MS Etiology and Pathogenesis

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Anti-Neurofascin auto-antibody demyelination

Last post by frodo « Fri Jul 09, 2021 2:53 pm

by frodo » Fri Jul 09, 2021 2:53 pm

Anti-neurofascin autoantibody and demyelination

Highlights

• Anti-neurofascin antibodies are found in multiple sclerosis, and chronic...

0 Replies

123 Views

Last post by frodo
Fri Jul 09, 2021 2:53 pm
Microglia in the pathogenesis of MS

Last post by frodo « Fri Jun 25, 2021 12:48 am
Replies: 23
by frodo » Mon Jul 23, 2018 11:13 am
1

2
First post

Microglia in the pathogenesis of MS

We postulate that the immune reaction initiates in the CNS and immune cells (including T cells/B cell)...

Last post

Microglia clean up toxic lipids in multiple sclerosis

Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination and...
23 Replies

4490 Views

Last post by frodo
Fri Jun 25, 2021 12:48 am
multifactorial pathogenesis not necessarily linked to inflammatory demyelination

Last post by frodo « Fri Jun 25, 2021 12:36 am

by frodo » Fri Jun 25, 2021 12:36 am

Microglial activation is accompanied by diffuse axonal loss in multiple sclerosis: in vivo evidence by multimodal 11C-PBR28 MR-PET and multi-shell...

0 Replies

154 Views

Last post by frodo
Fri Jun 25, 2021 12:36 am
automatic lesion pattern discrimination

Last post by frodo « Fri Jun 25, 2021 12:30 am

by frodo » Fri Jun 25, 2021 12:30 am

A R-Script for Generating Multiple Sclerosis Lesion Pattern Discrimination Plots

Abstract :

One significant characteristic of Multiple...

0 Replies

145 Views

Last post by frodo
Fri Jun 25, 2021 12:30 am
four groups on volume loss evolution

Last post by frodo « Fri Jun 25, 2021 12:17 am

by frodo » Fri Jun 25, 2021 12:17 am

Classification of multiple sclerosis based on patterns of CNS regional atrophy covariance

Abstract

There is evidence that multiple sclerosis...

0 Replies

152 Views

Last post by frodo
Fri Jun 25, 2021 12:17 am
retinal thinning, cortical lesions, meningeal inflammation, lesions and brain atrophy are linked

Last post by frodo « Fri Jun 25, 2021 12:13 am

by frodo » Fri Jun 25, 2021 12:13 am

Association of retinal atrophy with cortical lesions and leptomeningeal enhancement in multiple sclerosis on 7T MRI

Abstract
Background: Retinal...

0 Replies

157 Views

Last post by frodo
Fri Jun 25, 2021 12:13 am
subclinical activity in MS relatives

Last post by frodo « Thu Jun 24, 2021 12:34 pm

by frodo » Thu Jun 24, 2021 12:34 pm

Multiple sclerosis and subclinical neuropathology in healthy individuals with familial risk

Highlights

• MRI evidence of MS pathology in...

0 Replies

161 Views

Last post by frodo
Thu Jun 24, 2021 12:34 pm
Biomarkers: miR-155 and functional proteins of CD8+ T cells

Last post by frodo « Wed Jun 16, 2021 12:46 pm

by frodo » Wed Jun 16, 2021 12:46 pm

miR-155 and functional proteins of CD8+ T cells as potential prognostic biomarkers for Relapsing-Remitting Multiple Sclerosis

Highlights

•...

0 Replies

198 Views

Last post by frodo
Wed Jun 16, 2021 12:46 pm
Some MS cases could be due to bacteria

Last post by frodo « Sun Jun 13, 2021 6:33 am

by frodo » Sun Jun 13, 2021 6:33 am

Spinal fluid IgG antibodies from patients with demyelinating diseases bind multiple sclerosis-associated bacteria

Abstract

A panel of 10 IgG...

0 Replies

206 Views

Last post by frodo
Sun Jun 13, 2021 6:33 am
Diagnosis via retinal inspection improved

Last post by frodo « Mon May 31, 2021 3:27 am

by frodo » Mon May 31, 2021 3:27 am

Diagnosis of multiple sclerosis using multifocal erg data feature fusion

Abstract

The purpose of this paper is to implement a computer-aided...

