MS Etiology and Pathogenesis

New Topic

202 topics

Topics

Replies

Views

Last post

cladribine reduces oligoclonal bands (OCB)

Last post by frodo « 5 days ago

by frodo » 5 days ago

Cladribine reduces oligoclonal bands (OCB) in MS, and MS gets better without them. These are the conclusions of this study, which also points to a...

0 Replies

46 Views

Last post by frodo
5 days ago
IMPORTANT: New type of MS discovered.

Last post by frodo « 1 week ago
Replies: 4
by frodo » 5 months ago

First post

Researchers discover new subtype of multiple sclerosis (The Lancet)

Cleveland Clinic researchers have discovered a new subtype of multiple...

Last post

Perhaps you should research the scientific correctness of statements that you make before you post things on the board.

That statement is not...

4 Replies

853 Views

Last post by frodo
1 week ago
Wolfson Institute of Preventive Medicine. EBV is MS cause.

Last post by Kheuer « 1 week ago
Replies: 1
by frodo » 4 weeks ago

First post

There is strong evidence that Epstein Barr Virus (EBV) infection is a cause of Multiple Sclerosis. Immunisation against
EBV could in future prevent...

Last post

EBV and the Human Herpes Virus family activate the epigenetic pathway for the MS genetically prone.

The EBV does not cause MS.

An inflammatory...

1 Replies

442 Views

Last post by Kheuer
1 week ago
miR-223 in MS: Strong biomarker and probably pathogenic

Last post by frodo « 1 week ago
Replies: 2
by frodo » 1 month ago

First post

The miR-223: An Inflammatory MicroRNA Involved in Pathogenesis of Multiple Sclerosis

Full text link:

Abstract:

Multiple sclerosis (MS) is the...

Last post

Interesting. Both articles say more or less the opposite. For the first authors miR-223 is bad and for the others is good, but anyway they agree in...

2 Replies

538 Views

Last post by frodo
1 week ago
Targeting progression in MS (PPMS+SPMS)

Last post by frodo « 1 week ago

by frodo » 1 week ago

Source:

In 2018, the distinguishing pathological features of white matter lesions in patients with progressive multiple sclerosis (MS) were...

0 Replies

148 Views

Last post by frodo
1 week ago
miRNA dysregulation links EBV infection and vitamin D

Last post by frodo « 3 weeks ago

by frodo » 3 weeks ago

Integrational analysis of miRNAs data sets as a plausible missing linker between Epstein-Barr virus and vitamin D in relapsing remitting MS patients...

0 Replies

323 Views

Last post by frodo
3 weeks ago
summary of advances during 2018

Last post by frodo « 3 weeks ago

by frodo » 3 weeks ago

summary of advances during 2018

0 Replies

297 Views

Last post by frodo
3 weeks ago
Human endogenous retro-viruses HERVs and link to diabetes

Last post by frodo « 3 weeks ago
Replies: 1
by frodo » 4 weeks ago

First post

Not all the research points to EBV. HERVs could be also involved.

Preclinical research demonstrated that pathogenic HERV-W protein negatively...

Last post

Answering to myself, it seems that the HERVs retroviruses activation could be due to EBV. Therefore, it seems that all the evidence about HERV-W also...

1 Replies

321 Views

Last post by frodo
3 weeks ago
New entity set apart from MS

Last post by frodo « 3 weeks ago

by frodo » 3 weeks ago

After separation of Neuromyelitis optica (anti-AQP4) and anti-MOG demyelinating disease from MS, it seems that there is a new type of MS that could...

0 Replies

369 Views

Last post by frodo
3 weeks ago
Microglia in the pathogenesis of MS

Last post by Petr75 « 3 weeks ago
Replies: 9
by frodo » 6 months ago

First post

Microglia in the pathogenesis of MS

We postulate that the immune reaction initiates in the CNS and immune cells (including T cells/B cell)...

Last post

2018 Nov 21
Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Stanley Center for...

9 Replies

822 Views

Last post by Petr75
3 weeks ago
Atypical MS cases

Last post by frodo « 4 weeks ago

by frodo » 4 weeks ago

Multiple Sclerosis with atypical MRI presentation: results of a nationwide multicenter study in 57 consecutive cases.

They speak about four weird...

0 Replies

414 Views

Last post by frodo
4 weeks ago
Diferential diagnosis by CSF metab.: MS vs encephalomyelitis

Last post by frodo « 4 weeks ago

by frodo » 4 weeks ago

This is specially important to avoid misdiagnosis but also to elucidate pathogenesis.

NMR metabolomics of cerebrospinal fluid differentiates...

