most interesting studies of the previous years was the possibility of...

Last post

Last report found

Cerebrospinal Fluid Derived from Primary Progressive MS Delays Remyelination after Lysolecithin-induced Demyelination...

1 Replies

961 Views

Last post by frodo
Wed Feb 27, 2019 5:36 am
NATURE: Autoreplicating T-cells involved in MS

Last post by frodo « Wed Feb 27, 2019 3:09 am

by frodo » Wed Feb 27, 2019 3:09 am

Immune-cell crosstalk in multiple sclerosis

T cells from people with multiple sclerosis are more prone to divide in vitro than are T cells from...

0 Replies

63 Views

Last post by frodo
Wed Feb 27, 2019 3:09 am
NATURE: Specific T-cells induce grey matter degeneration

Last post by frodo « Wed Feb 27, 2019 2:34 am

by frodo » Wed Feb 27, 2019 2:34 am

An important article about T-cells has been published. There are some expert comments about it available at . They say that the progressive phase is...

0 Replies

76 Views

Last post by frodo
Wed Feb 27, 2019 2:34 am
new biomarker, in blood, and maybe able to classify patients

Last post by frodo « Thu Feb 21, 2019 6:47 pm

by frodo » Thu Feb 21, 2019 6:47 pm

Long non‐coding RNA AFAP1‐AS1 is upregulated in a subset of multiple sclerosis patients

Results

AFAP1‐AS1 was upregulated in male MS...

0 Replies

86 Views

Last post by frodo
Thu Feb 21, 2019 6:47 pm
Patterns thread: Selective treatment for the four patterns

Last post by frodo « Mon Feb 18, 2019 1:47 am
Replies: 14
by frodo » Sun Nov 26, 2017 4:04 am

First post

In this post I will try to keep track of the developments in the specific treatment of the four patterns, whose existence was at first disputed, but...

Last post

Mitochondrial defects in acute multiple sclerosis lesions.

Multiple sclerosis is a chronic inflammatory disease, which leads to focal plaques of...

14 Replies

2151 Views

Last post by frodo
Mon Feb 18, 2019 1:47 am
Vascular problems in MS

Last post by vesta « Mon Feb 11, 2019 12:48 am
Replies: 5
by frodo » Fri Aug 17, 2018 1:28 am

First post

Maybe CCSVI theory is wrong, but there must be something related to the vascular system in MS. Two more reports about vascular problems associated to...

Last post

I meant WILL refer to. Vesta

5 Replies

844 Views

Last post by vesta
Mon Feb 11, 2019 12:48 am
The picture of demyelinating diseases gets more complicated

Last post by frodo « Wed Feb 06, 2019 2:38 am

by frodo » Wed Feb 06, 2019 2:38 am

This is the current picture as far as the current knowledge suggest. The picture is more complex than previously thought, even if anti-neurofascin...

0 Replies

158 Views

Last post by frodo
Wed Feb 06, 2019 2:38 am
Immunoglobulin G analysis for diagnosis of MS

Last post by frodo « Tue Feb 05, 2019 11:49 pm

by frodo » Tue Feb 05, 2019 11:49 pm

High performance of cerebrospinal fluid immunoglobulin G analysis for diagnosis of multiple sclerosis

Background

The 2017 revision of the...

0 Replies

103 Views

Last post by frodo
Tue Feb 05, 2019 11:49 pm
Disordered immune system and lipid metabolism in MS

Last post by frodo « Tue Feb 05, 2019 2:38 am

by frodo » Tue Feb 05, 2019 2:38 am

A systems medicine approach reveals disordered immune system and lipid metabolism in multiple sclerosis patients

Identification of autoimmune...

0 Replies

127 Views

Last post by frodo
Tue Feb 05, 2019 2:38 am
maybe B-cells are not so important

Last post by frodo « Sun Feb 03, 2019 9:43 am
Replies: 2
by frodo » Sun Feb 03, 2019 7:41 am

First post

The success of anti-CD20 monoclonal antibodies has put the focus on CD20 B-cells, but it could be that the mechanism of action is about depleting...

Last post

I would say that for reduction of disease activity they mean relapses, not progresion.

2 Replies

144 Views

Last post by frodo
Sun Feb 03, 2019 9:43 am
CSF can separate RRMS from PPMS

Last post by frodo « Sun Feb 03, 2019 7:49 am

by frodo » Sun Feb 03, 2019 7:49 am

Biochemical Differences in Cerebrospinal Fluid between Secondary Progressive and Relapsing–Remitting Multiple Sclerosis

To better understand the...

0 Replies

148 Views

Last post by frodo
Sun Feb 03, 2019 7:49 am
Multi-shell diffusion MRI shows early WM changes

Last post by frodo « Sun Feb 03, 2019 1:46 am

by frodo » Sun Feb 03, 2019 1:46 am

It seems that multi-shell diffusion is some kind of new MRI protocol able to show the white matter early damage.

Evidence of early microstructural...

