I am really sorry about these poor mice, but at least this is not an absolutely useless experiment, like those on EAE.
NOTE: This is not the first report about passing real MS to mice. See for example viewtopic.php?f=59&t=30985
Intrathecal delivery of primary progressive MS cerebrospinal fluid induces behavioral deficits and spinal cord pathology in mice
https://tischms.org/research/published/ ... id-induces
OBJECTIVE: To develop an animal model of primary progressive MS (PPMS) that exhibits characteristic pathology in the cervical spinal cord to better understand underlying disease pathogenesis.
DESIGN/METHODS: Cerebrospinal fluid (CSF) obtained from either PPMS or relapsing-remitting (RRMS) patients was administered to mice intrathecally.
CONCLUSIONS: Intrathecal delivery of PPMS CSF induces motor weakness and is accompanied by reactive astrogliosis, axonal damage and GLT-1 upregulation. This mouse model should enable further investigation of mechanisms underlying PPMS.
mouse model of PPMS with REAL MS
mouse model of PPMS with REAL MS
Last edited by frodo on Wed Jun 05, 2019 1:48 am, edited 4 times in total.
Re: mouse model of PPMS
Yea sorry for the mice. However I guess this is the only way they can really do research on it. Unlike the EAE just like you mentioned. What a complete waste of money and time that is. And life. But it is good for the big companies to treat the symptoms I guess, rather than looking for the root of a disease. Symptoms you can treat for life, cures are just not as profitable.
Re: mouse model of PPMS
Why wasn't this done 10 years ago though.....
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Re: mouse model of PPMS
It must be amazing to be a mouse. Pretty MUCH EVERYTHING cures you.
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