0 Replies

394 Views

Last post by frodo
4 weeks ago
PPMS vs. RRMS/SPMS pathogenesis

Last post by frodo « 4 weeks ago

by frodo » 4 weeks ago

Pathogenic Mechanisms associated with Different Clinical Courses of Multiple Sclerosis

In the majority of patients multiple sclerosis starts with...

0 Replies

404 Views

Last post by frodo
4 weeks ago
Epstein Barr Virus review

Last post by frodo « 1 month ago

by frodo » 1 month ago

The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to in vivo imaging

Conclusion

The conclusion drawn from...

0 Replies

431 Views

Last post by frodo
1 month ago
Biomarkers of the underlying process

Last post by frodo « 1 month ago

by frodo » 1 month ago

Cerebrospinal Fluid Biomarkers Link Toxic Astrogliosis and Microglial Activation to Multiple Sclerosis Severity

HIGHLIGHTS

• Microglial/myeloid...

0 Replies

738 Views

Last post by frodo
1 month ago
Blood indicators of clinical status and plasma exchange prog

Last post by frodo « 1 month ago

by frodo » 1 month ago

Blood plasma thermal behavior and protein oxidation as indicators of multiple sclerosis clinical status and plasma exchange therapy progression...

0 Replies

736 Views

Last post by frodo
1 month ago
Anyone thought to have MS should be tested for biotinidase d

Last post by frodo « 1 month ago

by frodo » 1 month ago

ALL INDIVIDUALS THOUGHT TO HAVE MULIPLE SCLEROSIS SHOULD BE TESTED FOR BIOTINIDASE DEFICIENCY

Highlights

• Adults with biotinidase deficiency...

0 Replies

857 Views

Last post by frodo
1 month ago
Patterns thread: Selective treatment for the four patterns

Last post by frodo « 3 months ago
Replies: 13
by frodo » 1 year ago

First post

Pattern III MS (distal oligodendrogliopathy) could be reversed:

Sublethal oligodendrocyte injury: A reversible condition in multiple sclerosis?...

Last post

We can see what the team that found the new auto-antibody (GDP-L-fucose synthase) was doing when they found it. It is related to the four...

13 Replies

1723 Views

Last post by frodo
3 months ago
FINALLY AN AUTOANTIGEN - And gut microbioma connections.

Last post by frodo « 3 months ago
Replies: 1
by frodo » 3 months ago

First post

Maybe you have notice that I was completely sure about MS not being autoimmune.

Well, maybe I was wrong. Let's see if this report is confirmed....

Last post

More news about this. A clinical trial is coming up.

It seems that the autoimmune system can be re-educated. The same team in Zurich is trying to...

1 Replies

620 Views

Last post by frodo
3 months ago
what is an HLA DRB3 positive patient?

Last post by frodo « 3 months ago

by frodo » 3 months ago

Regarding my last post about an antigen found, it only appears in a group of patients that they call DRB3 positive. I have taken a look at what means...

0 Replies

634 Views

Last post by frodo
3 months ago
National MS society web: The word "autoimmune"dissapears.

Last post by jimmylegs « 3 months ago
Replies: 5
by frodo » 3 months ago

First post

After several years saying MS is an autoimmune disease that ... now they begin like this:

Multiple sclerosis (MS) is an unpredictable, often...

Last post

related

Taking into account the results of B‐cell‐depleting drugs, the production of autoantibodies as the driving force in MS pathology has...

5 Replies

626 Views

Last post by jimmylegs
3 months ago
Diagnosis based in serum lipids. Focus on lipid metabolism?

Last post by frodo « 3 months ago

by frodo » 3 months ago

Excerpts:

Based on increasing evidence suggesting that MS pathology involves alterations in bioactive lipid metabolism , the present analysis was...

0 Replies

523 Views

Last post by frodo
3 months ago
2018 correspondence - MS Genetics: Overview & New Directions

Last post by jimmylegs « 3 months ago

by jimmylegs » 3 months ago

Genetics of Multiple Sclerosis: An Overview and New Directions

Abstract
The contribution of genetic inheritance in multiple sclerosis was...

0 Replies

491 Views

Last post by jimmylegs
3 months ago
Interleukin 36 in MS

Last post by frodo « 3 months ago

by frodo » 3 months ago

Interleukin 36 is a cytokine normally associated with psoriasis. It seems that also appears disregulated in MS. It can be meassured in blood serum...

0 Replies

448 Views

Last post by frodo
3 months ago
Oligoclonal G bands. Up to 99.5% specificity

Last post by frodo « 3 months ago

by frodo » 3 months ago

Early Differential Diagnosis of Multiple Sclerosis Using a New Oligoclonal Band Test

Results

Intrathecal IgG synthesis was found in 127...

