Diet that mimics fasting may reduce MS symptoms

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Diet that mimics fasting may reduce MS symptoms

Post by MSUK » Fri May 27, 2016 5:37 am

Diet that mimics fasting may reduce multiple sclerosis symptoms

New evidence suggests a diet mimicking the effects of fasting has health benefits beyond weight loss, with a USC-led study indicating it may reduce symptoms of multiple sclerosis...Read more - http://www.ms-uk.org/may19
MS-UK - http://www.ms-uk.org/

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Full Text and Summary of USC Study

Post by Quest56 » Sat May 28, 2016 11:45 am

Read the full text and summary here:

http://tinyurl.com/zbuqsku

This info dovetails nicely with ideas from the Wahls/ketogenic diet.

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Re: Diet that mimics fasting may reduce MS symptoms

Post by NHE » Sun May 29, 2016 12:24 am

21 years ago it was published that fasting increases 2-buten-4-olide, a sugar acid, which has anti-inflammatory activity.

2-Buten-4-olide (2-B4O) inhibits experimental allergic encephalomyelitis (EAE) in Lewis rats.
J Autoimmunity 8(5): 727-739.
  • Abstract:
    Starvation is well known to induce immune suppression. Moreover, the concentration of 2-B4O, an endogenous sugar acid, is elevated in the circulation during starvation. To determine if these events are related, the influence of 2-B4O on experimental allergic encephalomyelitis (EAE) in Lewis rats, a model of human multiple sclerosis (MS), was studied. EAE, characterized by paralysis of hind legs, was induced by immunization with residues 68 to 84 (MB 68-84) of the guinea pig myelin basic protein (MBP) in complete adjuvant H37Ra. Interestingly, the daily administration of 2-B4O intraperitoneally from the day of MB 68-84 immunization (day 0) to day 20 dramatically suppressed the clinical severity of EAE. The daily administration of 2-B4O intraperitoneally from day 0 to day 7 also markedly reduced the clinical symptoms of EAE. In fact, passively induced EAE, using Con A activated spleen cells from rats immunized with MB 68-84 in H37Ra, was also inhibited by daily administration of 2-B4O. Histological examination confirmed clinical findings and revealed that mononuclear cell infiltration into the central nervous system was significantly inhibited by 2-B4O. To clarify the mechanism(s) responsible for suppression of EAE, the effects of 2-B4O on the immune responses to MB 68-84 were examined. When rats were treated daily with 2-B4O for 15 days after immunization with MB 68-84 in H37Ra, the delayed-type hypersensitivity (DTH) response to MB 68-84 was significantly reduced in 2-B4O treated rats as compared with saline treated rats. The proliferative response to MB 68-84 of spleen cells from 2-B4O treated rats was also significantly lower than that of saline treated rats. Our data demonstrate that 2-B4O has the potential to suppress autoimmune responses in both inductive and effector phases. 2-B4O may have significant potential to treat autoimmune diseases.
2-buten-4-olide has a similar chemical structure to other known Nrf2 activators.

While I have yet to read the above paper on fasting, it may be the case that the fasting diet also raises levels of 2-buten-4-olide and increases Nrf2 activity.

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Re: Diet that mimics fasting may reduce MS symptoms

Post by burg » Sun May 29, 2016 3:09 pm


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Re: Diet that mimics fasting may reduce MS symptoms

Post by CureOrBust » Mon May 30, 2016 4:12 am

Full text available at http://www.cell.com/cell-reports/fulltext/S2211-1247(16%2930576-9 including PDF download. The fasting involves 3 days! Haven't read the full article to see how it actually differs from total fasting (apart from water of course).

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Re: Diet that mimics fasting may reduce MS symptoms

Post by cheerleader » Mon May 30, 2016 8:26 am

Calorie restriction/fasting also increases nitric oxide bioavailability, decreases oxidative stress and heals the endothelium. Important, as the endothelium is the interface between our immune and vascular systems.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894368/
http://circres.ahajournals.org/content/102/5/519.full
http://www.ncbi.nlm.nih.gov/pubmed/20121721
http://www.nature.com/aps/journal/v31/n ... 0146a.html
http://www.ncbi.nlm.nih.gov/pubmed/24065292
http://www.ncbi.nlm.nih.gov/pubmed/23334601

Here's Dr. Longo, creator of the FMD, which is a 4 day low calorie restricted plan (not a true fast) on how this plan affects the vascular and immune system.
https://news.usc.edu/82959/diet-that-mi ... low-aging/

Been helping our family for 8 years now.
http://ccsviinms.blogspot.com/2016/04/t ... years.html
cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com

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Re: Diet that mimics fasting may reduce MS symptoms

Post by NHE » Tue May 31, 2016 2:33 am

This is all great, but with a BMI of about 18.8 I'm already at the bottom of the normal weight range and really don't have much to spare. With a diet mimicking fasting, I might just dry up and get blown away.

