Could Multiple Sclerosis begin in the gut?

[MSUK]

MS researchers are focusing on the content of the gut’s microbiome as a possible contributor to the body’s autoimmune attack on its nervous system.

Multiple sclerosis (MS) is an electrical disorder, or rather one of impaired myelin, a fatty, insulating substance that better allows electric current to bolt down our neurons and release the neurotransmitters that help run our bodies and brains. Researchers have speculated for some time that the myelin degradation seen in MS is due, at least in part, to autoimmune activity against the nervous system. Recent work presented at the MS Boston 2014 Meeting suggests that this aberrant immune response begins in the gut..... Read More - http://www.ms-uk.org/msetiology

[cheerleader]

This immune response happens whenever the endothelial layer of cells becomes permeable and things that are supposed to stay inside blood vessels and out of tissue gain access to tissue. It is not an "autoimmune" attack---the immune system is doing its job--going after foreign invaders that get past the endothelial layer. This same thing happens in the brain when the blood brain barrier is breached in stroke--and no one calls immune activity after stroke "autoimmune."

For instance, lymphocytes from stroke survivors show more activity against myelin than the lymphocytes from patients with multiple sclerosis. In addition, myelin-reactive T cells are found in higher numbers among patients with cerebrovascular disease. These data thus provide evidence that a cellular immune response to brain antigens occurs following stroke.

http://stroke.ahajournals.org/content/4 ... 1/S75.full

And it happens in the gut with intestinal permeability. Endothelial dysfunction can be systemic---in the gut, torso, brain. Plasmic particles are not supposed to have access to tissue. When they do, the immune system goes to work.

Dr. Alessio Fasano of Un. of Maryland has been looking at this connection for over decade, in regards to the protein zonulin as one of the gatekeepers of the endothelium. Other issues that allow for endothelial permeability are bacteria, slowed blood flow, lack of shear stress and hypercoagulation.
http://ccsviinms.blogspot.com/2011/05/z ... brain.html

The Endothelial Health Program was created to strengthen the endothelial layer of cells which line the 60,000 miles of our blood vessels. We want to keep plasmic particles out of tissue---in our brains, gut, organs, limbs, so that the immune system reaction backs down. http://ccsvi.org/index.php/helping-myse ... ial-health

HTH,
cheer

[Leonard]

I think it works a bit different, see also my other thread on a new concept and treatment options for MS.

The immune system runs down for a variety of reasons. The health of the gut microbiome certainly reflects immune system health.

When the immune system runs down, the herpes family of viruses resurfaces. It is never away, it is latent and kept under control by a healthy immune system. When the herpes virus resurfaces, the immune system "gets occupied" with the virus, produces relentlessly non-working immune complexes, and "forgets" about fungi and bacteria which get their chance.

The virus is with us for a lomg time, in our own life and in human beings. In periods of immune deficiency, it anchors its genetic material in permissible cells, including for instance OPCs.

If later on the virus resurfaces, the immune complexes start circulating and cross-react with transgenetic cells that were infected before. This explains auto-immunity and the formation of the typical MS plaques in the brains.

But the virus does other things. The immune complexes through biochemical reaction cause a high level of peroxynitrite. This causes huge oxidative stress, jams the cells and inhibits the ADP to ATP conversion. And poisons fat tissue and causes lesion in the brains. I think it also cause what is called herpetic neuralgia.

MS is thus a convolved issue of connection problems in the brains and connection problems in the periphery with the muscles/nerves.

[kengriff]

Multiple sclerosis is a disease is associated with autoimmunity. Scientists are always eager to know new things about any topic. It is the most remarkable invention that they invent. i want to appreciate them and to say thank to them.