Rosemary for MS

[frodo]

Microglia activation is one of the problems in MS. It seems that a natural compound, Carnosol, found in Rosemary can prevent it. The authors speak about EAE, which is not even close to MS, but it could be interesting.

Carnosol modulates Th17 cell differentiation and microglia switch in experimental autoimmune encephalomyelitis

https://www.frontiersin.org/articles/10 ... 7/abstract

Small natural molecules derived from medicinal plants have long been considered as a rich pool of novel therapeutic medicine. Carnosol is a bioactive diterpene compound derived from Rosmarinus officinalis (Rosemary) and Salvia officinalis, herbs widely used in traditional medicine for the treatment of various inflammatory diseases.

In this study, we investigated the effects and mechanism of action of carnosol in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Carnosol treatment effectively ameliorated clinical disease severity in the myelin oligodendrocyte glycoprotein (MOG) 35–55 peptide-induced EAE model, significantly decreased inflammatory cell infiltration into the CNS and reduced demyelination.

Further, carnosol inhibited Th17 cell differentiation and STAT3 phosphorylation, and blocked transcription factor NF-κB nuclear translocation. In the passive-EAE model, carnosol treatment also significantly prevented Th17 cell pathogenicity. Moreover, carnosol exerted its therapeutic effects in the chronic stage of EAE, and, remarkably, switched the phenotypes of infiltrated macrophage/microglia.

Taken together, our findings demonstrate that carnosol has significant potential as a therapeutic agent for autoimmune diseases such as MS.

[David1949]

Well once again, EAE is not MS and the animal models (usually mice) are not human beings.

Let me know when there is something we can buy now that stops the progression of the disease. And if you really want to get our antennas up tell us about something that can fix the damage done by MS.

[frodo]

Well once again, EAE is not MS and the animal models (usually mice) are not human beings.

Let me know when there is something we can buy now that stops the progression of the disease. And if you really want to get our antennas up tell us about something that can fix the damage done by MS.

Agreed. EAE is a bad model and an unrelated disease. But the interesting part is not that EAE responded. The interesting part is this:

"... switched the phenotypes of infiltrated macrophage/microglia."

Even if MS is unrelated to EAE, switching the microglia phenotype could be good.