The following article says that current DMTs (disease modifying therapies) do not alter the microglial activation which is the root problem. They only reduce the symptoms. Maybe this is the reason why they all fail in PPMS.
Neuroinflammation following disease modifying therapy in multiple sclerosis.
Source:http://www.jns-journal.com/article/S002 ... X/fulltext
The current results indicate that microglial activation may proceed in the entire brain of clinically stable MS patients even after receiving DMT.
Well. It could be. But maybe to inhibit microglial activation is wrong.tzootsi wrote:It is well known in medicine that vitamin D inhibits microglial activation.
This recent article says that microglial activation is directly produced by EBV infection. They have found the EBV DNA in the active lesions. If this is the case, to inhibit microglial activation could be even worse:
https://www.researchgate.net/profile/Ja ... sis-Lesion
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