NZ ms study
Posted: Thu Aug 14, 2014 3:36 pm
Some positive news from my neck of the woods. (New Zealand)
http://tvnz.co.nz/national-news/anti-ps ... dy-6057457
http://tvnz.co.nz/national-news/anti-ps ... dy-6057457
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Just when you think the researchers had reached the end of trying different kinds of heavy duty immune suppressive drugs they now are using anti-psychotic drugs for MS!! Hmmm....TonyNZ wrote:Some positive news from my neck of the woods. (New Zealand)
http://tvnz.co.nz/national-news/anti-ps ... dy-6057457
Hi Kronk,Kronk wrote:I have been following this for several months and I wouldn't be too quick to write it off... I agree that the immune suppression treats a symptom not the illness, like taking tylenol to reduce fever when you have the flu. Anti-depressants work by adjusting or blocking receptors for dopamine and serotonin in the brain. By taking small amounts of them it may in fact cause a rebound effect like that seen in LDN. Where a flood of receptors are created causing an overall increase. Two common symptoms of MS are Fatigue and Depression. Both tied to serotonin and dopamine levels, which are just neurotransmitters...
Whether it brings us closer to a cure or not who knows but another effective treatment with low side effects I am all for.
http://www.sciencedirect.com/science/ar ... 0X00004111
Very true... I guess they got frustrated by not being able to hit the target so they started carpet bombing. I am happy to see they are moving away from immune suppression and into alternative theories.HarryZ wrote: MS patients, over the years, have been sort of a "dumping ground" for drugs that are/were used for other diseases such as cancer.
Yes, the alternative venue has been gaining far more attention as it should. But the old boys club of immune system altering drugs do whatever they can to discredit the alternative work since it can threaten their cash cow drugs which makes them billions of dollars!Very true... I guess they got frustrated by not being able to hit the target so they started carpet bombing. I am happy to see they are moving away from immune suppression and into alternative theories.
http://ww.ncbi.nlm.nih.gov/pubmed/24711809
You appear to be saying this as a "bad thing" If only they had started with this years ago, who knows what they may of accidentally hit by now. its not like mice are an endangered species Actually, maybe these tests would of shown how bad the current MS mouse models are.HarryZ wrote:MS patients, over the years, have been sort of a "dumping ground" for drugs that are/were used for other diseases such as cancer.
Well, I'm not sure if one can categorize this as being good or bad. If it had lead to far better treatments for MS patients then it would have been good but these drugs had outlived their use in cancer treatments and the drug company decided "let's try them out on MS patients". The premise was based on the theory that MS was an autoimmune disease (never been proven) and that these drugs altered the immune system so give it a shot. In most cases they didn't have that much of an effect on the MS in the long run.CureOrBust wrote:You appear to be saying this as a "bad thing" If only they had started with this years ago, who knows what they may of accidentally hit by now. its not like mice are an endangered species Actually, maybe these tests would of shown how bad the current MS mouse models are.HarryZ wrote:MS patients, over the years, have been sort of a "dumping ground" for drugs that are/were used for other diseases such as cancer.
WOW... Tavist, which also is sold generically as clemastine fumarate. Again we see Fumarate or fumaric acid. It is the active ingredient in Tecifidera and is an intermediate in the citric acid cycle used by cells to produce ATP and the molecular building blocks for everything else in your body. The body naturally makes Fumaric Acid but it must have vitamin D.TonyNZ wrote:I am quite excited about the following link:
http://www.bizjournals.com/sanfrancisco ... l?page=all
For a while now, I have noticed that whenever I get a cold or flu and take med-lemon (lemsip in some countries) a soluble, cheap anti-flu medicine available in most supermarkets or 7/11 stores, I notice an improvement in some of my ms symptoms. I had mentioned this to my GP a while ago and received a knowing look in return, but this link is validation of my pet theory - that we will find solutions to ms from existent medicine.
Tecfidera is dimethylfumarate and the active metabolite is monomethylfumarate. These are both esters. However, regular fumarate is the salt of the carboxylic acid (a carboxylate) which is not an ester. The name fumarate can be confusing since both esters and carboxylates are both given the suffix -ate. See the following post for the difference in the molecular structures.Kronk wrote:WOW... Tavist, which also is sold generically as clemastine fumarate. Again we see Fumarate or fumaric acid. It is the active ingredient in Tecfidera and is an intermediate in the citric acid cycle used by cells to produce ATP and the molecular building blocks for everything else in your body. The body naturally makes Fumaric Acid but it must have vitamin D.