Bacterium Clostridium perfringens may be MS trigger

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slghmevp
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Bacterium Clostridium perfringens may be MS trigger

Post by slghmevp » Fri Oct 18, 2013 12:29 am

We have isolated Clostridium perfringens type B, an epsilon toxin-secreting bacillus, from a young woman at clinical presentation of Multiple Sclerosis (MS) with actively enhancing lesions on brain MRI. This finding represents the first time that C. perfringens type B has been detected in a human. Epsilon toxin’s tropism for the blood-brain barrier (BBB) and binding to oligodendrocytes/myelin makes it a provocative candidate for nascent lesion formation in MS. We examined a well-characterized population of MS patients and healthy controls for carriage of C. perfringens toxinotypes in the gastrointestinal tract. The human commensal Clostridium perfringens type A was present in approximately 50% of healthy human controls compared to only 23% in MS patients. We examined sera and CSF obtained from two tissue banks and found that immunoreactivity to ETX is 10 times more prevalent in people with MS than in healthy controls, indicating prior exposure to ETX in the MS population. C. perfringens epsilon toxin fits mechanistically with nascent MS lesion formation since these lesions are characterized by BBB permeability and oligodendrocyte cell death in the absence of an adaptive immune infiltrate.
http://www.plosone.org/article/info%3Ad ... ne.0076359

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cervocuit
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Re: Bacterium Clostridium perfringens may be MS trigger

Post by cervocuit » Fri Oct 18, 2013 12:55 am

Have they found the occult GI phatogen driving MS symptomes that Thomas Borody was talking about ?

From the abstract of MSRC
http://www.ms-uk.org/MSnews
...
"But one of my favorite approaches is development of a probiotic cocktail that delivers bacteria that compete with, and destroy, C. perfringens types B and D," Vartanian says. "It would be such a beautiful and natural way to treat the gastrointestinal system and solve the problem. We are also starting to work on this approach."
The ultimate probiotic cocktail already exist inside healthy persons and can be easily transplanted.
http://www.thisisms.com/forum/general-d ... 20297.html

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Re: Bacterium Clostridium perfringens may be MS trigger

Post by Leonard » Fri Oct 18, 2013 2:09 am

here is another article http://weill.cornell.edu/news/releases/ ... 6_13.shtml

fascinating...

noted the 33 kD protoxin; perhaps this is the mysterious 36,000 Dalton toxic protein in Gay's paper...

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cervocuit
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Re: Bacterium Clostridium perfringens may be MS trigger

Post by cervocuit » Sat Sep 20, 2014 3:25 am

This research has been presented at ECTRIMS 2014.
http://www.opus3.com/MSBoston_PressKit/ ... ournal.pdf
p369

Also, in my quest of convincing myself to completely stop coffee, I found this:

http://www.ncbi.nlm.nih.gov/pubmed/6271685
Stimulation of Clostridium perfringens enterotoxin formation by caffeine and theobromine.
Abstract: In the presence of 100 micrograms of caffeine per ml or 200 micrograms of theobromine per ml, sporulation of Clostridium perfringens NCTC 8679 rose from less than 1 to 80 or 85%. Enterotoxin concentration increased from undetectable levels to 450 micrograms/mg of cell extract protein….

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cervocuit
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Re: Bacterium Clostridium perfringens may be MS trigger

Post by cervocuit » Sun Sep 04, 2016 10:04 pm

Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens.
http://www.ncbi.nlm.nih.gov/pubmed/27398819

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Re: Bacterium Clostridium perfringens may be MS trigger

Post by NHE » Mon Sep 05, 2016 1:28 am

cervocuit wrote:Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens.
http://www.ncbi.nlm.nih.gov/pubmed/27398819
The full version is available at http://onlinelibrary.wiley.com/doi/10.1 ... .24718/pdf

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Re: Bacterium Clostridium perfringens may be MS trigger

Post by mrtmeo » Sun Sep 11, 2016 8:35 pm

Clostridium perfringens is easy killed off with iodine.
https://www.akademie-zwm.ch/uploads/med ... /18768.pdf
Mother was on Rituximab and prednisone for Microscopic Polyangiitis which attacked the kidneys and lungs.
Drs denied her dialysis and appropriate treatment for her MPA and forced her into hospice.
She is in heaven and free from pain.

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Re: Bacterium Clostridium perfringens may be MS trigger

Post by cervocuit » Tue Apr 24, 2018 12:51 am


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Re: Bacterium Clostridium perfringens may be MS trigger

Post by NHE » Tue Apr 24, 2018 4:04 am

This bacterium is considerably more common than the above article suggests.

https://www.foodsafety.gov/poisoning/ca ... index.html
Clostridium perfringens (C. perfringens) is one of the most common causes of food poisoning in the United States. According to some estimates, this type of bacteria causes nearly a million illnesses each year.

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cervocuit
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Re: Bacterium Clostridium perfringens may be MS trigger

Post by cervocuit » Tue Apr 24, 2018 4:57 am

The bacteria is common but the problem is supposed to be the toxin created by this bacteria.

They found 43% of MS patients were carrying antibodies to epsilon toxin VS 16% for controls

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Re: Bacterium Clostridium perfringens may be MS trigger

Post by cervocuit » Thu Mar 07, 2019 2:46 am

New study
Presented at ACTRIMS 2019
https://actrims.confex.com/actrims/2019 ... Paper/3996
- 21% of MS patients have presence of ETX producing bacteria, 0% in healthy controls.
- MS patients have more ETX in their blood.
- ETX administration in mice resulted in disease activity similar to MS (BBB permeability and focal demyelinisation).
“for our model of ETX-induced MS, we propose that ETX-producing bacteria colonize the human gastrointestinal tract, resulting in periodical blooms of exponential growth, leading to secretion of the toxin,"
https://multiplesclerosisnewstoday.com/ ... e-rodents/

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Re: Bacterium Clostridium perfringens may be MS trigger

Post by frodo » Tue Mar 12, 2019 7:12 am

cervocuit wrote:
Tue Apr 24, 2018 12:51 am
new study:
https://www.telegraph.co.uk/science/201 ... -suggests/
It seems that the original paper that opens this thread refers only to pattern III MS (balo-like lesions). They call it "nascent lesion formation" because back in 2013 some authors though that it was a pattern that could turn into anyone of the others. It does not apply anymore.

Quote from the paper: "... C. perfringens epsilon toxin fits mechanistically with nascent MS lesion formation since these lesions are characterized by BBB permeability and oligodendrocyte cell death in the absence of an adaptive immune infiltrate".

Anyway the possibility of this bacteria to be the culprit in that 23% of cases (which is close to the pattern III reported prevalence) is still possible.

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