Antibiotics in early life disrupt gut flora and immune system
Antibiotics in early life disrupt gut flora and immune system
Antibiotics in early life disrupt gut flora and immune system in MS rat study
https://www.ms-uk.org/antibiotics-early ... -rat-study
A study has found that antibiotic use in early life may have subsequent unfavourable effects on gut flora and the regulation of the immune system.
An imbalance of gut flora has been considered the essential element in the development of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE).
In this study, published in the journal Nature Scientific Reports, antibiotics were administered orally to Dark Agouti (DA) rats early in their life with the aim of unsettling gut flora and investigating the effects of such intervention on the course of EAE.
As a result, the diversity of the gut flora was reduced under the influence of antibiotics. Mainly, Firmicutes and Actinobacteria were replaced by Proteobacteria and Bacteroidetes, while decreased proportions of Clostridia and Bacilli classes were accompanied by an increase in Gamma-Proteobacteria in antibiotic-treated animals.
Interestingly, a notable decrease in the Helicobacteraceae, Spirochaetaceae and Turicibacteriaceae was scored in antibiotic-treated groups. Also, levels of short chain fatty acids were reduced in the faeces of antibiotic-treated rats. Consequently, aggravation of EAE, paralleled with stronger immune response in lymph nodes draining the site of immunisation, and increased inflammation within the central nervous system (CNS), were observed in antibiotic-treated DA rats. As a result, the alteration of gut microbiota leads to an escalation of CNS-directed autoimmunity in DA rats.
Researchers concluded the results of this study indicate that antibiotic use in early life may have subsequent unfavourable effects on the regulation of the immune system. Further research using humans is needed to understand the true effects.
-
- Similar Topics
- Replies
- Views
- Last post
-
-
Disordered immune system and lipid metabolism in MS
by frodo » Tue Feb 05, 2019 2:38 am » in MS Etiology and Pathogenesis - 0 Replies
- 449 Views
-
Last post by frodo
Tue Feb 05, 2019 2:38 am
-
-
-
Western lifestyle: Possible link to antibiotics consumption
by frodo » Tue Jan 12, 2021 10:40 am » in MS Etiology and Pathogenesis - 0 Replies
- 42 Views
-
Last post by frodo
Tue Jan 12, 2021 10:40 am
-
-
- 0 Replies
- 440 Views
-
Last post by frodo
Wed Dec 18, 2019 6:53 am
-
- 0 Replies
- 228 Views
-
Last post by frodo
Wed May 13, 2020 8:06 am
-
- 20 Replies
- 2688 Views
-
Last post by robbie
Thu Aug 22, 2019 5:41 am
-
- 0 Replies
- 1739 Views
-
Last post by zen2010
Fri Feb 14, 2020 12:45 am
-
- 1 Replies
- 1155 Views
-
Last post by robbie
Thu Jun 20, 2019 9:04 am
-
- 0 Replies
- 6312 Views
-
Last post by NHE
Mon Oct 07, 2019 10:34 am
-
-
Early MS lesions: Astrocytes involved
by frodo » Wed Jun 19, 2019 3:33 am » in MS Etiology and Pathogenesis - 0 Replies
- 565 Views
-
Last post by frodo
Wed Jun 19, 2019 3:33 am
-