Air pollution

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Petr75
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Air pollution

Post by Petr75 » Fri May 10, 2019 11:18 am

2019 Apr 5
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China
Emerging role of air pollution in autoimmune diseases.
https://www.ncbi.nlm.nih.gov/pubmed/30959217

Abstract
Autoimmune diseases (ADs) are a broad spectrum of disorders featured by the body's immune responses being directed against its own tissues, resulting in prolonged inflammation and subsequent tissue damage. Recently, the exposure to ambient air pollution has been implicated in the occurrence and development of ADs. Mechanisms linking air pollution exposures and ADs mainly include systemic inflammation, increased oxidative stress, epigenetic modifications induced by exposures and immune response caused by airway damage. The lung may be an autoimmunity initiation site in autoimmune diseases (ADs). Air pollutants can bind to the Aryl hydrocarbon receptor (AHR) to regulate Th17 and Treg cells. Oxidative stress and inducible bronchus associated lymphoid tissue caused by the pollutants can influence T, B cells, resulting in the production of proinflammatory cytokines. These cytokines stimulate B cell and dendritic cells, resulting in a lot of antibodies and self-reactive T lymphocytes. Moreover, air pollutants may induce epigenetic changes to contribute to ADs. In this review, we will concern the associations between air pollution and immune-inflammatory responses, as well as mechanisms linking air pollution exposure and autoimmunity. In addition, we focus on the potential roles of air pollution in major autoimmune diseases including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), and type 1 diabetes mellitus (T1DM).

dav75
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Re: Air pollution

Post by dav75 » Fri Jun 07, 2019 2:10 am

Thank you, this sheds some light on my condition. I breathed a chemical for 3 months in a new truck i was given. Something must have been leaking into the cabin which was like a burning plastic smell without the smoke. I had driven about 30 other trucks of same type and only smelt this in one other. A driver told me he believes it is a leaking chemical from the emissions cleaning system. The label reads, "Don't touch or breath this chemical". Had bad headaches for 3 months before they sent the truck to another state. My whole nervous system reacted shortly after and my lungs produced a thick clear jelly. I had all MS type symptoms and would fall over a few times a day. No strength in limbs and crushing fatigue. I had so many symptoms that the Dr. thought i was a hypochondriac and dismissed my search for answers. Now 5 years on i still fall over suddenly but only once or so a week. The lungs have gotten bad as i couldn't breath properly for 3 weeks a few months ago and since then have diminished breathing.The thick jelly from my inflamed lungs is ever coming out. I still struggle with all sorts of things like partially numb legs and nerve burning thru whole body and random muscle twitching, etc. etc. I fell over in the office at work today and since this has happened 3 times in 2 weeks, the boss asked me if i could see the company Dr. That could mean I loose my job if they deem me unfit to work.

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