Lipoic acid

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Lipoic acid

Post by frodo » Sun Dec 24, 2017 4:17 am

Effects of lipoic acid on migration of human B cells and monocyte-enriched peripheral blood mononuclear cells in relapsing remitting multiple sclerosis


•Monocytes are more migratory in RRMS populations compared to those in HC.
•Lipoic acid reduces monocyte and B cell migration in healthy control and RRMS samples.
•Lipoic acid may be able to reduce monocyte and B cell related disease progression in RRMS.


Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation and demyelination resulting in clinical disability. The rodent MS model suggests that infiltration of monocytes and B cells contributes to disease pathogenesis. Here, we compared the migratory capacity of human monocytes and B cells from healthy control (HC) and relapsing-remitting MS (RRMS) subjects, with or without lipoic acid (LA) treatment. Basal migration of monocyte-enriched PBMCs from RRMS subjects is significantly higher than HC PBMCs. LA treatment significantly inhibits monocyte and B cell migration in both cohorts, and may thus be therapeutically effective for treatment of MS.

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