Tropospheric ozone

[Petr75]

O3
1997 Mar
Department of Environmental Medicine, New York University Medical Center, Tuxedo, USA
Ozone-induced IL-8 expression and transcription factor binding in respiratory epithelial cells
https://pubmed.ncbi.nlm.nih.gov/9124608/

Abstract

Ozone, one of the most reactive oxidant gases to which humans are routinely exposed, induces inflammation in the lower airways. The airway epithelium is one of the first targets that inhaled ozone will encounter, but its role in airway inflammation is not well understood...

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MS
2023 Feb 19
IRCSS Neuromed, Pozzilli, Italy
Genetic regulation of IL-8 influences disease presentation of multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/36803228/

Conclusion: We describe for the first time a role of SNP rs2227306 of IL-8 gene in regulating the expression and the activity of this inflammatory cytokine in MS.

[Petr75]

O3

2023 Feb 16
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, China
Influence of different concentrations of ozone on the alteration of mitochondrial DNA copy numbers in human peripheral blood
https://pubmed.ncbi.nlm.nih.gov/36801339/

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MS

2008 Jul
VA Medical Center, 800 Irving Avenue, Syracuse, NY 13210, USA
Variations in mitochondrial DNA copy numbers in MS brains
https://pubmed.ncbi.nlm.nih.gov/18566918/

[Petr75]

[Petr75]

O3

October 2021
Dow Silicones Belgium SRL, Rue Jules Bordet, Parc Industriel Zone C, Belgium
Effects of ozone on stratum corneum lipid integrity and assembly
https://www.sciencedirect.com/science/a ... 8421000748

Highlights

•Ozone oxidizes unsaturated ceramides and cholesterol.
•Ozone alters ceramides headgroup architecture.
•Ozone exposed lipids form a less ordered lamellar phase.
•The changes in composition and organization alter the membranes barrier properties.
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MS

2023 Feb 12
Department of Neuroscience and Regenerative Medicine, Augusta University, Medical College of Georgia, Augusta, USA; Laboratory of Microbiome Immunobiology, Ludwik Hirszfeld Institute of Immunology & Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
Ceramide is implicated in humoral peripheral and intrathecal autoimmune response in MS patients
https://pubmed.ncbi.nlm.nih.gov/36821978/

Conclusion: Patients with MS have shown altered panels of anti-Cer IgGs in the CSF and serum, which might suggest a relevant, though limited role of Cer as a target for autoimmune humoral response. Utility of antibodies against Cer subspecies as potential markers for MS activity and progression deserves further investigations.

[Petr75]

O3

2016 Jan 7
Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Ozone-induced IL-17A and neutrophilic airway inflammation is orchestrated by the caspase-1-IL-1 cascade
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703985/

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MS

2023 Mar 1
Department of Neurology, University Hospital Bonn, Venusberg Campus, Bonn, Germany
IL-17A Facilitates Entry of Autoreactive T-Cells and Granulocytes into the CNS During EAE
https://pubmed.ncbi.nlm.nih.gov/36857006/

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MS

2020 Jun 26
Neutrophils: Underestimated Players in the Pathogenesis of Multiple Sclerosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349048/

[Petr75]

O3

December, 2022
Thelancet
Global trends in ozone concentration and attributable mortality for urban, peri-urban, and rural areas between 2000 and 2019: a modelling study
https://www.thelancet.com/journals/lanp ... 1/fulltext

...Results
We first compared population-weighted ozone and ozone-attributable mortality in URCAs worldwide between 2000 and 2019. We observed clear increasing trends in population-weighted ozone concentration in all URCAs worldwide (figure 1A; appendix p 5). Compared with all other URCAs, peri-urban areas had the greatest annual increase in population-weighted ozone concentration, which increased at an annual rate of 0·25 ppb (SE 0·03 ppb) from 47 ppb in 2000 to 52 ppb in 2019, and the greatest percent change (11%) in population-weighted ozone from 2000 to 2019 (table 1; appendix p 6). In terms of simple average ozone concentration, only hinterland areas had a decrease over the 20-year period (appendix p 23). The areas with the greatest percent change in simple average ozone concentration compared with all other URCAs from 2000 to 2019 were urban areas (5%) and hinterland areas (–5%).



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MS

2020 Nov 11
Clare Walton, Multiple Sclerosis International Federation, London, UK
Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720355/

...Findings

Highlights from the epidemiology survey are as follows:

The estimated number of people with MS worldwide has increased to 2.8 million in 2020. When applying the same methodology as in 2013, the estimate is 30% higher than in 2013. The 2020 global prevalence is 35.9 [95% CI: 35.87, 35.95] per 100,000 people.
MS prevalence has increased in every world region since 2013 (Table 1). Only 14% (11/81) of countries with data at both time points reported stable or declining prevalence.

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MS

2023 Feb 17
Department of Neurology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Ongoing increase in incidence and prevalence of multiple sclerosis in south-eastern Iran: A three decade study
https://pubmed.ncbi.nlm.nih.gov/36857854/