Protein that inhibits the development of autoimmune disease
Protein that inhibits the development of autoimmune disease
Scientists have identified the elementary function of the protein, Caveolin-1 in the plasma membrane of B-cells, which prevents the development of autoimmune conditions...Read more - http://www.ms-uk.org/protein-inhibits-d ... discovered
Re: Protein that inhibits the development of autoimmune dise
Nature Immunology (2017) doi:10.1038/ni.3813
- Caveolin-1 (Cav1) regulates the nanoscale organization and compartmentalization of the plasma membrane. Here we found that Cav1 controlled the distribution of nanoclusters of isotype-specific B cell antigen receptors (BCRs) on the surface of B cells. In mature B cells stimulated with antigen, the immunoglobulin M BCR (IgM-BCR) gained access to lipid domains enriched for GM1 glycolipids, by a process that was dependent on the phosphorylation of Cav1 by the Src family of kinases. Antigen-induced reorganization of nanoclusters of IgM-BCRs and IgD-BCRs regulated BCR signaling in vivo. In immature Cav1-deficient B cells, altered nanoscale organization of IgM-BCRs resulted in a failure of receptor editing and a skewed repertoire of B cells expressing immunoglobulin-μ heavy chains with hallmarks of poly- and auto-reactivity, which ultimately led to autoimmunity in mice. Thus, Cav1 emerges as a cell-intrinsic regulator that prevents B cell–induced autoimmunity by means of its role in plasma-membrane organization.
-
- Similar Topics
- Replies
- Views
- Last post
-
- 4 Replies
- 262 Views
-
Last post by NHE
Mon Aug 05, 2019 3:33 pm
-
-
Lipoic acid inhibits B cell migration across BBB in RRMS
by NHE » Sun Sep 02, 2018 12:03 am » in Natural Approach - 2 Replies
- 999 Views
-
Last post by Petr75
Tue Jun 11, 2019 7:57 am
-
-
-
DHA Supports Brain Development and Protects Nerve Function
by ElliotB » Wed Jan 02, 2019 5:26 am » in General Discussion - 0 Replies
- 410 Views
-
Last post by ElliotB
Wed Jan 02, 2019 5:26 am
-
-
-
Holland approves cannabis chewing gum development programme
by MSUK » Mon Jan 29, 2018 1:44 am » in General Discussion - 0 Replies
- 1012 Views
-
Last post by MSUK
Mon Jan 29, 2018 1:44 am
-
-
- 0 Replies
- 934 Views
-
Last post by NHE
Mon Dec 03, 2018 10:12 pm
-
- 0 Replies
- 89 Views
-
Last post by Petr75
Sun Jun 30, 2019 6:11 am
-
-
Protein related to angiogenesis found in MS
by frodo » Thu May 09, 2019 4:53 am » in Chronic Cerebrospinal Venous Insufficiency (CCSVI) - 1 Replies
- 316 Views
-
Last post by Cece
Tue May 21, 2019 12:08 pm
-
-
-
Molecular mimicry between MOG & milk protein butyrophilin
by NHE » Sat Aug 17, 2019 5:07 pm » in General Discussion - 0 Replies
- 97 Views
-
Last post by NHE
Sat Aug 17, 2019 5:07 pm
-
-
-
Why Don't We Have a Vaccine Against Autoimmune Diseases?
by Petr75 » Fri Sep 27, 2019 10:07 pm » in General Discussion - 1 Replies
- 189 Views
-
Last post by Leonard
Sat Sep 28, 2019 12:12 am
-