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Neuroimmunology Laboratory, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Reduced levels of Coco in sera of multiple sclerosis patients: A potential role in neuro-regeneration failure.
Demyelination, axonal loss and failure of tissue repair characterize MS lesions. Bone morphogenetic proteins (BMPs) signaling is associated with remyelination failure. Coco is one of the BMP antagonists. We found reduced Coco serum levels in relapsing-remitting MS (RR-MS) and primary progressive MS (PP-MS) patients compared to matched healthy controls (HC) and patients with rheumatoid arthritis. Exposure of P19 cells, in the presence of retinoic acid, BMP-2, or BMP-4 to Coco, at average sera level of MS patients failed to induce neuronal phenotype, in contrast to the average sera level of HC. Coco may be a player in the BMP dysregulation and the tissue repair failure in MS.
It's a protein that is naturally expressed that helps control the spread of cancers, like breast cancer, by modulating other proteins expressed in bone marrow. See https://www.ncbi.nlm.nih.gov/pubmed/125 ... t=Abstract
Probably a long way from being a conclusive element in MS development.