COULD M.S BEGIN IN THE GUT

[seeva]

HI Friends http://www.scientificamerican.com/artic ... n-the-gut/
MS researchers are focusing on the Gut's micro biome as possible contributor to the bodies autoimmune attack on its nervous system Please read more from the attached
regards
seeva

[PointsNorth]

My friend SqueakyCat suggested that we participate as a group in the following trial. I see that it is $99 to participate. A group of 100pwMS would be significant. Medi Crowd Sourcing. A way to circumnavigate Pharma.

Squeaky said to me:
"There is a way to get some quick answers on this. There is an open source project known as the American Gut project. If around 5,000 pwMS were to send in samples and pay the $200 to get them analyzed, we could see fairly quickly if there are common gut microbiomes in pwMS that are different than pw/o MS. All samples are available anonymously to researchers . . .

http://humanfoodproject.com/americangut/

[cervocuit]

There is also another project called µBiome. In addition to $351,193 raised on Indigogo, they recently raised $4.5M from angel investors.
http://www.thisisms.com/forum/general-d ... 21795.html

But I am not sure this is very useful. One scientist participate to both projects, and sent the same sample at the same time. And the results was very different:
http://mrheisenbug.wordpress.com/2014/0 ... ing-to-do/

Also, American gut has published preliminary results, and it doesn’t look very precise:
http://microbio.me/AmericanGut/static/img/mod1_main.pdf

I don’t think this is a way to circumnavigate Pharma. One day or another, those data will be used by Pharma to develop probiotics pills.

They are already interested:
Pfizer jumps on the microbiome bandwagon with expansive Second Genome deal
http://www.fiercebiotech.com/story/pfiz ... 2014-05-02

Previsions by financial experts:
Human Microbiome Market Worth $658 Million by 2023
http://finance.yahoo.com/news/human-mic ... 00313.html

We will have to count on Pharma’s big money.

[kengriff]

i have read from the link you provide here. It tells us that the microorganisms get pleasure from a home and a gradual food supply; scientists fancy the essential help they supply in varied metabolic and organic process functions. Our microbiomes conjointly facilitate calibrate our immune systems, thus our bodies acknowledge that co-inhabitants ought to be there and that shouldn't.

[Kronk]

Very interesting... there is definitely a connection with the gut in my mind. Apparently 60% of pwMS have low stomach acid. 80% of people with Rheumatoid Arthritis have low acid. And many other "auto-immune" disorders have this issue as well.

Low stomach acid is called Hypochlorhydria and the symptoms can include:

Malnutrition ( one study found the majority of pwMS are thinner than controls)
a. amino acid deficiencies due to poor digestion and assimilation of protein. Low grade amino acid deficiencies can be associated with muscle wasting, immuno-deficiency, nervous system dysfunction and reduce liver detoxification.
b. multiple mineral deficiencies particularly of calcium, iron, magnesium and possibly selenium, chromium, manganese, copper and other trace minerals.
Deficiencies of these minerals can further cause ill health and increased risk to degenerative diseases.
c. vitamin B12 deficiency. This is particularly seen in achlorhydric patients where there is no production of intrinsic factor. This is a chemical compound produced by the stomach which tags onto vitamin B12 released from protein in the stomach and carries it down the intestine to allow B12 to be absorbed in the lower part of the small intestine.

Food Intolerances (allergies is a suspect in MS)
When protein is poorly digested, partially digested fragments can gain access to the body and initiate an activation of the immune system causing conditions associated with food intolerance, e.g. arthritis, rhinitis, asthma, eczema, urticaria (hives) and colitis.

Colon Toxicity (a toxic environment could kill the beneficial bacteria that FMT replaces)
An increased lead of undigested protein fragments can get to the colon and feed a section of the flora there which overgrow, produce poisonous substances (like ammonia and various biogenic aminos) which are toxic to the body if allowed access to the general circulation. This is called putrefaction of the bowel.

I started testing my stomach acid with Betaine HCl with Pepsin. If it shows that I am low Betaine HCl is a very cheap supplement. Also interesting fact is that Betaine HCl is proven to lower the levels of Homocysteine implicated in Alzheimer's and other neurological disorders.