that said - some patients need to guard against deficit:
- Association of Serum Manganese Levels with Alzheimer’s Disease and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis
https://www.mdpi.com/2072-6643/9/3/231/htm
"Our findings show that the serum Mn levels are lower in AD patients, and Mn deficiency may be a risk factor for AD."
- SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice
https://www.pnas.org/content/115/8/E1769.short
- Hypermanganesemia due to mutations in SLC39A14: further insights into Mn deposition in the central nervous system
https://ojrd.biomedcentral.com/articles ... 018-0758-x
- SLC39A8 deficiency: biochemical correction and major clinical improvement by manganese therapy
https://www.nature.com/articles/gim2017106
- Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN‐γ expression in activated human T cells
https://jlb.onlinelibrary.wiley.com/doi ... lb.1208759
maybe encouraging??:
- Blood Manganese Concentration is Elevated in Iron Deficiency Anemia Patients, Whereas Globus Pallidus Signal Intensity is Minimally Affected
https://www.sciencedirect.com/science/a ... 3X04000865