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It seems that it is a new drug on trials. Has anybody tried it?

Bryostatin-1 as a macrolide and marine natural product has been selected as a therapeutic choice. Studies indicate that Bryostatin-1 has anti-inflammatory and antioxidant properties and decreases MMPs level and BBB damage. Furthermore, Bryostatin-1 has a neuroprotective effect and promotes neurogenesis and differentiation of oligodendrocyte progenitor stem cells as a critical step for remyelination/ myelogenesis. Based on these properties, we hypothesized here that Bryostatin-1 is an effective treatment in multiple sclerosis.

https://www.frontiersin.org/articles/10 ... 5/abstract

Bryostatin-1 as a potential treatment for MS, Alzheimer's and other diseases is being developed by Neurotrope, https://neurotrope.com/.

In the end, to the best of our knowledge, the majority of studies about the effects of Bryostatin-1 are on the cellular level. Therefore, it is necessary to focus on the molecular events occurred after treatment of the cells with Bryostatin-1 in the future studies

It will take many years before getting any result...

zen2010 wrote: ↑Mon Jun 03, 2019 6:09 am

In the end, to the best of our knowledge, the majority of studies about the effects of Bryostatin-1 are on the cellular level. Therefore, it is necessary to focus on the molecular events occurred after treatment of the cells with Bryostatin-1 in the future studies

It will take many years before getting any result...

Neurotrope's stock drops 77% on Sep 9, 2019 due to their phase II trial for Alzheimer's failing to achieve statistical significance.

https://www.cnn.com/business/newsfeeds/ ... 64253.html

Maybe they'll focus some of their work on MS now.

Noticed this conflict in contents of “55 ways...myelin” post yesterday. Statins negatively impact myelination?? Link to 2008 study abstract referenced in that blog post.

https://www.ncbi.nlm.nih.gov/m/pubmed/19074034/

Anonymoose wrote: ↑Tue Sep 10, 2019 6:41 am Noticed this conflict in contents of “55 ways...myelin” post yesterday. Statins negatively impact myelination?? Link to 2008 study abstract referenced in that blog post.

https://www.ncbi.nlm.nih.gov/m/pubmed/19074034/

I'm not sure why bryostatin carries the statin name as a suffix. However, the two molecules have significantly different structures and likely have different biochemical activity.

Bryostatin:




Statin:

Doh! I automatically sighed and thought of old MS news and beating dead horses when I saw “statin.” I guess I’d better temper my cynicism w MS research or I might miss something good. Didn’t in this case though!