GCMAF, VDRS, viruses, bacteria, nagalase, gut flora etc

[Anonymoose]

Merlyn,

I've been kicking an idea around but can't act on it now as I can't risk feeling unwell whilst in the midst of new puppydom (10,000 times worse than a baby!! Lol). Anyway, I thought I'd share the idea in case you wanted to give it a shot.

I've read people are cautioned against taking vitamin d when taking gcmaf because calcitriol can get too high. Both times I took valtrex (before and after rituxan), whenever I took vitamin d or exposed myself to significant time in the sun, I would experience severe pain and my calcitriol would get too high. More details can be found in a thread titled something like "jimmylegs too much vitamin d = ouch?" Maybe the valtrex cut down on Nagalase production by some virus and allowed for my immune system to properly respond to an infection causing high calcitriol and herx pain? Once I'm out of puppy heck (when...oh when?!!), I think I'm going to try valtrex again, testing Nagalase before and during valtrex and experiment with micro doses of vitamin d. Several people have reported they can't take valtrex because it makes them worse. Maybe they are taking vitamin d too? Scott1 took valtrex for years but never took vitamin d (I'm pretty sure he told me that anyway). I don't know...it just seems like there's something worth investigating there.

Just an idea for you to consider since gcmaf seems hard to come by these days.

Be well.

[Merlyn]

I just got the results of my vitamin D test back and I'm in shock. It came in a 93 and I have not been taking any supplements. I have been sitting in the sun, occasionally, but I am not that tanned or dark. The last time I tested years ago, it was 25, but I may not have been using enough thyroid, and thyroid hormone is intimately involved in the vitamin D regulation and utilization…

I put this on my other forum, supposedly, and I find this hard to believe is that spray dried plasma is sterile? Anyway, these products seem to be safe… My feeling is if you eat say 100 g of immunoglobulins (and you can find this amount in colostrum replacers), then surely among that profile of immunoglobulins, there should be some GC globulin? But I am not a biochemist, and my doctor could not answer this question. Nor could she answer whether any vitamin D binding protein in your bloodstream would already be occupied by vitamin D3 on the receptors of this carrier protein…

I gather that if the colostrum is collected within the first four hours of a calf being born, there are no bovine markers are proteins in the fluid. Any first 4 hour colostrum of any species can be used by any other species… I was not breast-fed, am lactose intolerant, which I understand is due to the small intestine, not producing the enzyme lactase, but that's generally because of bad gut bacteria, a lack of acidophilus. I am seriously looking at the last product, because the testimonials are quite astounding…




Okay, I am getting a tad obsessed with what started out to be research into the vitamin D binding protein a.k.a. GC globulin… But me being me, I had to ask why there is no vitamin D binding protein in supplemental form as they have known about its existence like forever… So then I started to wonder whether there was a food source of this particular GC globulin. This binding protein is made in the liver, but it is carried in the blood stream/plasma.

So then, my question was can we eat the immune system of a cow… I am just at the beginning of a new investigation, but I find it interesting that you can consume immunoglobulins of another species and not have allergic reactions. If you do not have the pathogenic infection that any particular immunoglobulin would go after, then it's neutral… What I'm finding interesting about some of these products, is how complete they must be, containing enzymes, all amino acids, transfer factors, etc.… I mean, immune boosters. I ordered the iherb product just to see how I react. ut, the last time I tested, my uric acid level was below normal reference range, which indicates very, very poor protein digestion. This is a whole new subject for me, but I like the thought of boosting my immunoglobulin profile…

http://www.amazon.com/Extreme-Immunity- ... R93%2C160_



http://ca.iherb.com/Vibrant-Health-Immu ... blets/4746



http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355420/

Go to:
Review
Immunoglobulin survival through the gastrointestinal tract: clinical data
Numerous studies have been performed demonstrating that Ig preparations derived from human sera as well as bovine colostrum and sera survive past the stomach, throughout the GI tract, and are present in fecal matter. These studies are summarized in Table 1. IgG was the predominant Ig in these preparations, but often either IgA and/or IgM was present in smaller amounts
http://www.oramune.com/custom.aspx?id=15

Don't Want to Overwhelm You, but it does get interesting…

[Merlyn]

I really have to wonder whether this is the GC immunoglobulin a.k.a. vitamin D binding protein…


Product Description


Extreme Immunity contains a protein that is the fundamental basis of your entire immune system. This breakthrough supplement has been engineered in the United States to deliver the most concentrated and consistent immune system support available. It contains precise components of your immune system, thus giving you an immediate and highly effective immune response.