0 Replies

88 Views

Last post by frodo
Sun Feb 03, 2019 1:46 am
status of the research as of 2019

Last post by frodo « Wed Jan 30, 2019 1:07 am

by frodo » Wed Jan 30, 2019 1:07 am

There is a review here summarising the status of knowledge:

Excerpts:

- Evidence from MRI and pathological assessment (biopsies and autopsies)...

0 Replies

149 Views

Last post by frodo
Wed Jan 30, 2019 1:07 am
Multiple sclerosis in 2018: new therapies and biomarkers

Last post by frodo « Mon Jan 28, 2019 7:52 am

by frodo » Mon Jan 28, 2019 7:52 am

Multiple sclerosis in 2018: new therapies and biomarkers

From my point of view, there are two remarkable advances:

- Ibudilast, a...

0 Replies

108 Views

Last post by frodo
Mon Jan 28, 2019 7:52 am
2018 update: Incidence and prevalence rates of Multiple Sclerosis in Canada

Last post by frodo « Mon Jan 28, 2019 6:12 am
Replies: 2
by jimmylegs » Sun Jan 27, 2019 7:38 am

First post

PHAC releases incidence and prevalence rates of Multiple Sclerosis in Canada (2018)

Background:

The Canadian Chronic Disease Surveillance System...

Last post

Just a remark. Prevalence rate increase could be due to a longer life and could be a good thing. Incidence rate increase is the big problem, but they...

2 Replies

141 Views

Last post by frodo
Mon Jan 28, 2019 6:12 am
Pre-active lesions hold clues to stop MS

Last post by frodo « Wed Jan 23, 2019 6:25 am

by frodo » Wed Jan 23, 2019 6:25 am

Preactive lesions in multiple sclerosis

Compelling evidence is accumulating for pathological changes in normal-appearing white matter of MS...

0 Replies

139 Views

Last post by frodo
Wed Jan 23, 2019 6:25 am
Biomarker for response to interferon

Last post by frodo « Tue Jan 22, 2019 4:28 am

by frodo » Tue Jan 22, 2019 4:28 am

Semaphorin 4A as a biomarker of multiple sclerosis and neuromyelitis optica spectrum disorder

Abstract

Selecting appropriate treatment from...

0 Replies

102 Views

Last post by frodo
Tue Jan 22, 2019 4:28 am
IMPORTANT: New type of MS discovered. Myelocortical MS.

Last post by frodo « Sat Jan 12, 2019 9:33 am
Replies: 4
by frodo » Thu Aug 23, 2018 5:03 am

First post

Researchers discover new subtype of multiple sclerosis (The Lancet)

Cleveland Clinic researchers have discovered a new subtype of multiple...

Last post

Perhaps you should research the scientific correctness of statements that you make before you post things on the board.

That statement is not...

4 Replies

1019 Views

Last post by frodo
Sat Jan 12, 2019 9:33 am
Wolfson Institute of Preventive Medicine. EBV is MS cause.

Last post by Kheuer « Wed Jan 09, 2019 8:50 am
Replies: 1
by frodo » Sun Dec 23, 2018 5:51 am

First post

There is strong evidence that Epstein Barr Virus (EBV) infection is a cause of Multiple Sclerosis. Immunisation against
EBV could in future prevent...

Last post

EBV and the Human Herpes Virus family activate the epigenetic pathway for the MS genetically prone.

The EBV does not cause MS.

An inflammatory...

1 Replies

535 Views

Last post by Kheuer
Wed Jan 09, 2019 8:50 am
miR-223 in MS: Strong biomarker and probably pathogenic

Last post by frodo « Wed Jan 09, 2019 8:23 am
Replies: 2
by frodo » Fri Dec 21, 2018 6:05 am

First post

The miR-223: An Inflammatory MicroRNA Involved in Pathogenesis of Multiple Sclerosis

Full text link:

Abstract:

Multiple sclerosis (MS) is the...

Last post

Interesting. Both articles say more or less the opposite. For the first authors miR-223 is bad and for the others is good, but anyway they agree in...

2 Replies

664 Views

Last post by frodo
Wed Jan 09, 2019 8:23 am
Targeting progression in MS (PPMS+SPMS)

Last post by frodo « Tue Jan 08, 2019 1:09 am

by frodo » Tue Jan 08, 2019 1:09 am

Source:

In 2018, the distinguishing pathological features of white matter lesions in patients with progressive multiple sclerosis (MS) were...

0 Replies

247 Views

Last post by frodo
Tue Jan 08, 2019 1:09 am
miRNA dysregulation links EBV infection and vitamin D

Last post by frodo « Thu Dec 27, 2018 7:21 am

by frodo » Thu Dec 27, 2018 7:21 am

Integrational analysis of miRNAs data sets as a plausible missing linker between Epstein-Barr virus and vitamin D in relapsing remitting MS patients...

0 Replies

402 Views

Last post by frodo
Thu Dec 27, 2018 7:21 am
summary of advances during 2018

Last post by frodo « Thu Dec 27, 2018 7:18 am

by frodo » Thu Dec 27, 2018 7:18 am

summary of advances during 2018

0 Replies

418 Views

Last post by frodo
Thu Dec 27, 2018 7:18 am

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