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has anybody heard about Bryostatin?

Posted: Wed May 30, 2018 10:41 pm
by frodo
It seems that it is a new drug on trials. Has anybody tried it?

Bryostatin-1 as a macrolide and marine natural product has been selected as a therapeutic choice. Studies indicate that Bryostatin-1 has anti-inflammatory and antioxidant properties and decreases MMPs level and BBB damage. Furthermore, Bryostatin-1 has a neuroprotective effect and promotes neurogenesis and differentiation of oligodendrocyte progenitor stem cells as a critical step for remyelination/ myelogenesis. Based on these properties, we hypothesized here that Bryostatin-1 is an effective treatment in multiple sclerosis.

https://www.frontiersin.org/articles/10 ... 5/abstract

Re: has anybody heard about Bryostatin?

Posted: Thu May 30, 2019 12:57 pm
by NHE
Bryostatin-1 as a potential treatment for MS, Alzheimer's and other diseases is being developed by Neurotrope, https://neurotrope.com/.

Re: has anybody heard about Bryostatin?

Posted: Mon Jun 03, 2019 6:09 am
by zen2010
In the end, to the best of our knowledge, the majority of studies about the effects of Bryostatin-1 are on the cellular level. Therefore, it is necessary to focus on the molecular events occurred after treatment of the cells with Bryostatin-1 in the future studies
It will take many years before getting any result...

Re: has anybody heard about Bryostatin?

Posted: Mon Sep 09, 2019 11:33 pm
by NHE
zen2010 wrote:
Mon Jun 03, 2019 6:09 am
In the end, to the best of our knowledge, the majority of studies about the effects of Bryostatin-1 are on the cellular level. Therefore, it is necessary to focus on the molecular events occurred after treatment of the cells with Bryostatin-1 in the future studies
It will take many years before getting any result...
Neurotrope's stock drops 77% on Sep 9, 2019 due to their phase II trial for Alzheimer's failing to achieve statistical significance.

https://www.cnn.com/business/newsfeeds/ ... 64253.html

Maybe they'll focus some of their work on MS now.

Re: has anybody heard about Bryostatin?

Posted: Tue Sep 10, 2019 6:41 am
by Anonymoose
Noticed this conflict in contents of “55 ways...myelin” post yesterday. Statins negatively impact myelination?? Link to 2008 study abstract referenced in that blog post.

https://www.ncbi.nlm.nih.gov/m/pubmed/19074034/

Re: has anybody heard about Bryostatin?

Posted: Tue Sep 10, 2019 7:05 am
by NHE
Anonymoose wrote:
Tue Sep 10, 2019 6:41 am
Noticed this conflict in contents of “55 ways...myelin” post yesterday. Statins negatively impact myelination?? Link to 2008 study abstract referenced in that blog post.

https://www.ncbi.nlm.nih.gov/m/pubmed/19074034/
I'm not sure why bryostatin carries the statin name as a suffix. However, the two molecules have significantly different structures and likely have different biochemical activity.

Bryostatin:

Image


Statin:

Image

Re: has anybody heard about Bryostatin?

Posted: Wed Sep 11, 2019 7:36 am
by Anonymoose
Doh! I automatically sighed and thought of old MS news and beating dead horses when I saw “statin.” I guess I’d better temper my cynicism w MS research or I might miss something good. Didn’t in this case though!