A forum to discuss research on the origins of MS and its development.
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Adolescent infection increases MS risk
by
NHE » Thu Apr 08, 2021 3:01 am
Hospital-diagnosed infections before age 20 and risk of a subsequent multiple sclerosis diagnosis
Brain. 2021 Mar 9;awab100.
The involvement of...
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- 79 Views
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Last post by NHE
Thu Apr 08, 2021 3:01 am
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- 2 Replies
- 766 Views
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Last post by DIM
Thu Apr 01, 2021 10:18 am
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QSM-MRI can show brain inflammation.
by
frodo » Tue Mar 16, 2021 10:55 am
QSM-MRI can show brain inflammation. Currently there is none.
QSM is an imaging biomarker for chronic glial activation inmultiple sclerosis lesions...
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- 148 Views
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Last post by frodo
Tue Mar 16, 2021 10:55 am
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MS transcriptome analysis
Replies: 1
by
jimmylegs » Fri Mar 12, 2021 8:59 am
First post
things about which i know nothing:
Whole transcriptome analysis of multiple Sclerosis patients reveals active inflammatory profile in relapsing...
Last post
looks like they are trying to separate RRMS from SPMS
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- 162 Views
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Last post by frodo
Tue Mar 16, 2021 10:47 am
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Microglia in the pathogenesis of MS
Replies: 21
by
frodo » Mon Jul 23, 2018 11:13 am
First post
Microglia in the pathogenesis of MS
We postulate that the immune reaction initiates in the CNS and immune cells (including T cells/B cell)...
Last post
2021 Feb 23
Neuroscience Institute and Department of Neuroscience and Physiology, NYU Grossman School of Medicine, New York, New York, USA
Activated...
- 21 Replies
- 3670 Views
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Last post by Petr75
Tue Mar 09, 2021 8:28 am
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Biomarkers. Extensive review as of 2021
by
frodo » Mon Mar 08, 2021 8:32 pm
Biomarkers in Multiple sclerosis: what place for oxysterols?
The main markers of multiple sclerosis that have been identified are involved in the...
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- 166 Views
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Last post by frodo
Mon Mar 08, 2021 8:32 pm
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MicroRNA in MS and other diseases
by
frodo » Mon Mar 08, 2021 8:17 pm
MiRNA dysregulation multiple sclerosis
MiRNAs dysregulation display strong association with multiple sclerosis (MS). Several MiRNAs were reported to...
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- 159 Views
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Last post by frodo
Mon Mar 08, 2021 8:17 pm
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Teri helps recovering optic nerve
by
frodo » Mon Mar 08, 2021 8:02 pm
Teriflunomide treatment is associated with optic nerve recovery in early multiple sclerosis
Beneficial properties of TRF beyond pure...
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- 155 Views
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Last post by frodo
Mon Mar 08, 2021 8:02 pm
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TNF demyelination considered as MS
by
frodo » Wed Feb 24, 2021 2:05 am
TNF-α blockers-associated multiple sclerosis
Conclusion
Our study confirmed that the exposure to TNFα blockers can be associated to a broad...
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- 208 Views
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Last post by frodo
Wed Feb 24, 2021 2:05 am
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EBV theory of MS. Some diagrams.
Replies: 1
by
frodo » Sat Feb 20, 2021 3:39 am
First post
A new paper about how EBV could lead to MS. I link the main diagram here below.
Epstein–Barr Virus in Multiple Sclerosis: Theory and Emerging...
Last post
Here's the full paper...
Epstein-Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies
Trends Mol Med. 2020 Mar;26(3):296-310....
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- 220 Views
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Last post by NHE
Sat Feb 20, 2021 7:21 am
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Myelin disruption precedes autoimmunity in NAWM
Replies: 1
by
NHE » Wed Feb 10, 2021 2:52 pm
First post
Axon-Myelin Unit Blistering as Early Event in MS Normal Appearing White Matter
Ann Neurol. 2021 Jan 6.
Objective: Multiple sclerosis (MS) is a...
Last post
thanks. interesting.
- 1 Replies
- 284 Views
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Last post by frodo
Sat Feb 20, 2021 3:41 am
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- 187 Views
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Last post by frodo
Mon Feb 08, 2021 11:02 am
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- 191 Views
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Last post by frodo
Mon Feb 08, 2021 10:55 am
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plasmablast: 100% specificity
by
frodo » Mon Feb 08, 2021 10:51 am
Plasmablast ( immature blood cells ) reported to have 36% sensivity and 100% specificity compared to other neurological diseases.
