Tropospheric ozone

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Petr75
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Re: Tropospheric ozone

Post by Petr75 »

Ozone induces BEL7402 cell apoptosis by increasing reactive oxygen species production and activating JNK.
Tang S, Xu B, Li J, Zhong M, Hong Z, Zhao W, Zeng T, He X.
Ann Transl Med. 2021 Aug;9(15):1257. doi: 10.21037/atm-21-3233.
PMID: 34532394 Free PMC article. https://pubmed.ncbi.nlm.nih.gov/34532394/

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Understanding Abnormal c-JNK/p38MAPK Signaling ...
https://link.springer.com › article
autor: A Singh · 2021 — Demyelination, immune dysregulation, and neuroinflammation are the most common triggers of motor neuron disorders https://link.springer.com/article/10.10 ... 21-00401-6
Last edited by Petr75 on Thu Nov 18, 2021 12:42 am, edited 1 time in total.
https://www.eboro.cz/book-of-ms-2/
Petr75
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Re: Tropospheric ozone

Post by Petr75 »


Imagine Dragons - Wrecked
Last edited by Petr75 on Thu Nov 18, 2021 12:53 am, edited 1 time in total.
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Petr75
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Re: Tropospheric ozone

Post by Petr75 »

2021 Nov 11
Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, China
Long-term exposure to ozone and diabetes incidence: A longitudinal cohort study in China
https://pubmed.ncbi.nlm.nih.gov/34774942/

Conclusions: Our findings provided initial support for a positive and robust association between long-term exposure to O3 and diabetes incidence in a developing country. More scientific and social attention should be attached to the ozone-induced risks of diabetes occurrence.

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Diabetes Care 2006 Aug
1Endocrinology Sections, Saad Specialist Hospital, Al Khobar, Saudi Arabia
2Department of Endocrinology, Cleveland Clinic Foundation, Cleveland, Ohio
Prevalence of Diabetes in Patients With Multiple Sclerosis
https://care.diabetesjournals.org/content/29/8/1984.1

..The prevalence of type 2 diabetes was higher in MS patients, probably because of muscle disease from nerve demylination or use of ACTH and glucocorticoids as treatments. Several investigators have found some metabolic disorders linking both diseases, such as abnormalities in fat, calcium, and vitamin D metabolism. Also, there is evidence of disruption of myelin due to changes in glucose levels (2). Whether this observation has implications for a link between diabetes and MS is merely speculative, and further evidence of a relationship should be confirmed.
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Petr75
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Re: Tropospheric ozone

Post by Petr75 »

2019 Dec 13
Mitochondrial Bioenergetics in Brain Following Ozone Exposure in Rats Maintained on Coconut, Fish and Olive Oil-Rich Diets
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941048/

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2021 Nov 29
John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, UK
Mitochondrial dysfunction as a trigger of programmed axon death
https://pubmed.ncbi.nlm.nih.gov/34852932/

Abstract

Mitochondrial failure has long been associated with programmed axon death (Wallerian degeneration, WD), a widespread and potentially preventable mechanism of axon degeneration. While early findings in axotomised axons indicated that mitochondria are involved during the execution steps of this pathway, recent studies suggest that in addition, mitochondrial dysfunction can initiate programmed axon death without physical injury. As mitochondrial dysfunction is associated with disorders involving early axon loss, including Parkinson's disease, peripheral neuropathies, and multiple sclerosis, the findings that programmed axon death is activated by mitochondrial impairment could indicate the involvement of druggable mechanisms whose disruption may protect axons in such diseases. Here, we review the latest developments linking mitochondrial dysfunction to programmed axon death and discuss their implications for injury and disease.
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Petr75
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Re: Tropospheric ozone

Post by Petr75 »

2005 Feb 8
INSERM U558, Faculté de Médecine, France
Ozone air pollution is associated with acute myocardial infarction
https://pubmed.ncbi.nlm.nih.gov/15699276/

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2022 Jan 11
Fulton Science Academy, 3035 Fanfare Way, Alpharetta, USA
Role of interleukin-17 signaling pathway in the interaction between multiple sclerosis and acute myocardial infarction
https://pubmed.ncbi.nlm.nih.gov/35063907/

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The connection is only my private theory! Petr
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Petr75
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Posts: 1436
Joined: Sat Oct 19, 2013 10:17 am
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Re: Tropospheric ozone

Post by Petr75 »

18 November 2021
School of Public Health, Capital Medical University, China
The association between ozone and ischemic stroke morbidity among patients with type 2 diabetes in Beijing, China
https://www.sciencedirect.com/science/a ... 9721068091

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2022 Jan 6
Nanshan School, Guangzhou Medical University, China
Myocardial infarction and stroke risks in multiple sclerosis patients: A two-sample Mendelian randomization study
https://pubmed.ncbi.nlm.nih.gov/35066269/