0 Replies

222 Views

Last post by frodo
Mon May 31, 2021 3:27 am
More evidence against EBV

Last post by frodo « Sat May 22, 2021 11:07 am

by frodo » Sat May 22, 2021 11:07 am

Exosomes From Subjects With Multiple Sclerosis Express EBV-Derived Proteins and Activate Monocyte-Derived Macrophages

Abstract

Objective To...

0 Replies

259 Views

Last post by frodo
Sat May 22, 2021 11:07 am
B Cell Dysfunction, Aging, Autoimmune Diseases

Last post by jimmylegs « Mon May 17, 2021 2:54 am
Replies: 6
by jimmylegs » Fri May 14, 2021 11:35 am

First post

starting to work on getting my head around anti b cell meds...

B Cell Dysfunction Associated With Aging and Autoimmune Diseases (2019)
fft:

......

Last post

guess who? mice...

Post-stroke administration of omega-3 polyunsaturated fatty acids promotes neurovascular restoration after ischemic stroke in...

6 Replies

365 Views

Last post by jimmylegs
Mon May 17, 2021 2:54 am
MS as a metabolic disease

Last post by frodo « Mon May 03, 2021 2:23 am

by frodo » Mon May 03, 2021 2:23 am

Pathology-supported genetic testing as a method for disability prevention in multiple sclerosis (MS). Part I. Targeting a metabolic model rather than...

0 Replies

222 Views

Last post by frodo
Mon May 03, 2021 2:23 am
automatic diagnosis of CNS diseases

Last post by frodo « Wed Apr 28, 2021 2:08 am

by frodo » Wed Apr 28, 2021 2:08 am

CSF biomarkers, processed by an algorithm, can help establishing an automatic diagnosis of CNS diseases.

0 Replies

217 Views

Last post by frodo
Wed Apr 28, 2021 2:08 am
Surface-in pathology

Last post by Petr75 « Wed Apr 21, 2021 3:42 am

by Petr75 » Wed Apr 21, 2021 3:42 am

2021 Apr 20
NMR Research Unit, Queen Square Multiple Sclerosis Centre, University College London, Institute of Neurology, London, UK
Surface-in...

0 Replies

219 Views

Last post by Petr75
Wed Apr 21, 2021 3:42 am
Adolescent infection increases MS risk

Last post by NHE « Thu Apr 08, 2021 3:01 am

by NHE » Thu Apr 08, 2021 3:01 am

Hospital-diagnosed infections before age 20 and risk of a subsequent multiple sclerosis diagnosis
Brain. 2021 Mar 9;awab100.

The involvement of...

0 Replies

201 Views

Last post by NHE
Thu Apr 08, 2021 3:01 am
Herpesvirus HHV-6B strain linked to MS

Last post by DIM « Thu Apr 01, 2021 10:18 am
Replies: 2
by frodo » Tue Dec 10, 2019 3:52 am

2 Replies

915 Views

Last post by DIM
Thu Apr 01, 2021 10:18 am
QSM-MRI can show brain inflammation.

Last post by frodo « Tue Mar 16, 2021 10:55 am

by frodo » Tue Mar 16, 2021 10:55 am

QSM-MRI can show brain inflammation. Currently there is none.

QSM is an imaging biomarker for chronic glial activation inmultiple sclerosis lesions...

0 Replies

218 Views

Last post by frodo
Tue Mar 16, 2021 10:55 am
MS transcriptome analysis

Last post by frodo « Tue Mar 16, 2021 10:47 am
Replies: 1
by jimmylegs » Fri Mar 12, 2021 8:59 am

First post

things about which i know nothing:

Whole transcriptome analysis of multiple Sclerosis patients reveals active inflammatory profile in relapsing...

Last post

looks like they are trying to separate RRMS from SPMS

1 Replies

239 Views

Last post by frodo
Tue Mar 16, 2021 10:47 am
Biomarkers. Extensive review as of 2021

Last post by frodo « Mon Mar 08, 2021 8:32 pm

by frodo » Mon Mar 08, 2021 8:32 pm

Biomarkers in Multiple sclerosis: what place for oxysterols?

