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HI FRIENDS
https://reliawire.com/clemastine-fumara ... Kztt0MYGgI

FDA approved antihistamine restores nervous system function in patient with chronic M.S
regards
seeva

This is old news...

+ the correct title should be "Clemastine Fumarate restores Myelin in RR MS"

Many PPMS (including me) have tried this med for several months, at the same dosage than the study (2 * 5.36 mg/day).
We haven't noticed any positive result.

I'm not saying it means CF definitely doesn't work for progressive ms, but keep in mind the study was performed on RR, not PP/SP

Whether Myelin is really restored by CLEMASTINE FUMARATE or not is yet to be proven. The major side effect of CLEMASTINE FUMARATE, drowsiness, is a major hurdle to deal with though.

BUT...

it has been found that Myelin does repair itself in time, slowly, up to about 8 years, but the fact that is does repair itself is exciting news!

ElliotB wrote: ↑Fri Mar 01, 2019 8:35 am Whether Myelin is really restored by CLEMASTINE FUMARATE or not is yet to be proven. The major side effect of CLEMASTINE FUMARATE, drowsiness, is a major hurdle to deal with though.

Clemastine is known to have anticholinergic activity and therefore may increase risks of dementia with long term use.

viewtopic.php?f=1&t=29484&p=249998#p249998

seeva wrote: ↑Thu Feb 28, 2019 7:21 pm CLEMASTINE FUMARATE RESTORES MYELIN IN M.S

It is really not important. Myelin is just the tip of the iceberg. The important therapy would be one that prevents cortical lesions and neuron damage.

More info...

https://www.neurologylive.com/view/clem ... ressive-ms

In the trial, investigators halted the clemastine arm because of 3 participants who increased in disability 5-times faster than compared with 18-month “baseline” progression slopes, ultimately triggering the protocol-defined safety stopping criteria. Authors noted that none of the remaining 55 patients treated for 106.9 patient-years with other TRAP-MS therapies had triggered the safety criteria. Notably, the patients treated with clemastine had increased erythrocyte sedimentation rate/C-reactive protein and gained weight. Investigators noted that this was corroborated by cerebrospinal fluid (CSF) proteomic profiling that demonstrated activation of innate immunity, increased purinergic/ATP signaling, and enhancement of immunogenic cell death, including pyroptosis.

https://encyclopedia.thefreedictionary.com/pyroptosis

Pyroptosis is a highly inflammatory form of lytic programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis can take place in immune cells and is also reported to occur in keratinocytes and some epithelial cells.

"High cholesterol level is essential for myelin membrane growth"

https://pubmed.ncbi.nlm.nih.gov/15793579/



"Analyzing the role of diet and exercise in myelin production"

https://www.mayoclinic.org/medical-prof ... c-20429394