Why Don't We Have a Vaccine Against Autoimmune Diseases?

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Petr75
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Why Don't We Have a Vaccine Against Autoimmune Diseases?

Post by Petr75 » Fri Sep 27, 2019 10:07 pm

2019
Roseman University College of Medicine, Las Vegas
Why Don't We Have a Vaccine Against Autoimmune Diseases? - A Review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640150/

Abstract
This review examines some of the reasons why we don't have a vaccine against autoimmune diseases and highlights the progress that has been made. Many autoimmune diseases, such as rheumatoid arthritis (RA), multiple sclerosis (MS) and type 1 diabetes (T1D), are driven by autoimmune T cell responses. Unlike vaccines for most infectious diseases, which elicit antibody responses, are intended for immuno-naive individuals and considered preventative, a vaccine for an autoimmune disease must be therapeutic and resolve or control the on-going autoimmune response and condition in the diseased host. Despite these differences, many of the same considerations for infectious disease vaccines must also be addressed to develop a therapeutic vaccine for autoimmune diseases. The disease initiator/triggers, antigens and autoantigens, nature of the immunopathogenic and protective/therapeutic immune response will be compared for infectious and autoimmune diseases as will approaches for developing vaccines including formulations, animal models and indicators of success. The rationale for a therapeutic vaccine for RA will be discussed in greater detail with a relatively limited discussion of T1D, MS and other autoimmune diseases.

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Leonard
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Re: Why Don't We Have a Vaccine Against Autoimmune Diseases?

Post by Leonard » Sat Sep 28, 2019 12:12 am

https://pdfs.semanticscholar.org/0e4f/f ... e44f6f.pdf

Vaccination and Autoimmunity—‘Vaccinosis’: A Dangerous Liaison?

quote
The question of a connection between vaccination and autoimmune illness (or phenomena) is surrounded by controversy. A heated debate is going on regarding the causality between vaccines, such as measles and anti-hepatits B virus (HBV), and multiple sclerosis (MS). Brain antibodies as well as clinical symptoms have been found in patients vaccinated against those diseases. Other autoimmune illnesses have been associated with vaccinations. Tetanus toxoid, influenza vaccines, polio vaccine, and others, have been related to phenomena ranging from autoantibodies production to full-blown illness (such as rheumatoid arthritis (RA)). Conflicting data exists regarding also the connection between autism and vaccination with measles vaccine.


As regards the remark on autism: 100 years ago, the incidence of autism was about 1:10,000. Now it is about 1:100.
There is a doctor in the US who has about 3,500 patients who were not vaccinated for measles. The total number of people with an autism: ZERO where you would expect about 35!

The role of Toll like Receptors ligands including TLR ligands from the microbiota and other vaccine adjuvants is of particular concern

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