The main markers of multiple sclerosis that have been identified are involved in the...

0 Replies

242 Views

Last post by frodo
Mon Mar 08, 2021 8:32 pm
MicroRNA in MS and other diseases

Last post by frodo « Mon Mar 08, 2021 8:17 pm

by frodo » Mon Mar 08, 2021 8:17 pm

MiRNA dysregulation multiple sclerosis

MiRNAs dysregulation display strong association with multiple sclerosis (MS). Several MiRNAs were reported to...

0 Replies

236 Views

Last post by frodo
Mon Mar 08, 2021 8:17 pm
Teri helps recovering optic nerve

Last post by frodo « Mon Mar 08, 2021 8:02 pm

by frodo » Mon Mar 08, 2021 8:02 pm

Teriflunomide treatment is associated with optic nerve recovery in early multiple sclerosis

Beneficial properties of TRF beyond pure...

0 Replies

232 Views

Last post by frodo
Mon Mar 08, 2021 8:02 pm
TNF demyelination considered as MS

Last post by frodo « Wed Feb 24, 2021 2:05 am

by frodo » Wed Feb 24, 2021 2:05 am

TNF-α blockers-associated multiple sclerosis

Conclusion

Our study confirmed that the exposure to TNFα blockers can be associated to a broad...

0 Replies

295 Views

Last post by frodo
Wed Feb 24, 2021 2:05 am
EBV theory of MS. Some diagrams.

Last post by NHE « Sat Feb 20, 2021 7:21 am
Replies: 1
by frodo » Sat Feb 20, 2021 3:39 am

First post

A new paper about how EBV could lead to MS. I link the main diagram here below.

Epstein–Barr Virus in Multiple Sclerosis: Theory and Emerging...

Last post

Here's the full paper...

Epstein-Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies
Trends Mol Med. 2020 Mar;26(3):296-310....

1 Replies

296 Views

Last post by NHE
Sat Feb 20, 2021 7:21 am
Myelin disruption precedes autoimmunity in NAWM

Last post by frodo « Sat Feb 20, 2021 3:41 am
Replies: 1
by NHE » Wed Feb 10, 2021 2:52 pm

First post

Axon-Myelin Unit Blistering as Early Event in MS Normal Appearing White Matter
Ann Neurol. 2021 Jan 6.

Objective: Multiple sclerosis (MS) is a...

Last post

thanks. interesting.

1 Replies

369 Views

Last post by frodo
Sat Feb 20, 2021 3:41 am
The lancet: More about the previous two epitopes

Last post by frodo « Mon Feb 08, 2021 11:02 am

by frodo » Mon Feb 08, 2021 11:02 am

Serum markers of multiple sclerosis - a new approach

Optic neuritis (ON) typically manifests with the classical triad of subacute unilateral...

0 Replies

269 Views

Last post by frodo
Mon Feb 08, 2021 11:02 am
Biomarkers: Two epitopes predict ON evolution to MS

Last post by frodo « Mon Feb 08, 2021 10:55 am

by frodo » Mon Feb 08, 2021 10:55 am

You can see what a epitope is at wikipedia:

Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis...

0 Replies

265 Views

Last post by frodo
Mon Feb 08, 2021 10:55 am
plasmablast: 100% specificity

Last post by frodo « Mon Feb 08, 2021 10:51 am

by frodo » Mon Feb 08, 2021 10:51 am

Plasmablast ( immature blood cells ) reported to have 36% sensivity and 100% specificity compared to other neurological diseases.

Summary...

0 Replies

223 Views

Last post by frodo
Mon Feb 08, 2021 10:51 am
A unified view of multiple sclerosis

Last post by frodo « Sat Jan 30, 2021 3:48 am

by frodo » Sat Jan 30, 2021 3:48 am

A unified view of multiple sclerosis

Abstract

The clinical course of multiple sclerosis (MS)is highly variable. To establish a standardized...