Summary...
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- 154 Views
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Last post by frodo
Mon Feb 08, 2021 10:51 am
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A unified view of multiple sclerosis
by
frodo » Sat Jan 30, 2021 3:48 am
A unified view of multiple sclerosis
Abstract
The clinical course of multiple sclerosis (MS)is highly variable. To establish a standardized...
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- 638 Views
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Last post by frodo
Sat Jan 30, 2021 3:48 am
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- 0 Replies
- 352 Views
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Last post by frodo
Tue Jan 26, 2021 12:56 pm
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- 310 Views
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Last post by frodo
Fri Jan 22, 2021 10:59 pm
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- 0 Replies
- 281 Views
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Last post by frodo
Fri Jan 22, 2021 10:52 pm
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miRNA dysregulation as the source of the disease
Replies: 15
by
frodo » Mon Oct 16, 2017 11:28 pm
First post
Micro-RNA ( miRNA ) has been proposed as a biomarker of axon degeneration, but some authors have proposed that they could be the source of the...
Last post
2021 Jan 16
Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
Identification of...
- 15 Replies
- 2899 Views
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Last post by Petr75
Mon Jan 18, 2021 11:56 pm
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serum biomarkers: Phospholipids
by
frodo » Wed Jan 13, 2021 5:31 am
Serum phospholipidomics reveals altered lipid profile and promising biomarkers in multiple sclerosis
Conclusion
From this study, we can...
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- 274 Views
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Last post by frodo
Wed Jan 13, 2021 5:31 am
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- 296 Views
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Last post by frodo
Tue Jan 12, 2021 10:40 am
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- 272 Views
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Last post by frodo
Tue Jan 12, 2021 9:05 am
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subtyping RRMS
by
frodo » Tue Jan 05, 2021 3:00 pm
Subtyping relapsing–remitting multiple sclerosis using structural MRI
Abstract
Background and purpose
Subtyping relapsing–remitting multiple...
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- 221 Views
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Last post by frodo
Tue Jan 05, 2021 3:00 pm
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Dogs can smell MS
Replies: 3
by
frodo » Wed Dec 04, 2019 12:54 am
First post
These Dogs Know When Their Owners Are About to Have an MS Flare
Health and wellness touch everyone’s life differently. Here are some stories....
Last post
Detecting Multiple Sclerosis via breath analysis using an eNose, a pilot study
Abstract
Objective: In the present study we investigated whether...
- 3 Replies
- 712 Views
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Last post by frodo
Tue Dec 22, 2020 12:27 pm
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Herpes simplex virus
by
Petr75 » Tue Dec 22, 2020 12:07 am
2020 Nov 19
Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
Positive...
- 0 Replies
- 191 Views
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Last post by Petr75
Tue Dec 22, 2020 12:07 am
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MRZ Reaction in PPMS
by
frodo » Tue Dec 01, 2020 5:45 am
Cerebrospinal Fluid Biomarkers in Relation to MRZ Reaction Status in Primary Progressive Multiple Sclerosis
Abstract
The MRZ reaction (MRZR)...
- 0 Replies
- 365 Views
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Last post by frodo
Tue Dec 01, 2020 5:45 am
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- 0 Replies
- 303 Views
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Last post by frodo
Tue Dec 01, 2020 5:37 am
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lipid metabolism and MS
by
frodo » Wed Nov 18, 2020 12:40 am
Serum phospholipidomics reveals altered lipid profile and promising biomarkers in multiple sclerosis
Abstract
Multiple sclerosis is a...
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- 277 Views
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Last post by frodo
Wed Nov 18, 2020 12:40 am
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- 266 Views
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Last post by frodo
Thu Nov 12, 2020 4:04 am
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MBP in saliva as biomarker
by
frodo » Tue Nov 10, 2020 5:13 am
Serum and saliva Myelin basic protein as Multiple sclerosis biomarker
Abstract:
Objective: Multiple sclerosis (MS) is considered as motor and...
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- 237 Views
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Last post by frodo
Tue Nov 10, 2020 5:13 am
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- 262 Views
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Last post by frodo
Fri Nov 06, 2020 5:09 am
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- 238 Views
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Last post by frodo
Fri Nov 06, 2020 2:45 am
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- 248 Views
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Last post by frodo
Tue Nov 03, 2020 6:09 am
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- 258 Views
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Last post by frodo
Tue Nov 03, 2020 6:07 am
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MS biomarker in serum
by
frodo » Tue Nov 03, 2020 6:04 am
Detection of Multiple Sclerosis Biomarkers in Serum by Ganglioside Microarrays and Surface Plasmon Resonance Imaging
Abstract
Multiple...
