Diet

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Petr75
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Re: Diet

Post by Petr75 » Fri Dec 27, 2019 10:30 am

2019 Jun
Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
The association between dietary sugar intake and neuromyelitis optica spectrum disorder: A case-control study.
https://www.ncbi.nlm.nih.gov/pubmed/30978652

Abstract
BACKGROUND:
Neuromyelitis optica spectrum disorder (NMOSD) is an uncommon autoimmune disease of the central nerves system (CNS) by inflammatory nature. The effects of high dietary sugar intake on inflammation and dysbiosis have been received more attention in recent years. The aim of the present study was to investigate the association between various types of dietary sugar intake and NMOSD odds and clinical features.
METHOD:
The current case-control study was conducted among 70 patients with definite NMOSD diagnosis based on 2015 international consensus criteria and 164 hospital-based controls. Demographic and anthropometric information in all participants and disease characteristics just in case group were obtained. Dietary data during the past year of study attendance was collected by a validated 168-item food frequency questionnaire. Participants were stratified into 3 tertiles according to each type of sugar intake and the third tertile considered as reference in multivariate regression models. The correlation between dietary sugar and disease features were analyzed using Pearson correlation test.
RESULTS:
The mean ± SD of total sugar intake increased from 80.73 ± 17.71 to 208.71 ± 57.93 g/day across tertiles of total sugar intake. In fully adjusted model, lower intake of sugar was associates with decreased odds of NMOSD in the first tertile vs third tertile by ORs of: 0.02(CI:0.00-0.08; p-for-trend:0.00), 0.02(CI:0.00-0.10; p-for-trend:0.00), 0.23(CI:0.08-0.61; p-for-trend:0.00), 0.19(CI:0.06-0.58; p-for-trend:0.00) and 0.16(CI:0.05-0.51; p-for-trend:0.00) for glucose, fructose, galactose, lactose and sucrose, respectively. The odds of NMOSD had a 1.72-fold (CI: 1.43-2.03; p-for-trend:0.00) significant raise per every 10 g increase for total sugar intake. There was no significant correlation between various types of dietary sugar intakes and relapse rate or patients' disability.
CONCLUSION:
The present study proposes a possible direct association between high intake of various sugar types and odds of suffering from NMOSD. More investigations are needed to prove this results.

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Petr75
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Re: Diet

Post by Petr75 » Sat Jan 18, 2020 5:58 am

2019 Dec 3
Section for Sport Science, Department of Public Health, Aarhus University, Aarhus, Denmark
Is diet associated with physical capacity and fatigue in persons with multiple sclerosis? -Results from a pilot study.
https://www.ncbi.nlm.nih.gov/pubmed/31951862

Abstract
BACKGROUND:
Diet may have immunomodulatory effects in persons with multiple sclerosis (PwMS) and studies suggest that diet may be considered a complementary treatment to control the progression of the disease. The role of nutrition in MS and related symptoms have been reported by several studies but remains controversial.
OBJECTIVE:
To explore the association between dietary intake and physical capacity and fatigue in PwMS.
METHODS:
An explorative cross-sectional pilot study was conducted, in which 23 ambulatory PwMS were enrolled. Dietary intake was assessed using a 4-day food record. Outcome variables included a 6-Minute Walk Test (6MWT), a VO2max test, and self-reported questionnaires assessing fatigue severity (Fatigue Severity Scale, FSS) and impact (Modified Fatigue Impact Scale, MFIS). Associations between variables were determined using simple and multiple regression analyses.
RESULTS:
In the simple but not the multiple (adjusted for sex and age) regression analyses the carbohydrate intake (% of total energy intake) was positively associated with physical capacity (i.e. the 6MWT and VO2max test), whereas fat intake (% of total energy intake) was inversely associated with physical capacity. In the multiple regression analyses the absolute intake of ω-3 and vitamin D showed trends towards a positive association with the MFIS physical subscale and VO2max, respectively.
CONCLUSION:
Although not consistent across analyses, these findings suggest that better physical capacity most often is associated with a diet rich in carbohydrates and reduced fat content. Further research and randomized controlled trials are required to fully assess the role and the efficacy of diet quality and content on physical capacity in PwMS.

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Petr75
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Re: Diet

Post by Petr75 » Mon Jan 27, 2020 9:27 am

2020 Jan 23
Doctoral Degree School, Catholic University of Valencia San Vicente Martir, Spain
The Impact of Coconut Oil and Epigallocatechin Gallate on the Levels of IL-6, Anxiety and Disability in Multiple Sclerosis Patients
https://pubmed.ncbi.nlm.nih.gov/3197930 ... -patients/

Abstract

Background: Due to the inflammatory nature of multiple sclerosis (MS), interleukin 6 (IL-6) is high in blood levels, and it also increases the levels of anxiety related to functional disability. Epigallocatechin gallate (EGCG) decreases IL-6, which could be enhanced by the anti-inflammatory effect of high ketone bodies after administering coconut oil (both of which are an anxiolytic). Therefore, the aim of this study was to assess the impact of coconut oil and EGCG on the levels of IL-6, anxiety and functional disability in patients with MS.
Methods: A pilot study was conducted for four months with 51 MS patients who were randomly divided into an intervention group and a control group. The intervention group received 800 mg of EGCG and 60 mL of coconut oil, and the control group was prescribed a placebo. Both groups followed the same isocaloric Mediterranean diet. State and trait anxiety were determined before and after the study by means of the State-Trait Anxiety Inventory (STAI). In addition, IL-6 in serum was measured using the ELISA technique and functional capacity was determined with the Expanded Disability Status Scale (EDSS) and the body mass index (BMI).
Results: State anxiety and functional capacity decreased in the intervention group and IL-6 decreasedin both groups.
Conclusions: EGCG and coconut oil improve state anxiety and functional capacity. In addition, a decrease in IL-6 is observed in patients with MS, possibly due to the antioxidant capacity of the Mediterranean diet and its impact on improving BMI.

