something even better than a blood test

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something even better than a blood test

Post by frodo » Thu Aug 03, 2017 1:41 am

If this is true, it would not only be the first reliable test for MS. It will also be much better than a blood test, or any other test under research (let alone those spinal taps!!)

Exhaled Breath Markers for Non-Imaging and Non-Invasive Measures for Detection of Multiple Sclerosis.

MS diagnosis is based on clinical characteristics and confirmed by examination of the cerebrospinal fluids or by magnetic resonance imaging of the brain and/or spinal cord. However, neither of the current diagnostic procedures are adequate as a routine tool to determine disease progression.

Thus, diagnostic biomarkers are needed. In the current study, a novel approach that could meet these expectations is presented. The approach is based on non-invasive analysis of volatile organic compounds (VOCs) in breath.

Exhaled breath was collected from 204 volunteers, 164 MS and 58 control individuals. Analysis was performed by: gas-chromatography mass-spectrometry (GC-MS) and nanomaterial-based sensors array. Predictive models were derived from the sensors, using Artificial Neural Networks. GC-MS analysis revealed significant differences in VOCs abundance between MS patients and Controls. Sensor data analysis on training sets were able to binary discriminate between MS patients and Controls with accuracies up-to 90%.

Blinded sets showed 95% positive predictive value between MS-remission and control and 100% sensitivity with 100% negative predictive value between MS not-treated (NT) and control, and 86% NPV between relapse and control.

More information in the etiology subforum:

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