0 Replies

526 Views

Last post by frodo
3 months ago
new diagnostic protocol proposed

Last post by frodo « 3 months ago
Replies: 2
by frodo » 3 months ago

First post

One of the worst problems of MS is the misdiagnosis. Given the strong side effects of some drugs neurologist wanto to be sure and delay the diagnosis...

Last post

A few days ago you posted info on a blood test for diagnosing MS. Not sure is this new diagnostic protocol is necessary if the accuracy of the blood...

2 Replies

515 Views

Last post by frodo
3 months ago
meningeal inflammation

Last post by frodo « 3 months ago

by frodo » 3 months ago

Abstract

The presence of leptomeningeal inflammation (LMI) in MS was first identified in 2004 and multiple subsequent studies have confirmed the...

0 Replies

466 Views

Last post by frodo
3 months ago
2018 study: optic nerves and dissemination in space

Last post by jimmylegs « 3 months ago

by jimmylegs » 3 months ago

well, my optic nerves were pristine at dx - not so much 12 yrs later (lefty seems to have taken a hit)

Inclusion of optic nerve involvement in...

0 Replies

447 Views

Last post by jimmylegs
3 months ago
Axonal Damage without T2-Lesions: Primary neurodegeneration?

Last post by frodo « 4 months ago

by frodo » 4 months ago

Evidence of Axonal Damage in Cerebellar Peduncles (CP) without T2-Lesions in Multiple Sclerosis

Highlights

• Cerebellar DTI abnormalities...

0 Replies

439 Views

Last post by frodo
4 months ago
2011 proposal: environment is MS' main cause; genetics minor

Last post by Petr75 « 4 months ago
Replies: 4
by jimmylegs » 4 months ago

First post

The major cause of multiple sclerosis is environmental: genetics has a minor role - Yes (2011)

Proposal
It is clear that multiple sclerosis (MS)...

Last post

Good article.

4 Replies

734 Views

Last post by Petr75
4 months ago
Familial MS could be different from normal MS

Last post by frodo « 4 months ago
Replies: 1
by frodo » 5 months ago

First post

Familial MS could be different from normal (sporadic) MS. They could be different diseases, needing different therapies, just like MS and NMO....

Last post

Notice that it could be related to this:

A mutation in a nuclear receptor (NR1H3) gene was detected in a familial, progressive form of multiple...

1 Replies

619 Views

Last post by frodo
4 months ago
miRNAs: Identification of MS-specific serum miRNAs

Last post by frodo « 4 months ago

by frodo » 4 months ago

Identification of MS-specific serum miRNAs in an international multicenter study

Abstract

Objective To identify circulating microRNAs (miRNAs)...

0 Replies

509 Views

Last post by frodo
4 months ago
Multiple Sclerosis: an "EMotional" issue. The microbian code

Last post by ElliotB « 4 months ago
Replies: 10
by hmacoli » 6 months ago

First post

This is an excerpt from my last page posted in my blog about MS as an emotional issue (not only but above)…that I would like to share with you.

It...

Last post

Thanks for the additional info. I did a quick check and the machines are available here but are very, very expensive.

I am having surprisingly good...

10 Replies

1019 Views

Last post by ElliotB
4 months ago
Vitamin D levels in MS impact Epstein-Barr viral load

Last post by jimmylegs « 5 months ago
Replies: 1
by frodo » 5 months ago

First post

Vitamin D levels in MS impact Epstein-Barr viral load

A study, published at ECTRIMS 2017, has revealed that serum vitamin D levels could be...

Last post

lab-supported anecdote - i've used nutritional boot camp to eradicate another's chronic EBV viral load.
took a connection of mine from being in line...

1 Replies

578 Views

Last post by jimmylegs
5 months ago
Barts blog: EBV and B-cells again

Last post by frodo « 5 months ago

by frodo » 5 months ago

B cell Cytokines in MS brain, may support B cell follicles.

Excerpts:

Although B cell depletion is an effective therapy of multiple sclerosis...

0 Replies

549 Views

Last post by frodo
5 months ago
For researchers: Red flags in diagnosis

Last post by frodo « 5 months ago

by frodo » 5 months ago

Some reports point to a 10% misdiagnosis, specially due to the appearance of lesions in MRI. It seems that non-demyelinating lesions are normal and...

0 Replies

535 Views

Last post by frodo
5 months ago
Barts Blog: Does degradation of brain fats cause MS?

