This Is MS Multiple Sclerosis Knowledge & Support Community

2019
FGBE 'National Medical Research Centre V.A. Almazov', St.-Petersburg, Russia; Military Medical Academy S.M. Kirov, St.-Petersburg, Russia
Progress and prospects of metabolic therapy in multiple sclerosis
https://www.ncbi.nlm.nih.gov/pubmed/31089100

Abstract
Side-effects and incomplete response to standard therapy of patients with multiple sclerosis (MS) stimulate the development of an alternative therapy, that influences, in particular, metabolic functions of MS patients. Metabolic therapy (vitamins, antioxidants and others) have been used for a long time in neurologic practice for the treatment of MS on the basis of pathophysiological mechanisms, positive clinical experience, low rate of side-effects and practical availability. Recent objective scientific data explain the necessity of correction of the disturbed metabolic profile (metabolome) in MS, and the first evidence of the efficacy of several metabolic agents, particularly, biotin and vitamin D, was shown. Taking into account the mechanisms of action and clinical experience, the authors consider the prospects of using the combined medicine cytoflavin, that contains succinate, nicotinamide, riboflavin and inosine, in metabolic therapy of MS.

hmm the inosine uric acid thing.... i am so glad i never tracked down inosine. as a precursor it might have increased characteristic low uric acid levels seen in ms, but it wouldn't have and couldn't have addressed all the other tasks fulfilled by essential zinc. personally, my system was missing zinc. when i topped that up, the uric acid level optimized in lockstep. i had spent years fighting with serum uric acid well below 200 umol/l and even below the ms average at times. zinc got it up into the 270s in a snap. no inosine required!