0 Replies

710 Views

Last post by frodo
Sat Jan 30, 2021 3:48 am
Biomarkers: Two new ones related to EBV

Last post by frodo « Tue Jan 26, 2021 12:56 pm

by frodo » Tue Jan 26, 2021 12:56 pm

Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients

0 Replies

429 Views

Last post by frodo
Tue Jan 26, 2021 12:56 pm
Nature: MRI can show biological heterogeneity

Last post by frodo « Fri Jan 22, 2021 10:59 pm

by frodo » Fri Jan 22, 2021 10:59 pm

Quantitative MRI phenotypes capture biological heterogeneity in multiple sclerosis patients

Abstract

Magnetization transfer ratio (MTR) and...

0 Replies

384 Views

Last post by frodo
Fri Jan 22, 2021 10:59 pm
Ibudilast for PPMS better than for SPMS

Last post by frodo « Fri Jan 22, 2021 10:52 pm

by frodo » Fri Jan 22, 2021 10:52 pm

Response to ibudilast treatment according to progressive multiple sclerosis disease phenotype

Discussion

The impetus to study ibudilast in...

0 Replies

349 Views

Last post by frodo
Fri Jan 22, 2021 10:52 pm
miRNA dysregulation as the source of the disease

Last post by Petr75 « Mon Jan 18, 2021 11:56 pm
Replies: 15
by frodo » Mon Oct 16, 2017 11:28 pm
1

2
First post

Micro-RNA ( miRNA ) has been proposed as a biomarker of axon degeneration, but some authors have proposed that they could be the source of the...

Last post

2021 Jan 16
Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
Identification of...
15 Replies

3124 Views

Last post by Petr75
Mon Jan 18, 2021 11:56 pm
serum biomarkers: Phospholipids

Last post by frodo « Wed Jan 13, 2021 5:31 am

by frodo » Wed Jan 13, 2021 5:31 am

Serum phospholipidomics reveals altered lipid profile and promising biomarkers in multiple sclerosis

Conclusion

From this study, we can...

0 Replies

350 Views

Last post by frodo
Wed Jan 13, 2021 5:31 am
Western lifestyle: Possible link to antibiotics consumption

Last post by frodo « Tue Jan 12, 2021 10:40 am

by frodo » Tue Jan 12, 2021 10:40 am

Holistic solution to an old mystery : the global role of antibiotic consumption patterns in the spread of certain non-contagious diseases in EU...

0 Replies

374 Views

Last post by frodo
Tue Jan 12, 2021 10:40 am
New medical entity overlapping with MS: DAF

Last post by frodo « Tue Jan 12, 2021 9:05 am

by frodo » Tue Jan 12, 2021 9:05 am

After NMO and anti-MOG, and following the non-autoimmune models of MS, it seems that there is a new entity entering the scene:

Demyelination with...

0 Replies

335 Views

Last post by frodo
Tue Jan 12, 2021 9:05 am
subtyping RRMS

Last post by frodo « Tue Jan 05, 2021 3:00 pm

by frodo » Tue Jan 05, 2021 3:00 pm

Subtyping relapsing–remitting multiple sclerosis using structural MRI

Abstract
Background and purpose

Subtyping relapsing–remitting multiple...

0 Replies

295 Views

Last post by frodo
Tue Jan 05, 2021 3:00 pm
Dogs can smell MS

Last post by frodo « Tue Dec 22, 2020 12:27 pm
Replies: 3
by frodo » Wed Dec 04, 2019 12:54 am

First post

These Dogs Know When Their Owners Are About to Have an MS Flare

Health and wellness touch everyone’s life differently. Here are some stories....

Last post

Detecting Multiple Sclerosis via breath analysis using an eNose, a pilot study

Abstract

Objective: In the present study we investigated whether...

3 Replies

807 Views

Last post by frodo
Tue Dec 22, 2020 12:27 pm
Herpes simplex virus

Last post by Petr75 « Tue Dec 22, 2020 12:07 am

by Petr75 » Tue Dec 22, 2020 12:07 am

2020 Nov 19
Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
Positive...

0 Replies

271 Views

Last post by Petr75
Tue Dec 22, 2020 12:07 am
MRZ Reaction in PPMS

Last post by frodo « Tue Dec 01, 2020 5:45 am

by frodo » Tue Dec 01, 2020 5:45 am

Cerebrospinal Fluid Biomarkers in Relation to MRZ Reaction Status in Primary Progressive Multiple Sclerosis

Abstract

The MRZ reaction (MRZR)...