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- 236 Views
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Last post by frodo
Tue Nov 03, 2020 6:04 am
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Complex genetic signatures
by
Petr75 » Wed Oct 14, 2020 8:35 am
2020 Oct
Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy
Complex genetic signatures in immune...
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- 250 Views
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Last post by Petr75
Wed Oct 14, 2020 8:35 am
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- 0 Replies
- 398 Views
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Last post by frodo
Fri Oct 09, 2020 7:12 am
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specific CSF biomarkers review
by
frodo » Fri Oct 02, 2020 6:11 am
CSF biomarkers in multiple sclerosis: beyond neuroinflammation
making a long story short:
Diagnostic biomarkers: IgG oligoclonal bands, IgG...
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- 305 Views
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Last post by frodo
Fri Oct 02, 2020 6:11 am
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lipids differentiate PPMS and SPMS
by
frodo » Fri Oct 02, 2020 4:47 am
Lipidomic UPLC-MS/MS Profiles of Normal-Appearing White Matter Differentiate Primary and Secondary Progressive Multiple Sclerosis
Abstract...
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- 292 Views
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Last post by frodo
Fri Oct 02, 2020 4:47 am
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OCBs can separate MS from lyme
by
frodo » Thu Oct 01, 2020 6:44 am
Cerebrospinal fluid oligoclonal bands in Neuroborreliosis are specific for Borrelia burgdorferi
Background
Cerebrospinal fluid (CSF)...
- 0 Replies
- 322 Views
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Last post by frodo
Thu Oct 01, 2020 6:44 am
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EBNA1 (EBV protein) reactive to OCBs
by
frodo » Fri Sep 25, 2020 7:21 am
Antibodies from multiple sclerosis brain identified Epstein-Barr virus nuclear antigen 1 & 2 epitopes which are recognized by oligoclonal bands...
- 0 Replies
- 310 Views
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Last post by frodo
Fri Sep 25, 2020 7:21 am
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biomarkers review
by
frodo » Tue Sep 22, 2020 11:21 am
Development of robust targeted proteomics assays for cerebrospinal fluid biomarkers in multiple sclerosis
Background
Verification of...
- 0 Replies
- 302 Views
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Last post by frodo
Tue Sep 22, 2020 11:21 am
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Creatine metabolic alterations in MS
by
frodo » Thu Sep 17, 2020 6:55 am
Creatine and multiple sclerosis
ABSTRACT
Multiple sclerosis (MS) is a complex and debilitating neurodegenerative disease, with unknown...
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- 328 Views
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Last post by frodo
Thu Sep 17, 2020 6:55 am
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Two molecular types of lesions via MRI
by
frodo » Mon Sep 14, 2020 1:34 am
Characterization of multiple sclerosis lesions with distinct clinical correlates through quantitative diffusion MRI
Highlights :
• Macroscopic...
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- 332 Views
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Last post by frodo
Mon Sep 14, 2020 1:34 am
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- 321 Views
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Last post by Petr75
Sat Sep 05, 2020 8:40 pm
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Three different biopsy patterns
by
frodo » Thu Sep 03, 2020 12:31 am
Different pathological processes for acute white matter lesions in multiple sclerosis
Abstract
Introduction :
Multiple sclerosis (MS) has...
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- 284 Views
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Last post by frodo
Thu Sep 03, 2020 12:31 am
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- 0 Replies
- 256 Views
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Last post by frodo
Tue Sep 01, 2020 5:25 am
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Reelin depletion for MS
by
jimmylegs » Sun Aug 30, 2020 10:48 am
Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes
...Our findings suggest Reelin...
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- 257 Views
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Last post by jimmylegs
Sun Aug 30, 2020 10:48 am
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- 0 Replies
- 264 Views
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Last post by frodo
Thu Aug 27, 2020 5:43 am
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NFL shows silent relapses in PPMS cases
by
frodo » Tue Aug 25, 2020 8:51 am
PPMS is supposed to advance in absence of relapses. Anyway, it seems than some silent relapses can be seen via NFL
CSF neurofilament light chain...
- 0 Replies
- 274 Views
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Last post by frodo
Tue Aug 25, 2020 8:51 am
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