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Re: Diet that mimics fasting may reduce MS symptoms

Post by CureOrBust » Tue May 31, 2016 4:56 am

Its not easy to find exactly what is meant by "FMD", and thats because he has patented it (https://www.google.com/patents/US20150004280) and teamed with a third party to market it http://l-nutra.com/prolon.aspx
NHE wrote:This is all great, but with a BMI of about 18.8 I'm already at the bottom of the normal weight range and really don't have much to spare. With a diet mimicking fasting, I might just dry up and get blown away.
No need to worry, you only have to "fast" for five days, and these five days of fast, still include 360 calories (about 1000 kj) I think its based around 1/2 of your standard intake, in a specific breakdown of protein-fat-carbs-nutrients. I found this link of an un-associated guy that has built recipies based on the work

There is also more reading at:
https://thequantifiedbody.net/fast-mimicking-diet/ at this link the guy monitors various effects on his body like weight, % fat, % muscle and various blood work etc etc
http://www.telegraph.co.uk/lifestyle/we ... et....html
My problem is that I just did my shopping and the fruits and veg etc will go off if I wait 5 days for a feast.

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Re: Diet that mimics fasting may reduce MS symptoms

Post by ElliotB » Tue May 31, 2016 8:50 am

Perhaps it makes more sense to fast on a daily basis by eating only two meals a day about 12 hours apart. Dr. Wahls covers this topic in detail in her book. And according to her, "when your body is not digesting, it can focus its energy on healing, eliminating toxins and re-calibrating your biochemistry". This makes sense as food digestion requires a lot of the body's available energy to complete and it does take a while. So once digestion is complete, the body works on repairing itself.

I have been on a 2 meal a day diet for about two years and I agree with this concept.

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Re: Diet that mimics fasting may reduce MS symptoms

Post by CureOrBust » Tue May 31, 2016 5:46 pm

ElliotB wrote:Perhaps it makes more sense to fast on a daily basis by eating only two meals a day about 12 hours apart.
This new work uses scientific methods which have shown that a specific mix of protein-carb-nutrient-fat etc etc results in a specific effect/results. Simple calorie restriction has a different effect which has been studied separately.

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Diet Derived from Longo Research at USC

Post by Quest56 » Wed Jun 01, 2016 5:35 pm

Here's a diet plan that is said to be similar to the FMD diet used in the USC study.

The URL is shortened using tinyUrl.com to make it useable for posting here:

http://tinyurl.com/zcfbw65

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Re: Diet that mimics fasting may reduce MS symptoms

Post by CureOrBust » Wed Jun 01, 2016 11:52 pm

that's the "recipe" link 3 posts above. You will also see that using the "URL" feature within the forum, you are able to shorten unworldly URL's without having to go through all the hassle of using tinyurl.

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Re: Diet that mimics fasting may reduce MS symptoms

Post by zenhead » Sun Jun 05, 2016 10:58 am

i have been using this diet - the so-called "5-2" diet, reducing calories by half two days each week, off and on for weight management. i admit i have not been strict enough to notice any effect. but the idea that it can also reduce inflammation will further encourage me to give it another shot. there's no magic bullet, but the combination of things, like diet, can combine - i hope - to reduce symptoms.
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Re: Diet that mimics fasting may reduce MS symptoms

Post by djurliv » Sun Sep 04, 2016 5:46 am

My wife (age 67, original dx 1995) and I have fasted 48+ hours for perhaps half a dozen times in the past 12 months. During these fasts, her only food is jicama, which she eats to allow her to take the hydrocodone that diminishes pain resulting from falls.

I recorded these observations from a fast earlier this year:
  • -Linda twitches almost every night. This has been the case for years. After the fast, she has not twitched that I observed. Her sleeping was very peaceful. We have seen this result on other fasts.
    -It has been difficult or impossible for years for Linda to raise her left arm above shoulder level. After the fast, she easily lifted her left arm straight over her head.
    -Linda's left leg has been rendered stiff by this affliction. Typically, it cannot be bent without external force; that is, muscles alone are not able to bend it. After the fast, the leg was completely free.
    -Linda often has relatively little energy. After the fast, Linda went grocery shopping and spent a couple of hours cleaning the house.
    -Interestingly, fasts shorter than about 48 hours do not produce these results.
Linda's original diagnosis was 1995. She lost substantial function (eyesight, walking, etc) but regained most of that by 2000. She began to lose function again in 2006, including her ability to walk unassisted, but stopped losing function about 2010-2012. There is no sign of active MS in a recent (July, 2016) MRI according to an interpretation by a radiologist and neurologist. She is currently slowly regaining strength as seen by her improving performance on resistance machines at a gym.

She was treated for CCSVI at Albany in 2010 (no stents). We have used the Wahl's protocol as the basis for most of our diet for the past two years. And, we have been in a Jesus community for the past four years where healing is common.

Our hope now is to regain innervation of leg and ankle muscles....and loss of pain. :smile:

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Re: Diet that mimics fasting may reduce MS symptoms

Post by ElliotB » Mon Sep 05, 2016 3:58 pm

"Fasting forces the body to burn..."

This may be true. Another option... eating the 'right' foods that our bodies were truly designed for. Believe it or not, a diet high in good fats provides weight loss and also contributes significantly to general health, moreso than fasting ever could (IMHO) - I base these comment on my own personal experience (I have not fasted but have been on a high good fat diet for about 2 1/2 years and lost a lot of weight and am in excellent health with no relapses since I started on this diet).

There is a book titled "Eat Fat, Get Thin" by Dr. Mark Hyman that details some of this info (I have not read this book but am familiar as to what it presents and have read other materials similar in content).

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