Threonine, and succinic acid as treatments
Posted: Fri Dec 15, 2017 4:47 pm
Hey all.
Succinic acid an organic acid in the krebs cycle which is in most cells in our body is a good treatment for MS, and 99% of all other diseases in world. When talking about any disease one of the main things to treat it is increase ATP production in the mitochondria. The bulk of our ATP is made, and used by muscles, second is brain/heart so succinic acid is especially good for treating diseases of these system as it directly makes ATP in the electron transport chain.
And also the amino acid threonine treats tight muscles/MS
Here is a folder full of info on succinic acid. Click download in the top right to download all of it. In the text file succinic acid info is a good overview of it. I will just copy paste the first two small paragraphs
Inside the mitochondria, succinate is one of the most prominent intermediates of the Krebs
cycle. Succinate oxidation in mitochondria provides the most powerful energy output per
unit time. Extra-mitochondrial succinate triggers a host of succinate receptor (SUCN1 or
GPR91)-mediated signaling pathways in many peripheral tissues including the hypothalamus. One of the actions of succinate is to stabilize the hypoxia and cellular stress conditions by inducing the transcriptional regulator HIF-1a. Through these actions, it is hypothesized that succinate has the potential to restore the gradual but significant loss in functions associated with cellular senescence and systemic aging
Succinate is an essential component of the Krebs or citric acid cycle and serves an electron donor in the production of fumaric acid and FADH2. It also has been shown to be a good "natural" antibiotic because of its relative acidic or caustic nature (high concentrations can even cause burns). Succinate supplements have been shown to help reduce the effects of hangovers by activating the degradation of acetaldehyde - a toxic byproduct of alcohol metabolism - into CO2 and H2O through aerobic metabolism. Succinic acid has been shown to stimulate neural system recovery and bolster the immune system. Claims have also been made that it boosts awareness, concentration and reflexes.
https://www.dropbox.com/sh/pdmu6o6tw4yi ... zT1la?dl=0
And a study on threonine for MS. When doctors study a natural compound, and find it to be effective, instead of touting its benefits sometimes they try to downplay it but they can't deny the data so they end up using double/triple/quadruple speak. See if you can spot it here:
To determine whether the naturally occurring amino acid threonine, a potential precursor for glycine biosynthesis in the spinal cord, has an effect on spasticity in multiple sclerosis, 26 ambulatory patients were entered into a randomized crossover trial. Threonine administered at a total daily dose of 7.5 g reduced signs of spasticity on clinical examination, although no symptomatic improvement could be detected by the examining physician or the patient. In contrast to the side effects of sedation and increased motor weakness associated with antispasticity drugs commonly used for the treatment of multiple sclerosis, no side effects or toxic effects of threonine were identified
These data indicate that modest suppression of the clin¬ ical signs of spasticity in a population of patients with MS was achieved with oral administration of threonine. De¬ spite this effect, no improvement in symptoms of spastic¬ ity or in global neurologic function was associated with therapy. While the clinical effects observed in this trial do not support the use of threonine in the treatment of MS, the clear reduction of spasticity scores in treated patients sug¬ gests that additional studies, employing higher daily dos¬ ages or combination therapies, may identify a therapeutic role for this amino acid in the treatment of this disease.
http://sci-hub.la/10.1001/archneur.1992.00530330045014
Succinic acid an organic acid in the krebs cycle which is in most cells in our body is a good treatment for MS, and 99% of all other diseases in world. When talking about any disease one of the main things to treat it is increase ATP production in the mitochondria. The bulk of our ATP is made, and used by muscles, second is brain/heart so succinic acid is especially good for treating diseases of these system as it directly makes ATP in the electron transport chain.
And also the amino acid threonine treats tight muscles/MS
Here is a folder full of info on succinic acid. Click download in the top right to download all of it. In the text file succinic acid info is a good overview of it. I will just copy paste the first two small paragraphs
Inside the mitochondria, succinate is one of the most prominent intermediates of the Krebs
cycle. Succinate oxidation in mitochondria provides the most powerful energy output per
unit time. Extra-mitochondrial succinate triggers a host of succinate receptor (SUCN1 or
GPR91)-mediated signaling pathways in many peripheral tissues including the hypothalamus. One of the actions of succinate is to stabilize the hypoxia and cellular stress conditions by inducing the transcriptional regulator HIF-1a. Through these actions, it is hypothesized that succinate has the potential to restore the gradual but significant loss in functions associated with cellular senescence and systemic aging
Succinate is an essential component of the Krebs or citric acid cycle and serves an electron donor in the production of fumaric acid and FADH2. It also has been shown to be a good "natural" antibiotic because of its relative acidic or caustic nature (high concentrations can even cause burns). Succinate supplements have been shown to help reduce the effects of hangovers by activating the degradation of acetaldehyde - a toxic byproduct of alcohol metabolism - into CO2 and H2O through aerobic metabolism. Succinic acid has been shown to stimulate neural system recovery and bolster the immune system. Claims have also been made that it boosts awareness, concentration and reflexes.
https://www.dropbox.com/sh/pdmu6o6tw4yi ... zT1la?dl=0
And a study on threonine for MS. When doctors study a natural compound, and find it to be effective, instead of touting its benefits sometimes they try to downplay it but they can't deny the data so they end up using double/triple/quadruple speak. See if you can spot it here:
To determine whether the naturally occurring amino acid threonine, a potential precursor for glycine biosynthesis in the spinal cord, has an effect on spasticity in multiple sclerosis, 26 ambulatory patients were entered into a randomized crossover trial. Threonine administered at a total daily dose of 7.5 g reduced signs of spasticity on clinical examination, although no symptomatic improvement could be detected by the examining physician or the patient. In contrast to the side effects of sedation and increased motor weakness associated with antispasticity drugs commonly used for the treatment of multiple sclerosis, no side effects or toxic effects of threonine were identified
These data indicate that modest suppression of the clin¬ ical signs of spasticity in a population of patients with MS was achieved with oral administration of threonine. De¬ spite this effect, no improvement in symptoms of spastic¬ ity or in global neurologic function was associated with therapy. While the clinical effects observed in this trial do not support the use of threonine in the treatment of MS, the clear reduction of spasticity scores in treated patients sug¬ gests that additional studies, employing higher daily dos¬ ages or combination therapies, may identify a therapeutic role for this amino acid in the treatment of this disease.
http://sci-hub.la/10.1001/archneur.1992.00530330045014