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Petr75
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Re: Diet

Post by Petr75 » Mon Feb 10, 2020 10:42 am

2020 Jan 26
Department of Public Health, Aarhus University, Bartholins Allé 2, Denmark; Hammel Neurorehabilitation Centre and University Research Clinic, Denmark
Diet Quality Is Not Associated With Late-Onset Multiple Sclerosis Risk- A Danish Cohort Study
https://pubmed.ncbi.nlm.nih.gov/3203536 ... ort-study/

Abstract

Background: Multiple sclerosis (MS) onset is commonly observed in adults aged 20-50 years of age. The incidence rate of MS-onset after age 50, late-onset MS, has increased along with the observed overall increase in MS incidence rate in the past 60 years. In general, the aetiology of MS is largely acknowledged to involve a complex interrelation of environmental and modifiable lifestyle risk factors in genetically susceptible individuals. Smoking is an established risk factor, while the role of the diet in the aetiology of MS remains inconclusive. However, even less is known about the role of diet and smoking in the aetiology of late-onset MS as this subgroup of patients has not gained much attention in the scientific literature. Therefore, the objective of this study was to investigate the association between diet quality and the hazards of late-onset MS diagnosis in relation to smoking habits, thus attempting to identify high-risk individuals.
Methods: The study was a prospective cohort study based on the Danish cohort Diet, Cancer and Health including middle-aged individuals (50-64 years) born and residing in Denmark. Cox' proportional hazards models were used to estimate the hazard ratios (HR) for tertiles of diet quality, assessed by means of the Alternative Healthy Eating Index-2010. Information on time-at-risk and diagnosis of MS was collected based on linked information from the Danish Civil Registration System and Danish National Patient Registry. Additionally, a stratified analysis according to smoking status (current smokers, former smokers and never smokers) was conducted while adjusting for sex.

Results: A total of 56,867 individuals were followed for a median of 20.4 years. During follow-up, 124 individuals were diagnosed with late-onset MS. No statistically significant association was found between diet quality at baseline and the hazard of MS diagnosis in adjusted analyses (HR highest vs lowest diet quality tertile: 0.79; 95%CI: 0.49-1.27, Test for trend: p = 0.22). Smoking status did not modify the association.

Conclusion: In this cohort of middle-aged Danes, diet quality was neither statistically significantly associated with the hazards of late-onset MS diagnosis in the entire sample, nor in sub-groups of current smokers, former smokers or never smokers.

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Petr75
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Re: Diet

Post by Petr75 » Sat Feb 22, 2020 12:01 am

2020 Jan 28
Department of Drug Sciences, University of Pavia, Pavia, Italy
Modulation of Keap1/Nrf2/ARE Signaling Pathway by Curcuma- And Garlic-Derived Hybrids
https://pubmed.ncbi.nlm.nih.gov/3204743 ... d-hybrids/

Abstract

Nrf2 is a basic leucine zipper transcription factor that binds to the promoter region of the antioxidant response element (ARE), inducing the coordinated up-regulation of antioxidant and detoxification genes. We recently synthesized a set of new molecules by combining the functional moieties of curcumin and diallyl sulfide, both known to induce the expression of antioxidant phase II enzymes by activating Nrf2 pathway. The aim of the study is to investigate the ability of such compounds to activate Keap1/Nrf2/ARE cytoprotective pathway, in comparison with two reference Nrf2-activators: curcumin and dimethyl fumarate, a drug approved for the treatment of relapsing-remitting multiple sclerosis. Furthermore, since Nrf2 pathway is known to be regulated also by epigenetic modifications, including key modifications in microRNA (miRNA) expression, the effects of the hybrids on the expression levels of selected miRNAs, associated with Nrf2 signaling pathway have also been investigated. The results show that compounds exert antioxidant effect by activating Nrf2 signaling pathway and inducing the ARE-regulated expression of its downstream target genes, such as HO-1 and NQO1, with two hybrids to a higher extent than curcumin. In addition, some molecules induce changes in the expression levels of miR-125b-5p, even if to a lesser extent than curcumin. However, no changes have been observed in the expression levels of mRNA coding for glutathione synthetase, suggesting that the modulation of this mRNA is not strictly under the control of miR-125b-5p, which could be influenced by other miRNAs.

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NHE
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Re: Diet

Post by NHE » Sat Feb 22, 2020 6:30 am

Petr75 wrote:
Sat Feb 22, 2020 12:01 am
2020 Jan 28
Department of Drug Sciences, University of Pavia, Pavia, Italy
Modulation of Keap1/Nrf2/ARE Signaling Pathway by Curcuma- And Garlic-Derived Hybrids
https://pubmed.ncbi.nlm.nih.gov/3204743 ... d-hybrids/

Free full text. https://www.ncbi.nlm.nih.gov/pmc/articl ... -01597.pdf

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