Abstract
Observational studies indicated multiple sclerosis (MS) patients may have a higher risk of myocardial infarction (MI) and stroke than the general population, whereas the previously reported findings were inconsistent. Using two-sample Mendelian randomization (MR) analysis with genetic data from large-scale genome-wide association studies (International Multiple Sclerosis Genetics Consortium containing 14,498 MS cases, Coronary ARtery DIsease Genome wide Replication and Meta-analysis plus The Coronary Artery Disease Genetics consortium containing 43,676 MI cases and 40,585 stroke cases), we found that MS was causally associated with an increased risk of MI (OR = 1.03; 95%CI 1.00-1.06; P = 0.0243), directionally consistent in the weighted median, MR-Egger, and the MR-PRESSO methods. No causal association between MS and stroke was observed (OR = 1.01; 95%CI 0.99-1.04; P = 0.2974). Therefore, timelier and more effective measures should be conducted among MS patients to decrease the burden of both diseases.
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Petr75
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Re: Tropospheric ozone

Post by Petr75 »


Океан Ельзи - Місто Марії
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Petr75
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Re: Tropospheric ozone

Post by Petr75 »

November 2004
On the action of ozone on the haemoglobin prosthetic group, haemin and haematoporphyrin: A comparison with the synthetic copper phthalocyanines
https://www.researchgate.net/publicatio ... locyanines

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2022 May 13
Institute of Infection, Immunity and Inflammation, University of Glasgow, United Kingdom
Myelinated axons are the primary target of hemin-mediated oxidative damage in a model of the central nervous system

https://pubmed.ncbi.nlm.nih.gov/35569511/
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Petr75
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Re: Tropospheric ozone

Post by Petr75 »

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Petr75
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Re: Tropospheric ozone

Post by Petr75 »

2022 Jul 8
Department of General Surgery, Xiangya Hospital Central South University, Hunan, China
Association of Ozone Exposures with the risk of thyroid nodules in Hunan Province: a population-based cohort study
https://pubmed.ncbi.nlm.nih.gov/35799180/

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2021
Medically reviewed by Nancy Hammond, M.D.
The connection between multiple sclerosis and thyroid conditions
https://www.medicalnewstoday.com/articl ... s-the-link

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2009
Article in Russian
Pathology of the thyroid gland and multiple sclerosis: a possible influence on efficacy and tolerability of treatment
https://pubmed.ncbi.nlm.nih.gov/19156080/
https://www.eboro.cz/book-of-ms-2/
Petr75
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Re: Tropospheric ozone

Post by Petr75 »

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Petr75
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Re: Tropospheric ozone

Post by Petr75 »

O3
2022 Jul 15
Laboratorio de Neurofisiología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico
Curcumin Modifies the Activity of Plasmatic Antioxidant Enzymes and the Hippocampal Oxidative Profile in Rats upon Acute and Chronic Exposure to Ozone
https://pubmed.ncbi.nlm.nih.gov/35889405/

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MS
2019 Aug
Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran
Curcumin as a therapeutic candidate for multiple sclerosis: Molecular mechanisms and targets
https://pubmed.ncbi.nlm.nih.gov/30536381/
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Petr75
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Re: Tropospheric ozone

Post by Petr75 »

2022 Aug 21
Dept. of Neuroscience and Rehabilitation, University of Ferrara, Italy
Ubiquitination as a key regulatory mechanism for O 3-induced cutaneous redox inflammasome activation
https://pubmed.ncbi.nlm.nih.gov/36027676/

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14 October 2020
Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Italy
Overexpression of the ubiquitin-editing enzyme A20 in the brain lesions of Multiple Sclerosis patients: moving from systemic to central nervous system inflammation
https://onlinelibrary.wiley.com/doi/ful ... /bpa.12906

Abstract

Multiple Sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) in which inflammation plays a key pathological role. Recent evidences showed that systemic inflammation induces increasing cell infiltration within meninges and perivascular spaces in the brain parenchyma, triggering resident microglial and astrocytic activation. The anti-inflammatory enzyme A20, also named TNF associated protein 3 (TNFAIP3), is considered a central gatekeeper in inflammation and peripheral immune system regulation through the inhibition of NF-kB. The TNFAIP3 locus is genetically associated to MS and its transcripts is downregulated in blood cells in treatment-naïve MS patients. Recently, several evidences in mouse models have led to hypothesize a function of A20 also in the CNS. Thus, here we aimed to unveil a possible contribution of A20 to the CNS human MS pathology. By immunohistochemistry/immunofluorescence and biomolecular techniques on post-mortem brain tissue blocks obtained from control cases (CC) and progressive MS cases, we demonstrated that A20 is present in CC brain tissues in both white matter (WM) regions, mainly in few parenchymal astrocytes, and in grey matter (GM) areas, in some neuronal ...
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Petr75
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Re: Tropospheric ozone

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2022 Aug 20
The Cyprus Institute, Nicosia, Cyprus
Spatiotemporal variations of ozone exposure and its risks to vegetation and human health in Cyprus: an analysis across a gradient of altitudes
https://pubmed.ncbi.nlm.nih.gov/36033836/

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1991 May
Cyprus Institute of Neurology and Genetics, Nicosia
Multiple sclerosis in Cyprus
https://pubmed.ncbi.nlm.nih.gov/1865229/
https://www.eboro.cz/book-of-ms-2/
Petr75
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Re: Tropospheric ozone

Post by Petr75 »

2022 Aug 27
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, China
Ozone exposure induced risk of gestational diabetes mellitus
https://pubmed.ncbi.nlm.nih.gov/36041521/

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September 2009
journals.lww.com
Gestational Diabetes and Multiple Sclerosis
https://journals.lww.com/epidem/fulltex ... is.32.aspx
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