Well, I discovered this stuff, which is prescription and incredibly expensive. On the IBS/Crohn's forums, they say that the product ImmunoLin was very good and far more affordable because the prescription food is costing $375 a month! I am very interested in trying this because I believe the hype from my problems resulted from being on antibiotics for the years that I was and that it screwed up my digestion, big time…


http://www.amazon.com/Extreme-Immunity- ... B0010ZJTM4

http://www.drugs.com/enteragam.html

[Merlyn]

http://www.drugs.com/ppa/immune-globulin-iv-igiv.html

I seem to remember when this was a popular but very expensive treatment… But it seems that IgG immunoglobulins survive digestion very well…

http://www.enterahealth.com/news/digest ... stribution
I have ordered this:

http://extremeimmunity.com/

[Scott1]

Hi,

I've just been looking through this post.

Uric acid is the final stage of the metabolism of purines not proteins. It travels through the blood and is finally excreted by the kidneys. Hence a blood test gives you the reading. If you are below the normal range for Uric acid it would suggest you probably have a problem in the ADP/ATP cycle in the mitochondria.
When ATP is made in the mitochondria it travels through the mitochondrial membrane by use of carnitine and then travels to the cell wall when it donates a phosphate molecule to open the sodium/potassium pump. The ATP then becomes ADP and needs to return to the mitochondria to restore to ATP. This also requires carnitine to again cross the mitochondrial membrane. If it cannot re-enter the mitochondria the cell will combine two ADP to make one ATP and one AMP. The AMP is useless so it washes out of the cell. The ATP is then spent to become ADP and the cycle repeats. Over time the adenosine (the 'A') level falls. This is a purine and needs to be maintained.
The cell looses viability when the ATP falls too much. It becomes sodium logged. The excessive level of sodium will trigger calcium to be released into the cell from the sarcoplasmic reticulum. It is this flood of calcium that signals the strands of protein in muscles to adhere to each other to contract. The signal to relax the contraction is driven by ATP. If it is in short supply then muscles will contract and be unable to relax. The sodium/potassium pump will operate sub-optimally and fatigue will arise.
This is why I use Q10 and acetyl-l-carnitine as both are integral to the proper functioning of the cell.
It will also suggest, at least to me, that you have a problem with peroxynitrite. The requires you address the excessive production of superoxide and predominance of iNOS over eNOS. (now I'm rambling so I'll shut)

Regards

[Merlyn]

http://www.jacionline.org/article/S0091-6749(13%2901966-0/fulltext

under MS, it mentions re-myelination!

[Merlyn]

https://iontheworld.wordpress.com/2008/ ... -and-diet/

I don't know, I think, high-protein diets, purines or not, are still involved in the creation of uric acid. My ND, said in her experience, the low uric acid levels like mine that are below reference range indicate malabsorption. My M.D. says it's an indication of poor protein digestion… I am a blood type A– and as I understand things, we are notorious for not producing much stomach acid… I do know that this Extreme Immunity product will be interesting to try…

http://www.oramune.com/ProductInfo.aspx ... NFECTIVADE

I was on multiple, multiple courses of antibiotics and when I did a test called Digestive Stool Analysis. It showed that I had 0/nada good bacteria in my gut…

[Merlyn]

http://www.drpincott.com/pdf/RMA%20Blood.pdf

. This also says it is poor protein utilization

[Scott1]

Hi,

Uric acid and Urea are often confused. We are mammals. Birds are different and they do what that article suggests.

Many doctors get this wrong. This might help.

http://renaldisorders.blogspot.com.au/2 ... ls-of.html

Regards

[Merlyn]

http://extremeimmunity.com/



I would assume that the bovine serum globulins would contain at least the precursor globulin to GcMAF. The precursor globulin is called DG3.
Looks like DG3 is also good for getting rid of cancer according to this abstract.

Background: Group-specific component (Gc)-globulin-derived macrophage-activating factor (GcMAF) generated by a cascade of catalytic reactions with deglycosidase enzymes exerts antitumor activity. We hypothesized that degalactosyl Gc-globulin (DG3), a precursor of GcMAF, also plays a role in recovery from cancer as well as GcMAF due to progression of deglycosylation by generally resident sialidases and mannosidases. Materials and Methods: We prepared the subtypes of DG3, such as 1f1f and 1s1s and its 22 homodimers, by using vitamin D3-binding Sepharose CL-6B and examined their antitumor activity in mice bearing Lewis lung carcinoma cells, by counting the number of nodules formed in their lungs. Results: Antitumor activity of DG3 was observed regardless of its subtype, being equivalent to that of GcMAF. The injection route of DG3 affected its antitumor activity, with subcutaneous and intramuscular administration being more favorable than the intraperitoneal or intravenous route. In order to obtain significant antitumor activity, more than 160 ng/kg of DG3 were required.
Conclusion: DG3 proved to be promising as an antitumor agent, similarly to GcMAF.

[Merlyn]

Scott1: I read the article about uric acid/urea, and I have a creatinine clearance that is bordering on below reference range… Such low numbers do indicate kidney problems, although my hematologist thought they were great numbers… There is a little glitch in my system in that I have 3 kidneys… A duplex system on my right side and I have kidney stones…

Thanks for the link…

[Merlyn]

http://extremeimmunity.com/testimonials/

as luck would have it, my ND from Seattle came to visit me and brought with her a 300 g package of Extreme Immunity. I took 2.5 g this morning, the taste is not that bad when mixed with almond milk… Now I seem to be one of those people with primary progressive MS that never gets sick… I don't catch flu/colds/viruses…

[leonardo]

not sure if this has already been posted:

Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters.

Abstract
The pathogenesis of multiple sclerosis (MS), an autoimmune disease affecting the brain and spinal cord, remains poorly understood. Patients with MS typically present with recurrent episodes of neurological dysfunctions such as blindness, paresis, and sensory disturbances. Studies on experimental autoimmune encephalomyelitis (EAE) animal models have led to a number of testable hypotheses including a hypothetical role of altered gut microbiota in the development of MS. To investigate whether gut microbiota in patients with MS is altered, we compared the gut microbiota of 20 Japanese patients with relapsing-remitting (RR) MS (MS20) with that of 40 healthy Japanese subjects (HC40) and an additional 18 healthy subjects (HC18). All the HC18 subjects repeatedly provided fecal samples over the course of months (158 samples in total). Analysis of the bacterial 16S ribosomal RNA (rRNA) gene by using a high-throughput culture-independent pyrosequencing method provided evidence of a moderate dysbiosis in the structure of gut microbiota in patients with MS. Furthermore, we found 21 species that showed significant differences in relative abundance between the MS20 and HC40 samples. On comparing MS samples to the 158 longitudinal HC18 samples, the differences were found to be reproducibly significant for most of the species. These taxa comprised primarily of clostridial species belonging to Clostridia clusters XIVa and IV and Bacteroidetes. The phylogenetic tree analysis revealed that none of the clostridial species that were significantly reduced in the gut microbiota of patients with MS overlapped with other spore-forming clostridial species capable of inducing colonic regulatory T cells (Treg), which prevent autoimmunity and allergies; this suggests that many of the clostridial species associated with MS might be distinct from those broadly associated with autoimmune conditions. Correcting the dysbiosis and altered gut microbiota might deserve consideration as a potential strategy for the prevention and treatment of MS.

http://www.ncbi.nlm.nih.gov/pubmed/26367776

I wonder how this influneces biotin production and vit. D absorption which we know are not sufficient in MS.

[Merlyn]

Roche drug succeeds in hard-to-treat form of multiple sclerosis
http://www.reuters.com/article/2015/09/ ... KL20150928
Gut Bacteria Role in Multiple Sclerosis Treatment?
http://www.emaxhealth.com/1275/gut-bact ... -treatment

Melatonin Linked to Seasonal Relapses of Multiple Sclerosis
http://www.scientificamerican.com/artic ... sclerosis/

[Merlyn]

>>>
>>> There's a really good book, published in 2013, called "Bugs, Bowels,
and Behavior: the Groundbreaking Story of the Gut-Brain Connection." (Edited by Teri Arranga, Claire I. Viadro, and Lauren
Underwood)
>>>
>>> It goes way beyond gut-neuro stuff -- has 15 chapters, each written
by a different expert. (And it's highly technical.)
>>>
>>>
>>>
>>> In the chapter on biofilm, written by John H. Hicks III, MD, it
says: "Biofilms and certain other intracellular organisms produce compounds that bind and inhibit vitamin D receptor function. As a result, microbial pathogens increase and cause persistent infection and inflammation, with suppression of the needed cell-mediated immune response."
>>>
>>>
>>>
>>> So you may actually be producing/absorbing enough Vit D, but the
bacteria could be preventing it from getting through.