Antioxidants reported as necessary
Re: Antioxidants reported as necessary
Brain injuries in multiple sclerosis (MS) involve immunopathological, structural and metabolic defects on myelin sheath, oligodendrocytes (OLs), axons and neurons suggesting that different cellular mechanisms ultimately result in the formation of MS plaques, demyelination, inflammation and brain damage. Bioenergetics, oxygen and ion metabolism dominate the metabolic and biochemical pathways that maintain neuronal viability and impulse transmission which directly or indirectly point to mitochondrial integrity and adenosine triphosphate (ATP) availability indicating the involvement of mitochondria in the pathogenesis of MS.
Re: Antioxidants reported as necessary
bouncing over from the pathogenesis/iron/zinc arena
non specific search for 2017 zeroes in on iron eg:
Mitochondria and Iron: current questions (2017)
http://www.tandfonline.com/doi/abs/10.1 ... 16.1268047
"...Much of our understanding of mitochondrial iron metabolism has been revealed by pathologies that disrupt normal iron metabolism. These conditions affect not only iron metabolism but mitochondrial function and systemic health. Therefore, this article also discusses these pathologies, including conditions of systemic and mitochondrial iron dysregulation as well as cancer..."
which brings us back to zinc and iron interactions (well, it brings *me* back to iron zinc interactions at least...)
which delivers as follows:
Low Plasma Zinc Is Associated with Higher Mitochondrial Oxidative Stress and Faster Liver Fibrosis Development in the Miami Adult Studies in HIV Cohort (2017)
http://jn.nutrition.org/content/147/4/556.short
"Plasma zinc deficiency was defined as <0.75 mg/L."
yikes. wonder what their stats would have looked like if they defined deficiency as <90
(so glad 90 is my hospital's lower cutoff, even though at 56 mg/L i still would have flagged deficient for zinc when i requested my first test...)
abstract is a little thin on the details; have full text access but no time to dig in right this sec
interesting nuance, if you're a croaker i guess:
Organ-specific effects of low-dose zinc pre-exposure on high-dose zinc induced mitochondrial dysfunction in large yellow croaker Pseudosciaena crocea (2017)
https://link.springer.com/article/10.10 ... 016-0319-y
sooo many interconnections
Zinc deficiency induces apoptosis via mitochondrial p53-and caspase-dependent pathways in human neuronal precursor cells (2015)
http://www.sciencedirect.com/science/ar ... 2X14001904
non specific search for 2017 zeroes in on iron eg:
Mitochondria and Iron: current questions (2017)
http://www.tandfonline.com/doi/abs/10.1 ... 16.1268047
"...Much of our understanding of mitochondrial iron metabolism has been revealed by pathologies that disrupt normal iron metabolism. These conditions affect not only iron metabolism but mitochondrial function and systemic health. Therefore, this article also discusses these pathologies, including conditions of systemic and mitochondrial iron dysregulation as well as cancer..."
which brings us back to zinc and iron interactions (well, it brings *me* back to iron zinc interactions at least...)
which delivers as follows:
Low Plasma Zinc Is Associated with Higher Mitochondrial Oxidative Stress and Faster Liver Fibrosis Development in the Miami Adult Studies in HIV Cohort (2017)
http://jn.nutrition.org/content/147/4/556.short
"Plasma zinc deficiency was defined as <0.75 mg/L."
yikes. wonder what their stats would have looked like if they defined deficiency as <90
(so glad 90 is my hospital's lower cutoff, even though at 56 mg/L i still would have flagged deficient for zinc when i requested my first test...)
abstract is a little thin on the details; have full text access but no time to dig in right this sec
interesting nuance, if you're a croaker i guess:
Organ-specific effects of low-dose zinc pre-exposure on high-dose zinc induced mitochondrial dysfunction in large yellow croaker Pseudosciaena crocea (2017)
https://link.springer.com/article/10.10 ... 016-0319-y
sooo many interconnections
Zinc deficiency induces apoptosis via mitochondrial p53-and caspase-dependent pathways in human neuronal precursor cells (2015)
http://www.sciencedirect.com/science/ar ... 2X14001904
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Re: Antioxidants reported as necessary
This fully aligns with my view on things http://www.thisisms.com/forum/general-d ... ml#p248066