0 Replies

442 Views

Last post by frodo
Tue Dec 01, 2020 5:45 am
Iron heterogeneity in MS: Patterns can be separated!!

Last post by frodo « Tue Dec 01, 2020 5:37 am

by frodo » Tue Dec 01, 2020 5:37 am

Iron heterogeneity in early active multiple sclerosis lesions.

Abstract

OBJECTIVE :

Multiple sclerosis (MS) is a heterogeneous inflammatory...

0 Replies

370 Views

Last post by frodo
Tue Dec 01, 2020 5:37 am
lipid metabolism and MS

Last post by frodo « Wed Nov 18, 2020 12:40 am

by frodo » Wed Nov 18, 2020 12:40 am

Serum phospholipidomics reveals altered lipid profile and promising biomarkers in multiple sclerosis

Abstract

Multiple sclerosis is a...

0 Replies

356 Views

Last post by frodo
Wed Nov 18, 2020 12:40 am
Twins comparison suggest lipids metabolism implications

Last post by frodo « Thu Nov 12, 2020 4:04 am

by frodo » Thu Nov 12, 2020 4:04 am

Plasma lipidomics of monozygotic twins discordant for multiple sclerosis

Abstract

Blood biomarkers of multiple sclerosis (MS) can provide a...

0 Replies

341 Views

Last post by frodo
Thu Nov 12, 2020 4:04 am
MBP in saliva as biomarker

Last post by frodo « Tue Nov 10, 2020 5:13 am

by frodo » Tue Nov 10, 2020 5:13 am

Serum and saliva Myelin basic protein as Multiple sclerosis biomarker

Abstract:

Objective: Multiple sclerosis (MS) is considered as motor and...

0 Replies

306 Views

Last post by frodo
Tue Nov 10, 2020 5:13 am
type-1 diabetes and MS. New kind of cells discovered.

Last post by frodo « Fri Nov 06, 2020 5:09 am

by frodo » Fri Nov 06, 2020 5:09 am

Newly Discovered Hybrid Immune Cell Could Finally Explain The Cause of Type 1 Diabetes

Both the peptide and hybrid white cells were more likely...

0 Replies

336 Views

Last post by frodo
Fri Nov 06, 2020 5:09 am
New microglial modulator inhibits activated microglia

Last post by frodo « Fri Nov 06, 2020 2:45 am

by frodo » Fri Nov 06, 2020 2:45 am

The new modulator inhibits something called CSF1R and it has been shown to reduce altered microglia. They also say that NAWM microglia shows an...

0 Replies

306 Views

Last post by frodo
Fri Nov 06, 2020 2:45 am
changes in NAWM precede lesion development

Last post by frodo « Tue Nov 03, 2020 6:09 am

by frodo » Tue Nov 03, 2020 6:09 am

Role of Magnetic Resonance Imaging with Diffusion Sequences in Assessment of Multiple Sclerosis in Brain Versus Normally Appearing White Matter...

0 Replies

319 Views

Last post by frodo
Tue Nov 03, 2020 6:09 am
Retinal damage reflects MS progression, not relapses

Last post by frodo « Tue Nov 03, 2020 6:07 am

by frodo » Tue Nov 03, 2020 6:07 am

Retinal layer thinning is reflecting disability progression independent of relapse activity in multiple sclerosis

Background
PIRA (progression...

0 Replies

350 Views

Last post by frodo
Tue Nov 03, 2020 6:07 am
MS biomarker in serum

Last post by frodo « Tue Nov 03, 2020 6:04 am

by frodo » Tue Nov 03, 2020 6:04 am

Detection of Multiple Sclerosis Biomarkers in Serum by Ganglioside Microarrays and Surface Plasmon Resonance Imaging

Abstract

Multiple...

0 Replies

305 Views

Last post by frodo
Tue Nov 03, 2020 6:04 am
Complex genetic signatures

Last post by Petr75 « Wed Oct 14, 2020 8:35 am

by Petr75 » Wed Oct 14, 2020 8:35 am

2020 Oct
Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy
Complex genetic signatures in immune...

0 Replies

334 Views

Last post by Petr75
Wed Oct 14, 2020 8:35 am

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