VLA-2 blockade

[Petr75]

2019 Feb 19
Clinic of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany
Sanofi, Cambridge, MA, USA
VLA-2 blockade in vivo by vatelizumab induces CD4+FoxP3+ regulatory T cells
https://www.ncbi.nlm.nih.gov/pubmed/30783682

Abstract
Integrin α2β1, also known as Very Late Antigen (VLA)-2, is a collagen-binding molecule expressed constitutively on platelets. Vatelizumab, a monoclonal antibody targeting the α2 subunit (CD49b) of VLA-2, was recently investigated for its safety and efficacy during a Phase 2 clinical study in multiple sclerosis patients, as integrin-mediated collagen binding at the site of inflammation is central to a number of downstream pro-inflammatory events. In the course of this study, we could show that VLA-2 is expressed ex vivo on platelets, platelet-T-cell aggregates, as well as a small population of highly activated memory T cells. Even though the clinical trial did not meet its primary clinical endpoint (reduction in the cumulative number of new contrast-enhancing lesions on MRI), we observed enhanced frequencies of regulatory T cells (TREG) following vatelizumab treatment. Elevated TREG frequencies might be explained by the inhibition of p38 mitogen-activated protein kinase (MAPK) signaling, which is critically involved in the polarization of T helper 17 cells and is activated by the α2 integrin cytoplasmic domain. Our findings suggest that blockade of VLA-2 might be a way to safely shift the T helper 17 / TREG balance by inducing TREGin vivo.