Positive results - chronic toxicity study of ATL1102 in MS

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MSUK
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Positive results - chronic toxicity study of ATL1102 in MS

Post by MSUK » Wed Apr 02, 2014 3:22 am

Antisense Therapeutics Limited is pleased to advise that results from a chronic toxicity study in monkeys indicate that ATL1102, an antisense oligonucleotide currently under development for the treatment of multiple sclerosis (MS), was well-tolerated when given subcutaneously for a 6-month dosing period at the 2 dose levels tested (1.5 and 3mg/kg/dose)..... Read More - http://www.ms-uk.org/ATL1102
MS-UK - http://www.ms-uk.org/

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eric593
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Re: Positive results - chronic toxicity study of ATL1102 in

Post by eric593 » Wed Apr 02, 2014 6:01 pm

Is it China that is using monkeys in this study? I didn't think anyone used monkeys anymore in labs, I thought it was no longer permitted.

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CureOrBust
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Re: Positive results - chronic toxicity study of ATL1102 in

Post by CureOrBust » Thu Apr 03, 2014 2:14 am

Tread carefully on following this one. Implication to working in a similar way to natalizumab
VLA-4 blockade, as shown by monoclonal antibodies such as natalizumab, prevents activated lymphocytes from migrating into the CNS and significantly reduces disease activity in MS.
http://www.drugs.com/clinical_trials/at ... -5608.html

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