Hi Scott, all,
As Joanne Ingwall says:
ATP is the fundamental currency for movement: contraction, ion movement and synthesis. The requirement for ATP is absolute; regulation and integration of a myriad of metabolic pathways to supply the ATP is crucial. In disease, there is a molecular reprogramming where fuels available for ATP synthesis change.
https://www.amazon.com/ATP-Heart-Basic- ... 1402070934
The ATP biochemistry is the central theme in both inflammatory and progressive MS. But although SNPs and HERV segments in the epigenetic make-up of our cells play a major role in the mitochondrial failure and the impairment of ATP production, the mechanisms underlying the failure are a bit different. A synopsis on the problem could then flow a bit as follows:
[Title: MS Etiology and Pathogenesis; Arresting Decline, Boosting Recovery
Preface: my own story as an MS patient in crisis; diagnosis IBS, diagnosis MS, diagnosis ccsvi/family lived for generations in the shadow of the heavy metal industry, EBV trail in my family NPC/coronary artery aneurism/mitochondrial energy failure/Hodgkin, MRI results/NMES response spasticity; extensive blood analysis shows only two values out of range: herpes immune complexes, smooth muscle titres; and how it all fits together]
0. Intro, vit D (= cholesterol under the skin + sun exposure) and number of mitochondria per cell [lifestyle relation: low fat diet - low cholesterol, indoor life- low sun exposure, washing vit D under the skin away, migration - darker skin types at more northern lattitudes], identical twins that get separated before adolescence, double peak in graph age of onset two mechanisms, gender bias inflammatory disease, MS patients have an overall reduced cancer risk, MS in primates, low fat [Swank] butyrate and other LMW substances, oxygen tank, air pressure, temperature effects, ccsvi, walk-stop-walk ATP-ion pump, eye nerve degradation no myelin, mitochondrial disorder and (cellular) atrophy, atrophy and acyclovir LDL and Simvastatin [The Lancet March 2014], cortisol cellular feeding metabolic processes and pregnancy
http://www.thisisms.com/forum/general-d ... ml#p247214 , fish consumption and anti-sense RNA,
1. double-stranded DNA herpes virus and immunity, SNPs and double stranded DNA viral recognition, immune sysem never got rid off herpes completely, herpes even in fish, EBV more recent, herpes surpressed under secondary immunity but bad diet/lifestyle weakens immunity
2. nasopharynx, ccsvi, hypoperfusion, low immunity, CNS meningal layer, viral spread, viral tolerance, microbleeds breach BBB, EBV spread
3. VZV T-cells immune evasion, immune deficiency, MAVS deficiency, mitochondrial failure,
ATP depletion, acute relapse, SNPs in X-chromosome and gender bias
4. methylation, citrullination, myeline basic protein, death of the brain cells that produce myelin, triggering a subsequent immune system mop-up operation to clean up the cells and the myelin, demyelination
https://www.sciencedaily.com/releases/2 ... 075914.htm
5a. interaction between various immune T/B cells including regulatory cells, EBV and other herpes virinae and the fat metabolism; EBV B cells not cleaned up; immortalised EBV B cells; transition from the inflammatory to the progressive phase
5b. EBV B-cells, interaction with Peyer's Patches, IgA Deficiency; leaky gut; LMW substances; HERV expression; autoimmunity
5c. micro-biome, SNPs shown association with microbiome configuration and susceptibility to several diseases including MS and other auto inflammatory disorders, LMW substances such as butyrate, LDL, HERV expression, SNPs in HERV loci,
6. EBV B-cells, superoxide, ADMA, iNOS, peroxynitrite, ischemic conditions, biochemistry, mitochondria slow down,
ATP production down, slow progression, 6a. above age 60 B-cells production down, PP start to work better, gut microbiota improves, HERV expression down + B cell oxidate stress down, stabilisation
7. ion pump lacks ATP, nerve connectivity down, inhibited tendon reflex, anti-oxidant depletion, lacks ATP to break bonds muscle cells, ATP muscle spasticity
8. therapeutic options: anti-HIV HAART experiences; Borody's experience with gut microbiota transplantation, experiences with ccsvi liberation, experiences with chemo cyclophosphamide, cyclophosphamide, mitoxantrone, HSCT, others
8a. arresting decline; anti viral; anti-HERV; probiotics for micro-biome; anti EBV B-cells;
8b. boosting recovery; detoxification, anti-oxidant supplementation
9. next steps, action plan
I am sure that once we have got this high-level assessment right, the detail could and would be filled in by an army of professionals rather quickly. The challenge is to get
the big picture right.
We are close but I need the reflection power of a group of professionals. I wish medical professionals would jump on this train and help me out with the preparation.
Regards,