BREAKTHROUGH HOPE FOR MS TREATMENT AS SCIENTISTS DISCOVERS

[seeva]

http://www.dailymail.co.uk/health/artic ... eases.html
TEAM OF BRISTOL UNIVERSITY HAVE DESCRIBED THIER WORK AS AN BREAKTHROUGH CONDITIONS WHICH COULD BENEFIT INCLUDING MS AND TYPE1 DIABETES READ MORE FROM ATTACHED
REGARDS
seeva

[gibbledygook]

Isn't this like Tovaxin?

[cheerleader]

Hey Gibs--
how's it going? Hope you and the family are well!!!

I wrote up a blog post on this "new breakthrough" which looks a lot like Copaxone, and was tested on mice with EAE---not humans with MS.

In reading the paper, we learn that this new "breakthrough" is remarkebly reminiscent of Copaxone treatment, in which killer T cells are said to be modulated to helpful T cells by means of exposing them to an antigen (in Copaxone's case, that's a mimic of the proteins found in myelin basic protein---glatiramer acetate.) This particular "new breakthrough hope" therapy is going after CD4+ T cells, using injected peptide epitopes, rather than intact antigens--which are said to be "more effective."

The whole paper is available in Nature-- a bit less WOW! than the press releases--
http://www.nature.com/ncomms/2014/14090 ... s5741.html

CD4+ t cells (the target) are also found to be inflammatory in stroke and reperfusion injury. They are certainly not unique to MS----and they are not always related to "autoimmune" disease. They are activated in reperfusion, hypoperfusion, and ischemic situations...which always makes me wonder why the immunologists don't work with vascular researchers. But those silos are pretty far apart.
http://ccsviinms.blogspot.com/2014/09/m ... witch.html

hope this all helps explain it--
Hyperbole, once again.
cheer

[gibbledygook]

Hi Cheereo! I am BUSY with kids and life in general but am always logging into Pubmed to see updates these days as somehow this site is quite unwieldy. I also spend time on the Bart's Hospital webblog run by Dr Giovannoni, a great neurologist in London. He's running the raltegravir trial which I am following closely. The retroviral theory is quite attractive. Unfortunately I had a very bad response to my 3rd venoplasty so have had to fold on that one! I use a plastic caliper to walk these days and motor dysfunction has started to emerge in my other leg. So things MS wise are not good but family life keeps my mind off things.

I hope Jeff is still doing well.

Alex