Last post by frodo « 5 months ago

by frodo » 5 months ago

Does degradation of brain fats cause MS?

This is to let you know about a research project based on a novel idea of how MS develops. I am a...

0 Replies

497 Views

Last post by frodo
5 months ago
EBV again. Genetic evidence of its involvement

Last post by frodo « 5 months ago

by frodo » 5 months ago

Genetic evidence that the latency III stage of Epstein-Barr Virus infection is a therapeutic target for Multiple Sclerosis

Abstract

Genome wide...

0 Replies

513 Views

Last post by frodo
5 months ago
Vascular problems in MS

Last post by frodo « 5 months ago

by frodo » 5 months ago

Maybe CCSVI theory is wrong, but there must be something related to the vascular system in MS. Two more reports about vascular problems associated to...

0 Replies

519 Views

Last post by frodo
5 months ago
Biomarkers: proteomic profiling of human saliva

Last post by frodo « 5 months ago

by frodo » 5 months ago

Top-down proteomic profiling of human saliva in multiple sclerosis patients.

Abstract

Multiple sclerosis is a chronic disease of the central...

0 Replies

633 Views

Last post by frodo
5 months ago
review about neurofilaments

Last post by frodo « 5 months ago

by frodo » 5 months ago

Editorial of the Multiple Sclerosis Journal

Are neurofilaments valuable biomarkers for long-term disease prognostication in MS?

Neuroaxonal...

0 Replies

579 Views

Last post by frodo
5 months ago
DNA methiylation signatures in MS twins

Last post by frodo « 5 months ago

by frodo » 5 months ago

DNA methylation signatures of a large cohort monozygotic twins clinically discordant for multiple sclerosis

Abstract

Multiple sclerosis (MS) is...

0 Replies

598 Views

Last post by frodo
5 months ago
Neurofilaments in CSF predict behaviour of MS in ten years

Last post by frodo « 5 months ago

by frodo » 5 months ago

This could save some people with mild MS from being treated

Neurofilaments and 10-year follow-up in multiple sclerosis

Background:

The role...

0 Replies

559 Views

Last post by frodo
5 months ago
Microglia is just another sympthom, not the cause

Last post by frodo « 5 months ago

by frodo » 5 months ago

It seems that microglia activation could be a symptom of axonal damage, and not the ultimate cause nor related to pre-active lesions. Microglia...

0 Replies

662 Views

Last post by frodo
5 months ago
Can we tame microglia?

Last post by frodo « 5 months ago

by frodo » 5 months ago

It seems so.

Microglia P2X4 receptors as pharmacological targets for demyelinating diseases

Multiple sclerosis (MS) is a chronic inflammatory...

0 Replies

635 Views

Last post by frodo
5 months ago
Epstein Barr virus again

Last post by frodo « 5 months ago
Replies: 1
by frodo » 1 year ago

First post

Transcriptional profile and Epstein-Barr virus infection status of laser-cut immune infiltrates from the brain of patients with progressive multiple...

Last post

This article also points out a connection between the four patterns theory and the EBV brain infection.

It is also known that the CNS immune...

1 Replies

1066 Views

Last post by frodo
5 months ago
IgM+ patients should not be treated with interferon

Last post by frodo « 5 months ago

by frodo » 5 months ago

MS patients present oligoclonal bands (OCB) in their cerebrospinal fluid (CSF). Among the oligoclonal bands there could be some related to...

0 Replies

627 Views

Last post by frodo
5 months ago
Dysregulated EBV infection in MS. Old but relevant.

Last post by jimmylegs « 5 months ago
Replies: 2
by frodo » 6 months ago

First post

They know since 2007 that EBV is to blame. What are they waiting for to try antiviral therapies??

Dysregulated Epstein-Barr virus infection in the...

Last post

my 2c: correlation vs causation. i have limited but lab documented evidence of reducing both EBV viral load and food sensitivities (n=1, but not me)...

2 Replies

611 Views

Last post by jimmylegs
5 months ago
review of PET in several diseases, including MS

Last post by frodo « 6 months ago

by frodo » 6 months ago

Drugs evaluated in these studies include specific therapeutics which have already granted FDA licensure like interferon beta, glatiramer acetate, and...

0 Replies

607 Views

Last post by frodo
6 months ago
Lesions evolution under PET

Last post by frodo « 6 months ago

by frodo » 6 months ago

PET (Positron imaging technology) is a imaging method able to show the molecular structure of a lesion.

Several radioligands, compounds that work as...

0 Replies

610 Views

Last post by frodo
6 months ago

New Topic

202 topics

Return to Board Index

Forum permissions

You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum