Another clue in understanding multiple sclerosis?

[MSUK]

Scientists at the University of Toronto say they have found another clue in understanding the cause of what drives multiple sclerosis, a disease where the immune system attacks the brain. It has no known cause and no cure...Read more - http://www.ms-uk.org/MSnews

[Leonard]

Scientists at the University of Toronto say they have found another clue in understanding the cause of what drives multiple sclerosis, a disease where the immune system attacks the brain. It has no known cause and no cure...Read more - http://www.ms-uk.org/MSnews

They may be right. I think the viral replication starts in the naso pharynx (due to a weakened immunity that may be caused by CCSVI/hypoperfusion, bad diet, low sunshine/Vit D, other factors) and spills over into the lymphatic system in the neck and into the CNS (meninges and Virchow-Robin perivascular spaces). http://www.unboundmedicine.com/medline/ ... _Sclerosis_


And I am sure that there will be all sort of processes or concepts one may think of including TLTs etc.

[MSbro]

Done on the mouse model of MS....which I've read really isn't human MS at all. So how accurate can this research be other than finding something different in mouse MS?

[Scott1]

Hi.

That might be a bit harsh. The reaction can be observed. Its a pity they defined the lymphatic system that way. Cheerleader did note some Israeli work that found the lymphatic system extended into the brain. That tipped 100 years of thinking on its head so little connections like this can be helpful.

Regards,

[MSbro]

Hi.

That might be a bit harsh. The reaction can be observed. Its a pity they defined the lymphatic system that way. Cheerleader did note some Israeli work that found the lymphatic system extended into the brain. That tipped 100 years of thinking on its head so little connections like this can be helpful.

Regards,

While I haven't been a part of this board for all that long I have spent a fair amount of time reading several threads and whenever I read anything about discoveries involving the MS mouse, I have failed to find anything beneficial to MS patients that has resulted. There appears to have been drugs, treatments etc that have stopped, cured and reversed MS in the mouse but whenever they have tried to apply it to human MS, it's been a lot of failures and dead ends. Maybe one day it may change and that would be great until that happens I won't get too excited about MS mouse discoveries.

[cheerleader]

Just wanted to discuss the actual research linked in the first post. Here's the abstract.
http://www.sciencedirect.com/science/ar ... 1315004628

It's a mouse model, but it is looking at something we know which happens in people with MS. There are "tertiary lymphatic tissues", or TLTs, formed in the meninges of people with MS. This is not normal. New tissue, or a neo-lymphoid organ, is created in the MS brain. It is associated with inflammation. As Scott mentions, this research does tie in to the recent discovery of the lymphatic vessels which connect the brain to the peripheral immune system. http://discovermagazine.com/2016/janfeb ... connection It's not about the nasopharangeal system...it's about the newly discovered meningeal CNS connection thru lymphatic vessels which drain thru the neck.

Normally, immune responses are triggered in lymph nodes and other lymphoid organs to provide protection a virus or pathogen. However, scientists have observed that lymphocytes can sometimes congregate into so-called "tertiary lymphoid tissues (TLTs)" in the brain of MS patients. These structures are similar to lymph nodes, but are found within the brain’s meninges. They often coincide with the appearance of tell-tale brain inflammation associated with progressive MS. But how the TLTs are formed and what keeps them there has been unclear.

The Toronto researchers, led by Jennifer Gommerman, Ph.D., of the department of immunology, discovered that TLTs were created by the presence of stromal cells, specialised cells that produce an intricate network of fibres. They can effectively create a net which, once formed, become a gathering place for T helper 17 cells (Th17).

"While T cells are an important part of the body's ability to ward off infection and disease, in autoimmune disorders, they can mistake healthy tissue for potential threats and respond by lashing out, causing damage. The team observed that this Th17 response resulted in the type of brain tissue inflammation associated with MS," says Dr. Gommerman.

Moreover, Th17 cells could also influence how the stromal cells organised. The resulting structure that developed was remarkably similar to normal lymphatic tissue, such as you might find in your tonsils or lymph nodes in your neck.

According to Dr. Gommerman, this study, which was conducted using animal modeling, doesn't deliver a definitive answer to what causes MS, but it does appear to be a smoking gun associated with MS pathology. With further research, it may point to potential treatment options, such as targeted Th17 blockers.

Here's further commentary on this discovery.

Lymph node development depends on well-orchestrated interactions between lymphoid tissue inducer cells and stromal cells. In this issue of Immunity, Pikor and colleagues (2015) find that signals from IL-17-producing T helper cells can alter the stromal microenvironment of the inflamed brain to generate a neo-lymphoid organ that drives further inflammation.

http://www.sciencedirect.com/science/ar ... 1315004999

Hope that explains it better-and the links are helpful,
cheer

[MSbro]

Cheer,

It looks like a very big longshot trying to tie together all of these little bits of info from the MS mouse research. This kind of investigation can take years of work but then again, after decades and decades of MS research resulting in no cause or cure, what's another 10 years or so! Makes you wonder if other avenues of research other than the drug company immune system altering drug route had more backing and money, we would be much further along as to a cause and possible cure.

[cheerleader]

http://ccsviinms.blogspot.com/2015/06/p ... words.html

the isnvd is looking at this. Kipnis is the keynote speaker in NYC next year.
http://ccsviinms.blogspot.com/2015/12/m ... rward.html
Getting there,
cheer/Joan

[MSbro]

http://ccsviinms.blogspot.com/2015/06/p ... words.html

the isnvd is looking at this. Kipnis is the keynote speaker in NYC next year.
http://ccsviinms.blogspot.com/2015/12/m ... rward.html
Getting there,
cheer/Joan

Thanks for the info, Cheer.

Not very comforting to read that the docs are debating with one another on what is scientifically correct when it comes to brain circulation! Probably some reputations at issue here within the medical community.

[cheerleader]

Not very comforting to read that the docs are debating with one another on what is scientifically correct when it comes to brain circulation! Probably some reputations at issue here within the medical community.

Not much debate in the research world---scientists know that this newly discovered (g)lymphatic clearance pathway via the venous system is vitally important to brain health. And they want to learn more.
http://www.ncbi.nlm.nih.gov/pubmed/?ter ... tic+system
http://www.ncbi.nlm.nih.gov/pubmed/?ter ... tic+system

The debate is a false one, created by MS neuroimmunologists who are kept on the pharma payroll.
From Dollars for Docs--thanks to the Affordable Care Act, we know who is paid what in the US https://projects.propublica.org/docdollars/

Dr. Omar Khan, Wayne State University Dept. of Neurology $377,000
($222,000 for Copaxone!!!! YOWZA!)
Author of some of the most vitriolic, anti-CCSVI research papers ever published.
Dr. Elliot Frohman, Head of MS Center UT Southwestern Medical Center $340,000 ($191,000 from Aubagio alone!)
(Invited to speak at first CCSVI conference, he admitted CCSVI looked a lot like normal pressure hydrocephalus---but later determined CCSVI was not something very valuable to study. Wonder why?)
Dr. Edward Fox, MS specialist, Director of Central Texas MS Clinic $377,000
(on the NMMS research committee---deciding which research gets funded. Really???)
Dr. Patricia Coyle, Stony Brook MS Care Center, NY $245,000 ($104,000 from Aubagio!)
Also an invited guest at the first CCSVI conference in Bologna--decided not to follow up any any more vascular research. How can neurologists make money treating a vascular condition?
Dr. Aaron Miller, head of MS Center at Mount Sinai Hospital, NY $129,000
Dr. Miller also advises the National MS Society on which research projects should be funded.
(He laughed in my face at the AAN Brain Fair---saying that there was no connection between blood flow and MS)

cheer

[ElliotB]

I have been reading a couple of books by Dr. David Perlmutter. He effectively deals with and provides and understanding of the root causes of diseases of inflammation (MS is but one of them), and how to effectively treat them. Many are reporting very favorable results. I strongly recommend his books.